diff --git a/ini/samd51.ini b/ini/samd51.ini
index 70bda9ca52d0..cf1f9ed8c0b5 100644
--- a/ini/samd51.ini
+++ b/ini/samd51.ini
@@ -15,11 +15,12 @@
 [env:SAMD51_grandcentral_m4]
 platform         = atmelsam
 board            = adafruit_grandcentral_m4
-build_flags      = ${common.build_flags} -std=gnu++17
+build_flags      = ${common.build_flags} -std=gnu++17 -DUSE_TINYUSB
 build_unflags    = -std=gnu++11
 build_src_filter = ${common.default_src_filter} +<src/HAL/SAMD51>
 lib_deps         = ${common.lib_deps}
                    SoftwareSerialM
+                   Adafruit TinyUSB Library
 extra_scripts    = ${common.extra_scripts}
                    pre:buildroot/share/PlatformIO/scripts/SAMD51_grandcentral_m4.py
 custom_marlin.HAS_MEDIA = SdFat - Adafruit Fork, Adafruit SPIFlash