diff --git a/Marlin/src/HAL/SAMD51/HAL.cpp b/Marlin/src/HAL/SAMD51/HAL.cpp
index 648e0a4f144b..bd1c98bfa1d9 100644
--- a/Marlin/src/HAL/SAMD51/HAL.cpp
+++ b/Marlin/src/HAL/SAMD51/HAL.cpp
@@ -598,7 +598,7 @@ void MarlinHAL::dma_init() {
 void MarlinHAL::init() {
   TERN_(DMA_IS_REQUIRED, dma_init());
   #if ENABLED(SDSUPPORT)
-    #if SD_CONNECTION_IS(ONBOARD) && PIN_EXISTS(SD_DETECT)
+    #if HAS_SD_DETECT && SD_CONNECTION_IS(ONBOARD)
       SET_INPUT_PULLUP(SD_DETECT_PIN);
     #endif
     OUT_WRITE(SDSS, HIGH);  // Try to set SDSS inactive before any other SPI users start up
diff --git a/Marlin/src/inc/Conditionals_post.h b/Marlin/src/inc/Conditionals_post.h
index 7eba3b6adcca..b3758b3d7a34 100644
--- a/Marlin/src/inc/Conditionals_post.h
+++ b/Marlin/src/inc/Conditionals_post.h
@@ -517,20 +517,28 @@
     #define HAS_SHARED_MEDIA 1
   #endif
 
-  // Set SD_DETECT_STATE based on hardware if not overridden
-  #if PIN_EXISTS(SD_DETECT) && !defined(SD_DETECT_STATE)
-    #if BOTH(HAS_MARLINUI_MENU, ELB_FULL_GRAPHIC_CONTROLLER) && (SD_CONNECTION_IS(LCD) || !defined(SDCARD_CONNECTION))
-      #define SD_DETECT_STATE HIGH
-    #else
-      #define SD_DETECT_STATE LOW
-    #endif
-  #endif
-
   // Extender cable doesn't support SD_DETECT_PIN
   #if ENABLED(NO_SD_DETECT)
     #undef SD_DETECT_PIN
   #endif
 
+  // Not onboard or custom cable
+  #if SD_CONNECTION_IS(LCD) || !defined(SDCARD_CONNECTION)
+    #define SD_CONNECTION_TYPICAL 1
+  #endif
+
+  // Set SD_DETECT_STATE based on hardware if not overridden
+  #if PIN_EXISTS(SD_DETECT)
+    #define HAS_SD_DETECT 1
+    #ifndef SD_DETECT_STATE
+      #if ALL(SD_CONNECTION_TYPICAL, HAS_MARLINUI_MENU, ELB_FULL_GRAPHIC_CONTROLLER)
+        #define SD_DETECT_STATE HIGH
+      #else
+        #define SD_DETECT_STATE LOW
+      #endif
+    #endif
+  #endif
+
   #if DISABLED(USB_FLASH_DRIVE_SUPPORT) || BOTH(MULTI_VOLUME, VOLUME_SD_ONBOARD)
     #if ENABLED(SDIO_SUPPORT)
       #define NEED_SD2CARD_SDIO 1
@@ -539,10 +547,10 @@
     #endif
   #endif
 
-#endif
+  #if HAS_SD_DETECT && NONE(HAS_GRAPHICAL_TFT, LCD_USE_DMA_FSMC, HAS_FSMC_GRAPHICAL_TFT, HAS_SPI_GRAPHICAL_TFT, IS_DWIN_MARLINUI, EXTENSIBLE_UI, HAS_DWIN_E3V2)
+    #define REINIT_NOISY_LCD 1  // Have the LCD re-init on SD insertion
+  #endif
 
-#if PIN_EXISTS(SD_DETECT) && NONE(HAS_GRAPHICAL_TFT, LCD_USE_DMA_FSMC, HAS_FSMC_GRAPHICAL_TFT, HAS_SPI_GRAPHICAL_TFT, IS_DWIN_MARLINUI, EXTENSIBLE_UI, HAS_DWIN_E3V2)
-  #define REINIT_NOISY_LCD 1  // Have the LCD re-init on SD insertion
 #endif
 
 /**
diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index b158e68967b8..de52c144d438 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -895,9 +895,10 @@ static_assert(COUNT(arm) == LOGICAL_AXES, "AXIS_RELATIVE_MODES must contain " _L
 /**
  * SD Card Settings
  */
-#if ALL(SDSUPPORT, ELB_FULL_GRAPHIC_CONTROLLER, HAS_MARLINUI_MENU) && PIN_EXISTS(SD_DETECT) && SD_DETECT_STATE != HIGH && (SD_CONNECTION_IS(LCD) || !defined(SDCARD_CONNECTION))
+#if ALL(SDSUPPORT, HAS_SD_DETECT, SD_CONNECTION_TYPICAL, ELB_FULL_GRAPHIC_CONTROLLER, HAS_MARLINUI_MENU) && SD_DETECT_STATE == LOW
   #error "SD_DETECT_STATE must be set HIGH for SD on the ELB_FULL_GRAPHIC_CONTROLLER."
 #endif
+#undef SD_CONNECTION_TYPICAL
 
 /**
  * SD File Sorting
diff --git a/Marlin/src/lcd/extui/anycubic_i3mega/anycubic_i3mega_lcd.cpp b/Marlin/src/lcd/extui/anycubic_i3mega/anycubic_i3mega_lcd.cpp
index 63c17565c0fb..3533a9561650 100644
--- a/Marlin/src/lcd/extui/anycubic_i3mega/anycubic_i3mega_lcd.cpp
+++ b/Marlin/src/lcd/extui/anycubic_i3mega/anycubic_i3mega_lcd.cpp
@@ -86,7 +86,7 @@ void AnycubicTFTClass::OnSetup() {
   delay_ms(10);
 
   // Init the state of the key pins running on the TFT
-  #if ENABLED(SDSUPPORT) && PIN_EXISTS(SD_DETECT)
+  #if BOTH(SDSUPPORT, HAS_SD_DETECT)
     SET_INPUT_PULLUP(SD_DETECT_PIN);
   #endif
   #if ENABLED(FILAMENT_RUNOUT_SENSOR)
@@ -916,7 +916,7 @@ void AnycubicTFTClass::GetCommandFromTFT() {
 }
 
 void AnycubicTFTClass::DoSDCardStateCheck() {
-  #if ENABLED(SDSUPPORT) && PIN_EXISTS(SD_DETECT)
+  #if BOTH(SDSUPPORT, HAS_SD_DETECT)
     bool isInserted = isMediaInserted();
     if (isInserted)
       SENDLINE_DBG_PGM("J00", "TFT Serial Debug: SD card state changed... isInserted");
diff --git a/Marlin/src/lcd/extui/dgus_reloaded/DGUSRxHandler.cpp b/Marlin/src/lcd/extui/dgus_reloaded/DGUSRxHandler.cpp
index cef9c772e9df..88fe30a0273f 100644
--- a/Marlin/src/lcd/extui/dgus_reloaded/DGUSRxHandler.cpp
+++ b/Marlin/src/lcd/extui/dgus_reloaded/DGUSRxHandler.cpp
@@ -47,9 +47,7 @@ void DGUSRxHandler::ScreenChange(DGUS_VP &vp, void *data_ptr) {
 
   if (vp.addr == DGUS_Addr::SCREENCHANGE_SD) {
     #if ENABLED(SDSUPPORT)
-      #if !PIN_EXISTS(SD_DETECT)
-        card.mount();
-      #endif
+      IF_DISABLED(HAS_SD_DETECT, card.mount());
 
       if (!ExtUI::isMediaInserted()) {
         dgus_screen_handler.SetStatusMessage(GET_TEXT_F(MSG_NO_MEDIA));
diff --git a/Marlin/src/lcd/extui/mks_ui/tft_lvgl_configuration.cpp b/Marlin/src/lcd/extui/mks_ui/tft_lvgl_configuration.cpp
index 378521031509..38612358110b 100644
--- a/Marlin/src/lcd/extui/mks_ui/tft_lvgl_configuration.cpp
+++ b/Marlin/src/lcd/extui/mks_ui/tft_lvgl_configuration.cpp
@@ -137,8 +137,7 @@ void tft_lvgl_init() {
     uint16_t usb_flash_loop = 1000;
     #if ENABLED(MULTI_VOLUME) && !HAS_SD_HOST_DRIVE
       SET_INPUT_PULLUP(SD_DETECT_PIN);
-      if (READ(SD_DETECT_PIN) == LOW) card.changeMedia(&card.media_driver_sdcard);
-      else card.changeMedia(&card.media_driver_usbFlash);
+      card.changeMedia(IS_SD_INSERTED() ? &card.media_driver_sdcard : &card.media_driver_usbFlash);
     #endif
     do {
       card.media_driver_usbFlash.idle();
diff --git a/Marlin/src/lcd/marlinui.cpp b/Marlin/src/lcd/marlinui.cpp
index 8958de657ca0..3976c48dc76b 100644
--- a/Marlin/src/lcd/marlinui.cpp
+++ b/Marlin/src/lcd/marlinui.cpp
@@ -1756,7 +1756,7 @@ void MarlinUI::init() {
       if (old_status < 2) {
         #if ENABLED(EXTENSIBLE_UI)
           ExtUI::onMediaRemoved();
-        #elif PIN_EXISTS(SD_DETECT)
+        #elif HAS_SD_DETECT
           LCD_MESSAGE(MSG_MEDIA_REMOVED);
           #if HAS_MARLINUI_MENU
             if (!defer_return_to_status) return_to_status();
diff --git a/Marlin/src/lcd/menu/menu_main.cpp b/Marlin/src/lcd/menu/menu_main.cpp
index fdedddb6ddda..518f1e0f502d 100644
--- a/Marlin/src/lcd/menu/menu_main.cpp
+++ b/Marlin/src/lcd/menu/menu_main.cpp
@@ -246,7 +246,7 @@ void menu_main() {
 
       if (card_detected) {
         if (!card_open) {
-          #if PIN_EXISTS(SD_DETECT)
+          #if HAS_SD_DETECT
             GCODES_ITEM(MSG_CHANGE_MEDIA, F("M21"));        // M21 Change Media
           #else                                             // - or -
             ACTION_ITEM(MSG_RELEASE_MEDIA, []{              // M22 Release Media
@@ -262,7 +262,7 @@ void menu_main() {
         }
       }
       else {
-        #if PIN_EXISTS(SD_DETECT)
+        #if HAS_SD_DETECT
           ACTION_ITEM(MSG_NO_MEDIA, nullptr);               // "No Media"
         #else
           GCODES_ITEM(MSG_ATTACH_MEDIA, F("M21"));          // M21 Attach Media
diff --git a/Marlin/src/lcd/menu/menu_media.cpp b/Marlin/src/lcd/menu/menu_media.cpp
index e979f04e119d..20ef6e3d198f 100644
--- a/Marlin/src/lcd/menu/menu_media.cpp
+++ b/Marlin/src/lcd/menu/menu_media.cpp
@@ -122,7 +122,7 @@ void menu_media_filelist() {
     BACK_ITEM_F(TERN1(BROWSE_MEDIA_ON_INSERT, screen_history_depth) ? GET_TEXT_F(MSG_MAIN) : GET_TEXT_F(MSG_BACK));
   #endif
   if (card.flag.workDirIsRoot) {
-    #if !PIN_EXISTS(SD_DETECT)
+    #if !HAS_SD_DETECT
       ACTION_ITEM(MSG_REFRESH, []{ encoderTopLine = 0; card.mount(); });
     #endif
   }
diff --git a/Marlin/src/sd/cardreader.cpp b/Marlin/src/sd/cardreader.cpp
index 0aa06e47c9f4..5e03795692da 100644
--- a/Marlin/src/sd/cardreader.cpp
+++ b/Marlin/src/sd/cardreader.cpp
@@ -171,7 +171,7 @@ CardReader::CardReader() {
   workDirDepth = 0;
   ZERO(workDirParents);
 
-  #if ENABLED(SDSUPPORT) && PIN_EXISTS(SD_DETECT)
+  #if BOTH(SDSUPPORT, HAS_SD_DETECT)
     SET_INPUT_PULLUP(SD_DETECT_PIN);
   #endif
 
@@ -456,10 +456,11 @@ void CardReader::mount() {
 
   if (flag.mounted)
     cdroot();
-  #if ENABLED(USB_FLASH_DRIVE_SUPPORT) || PIN_EXISTS(SD_DETECT)
-    else if (marlin_state != MF_INITIALIZING)
-      LCD_ALERTMESSAGE(MSG_MEDIA_INIT_FAIL);
-  #endif
+  else {
+    #if EITHER(HAS_SD_DETECT, USB_FLASH_DRIVE_SUPPORT)
+      if (marlin_state != MF_INITIALIZING) LCD_ALERTMESSAGE(MSG_MEDIA_INIT_FAIL);
+    #endif
+  }
 
   ui.refresh();
 }
@@ -496,15 +497,15 @@ void CardReader::manage_media() {
     if (TERN1(SD_IGNORE_AT_STARTUP, old_stat != 2)) mount();
     if (!isMounted()) {             // Not mounted?
       stat = 0;
-      IF_DISABLED(SD_IGNORE_AT_STARTUP, prev_stat = 0);
+      #if HAS_SD_DETECT && DISABLED(SD_IGNORE_AT_STARTUP)
+        prev_stat = 0;
+      #endif
     }
 
     TERN_(RESET_STEPPERS_ON_MEDIA_INSERT, reset_stepper_drivers()); // Workaround for Cheetah bug
   }
   else {
-    #if PIN_EXISTS(SD_DETECT)
-      release();                    // Card is released
-    #endif
+    TERN_(HAS_SD_DETECT, release()); // Card is released
   }
 
   ui.media_changed(old_stat, stat); // Update the UI or flag an error
diff --git a/Marlin/src/sd/cardreader.h b/Marlin/src/sd/cardreader.h
index 483ab8139584..d2f462c2a777 100644
--- a/Marlin/src/sd/cardreader.h
+++ b/Marlin/src/sd/cardreader.h
@@ -362,7 +362,7 @@ class CardReader {
 
 #if ENABLED(USB_FLASH_DRIVE_SUPPORT)
   #define IS_SD_INSERTED() DiskIODriver_USBFlash::isInserted()
-#elif PIN_EXISTS(SD_DETECT)
+#elif HAS_SD_DETECT
   #define IS_SD_INSERTED() (READ(SD_DETECT_PIN) == SD_DETECT_STATE)
 #else
   // No card detect line? Assume the card is inserted.