diff --git a/ui/components/multichain/network-list-menu/network-list-menu.js b/ui/components/multichain/network-list-menu/network-list-menu.js
index 8c44bf368132..6a1f54556b4c 100644
--- a/ui/components/multichain/network-list-menu/network-list-menu.js
+++ b/ui/components/multichain/network-list-menu/network-list-menu.js
@@ -34,6 +34,7 @@ import {
   getUseRequestQueue,
   getNetworkConfigurations,
   getEditedNetwork,
+  getAllDomains,
 } from '../../../selectors';
 import ToggleButton from '../../ui/toggle-button';
 import {
@@ -100,6 +101,7 @@ export const NetworkListMenu = ({ onClose }) => {
   const selectedTabOrigin = useSelector(getOriginOfCurrentTab);
   const useRequestQueue = useSelector(getUseRequestQueue);
   const networkConfigurations = useSelector(getNetworkConfigurations);
+  const domains = useSelector(getAllDomains);
 
   const dispatch = useDispatch();
   const history = useHistory();
@@ -307,10 +309,14 @@ export const NetworkListMenu = ({ onClose }) => {
             dispatch(setActiveNetwork(network.id));
           }
 
-          // If presently on a dapp, communicate a change to
-          // the dapp via silent switchEthereumChain that the
-          // network has changed due to user action
-          if (useRequestQueue && selectedTabOrigin) {
+          // If presently on and connected to a dapp, communicate a change to
+          // the dapp via silent switchEthereumChain that the network has
+          // changed due to user action
+          if (
+            useRequestQueue &&
+            selectedTabOrigin &&
+            domains[selectedTabOrigin]
+          ) {
             setNetworkClientIdForDomain(selectedTabOrigin, network.id);
           }
 
diff --git a/ui/components/multichain/network-list-menu/network-list-menu.test.js b/ui/components/multichain/network-list-menu/network-list-menu.test.js
index 544b0880048e..4a170fc139d7 100644
--- a/ui/components/multichain/network-list-menu/network-list-menu.test.js
+++ b/ui/components/multichain/network-list-menu/network-list-menu.test.js
@@ -34,6 +34,7 @@ const render = ({
   providerConfigId = 'chain5',
   isUnlocked = true,
   origin = MOCK_ORIGIN,
+  selectedTabOriginInDomainsState = true,
 } = {}) => {
   const state = {
     metamask: {
@@ -48,6 +49,11 @@ const render = ({
         showTestNetworks,
       },
       useRequestQueue: true,
+      domains: {
+        ...(selectedTabOriginInDomainsState
+          ? { [origin]: providerConfigId }
+          : {}),
+      },
     },
     activeTab: {
       origin,
@@ -61,6 +67,7 @@ const render = ({
 describe('NetworkListMenu', () => {
   beforeEach(() => {
     process.env.ENABLE_NETWORK_UI_REDESIGN = 'false';
+    jest.clearAllMocks();
   });
 
   it('renders properly', () => {
@@ -158,22 +165,32 @@ describe('NetworkListMenu', () => {
     ).toHaveLength(0);
   });
 
-  it('fires setNetworkClientIdForDomain when network item is clicked', () => {
-    const { getByText } = render();
-    fireEvent.click(getByText(MAINNET_DISPLAY_NAME));
-    expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
-      MOCK_ORIGIN,
-      NETWORK_TYPES.MAINNET,
-    );
+  describe('selectedTabOrigin is connected to wallet', () => {
+    it('fires setNetworkClientIdForDomain when network item is clicked', () => {
+      const { getByText } = render();
+      fireEvent.click(getByText(MAINNET_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
+        MOCK_ORIGIN,
+        NETWORK_TYPES.MAINNET,
+      );
+    });
+
+    it('fires setNetworkClientIdForDomain when test network item is clicked', () => {
+      const { getByText } = render({ showTestNetworks: true });
+      fireEvent.click(getByText(SEPOLIA_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
+        MOCK_ORIGIN,
+        NETWORK_TYPES.SEPOLIA,
+      );
+    });
   });
 
-  it('fires setNetworkClientIdForDomain when test network item is clicked', () => {
-    const { getByText } = render({ showTestNetworks: true });
-    fireEvent.click(getByText(SEPOLIA_DISPLAY_NAME));
-    expect(mockSetNetworkClientIdForDomain).toHaveBeenCalledWith(
-      MOCK_ORIGIN,
-      NETWORK_TYPES.SEPOLIA,
-    );
+  describe('selectedTabOrigin is not connected to wallet', () => {
+    it('does not fire setNetworkClientIdForDomain when network item is clicked', () => {
+      const { getByText } = render({ selectedTabOriginInDomainsState: false });
+      fireEvent.click(getByText(MAINNET_DISPLAY_NAME));
+      expect(mockSetNetworkClientIdForDomain).not.toHaveBeenCalled();
+    });
   });
 
   describe('NetworkListMenu with ENABLE_NETWORK_UI_REDESIGN', () => {