diff --git a/packages/core/src/domain/automaticErrorCollection.ts b/packages/core/src/domain/automaticErrorCollection.ts
index ab998c9f60..18934372da 100644
--- a/packages/core/src/domain/automaticErrorCollection.ts
+++ b/packages/core/src/domain/automaticErrorCollection.ts
@@ -3,7 +3,7 @@ import { resetXhrProxy, startXhrProxy, XhrCompleteContext } from '../browser/xhr
 import { ErrorSource, formatUnknownError, RawError, toStackTraceString } from '../tools/error'
 import { Observable } from '../tools/observable'
 import { jsonStringify, ONE_MINUTE, RequestType } from '../tools/utils'
-import { Configuration, isIntakeRequest } from './configuration'
+import { Configuration } from './configuration'
 import { monitor } from './internalMonitoring'
 import { computeStackTrace, Handler, report, StackTrace } from './tracekit'
 
@@ -94,7 +94,7 @@ export function trackNetworkError(configuration: Configuration, errorObservable:
   startFetchProxy().onRequestComplete((context) => handleCompleteRequest(RequestType.FETCH, context))
 
   function handleCompleteRequest(type: RequestType, request: XhrCompleteContext | FetchCompleteContext) {
-    if (!isIntakeRequest(request.url, configuration) && (isRejected(request) || isServerError(request))) {
+    if (!configuration.isIntakeUrl(request.url) && (isRejected(request) || isServerError(request))) {
       errorObservable.notify({
         message: `${format(type)} error ${request.method} ${request.url}`,
         resource: {
diff --git a/packages/core/src/domain/configuration.spec.ts b/packages/core/src/domain/configuration.spec.ts
index a063e19f08..b9936680ba 100644
--- a/packages/core/src/domain/configuration.spec.ts
+++ b/packages/core/src/domain/configuration.spec.ts
@@ -1,5 +1,5 @@
 import { BuildEnv, BuildMode, Datacenter } from '../boot/init'
-import { buildConfiguration, isIntakeRequest } from './configuration'
+import { buildConfiguration } from './configuration'
 
 describe('configuration', () => {
   const clientToken = 'some_client_token'
@@ -52,9 +52,9 @@ describe('configuration', () => {
 
   describe('proxyHost', () => {
     it('should replace endpoint host add set it as a query parameter', () => {
-      const configuration = buildConfiguration({ clientToken, proxyHost: 'proxy.io' }, usEnv)
+      const configuration = buildConfiguration({ clientToken, site: 'datadoghq.eu', proxyHost: 'proxy.io' }, usEnv)
       expect(configuration.rumEndpoint).toMatch(/^https:\/\/proxy\.io\//)
-      expect(configuration.rumEndpoint).toContain('?ddhost=rum-http-intake.logs.datadoghq.com&')
+      expect(configuration.rumEndpoint).toContain('?ddhost=rum-http-intake.logs.datadoghq.eu&')
     })
   })
 
@@ -104,31 +104,68 @@ describe('configuration', () => {
     })
   })
 
-  describe('isIntakeRequest', () => {
+  describe('isIntakeUrl', () => {
     it('should not detect non intake request', () => {
       const configuration = buildConfiguration({ clientToken }, usEnv)
-      expect(isIntakeRequest('https://www.foo.com', configuration)).toBe(false)
+      expect(configuration.isIntakeUrl('https://www.foo.com')).toBe(false)
     })
 
-    it('should detect intake request', () => {
+    it('should detect intake request for EU site', () => {
+      const configuration = buildConfiguration({ clientToken, site: 'datadoghq.eu' }, usEnv)
+      expect(configuration.isIntakeUrl('https://rum-http-intake.logs.datadoghq.eu/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://browser-http-intake.logs.datadoghq.eu/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://public-trace-http-intake.logs.datadoghq.eu/v1/input/xxx')).toBe(true)
+    })
+
+    it('should detect intake request for US site', () => {
       const configuration = buildConfiguration({ clientToken }, usEnv)
-      expect(isIntakeRequest('https://rum-http-intake.logs.datadoghq.com/v1/input/xxx', configuration)).toBe(true)
-      expect(isIntakeRequest('https://browser-http-intake.logs.datadoghq.com/v1/input/xxx', configuration)).toBe(true)
-      expect(isIntakeRequest('https://public-trace-http-intake.logs.datadoghq.com/v1/input/xxx', configuration)).toBe(
+
+      expect(configuration.isIntakeUrl('https://rum-http-intake.logs.datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://browser-http-intake.logs.datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://public-trace-http-intake.logs.datadoghq.com/v1/input/xxx')).toBe(true)
+    })
+
+    it('should detect alternate intake domains for US site', () => {
+      const configuration = buildConfiguration({ clientToken, useAlternateIntakeDomains: true }, usEnv)
+      expect(configuration.isIntakeUrl('https://rum.browser-intake-datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://logs.browser-intake-datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://trace.browser-intake-datadoghq.com/v1/input/xxx')).toBe(true)
+    })
+
+    it('should handle sites with subdomains and classic intake', () => {
+      const configuration = buildConfiguration({ clientToken, site: 'us3.datadoghq.com' }, usEnv)
+      expect(configuration.isIntakeUrl('https://rum-http-intake.logs.us3.datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://browser-http-intake.logs.us3.datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://public-trace-http-intake.logs.us3.datadoghq.com/v1/input/xxx')).toBe(
         true
       )
     })
 
+    it('should handle sites with subdomains and alternate intake', () => {
+      const configuration = buildConfiguration(
+        { clientToken, site: 'us3.datadoghq.com', useAlternateIntakeDomains: true },
+        usEnv
+      )
+      expect(configuration.isIntakeUrl('https://rum.browser-intake-us3-datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://logs.browser-intake-us3-datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://trace.browser-intake-us3-datadoghq.com/v1/input/xxx')).toBe(true)
+    })
+
     it('should detect proxy intake request', () => {
       let configuration = buildConfiguration({ clientToken, proxyHost: 'www.proxy.com' }, usEnv)
-      expect(isIntakeRequest('https://www.proxy.com/v1/input/xxx', configuration)).toBe(true)
+      expect(configuration.isIntakeUrl('https://www.proxy.com/v1/input/xxx')).toBe(true)
+      configuration = buildConfiguration(
+        { clientToken, proxyHost: 'www.proxy.com', useAlternateIntakeDomains: true },
+        usEnv
+      )
+      expect(configuration.isIntakeUrl('https://www.proxy.com/v1/input/xxx')).toBe(true)
       configuration = buildConfiguration({ clientToken, proxyHost: 'www.proxy.com/custom/path' }, usEnv)
-      expect(isIntakeRequest('https://www.proxy.com/custom/path/v1/input/xxx', configuration)).toBe(true)
+      expect(configuration.isIntakeUrl('https://www.proxy.com/custom/path/v1/input/xxx')).toBe(true)
     })
 
     it('should not detect request done on the same host as the proxy', () => {
       const configuration = buildConfiguration({ clientToken, proxyHost: 'www.proxy.com' }, usEnv)
-      expect(isIntakeRequest('https://www.proxy.com/foo', configuration)).toBe(false)
+      expect(configuration.isIntakeUrl('https://www.proxy.com/foo')).toBe(false)
     })
 
     it('should detect replica intake request', () => {
@@ -136,12 +173,25 @@ describe('configuration', () => {
         { clientToken, site: 'foo.com', replica: { clientToken } },
         { ...usEnv, buildMode: BuildMode.STAGING }
       )
-      expect(isIntakeRequest('https://rum-http-intake.logs.foo.com/v1/input/xxx', configuration)).toBe(true)
-      expect(isIntakeRequest('https://browser-http-intake.logs.foo.com/v1/input/xxx', configuration)).toBe(true)
-      expect(isIntakeRequest('https://public-trace-http-intake.logs.foo.com/v1/input/xxx', configuration)).toBe(true)
+      expect(configuration.isIntakeUrl('https://rum-http-intake.logs.foo.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://browser-http-intake.logs.foo.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://public-trace-http-intake.logs.foo.com/v1/input/xxx')).toBe(true)
+
+      expect(configuration.isIntakeUrl('https://rum-http-intake.logs.datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://browser-http-intake.logs.datadoghq.com/v1/input/xxx')).toBe(true)
+    })
+
+    it('should detect replica intake request with alternate intake domains', () => {
+      const configuration = buildConfiguration(
+        { clientToken, site: 'foo.com', replica: { clientToken }, useAlternateIntakeDomains: true },
+        { ...usEnv, buildMode: BuildMode.STAGING }
+      )
+      expect(configuration.isIntakeUrl('https://rum.browser-intake-foo.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://logs.browser-intake-foo.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://trace.browser-intake-foo.com/v1/input/xxx')).toBe(true)
 
-      expect(isIntakeRequest('https://rum-http-intake.logs.datadoghq.com/v1/input/xxx', configuration)).toBe(true)
-      expect(isIntakeRequest('https://browser-http-intake.logs.datadoghq.com/v1/input/xxx', configuration)).toBe(true)
+      expect(configuration.isIntakeUrl('https://rum.browser-intake-datadoghq.com/v1/input/xxx')).toBe(true)
+      expect(configuration.isIntakeUrl('https://logs.browser-intake-datadoghq.com/v1/input/xxx')).toBe(true)
     })
   })
 })
diff --git a/packages/core/src/domain/configuration.ts b/packages/core/src/domain/configuration.ts
index 605cf91a06..2cb04c6f49 100644
--- a/packages/core/src/domain/configuration.ts
+++ b/packages/core/src/domain/configuration.ts
@@ -1,6 +1,5 @@
 import { BuildEnv, BuildMode, Datacenter, INTAKE_SITE } from '../boot/init'
 import { CookieOptions, getCurrentSite } from '../browser/cookie'
-import { getPathName, haveSameOrigin } from '../tools/urlPolyfill'
 import { includes, ONE_KILO_BYTE, ONE_SECOND } from '../tools/utils'
 
 export const DEFAULT_CONFIGURATION = {
@@ -55,6 +54,7 @@ export interface UserConfiguration {
   env?: string
   version?: string
 
+  useAlternateIntakeDomains?: boolean
   useCrossSiteSessionCookie?: boolean
   useSecureSessionCookie?: boolean
   trackSessionAcrossSubdomains?: boolean
@@ -79,6 +79,7 @@ export type Configuration = typeof DEFAULT_CONFIGURATION & {
   service?: string
 
   isEnabled: (feature: string) => boolean
+  isIntakeUrl: (url: string) => boolean
 
   // only on staging build mode
   replica?: ReplicaConfiguration
@@ -104,6 +105,21 @@ interface TransportConfiguration {
   version?: string
 }
 
+const ENDPOINTS = {
+  alternate: {
+    logs: 'logs',
+    rum: 'rum',
+    trace: 'trace',
+  },
+  classic: {
+    logs: 'browser',
+    rum: 'rum',
+    trace: 'public-trace',
+  },
+}
+type IntakeType = keyof typeof ENDPOINTS
+type EndpointType = keyof (typeof ENDPOINTS)[IntakeType]
+
 export function buildConfiguration(userConfiguration: UserConfiguration, buildEnv: BuildEnv): Configuration {
   const transportConfiguration: TransportConfiguration = {
     applicationId: userConfiguration.applicationId,
@@ -121,21 +137,26 @@ export function buildConfiguration(userConfiguration: UserConfiguration, buildEn
     ? userConfiguration.enableExperimentalFeatures
     : []
 
+  const intakeType: IntakeType = userConfiguration.useAlternateIntakeDomains ? 'alternate' : 'classic'
+  const intakeUrls = getIntakeUrls(intakeType, transportConfiguration, userConfiguration.replica !== undefined)
   const configuration: Configuration = {
     cookieOptions: buildCookieOptions(userConfiguration),
     isEnabled: (feature: string) => {
       return includes(enableExperimentalFeatures, feature)
     },
-    logsEndpoint: getEndpoint('browser', transportConfiguration),
+    logsEndpoint: getEndpoint(intakeType, 'logs', transportConfiguration),
     proxyHost: userConfiguration.proxyHost,
-    rumEndpoint: getEndpoint('rum', transportConfiguration),
+    rumEndpoint: getEndpoint(intakeType, 'rum', transportConfiguration),
     service: userConfiguration.service,
-    traceEndpoint: getEndpoint('public-trace', transportConfiguration),
+    traceEndpoint: getEndpoint(intakeType, 'trace', transportConfiguration),
+
+    isIntakeUrl: (url) => intakeUrls.some((intakeUrl) => url.indexOf(intakeUrl) === 0),
     ...DEFAULT_CONFIGURATION,
   }
   if (userConfiguration.internalMonitoringApiKey) {
     configuration.internalMonitoringEndpoint = getEndpoint(
-      'browser',
+      intakeType,
+      'logs',
       transportConfiguration,
       'browser-agent-internal-monitoring'
     )
@@ -174,12 +195,13 @@ export function buildConfiguration(userConfiguration: UserConfiguration, buildEn
       configuration.replica = {
         applicationId: userConfiguration.replica.applicationId,
         internalMonitoringEndpoint: getEndpoint(
-          'browser',
+          intakeType,
+          'logs',
           replicaTransportConfiguration,
           'browser-agent-internal-monitoring'
         ),
-        logsEndpoint: getEndpoint('browser', replicaTransportConfiguration),
-        rumEndpoint: getEndpoint('rum', replicaTransportConfiguration),
+        logsEndpoint: getEndpoint(intakeType, 'logs', replicaTransportConfiguration),
+        rumEndpoint: getEndpoint(intakeType, 'rum', replicaTransportConfiguration),
       }
     }
   }
@@ -200,13 +222,18 @@ export function buildCookieOptions(userConfiguration: UserConfiguration) {
   return cookieOptions
 }
 
-function getEndpoint(type: string, conf: TransportConfiguration, source?: string) {
+function getEndpoint(
+  intakeType: IntakeType,
+  endpointType: EndpointType,
+  conf: TransportConfiguration,
+  source?: string
+) {
   const tags =
     `sdk_version:${conf.sdkVersion}` +
     `${conf.env ? `,env:${conf.env}` : ''}` +
     `${conf.service ? `,service:${conf.service}` : ''}` +
     `${conf.version ? `,version:${conf.version}` : ''}`
-  const datadogHost = `${type}-http-intake.logs.${conf.site}`
+  const datadogHost = getHost(intakeType, endpointType, conf.site)
   const host = conf.proxyHost ? conf.proxyHost : datadogHost
   const proxyParameter = conf.proxyHost ? `ddhost=${datadogHost}&` : ''
   const applicationIdParameter = conf.applicationId ? `_dd.application_id=${conf.applicationId}&` : ''
@@ -215,18 +242,33 @@ function getEndpoint(type: string, conf: TransportConfiguration, source?: string
   return `https://${host}/v1/input/${conf.clientToken}?${parameters}`
 }
 
-export function isIntakeRequest(url: string, configuration: Configuration) {
-  return (
-    getPathName(url).indexOf('/v1/input/') !== -1 &&
-    (haveSameOrigin(url, configuration.logsEndpoint) ||
-      haveSameOrigin(url, configuration.rumEndpoint) ||
-      haveSameOrigin(url, configuration.traceEndpoint) ||
-      (!!configuration.internalMonitoringEndpoint && haveSameOrigin(url, configuration.internalMonitoringEndpoint)) ||
-      (!!configuration.replica &&
-        (haveSameOrigin(url, configuration.replica.logsEndpoint) ||
-          haveSameOrigin(url, configuration.replica.rumEndpoint) ||
-          haveSameOrigin(url, configuration.replica.internalMonitoringEndpoint))))
-  )
+function getHost(intakeType: IntakeType, endpointType: EndpointType, site: string) {
+  const endpoint = ENDPOINTS[intakeType][endpointType]
+  if (intakeType === 'classic') {
+    return `${endpoint}-http-intake.logs.${site}`
+  }
+  const domainParts = site.split('.')
+  const extension = domainParts.pop()
+  const suffix = `${domainParts.join('-')}.${extension}`
+  return `${endpoint}.browser-intake-${suffix}`
+}
+
+function getIntakeUrls(intakeType: IntakeType, conf: TransportConfiguration, withReplica: boolean) {
+  if (conf.proxyHost) {
+    return [`https://${conf.proxyHost}/v1/input/`]
+  }
+  const sites = [conf.site]
+  if (conf.buildMode === BuildMode.STAGING && withReplica) {
+    sites.push(INTAKE_SITE[Datacenter.US])
+  }
+  const urls = []
+  const endpointTypes = Object.keys(ENDPOINTS[intakeType]) as EndpointType[]
+  for (const site of sites) {
+    for (const endpointType of endpointTypes) {
+      urls.push(`https://${getHost(intakeType, endpointType, site)}/v1/input/`)
+    }
+  }
+  return urls
 }
 
 function mustUseSecureCookie(userConfiguration: UserConfiguration) {
diff --git a/packages/core/src/index.ts b/packages/core/src/index.ts
index f2d9ed3705..e5356f2eb7 100644
--- a/packages/core/src/index.ts
+++ b/packages/core/src/index.ts
@@ -1,10 +1,4 @@
-export {
-  DEFAULT_CONFIGURATION,
-  Configuration,
-  UserConfiguration,
-  isIntakeRequest,
-  buildCookieOptions,
-} from './domain/configuration'
+export { DEFAULT_CONFIGURATION, Configuration, UserConfiguration, buildCookieOptions } from './domain/configuration'
 export { startAutomaticErrorCollection, ErrorObservable } from './domain/automaticErrorCollection'
 export { computeStackTrace } from './domain/tracekit'
 export {
diff --git a/packages/core/src/tools/specHelper.ts b/packages/core/src/tools/specHelper.ts
index a1ff5af86f..e51d760a6c 100644
--- a/packages/core/src/tools/specHelper.ts
+++ b/packages/core/src/tools/specHelper.ts
@@ -6,6 +6,16 @@ export const SPEC_ENDPOINTS: Partial<Configuration> = {
   logsEndpoint: 'https://logs-intake.com/v1/input/abcde?foo=bar',
   rumEndpoint: 'https://rum-intake.com/v1/input/abcde?foo=bar',
   traceEndpoint: 'https://trace-intake.com/v1/input/abcde?foo=bar',
+
+  isIntakeUrl: (url: string) => {
+    const intakeUrls = [
+      'https://monitoring-intake.com/v1/input/',
+      'https://logs-intake.com/v1/input/',
+      'https://rum-intake.com/v1/input/',
+      'https://trace-intake.com/v1/input/',
+    ]
+    return intakeUrls.some((intakeUrl) => url.indexOf(intakeUrl) === 0)
+  },
 }
 
 export function isSafari() {
diff --git a/packages/rum/src/domain/rumEventsCollection/resource/resourceUtils.ts b/packages/rum/src/domain/rumEventsCollection/resource/resourceUtils.ts
index 7764df0dad..c4115f4e62 100644
--- a/packages/rum/src/domain/rumEventsCollection/resource/resourceUtils.ts
+++ b/packages/rum/src/domain/rumEventsCollection/resource/resourceUtils.ts
@@ -3,7 +3,6 @@ import {
   Configuration,
   getPathName,
   includes,
-  isIntakeRequest,
   isValidUrl,
   msToNs,
   ResourceType,
@@ -204,5 +203,5 @@ export function computeSize(entry: RumPerformanceResourceTiming) {
 }
 
 export function isAllowedRequestUrl(configuration: Configuration, url: string) {
-  return url && !isIntakeRequest(url, configuration)
+  return url && !configuration.isIntakeUrl(url)
 }