diff --git a/.github/workflows/ccpp.yml b/.github/workflows/ccpp.yml
index 2b2fadd990..fefe785875 100644
--- a/.github/workflows/ccpp.yml
+++ b/.github/workflows/ccpp.yml
@@ -93,12 +93,14 @@ jobs:
           python-version: "3.12"
 
       - name: Install Python build dependencies
+        working-directory: python
         run: |
-          pip -v install --upgrade -r python/build-requirements.txt
+          pip install scikit-build-core setuptools
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
 
       - name: Install FEniCS Python components
         run: |
-          pip install --no-build-isolation git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
+          pip install git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.basix_repository }}.git@${{ env.basix_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.ffcx_repository }}.git@${{ env.ffcx_ref }}
 
@@ -187,11 +189,14 @@ jobs:
         run: cat .github/workflows/fenicsx-refs.env >> $GITHUB_ENV
 
       - name: Install Python build dependencies
-        run: pip install -r python/build-requirements.txt
+        working-directory: python
+        run: |
+          pip install scikit-build-core
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
 
       - name: Install FEniCS Python components
         run: |
-          pip install --no-build-isolation git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
+          pip install git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.basix_repository }}.git@${{ env.basix_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.ffcx_repository }}.git@${{ env.ffcx_ref }}
 
@@ -292,10 +297,15 @@ jobs:
       - name: Load environment variables
         run: cat .github/workflows/fenicsx-refs.env >> $GITHUB_ENV
 
+      - name: Install Python build dependencies
+        working-directory: python
+        run: |
+          pip install scikit-build-core setuptools
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
+
       - name: Install FEniCS Python components
         run: |
-          pip install -r python/build-requirements.txt
-          pip install --no-build-isolation git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
+          pip install git+https://github.com/${{ env.ufl_repository }}.git@${{ env.ufl_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.basix_repository }}.git@${{ env.basix_ref }}
           pip install --no-build-isolation git+https://github.com/${{ env.ffcx_repository }}.git@${{ env.ffcx_ref }}
 
diff --git a/.github/workflows/clang-tidy.yml b/.github/workflows/clang-tidy.yml
index 175b7e1fd2..6f2f363a97 100644
--- a/.github/workflows/clang-tidy.yml
+++ b/.github/workflows/clang-tidy.yml
@@ -33,7 +33,12 @@ jobs:
         run: |
           apt-get update
           apt-get install -y clang-tidy catch2
-          pip install -r python/build-requirements.txt
+        
+      - name: Install Python build dependencies
+        working-directory: python
+        run: |
+          pip install scikit-build-core
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
 
       - name: Load environment variables
         run: cat .github/workflows/fenicsx-refs.env >> $GITHUB_ENV
diff --git a/.github/workflows/macos.yml b/.github/workflows/macos.yml
index 24541b633f..0433af5ae6 100644
--- a/.github/workflows/macos.yml
+++ b/.github/workflows/macos.yml
@@ -105,9 +105,11 @@ jobs:
           mpiexec -np 3 ctest -V --output-on-failure -R unittests
 
       - name: Build and install DOLFINx Python interface
+        working-directory: python
         run: |
-          pip install -r python/build-requirements.txt
-          pip install --check-build-dependencies --no-build-isolation 'python/[test]'
+          pip install scikit-build-core
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
+          pip install --check-build-dependencies --no-build-isolation './[test]'
 
       - name: Basic test
         run: |
diff --git a/.github/workflows/windows.yml b/.github/workflows/windows.yml
index c170d02f4d..be44531bbf 100644
--- a/.github/workflows/windows.yml
+++ b/.github/workflows/windows.yml
@@ -142,7 +142,8 @@ jobs:
       - name: Install DOLFINx Python build dependencies
         working-directory: dolfinx-src/python
         run: |
-          pip -v install --no-binary mpi4py -r build-requirements.txt
+          pip install scikit-build-core
+          python -m pip install --no-binary mpi4py (python -m scikit_build_core.build requires | Out-String | ConvertFrom-Json)
 
       - name: Install DOLFINx (Python)
         working-directory: dolfinx-src/python
diff --git a/README.md b/README.md
index f2955b5917..93cb18af8b 100644
--- a/README.md
+++ b/README.md
@@ -46,7 +46,8 @@ To install the Python interface, first install the C++ core, and then in
 the `python/` directory run:
 
 ```shell
-pip install -r build-requirements.txt
+pip install scikit-build-core
+python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
 pip install --check-build-dependencies --no-build-isolation .
 ```
 
diff --git a/docker/Dockerfile.end-user b/docker/Dockerfile.end-user
index 8942553c14..ebbbe32a85 100644
--- a/docker/Dockerfile.end-user
+++ b/docker/Dockerfile.end-user
@@ -71,7 +71,9 @@ ONBUILD ARG DOLFINX_CMAKE_BUILD_TYPE="Release"
 # Using pip install `.[test]` with --no-dependencies and --no-build-isolation
 # does not install necessary packages, hence install build and optional
 # dependencies manually here.
-ONBUILD RUN pip install --no-cache-dir -r dolfinx/python/build-requirements.txt && \
+ONBUILD RUN cd dolfinx/python &&
+            pip install --no-cache-dir scikit-build-core && 
+            python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install --no-cache-dir && \
             pip install --no-cache-dir pyamg pytest scipy matplotlib numba # test + optional set
 
 # The dolfinx-onbuild container expects to have folders basix/ ufl/
diff --git a/python/README.md b/python/README.md
index 446911e9e6..282724a142 100644
--- a/python/README.md
+++ b/python/README.md
@@ -6,7 +6,8 @@ Below is guidance for building the DOLFINx Python interface.
 
 2. Ensure the Python interface build requirements are installed:
 
-          pip install -r build-requirements.txt
+          pip install scikit-build-core
+          python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
 
 3. Build DOLFINx Python interface:
 
diff --git a/python/build-requirements.txt b/python/build-requirements.txt
deleted file mode 100644
index 5c54a707e1..0000000000
--- a/python/build-requirements.txt
+++ /dev/null
@@ -1,4 +0,0 @@
-nanobind>=2.5.0
-scikit-build-core[pyproject]>=0.10
-mpi4py
-setuptools
diff --git a/python/doc/source/installation.rst b/python/doc/source/installation.rst
index d6663fae38..27d063fdfc 100644
--- a/python/doc/source/installation.rst
+++ b/python/doc/source/installation.rst
@@ -105,7 +105,7 @@ Python
 After installation of the C++ interface, from the ``python/`` directory
 the Python interface can be installed using::
 
-    pip install -r build-requirements.txt
+    python -m scikit_build_core.build requires | python -c "import sys, json; print(' '.join(json.load(sys.stdin)))" | xargs pip install
     pip install --check-build-dependencies --no-build-isolation .
 
 
diff --git a/python/pyproject.toml b/python/pyproject.toml
index ae295b2eb4..0d5587dcae 100644
--- a/python/pyproject.toml
+++ b/python/pyproject.toml
@@ -3,7 +3,6 @@
 # system built petsc4py and mpi4py.
 # NOTE: petsc4py is an optional build dependency, therefore we don't
 # list it here.
-# pip install -r build-requirements.txt
 [build-system]
 requires = ["scikit-build-core[pyproject]>=0.10", "nanobind>=2.5.0", "mpi4py"]
 build-backend = "scikit_build_core.build"