diff --git a/.buildkite/pipelines/main/0_webui.yml b/.buildkite/pipelines/main/0_webui.yml
index af68158f9a51f..79eefd909bdc4 100644
--- a/.buildkite/pipelines/main/0_webui.yml
+++ b/.buildkite/pipelines/main/0_webui.yml
@@ -19,5 +19,7 @@ steps:
           # Our signed pipelines must have a `signature` or `signature_file` parameter that
           # verifies the treehash of the pipeline itself and the inputs listed in `inputs`
           signed_pipelines:
-            - pipeline: .buildkite/pipelines/main/misc/signed_pipeline_test.yml
+            - pipeline:       .buildkite/pipelines/main/misc/signed_pipeline_test.yml
               signature_file: .buildkite/pipelines/main/misc/signed_pipeline_test.yml.signature
+            - pipeline:       .buildkite/pipelines/main/upload_s3/musl.yml
+              signature_file: .buildkite/pipelines/main/upload_s3/musl.yml.signature
diff --git a/.buildkite/pipelines/main/upload_s3/musl.yml b/.buildkite/pipelines/main/upload_s3/musl.yml
new file mode 100644
index 0000000000000..ab2b9a0c821c3
--- /dev/null
+++ b/.buildkite/pipelines/main/upload_s3/musl.yml
@@ -0,0 +1,43 @@
+agents:
+  queue: "julia"
+  # Only run on `sandbox.jl` machines (not `docker`-isolated ones) since we need nestable sandboxing
+  sandbox.jl: "true"
+  os: "linux"
+
+steps:
+  - label: "upload_s3_musl64"
+    key: upload_s3_musl64
+    depends_on: package_musl64
+    if: |
+      (pipeline.slug == "julia-master") && (build.branch == "master") && (build.pull_request.id == null)
+    commands: |
+      echo "--- Print the full and short commit hashes"
+      SHORT_COMMIT_LENGTH=10
+      SHORT_COMMIT=`echo $${BUILDKITE_COMMIT:?} | cut -c1-$${SHORT_COMMIT_LENGTH:?}`
+      ARTIFACT_FILENAME="julia-$${SHORT_COMMIT:?}-musl64.tar.gz"
+
+      echo "--- Download build artifacts"
+      rm -rf $${ARTIFACT_FILENAME:?}
+      buildkite-agent artifact download $${ARTIFACT_FILENAME:?} .
+
+      echo "--- Upload build artifacts to S3"
+      # Upload to the following URL:
+      # https://julialangnightlies-s3.julialang.org/bin/linux/x64/julia-latest-musl64.tar.gz
+      export NEW_ARTIFACT_FILENAME="julia-latest-musl64.tar.gz"
+      export BUILDKITE_ARTIFACT_UPLOAD_DESTINATION="s3://julialangnightlies-s3/bin/linux/x64"
+      export BUILDKITE_S3_DEFAULT_REGION="us-east-1"
+      if [[ "$${ARTIFACT_FILENAME:?}" != "$${NEW_ARTIFACT_FILENAME:?}" ]]; then
+        mv $${ARTIFACT_FILENAME:?} $${NEW_ARTIFACT_FILENAME:?}
+      fi
+
+      # From the Buildkite documentation:
+      # > By default the agent will create objects with public-read permissions, so that
+      # > clicking on an artifact link in the Buildkite web interface can go directly to the
+      # > S3 object to be viewed in the browser.
+
+      buildkite-agent artifact upload $${ARTIFACT_FILENAME:?}
+    timeout_in_minutes: 60
+
+# We must accept the signed job id secret in order to propagate secrets
+env:
+  BUILDKITE_PLUGIN_CRYPTIC_BASE64_SIGNED_JOB_ID_SECRET: ${BUILDKITE_PLUGIN_CRYPTIC_BASE64_SIGNED_JOB_ID_SECRET?}
diff --git a/.buildkite/pipelines/main/upload_s3/musl.yml.signature b/.buildkite/pipelines/main/upload_s3/musl.yml.signature
new file mode 100644
index 0000000000000..1a82b1012a686
--- /dev/null
+++ b/.buildkite/pipelines/main/upload_s3/musl.yml.signature
@@ -0,0 +1 @@
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