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Why doesn't Atlas offer CBU 4/6 search where locus A and B are antigen-matched, and DRB1 is allele matched? |
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Historically, CBU search consisted of performing a 4/6 search with antigen-level matching at locus A and B, and allele-level matching at DRB1 (a.k.a. "classical" or "low-high" CBU search). However, the latest guidelines for CBU search recommend running 4/8 search at the allele-level at all loci, which is what Atlas supports. See linked documents below for detailed guidance: BSHI guidelines pdf_Jan2021.pdf; p3, table 1, 9.2.2 & p14, section 9.2.2 US CBU selection guidelines_July 2020_Politicos_Barker.pdf; p5-6 Update (02/05/2023): matching remains at the allele level, however scoring has now been extended to calculate whether a position is antigen matched or not. This can be used in conjunction with mismatch CBU search to rank/filter for those units that maybe allele mismatched at class I loci but are still antigen matched. See #884 for more info. |
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Historically, CBU search consisted of performing a 4/6 search with antigen-level matching at locus A and B, and allele-level matching at DRB1 (a.k.a. "classical" or "low-high" CBU search).
However, the latest guidelines for CBU search recommend running 4/8 search at the allele-level at all loci, which is what Atlas supports.
See linked documents below for detailed guidance:
BSHI guidelines pdf_Jan2021.pdf; p3, table 1, 9.2.2 & p14, section 9.2.2
US CBU selection guidelines_July 2020_Politicos_Barker.pdf; p5-6
Update (02/05/2023): matching remains at the allele level, however scoring has now been extended to calculate whether a position is antigen matched or not. This can be used in conjun…