diff --git a/packages/rum-core/src/domain/view/viewMetrics/trackScrollMetrics.ts b/packages/rum-core/src/domain/view/viewMetrics/trackScrollMetrics.ts
index f9379b2a14..11b70fde20 100644
--- a/packages/rum-core/src/domain/view/viewMetrics/trackScrollMetrics.ts
+++ b/packages/rum-core/src/domain/view/viewMetrics/trackScrollMetrics.ts
@@ -102,7 +102,9 @@ export function createScrollValuesObservable(
 
       const observerTarget = document.scrollingElement || document.documentElement
       const resizeObserver = new ResizeObserver(monitor(throttledNotify.throttled))
-      resizeObserver.observe(observerTarget)
+      if (observerTarget) {
+        resizeObserver.observe(observerTarget)
+      }
       const eventListener = addEventListener(configuration, window, DOM_EVENT.SCROLL, throttledNotify.throttled, {
         passive: true,
       })
diff --git a/test/e2e/lib/framework/index.ts b/test/e2e/lib/framework/index.ts
index 27ce98ee34..35e8a53f9d 100644
--- a/test/e2e/lib/framework/index.ts
+++ b/test/e2e/lib/framework/index.ts
@@ -5,3 +5,4 @@ export { getTestServers, waitForServersIdle } from './httpServers'
 export { flushEvents } from './flushEvents'
 export { waitForRequests } from './waitForRequests'
 export { LARGE_RESPONSE_MIN_BYTE_SIZE } from './serverApps/mock'
+export { RUM_BUNDLE } from './sdkBuilds'
diff --git a/test/e2e/scenario/rum/s8sInject.scenario.ts b/test/e2e/scenario/rum/s8sInject.scenario.ts
new file mode 100644
index 0000000000..b13c1d76fc
--- /dev/null
+++ b/test/e2e/scenario/rum/s8sInject.scenario.ts
@@ -0,0 +1,41 @@
+import * as fs from 'fs'
+import { RUM_BUNDLE } from '../../lib/framework'
+import { APPLICATION_ID, CLIENT_TOKEN } from '../../lib/helpers/configuration'
+
+describe('Inject RUM with Puppeteer', () => {
+  // S8s tests inject RUM with puppeteer evaluateOnNewDocument
+  it('should not throw error in chrome', async () => {
+    const isInjected = await injectRumWithPuppeteer()
+    expect(isInjected).toBe(true)
+  })
+})
+
+async function injectRumWithPuppeteer() {
+  const ddRUM = fs.readFileSync(RUM_BUNDLE, 'utf8')
+  const puppeteerBrowser = await browser.getPuppeteer()
+  let injected = true
+
+  await browser.call(async () => {
+    const page = await puppeteerBrowser.newPage()
+    await page.evaluateOnNewDocument(
+      `
+        if (location.href !== 'about:blank') {
+          ${ddRUM}
+          window.DD_RUM._setDebug(true)
+          window.DD_RUM.init({
+            applicationId: ${APPLICATION_ID},
+            clientToken: ${CLIENT_TOKEN},
+          })
+          window.DD_RUM.startView()
+        }
+      `
+    )
+    page.on('console', (msg) => {
+      if (msg.type() === 'error') {
+        injected = false
+      }
+    })
+    await page.goto('https://webdriver.io')
+  })
+  return injected
+}
diff --git a/test/e2e/wdio.bs.conf.ts b/test/e2e/wdio.bs.conf.ts
index 5b48fa81ac..3e369cd75f 100644
--- a/test/e2e/wdio.bs.conf.ts
+++ b/test/e2e/wdio.bs.conf.ts
@@ -7,7 +7,7 @@ export const config: Options.Testrunner = {
   ...baseConfig,
 
   specFileRetries: 1,
-
+  exclude: [...baseConfig.exclude!, './scenario/rum/s8sInject.scenario.ts'],
   capabilities: browserConfigurations.map((configuration) =>
     // See https://www.browserstack.com/automate/capabilities?tag=selenium-4
     // Make sure to look at the "W3C Protocol" tab