diff --git a/Formula/node@16.rb b/Formula/node@16.rb
new file mode 100644
index 0000000000000..882e606a4c016
--- /dev/null
+++ b/Formula/node@16.rb
@@ -0,0 +1,111 @@
+class NodeAT16 < Formula
+  desc "Platform built on V8 to build network applications"
+  homepage "https://nodejs.org/"
+  url "https://nodejs.org/dist/v16.12.0/node-v16.12.0.tar.xz"
+  sha256 "5f620a6a400901a6565aa0c07309cde3aab3dbaa765cecb934241de520d36bac"
+  license "MIT"
+
+  livecheck do
+    url "https://nodejs.org/dist/"
+    regex(%r{href=["']?v?(16(?:\.\d+)+)/?["' >]}i)
+  end
+
+  keg_only :versioned_formula
+
+  depends_on "pkg-config" => :build
+  depends_on "brotli"
+  depends_on "c-ares"
+  depends_on "icu4c"
+  depends_on "libnghttp2"
+  depends_on "libuv"
+  depends_on "openssl@1.1"
+  depends_on "python@3.10"
+
+  uses_from_macos "zlib"
+
+  on_linux do
+    depends_on "gcc"
+  end
+
+  fails_with :clang do
+    build 1099
+    cause "Node requires Xcode CLT 11+"
+  end
+
+  fails_with gcc: "5"
+
+  # Fix build with brewed c-ares.
+  # https://github.com/nodejs/node/pull/39739
+  #
+  # Remove when the following lands in a *c-ares* release:
+  # https://github.com/c-ares/c-ares/commit/7712fcd17847998cf1ee3071284ec50c5b3c1978
+  # https://github.com/c-ares/c-ares/pull/417
+  patch do
+    url "https://github.com/nodejs/node/commit/8699aa501c4d4e1567ebe8901e5ec80cadaa9323.patch?full_index=1"
+    sha256 "678643c79258372d5054d3da16bc0c5db17130f151f0e72b6e4f20817987aac9"
+  end
+
+  def install
+    # make sure subprocesses spawned by make are using our Python 3
+    ENV["PYTHON"] = which("python3")
+
+    args = %W[
+      --prefix=#{prefix}
+      --with-intl=system-icu
+      --shared-libuv
+      --shared-nghttp2
+      --shared-openssl
+      --shared-zlib
+      --shared-brotli
+      --shared-cares
+      --shared-libuv-includes=#{Formula["libuv"].include}
+      --shared-libuv-libpath=#{Formula["libuv"].lib}
+      --shared-nghttp2-includes=#{Formula["libnghttp2"].include}
+      --shared-nghttp2-libpath=#{Formula["libnghttp2"].lib}
+      --shared-openssl-includes=#{Formula["openssl@1.1"].include}
+      --shared-openssl-libpath=#{Formula["openssl@1.1"].lib}
+      --shared-brotli-includes=#{Formula["brotli"].include}
+      --shared-brotli-libpath=#{Formula["brotli"].lib}
+      --shared-cares-includes=#{Formula["c-ares"].include}
+      --shared-cares-libpath=#{Formula["c-ares"].lib}
+      --openssl-use-def-ca-store
+    ]
+    system "python3", "configure.py", *args
+    system "make", "install"
+
+    # Make sure that:
+    # - `node` can find our keg-only `python3`
+    # - npm and npx use our keg-only `node`
+    bin.env_script_all_files libexec, PATH: "#{which("python3").dirname}:#{bin}:${PATH}"
+  end
+
+  def post_install
+    (lib/"node_modules/npm/npmrc").atomic_write("prefix = #{HOMEBREW_PREFIX}\n")
+  end
+
+  test do
+    path = testpath/"test.js"
+    path.write "console.log('hello');"
+
+    output = shell_output("#{bin}/node #{path}").strip
+    assert_equal "hello", output
+    output = shell_output("#{bin}/node -e 'console.log(new Intl.NumberFormat(\"en-EN\").format(1234.56))'").strip
+    assert_equal "1,234.56", output
+
+    output = shell_output("#{bin}/node -e 'console.log(new Intl.NumberFormat(\"de-DE\").format(1234.56))'").strip
+    assert_equal "1.234,56", output
+
+    # make sure npm can find node
+    ENV.prepend_path "PATH", opt_bin
+    ENV.delete "NVM_NODEJS_ORG_MIRROR"
+    assert_equal which("node"), opt_bin/"node"
+    assert_predicate bin/"npm", :exist?, "npm must exist"
+    assert_predicate bin/"npm", :executable?, "npm must be executable"
+    npm_args = ["-ddd", "--cache=#{HOMEBREW_CACHE}/npm_cache", "--build-from-source"]
+    system "#{bin}/npm", *npm_args, "install", "npm@latest"
+    system "#{bin}/npm", *npm_args, "install", "ref-napi"
+    assert_predicate bin/"npx", :exist?, "npx must exist"
+    assert_predicate bin/"npx", :executable?, "npx must be executable"
+    assert_match "< hello >", shell_output("#{bin}/npx cowsay hello")
+  end
+end