diff --git a/CHANGELOG.md b/CHANGELOG.md
index 38864293e79..7edc720dda9 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -82,6 +82,8 @@
 
 - **ACME**: acme plugin now supports configuring an `account_key` in `keys` and `key_sets`
   [#9746](https://github.com/Kong/kong/pull/9746)
+- **Proxy-Cache**: add `ignore_uri_case` to configuring cache-key uri to be handled as lowercase
+  [#10453](https://github.com/Kong/kong/pull/10453)
 
 ### Fixes
 
diff --git a/kong/clustering/compat/removed_fields.lua b/kong/clustering/compat/removed_fields.lua
index dcdca39cd1b..f68912597f1 100644
--- a/kong/clustering/compat/removed_fields.lua
+++ b/kong/clustering/compat/removed_fields.lua
@@ -59,6 +59,9 @@ return {
   [3003000000] = {
     acme = {
       "account_key",
+    },
+    proxy_cache = {
+      "ignore_uri_case",
     }
   },
 }
diff --git a/kong/plugins/proxy-cache/handler.lua b/kong/plugins/proxy-cache/handler.lua
index af99c394caa..51f057057e8 100644
--- a/kong/plugins/proxy-cache/handler.lua
+++ b/kong/plugins/proxy-cache/handler.lua
@@ -287,6 +287,12 @@ function ProxyCacheHandler:access(conf)
   local consumer = kong.client.get_consumer()
   local route = kong.router.get_route()
   local uri = ngx_re_sub(ngx.var.request, "\\?.*", "", "oj")
+
+  -- if we want the cache-key uri only to be lowercase
+  if conf.ignore_uri_case then
+    uri = lower(uri)
+  end
+
   local cache_key, err = cache_key.build_cache_key(consumer and consumer.id,
                                                    route    and route.id,
                                                    kong.request.get_method(),
diff --git a/kong/plugins/proxy-cache/schema.lua b/kong/plugins/proxy-cache/schema.lua
index 69416012218..56a645a4dad 100644
--- a/kong/plugins/proxy-cache/schema.lua
+++ b/kong/plugins/proxy-cache/schema.lua
@@ -58,6 +58,11 @@ return {
             default = false,
             required = true,
           }},
+          { ignore_uri_case = {
+            type = "boolean",
+            default = false,
+            required = false,
+          }},
           { storage_ttl = {
             type = "integer",
           }},
diff --git a/spec/03-plugins/31-proxy-cache/02-access_spec.lua b/spec/03-plugins/31-proxy-cache/02-access_spec.lua
index e0e7f27ac78..5716a6ea458 100644
--- a/spec/03-plugins/31-proxy-cache/02-access_spec.lua
+++ b/spec/03-plugins/31-proxy-cache/02-access_spec.lua
@@ -71,21 +71,27 @@ do
       local route14 = assert(bp.routes:insert {
         hosts = { "route-14.com" },
       })
-      local route15 = assert(bp.routes:insert({
+      local route15 = assert(bp.routes:insert {
         hosts = { "route-15.com" },
-      }))
-      local route16 = assert(bp.routes:insert({
+      })
+      local route16 = assert(bp.routes:insert {
         hosts = { "route-16.com" },
-      }))
-      local route17 = assert(bp.routes:insert({
+      })
+      local route17 = assert(bp.routes:insert {
         hosts = { "route-17.com" },
-      }))
-      local route18 = assert(bp.routes:insert({
+      })
+      local route18 = assert(bp.routes:insert {
         hosts = { "route-18.com" },
-      }))
-      local route19 = assert(bp.routes:insert({
+      })
+      local route19 = assert(bp.routes:insert {
         hosts = { "route-19.com" },
-      }))
+      })
+      local route20 = assert(bp.routes:insert {
+        hosts = { "route-20.com" },
+      })
+      local route21 = assert(bp.routes:insert {
+        hosts = { "route-21.com" },
+      })
 
 
       local consumer1 = assert(bp.consumers:insert {
@@ -282,6 +288,30 @@ do
         },
       })
 
+      assert(bp.plugins:insert {
+        name = "proxy-cache",
+        route = { id = route20.id },
+        config = {
+          strategy = policy,
+          response_code = {404},
+          ignore_uri_case = true,
+          content_type = { "text/plain", "application/json" },
+          [policy] = policy_config,
+        },
+      })
+
+      assert(bp.plugins:insert {
+        name = "proxy-cache",
+        route = { id = route21.id },
+        config = {
+          strategy = policy,
+          response_code = {404},
+          ignore_uri_case = false,
+          content_type = { "text/plain", "application/json" },
+          [policy] = policy_config,
+        },
+      })
+
       assert(helpers.start_kong({
         plugins = "bundled",
         nginx_conf = "spec/fixtures/custom_nginx.template",
@@ -1346,5 +1376,69 @@ do
         assert.same("Bypass", res.headers["X-Cache-Status"])
       end)
     end)
+
+    it("ignore uri case in cache_key", function()
+      local res = assert(client:send {
+        method = "GET",
+        path = "/ignore-case/kong",
+        headers = {
+          host = "route-20.com",
+        },
+      })
+
+      local body1 = assert.res_status(404, res)
+      assert.same("Miss", res.headers["X-Cache-Status"])
+
+      local cache_key1 = res.headers["X-Cache-Key"]
+      assert.matches("^[%w%d]+$", cache_key1)
+      assert.equals(64, #cache_key1)
+
+      local res = client:send {
+        method = "GET",
+        path = "/ignore-case/KONG",
+        headers = {
+          host = "route-20.com",
+        },
+      }
+
+      local body2 = assert.res_status(404, res)
+      assert.same("Hit", res.headers["X-Cache-Status"])
+      local cache_key2 = res.headers["X-Cache-Key"]
+      assert.same(cache_key1, cache_key2)
+
+      assert.same(body1, body2)
+    end)
+
+    it("acknowledge uri case in cache_key", function()
+      local res = assert(client:send {
+        method = "GET",
+        path = "/acknowledge-case/kong",
+        headers = {
+          host = "route-21.com",
+        },
+      })
+
+      assert.res_status(404, res)
+      local x_cache_status = assert.response(res).has_header("X-Cache-Status")
+      assert.same("Miss", x_cache_status)
+
+      local cache_key1 = res.headers["X-Cache-Key"]
+      assert.matches("^[%w%d]+$", cache_key1)
+      assert.equals(64, #cache_key1)
+
+      res = assert(client:send {
+        method = "GET",
+        path = "/acknowledge-case/KONG",
+        headers = {
+          host = "route-21.com",
+        },
+      })
+
+      x_cache_status = assert.response(res).has_header("X-Cache-Status")
+      local cache_key2 = assert.response(res).has_header("X-Cache-Key")
+      assert.same("Miss", x_cache_status)
+      assert.not_same(cache_key1, cache_key2)
+    end)
+
   end)
 end