diff --git a/stdlib/REPL/src/REPL.jl b/stdlib/REPL/src/REPL.jl
index 19f46c472ba729..d179763ef114b5 100644
--- a/stdlib/REPL/src/REPL.jl
+++ b/stdlib/REPL/src/REPL.jl
@@ -1421,6 +1421,7 @@ function out_transform(@nospecialize(x), n::Ref{Int})
 end
 
 function get_usings!(usings, ex)
+    ex isa Expr || return usings
     # get all `using` and `import` statements which are at the top level
     for (i, arg) in enumerate(ex.args)
         if Base.isexpr(arg, :toplevel)
diff --git a/stdlib/REPL/test/repl.jl b/stdlib/REPL/test/repl.jl
index 6049f2214bc4f2..2267f6550cbec1 100644
--- a/stdlib/REPL/test/repl.jl
+++ b/stdlib/REPL/test/repl.jl
@@ -1650,6 +1650,10 @@ fake_repl() do stdin_write, stdout_read, repl
     @test !contains(s, "ERROR")
     @test contains(s, "Test Passed")
 
+    # Test for https://github.com/JuliaLang/julia/issues/49319
+    s = sendrepl2("# comment", "In [16]")
+    @test !contains(s, "ERROR")
+
     write(stdin_write, '\x04')
     Base.wait(repltask)
 end