diff --git a/Rakefile b/Rakefile
index 3d45ad1d22b..6e6f0878051 100644
--- a/Rakefile
+++ b/Rakefile
@@ -17,6 +17,12 @@ TEST_METADATA = {
   'appsec:main' => {
     '' => '✅ 2.1 / ✅ 2.2 / ✅ 2.3 / ✅ 2.4 / ✅ 2.5 / ✅ 2.6 / ✅ 2.7 / ✅ 3.0 / ✅ 3.1 / ✅ 3.2 / ✅ 3.3 / ✅ jruby'
   },
+  'profiling:main' => {
+    '' => '✅ 2.1 / ✅ 2.2 / ✅ 2.3 / ✅ 2.4 / ✅ 2.5 / ✅ 2.6 / ✅ 2.7 / ✅ 3.0 / ✅ 3.1 / ✅ 3.2 / ✅ 3.3 / ✅ jruby'
+  },
+  'profiling:ractors' => {
+    '' => '❌ 2.1 / ❌ 2.2 / ❌ 2.3 / ❌ 2.4 / ❌ 2.5 / ❌ 2.6 / ❌ 2.7 / ✅ 3.0 / ✅ 3.1 / ✅ 3.2 / ✅ 3.3 / ✅ jruby'
+  },
   'contrib' => {
     '' => '✅ 2.1 / ✅ 2.2 / ✅ 2.3 / ✅ 2.4 / ✅ 2.5 / ✅ 2.6 / ✅ 2.7 / ✅ 3.0 / ✅ 3.1 / ✅ 3.2 / ✅ 3.3 / ✅ jruby'
   },
@@ -535,6 +541,29 @@ namespace :spec do
   end
 
   task appsec: [:'appsec:all']
+
+  namespace :profiling do
+    task all: [:main, :ractors]
+
+    # Datadog Profiling main specs without Ractor creation
+    # NOTE: Ractor creation will transition the entire Ruby VM into multi-ractor mode. This cannot be undone
+    #       and, as such, may introduce side-effects between tests and make them flaky depending on order of
+    #       execution. By splitting in two separate suites, the side-effect impact should be mitigated as
+    #       the non-ractor VM will never trigger the transition into multi-ractor mode.
+    desc '' # "Explicitly hiding from `rake -T`"
+    RSpec::Core::RakeTask.new(:main) do |t, args|
+      t.pattern = 'spec/datadog/profiling/**/*_spec.rb'
+      t.rspec_opts = [*args.to_a, '-t ~ractors'].join(' ')
+    end
+
+    desc '' # "Explicitly hiding from `rake -T`"
+    RSpec::Core::RakeTask.new(:ractors) do |t, args|
+      t.pattern = 'spec/datadog/profiling/**/*_spec.rb'
+      t.rspec_opts = [*args.to_a, '-t ractors'].join(' ')
+    end
+  end
+
+  task profiling: [:'profiling:all']
 end
 
 if defined?(RuboCop::RakeTask)
diff --git a/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb b/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
index 21888900e7c..ef2bc0e7433 100644
--- a/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
+++ b/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
@@ -676,7 +676,7 @@
       end
     end
 
-    context 'when called from a background ractor' do
+    context 'when called from a background ractor', :ractors => true do
       # Even though we're not testing it explicitly, the GC profiling hooks can sometimes be called when running these
       # specs. Unfortunately, there's a VM crash in that case as well -- https://bugs.ruby-lang.org/issues/18464 --
       # so this must be disabled when interacting with Ractors.
diff --git a/spec/datadog/profiling/native_extension_spec.rb b/spec/datadog/profiling/native_extension_spec.rb
index f2a4c6ebe63..1cf75cdd5fd 100644
--- a/spec/datadog/profiling/native_extension_spec.rb
+++ b/spec/datadog/profiling/native_extension_spec.rb
@@ -82,7 +82,7 @@
         it { is_expected.to be true }
       end
 
-      context 'on a background Ractor' do
+      context 'on a background Ractor', :ractors => true do
         # @ivoanjo: When we initially added this test, our test suite kept deadlocking in CI in a later test (not on
         # this one).
         #