diff --git a/examples/florence2_inference.py b/examples/florence2_inference.py
new file mode 100644
index 0000000000000..b58ac2e1f7ed4
--- /dev/null
+++ b/examples/florence2_inference.py
@@ -0,0 +1,44 @@
+'''
+Demonstrate prompting of text-to-text
+encoder/decoder models, specifically Florence-2
+'''
+# TODO(Isotr0py):
+# Move to offline_inference_vision_language.py after porting vision backbone
+from vllm import LLM, SamplingParams
+
+dtype = "float"
+
+# Create a Florence-2 encoder/decoder model instance
+llm = LLM(
+    model="microsoft/Florence-2-base",
+    tokenizer="facebook/bart-base",
+    dtype=dtype,
+    trust_remote_code=True,
+)
+
+prompts = [
+    "<CAPTION>", "<DETAILED_CAPTION>", "<MORE_DETAILED_CAPTION>",
+    "<CAPTION_TO_PHRASE_GROUNDING>", "<OD>", "<DENSE_REGION_CAPTION>",
+    "<REGION_PROPOSAL>", "<OCR>", "<OCR_WITH_REGION>"
+]
+# Create a sampling params object.
+sampling_params = SamplingParams(
+    temperature=0,
+    top_p=1.0,
+    min_tokens=0,
+    max_tokens=20,
+)
+
+# Generate output tokens from the prompts. The output is a list of
+# RequestOutput objects that contain the prompt, generated
+# text, and other information.
+outputs = llm.generate(prompts, sampling_params)
+
+# Print the outputs.
+for output in outputs:
+    prompt = output.prompt
+    encoder_prompt = output.encoder_prompt
+    generated_text = output.outputs[0].text
+    print(f"Encoder prompt: {encoder_prompt!r}, "
+          f"Decoder prompt: {prompt!r}, "
+          f"Generated text: {generated_text!r}")
diff --git a/tests/conftest.py b/tests/conftest.py
index 76f581e0363f7..b11bbcb4ab7d1 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -253,7 +253,9 @@ def __init__(
         dtype: str = "half",
         *,
         model_kwargs: Optional[Dict[str, Any]] = None,
+        is_embedding_model: bool = False,
         is_sentence_transformer: bool = False,
+        skip_tokenizer_init: bool = False,
         auto_cls: Type[_BaseAutoModelClass] = AutoModelForCausalLM,
         postprocess_inputs: Callable[[BatchEncoding],
                                      BatchEncoding] = identity,
@@ -281,11 +283,12 @@ def __init__(
                     **model_kwargs,
                 ))
 
-        self.tokenizer = AutoTokenizer.from_pretrained(
-            model_name,
-            torch_dtype=torch_dtype,
-            trust_remote_code=True,
-        )
+        if not skip_tokenizer_init:
+            self.tokenizer = AutoTokenizer.from_pretrained(
+                model_name,
+                torch_dtype=torch_dtype,
+                trust_remote_code=True,
+            )
 
         # don't put this import at the top level
         # it will call torch.cuda.device_count()
@@ -295,6 +298,8 @@ def __init__(
             torch_dtype=torch_dtype,
             trust_remote_code=True,
         )
+        if skip_tokenizer_init:
+            self.tokenizer = self.processor.tokenizer
 
         self.postprocess_inputs = postprocess_inputs
 
@@ -535,6 +540,7 @@ def generate_encoder_decoder_greedy_logprobs_limit(
         encoder_decoder_prompts: List[ExplicitEncoderDecoderPrompt[str, str]],
         max_tokens: int,
         num_logprobs: int,
+        images: Optional[PromptImageInput] = None,
         **kwargs: Any,
     ) -> List[TokensTextLogprobs]:
         '''
@@ -545,11 +551,17 @@ def generate_encoder_decoder_greedy_logprobs_limit(
         all_output_ids: List[List[int]] = []
         all_output_strs: List[str] = []
 
-        for (encoder_prompt,
-             decoder_prompt) in to_enc_dec_tuple_list(encoder_decoder_prompts):
+        for i, (encoder_prompt, decoder_prompt) in enumerate(
+                to_enc_dec_tuple_list(encoder_decoder_prompts)):
+            processor_kwargs: Dict[str, Any] = {
+                "text": encoder_prompt,
+                "return_tensors": "pt",
+            }
+            if images is not None and images[i] is not None:
+                processor_kwargs["images"] = images[i]
 
             encoder_input_ids = self.wrap_device(
-                self.tokenizer(encoder_prompt, return_tensors="pt").input_ids,
+                self.processor(**processor_kwargs).input_ids,
                 device=self.model.device.type,
             )
 
diff --git a/tests/models/encoder_decoder/vision_language/test_florence2.py b/tests/models/encoder_decoder/vision_language/test_florence2.py
new file mode 100644
index 0000000000000..483773f069133
--- /dev/null
+++ b/tests/models/encoder_decoder/vision_language/test_florence2.py
@@ -0,0 +1,102 @@
+from functools import partial
+from typing import List, Optional, Tuple, Type
+
+import pytest
+from PIL import Image
+
+from vllm.inputs.data import ExplicitEncoderDecoderPrompt
+from vllm.sequence import SampleLogprobs
+
+from ....conftest import HfRunner, VllmRunner
+from ...utils import check_logprobs_close
+
+Florence2Prompt = partial(ExplicitEncoderDecoderPrompt,
+                          decoder_prompt=None,
+                          mm_processor_kwargs=None)
+
+MODELS = ["microsoft/Florence-2-base"]
+# Florence-2 uses BartFastTokenizer which can't be loaded from AutoTokenizer
+# Therefore, we borrow the BartTokenizer from the original Bart model
+TOKENIZER = "facebook/bart-base"
+PROMPTS = [
+    Florence2Prompt(encoder_prompt="<CAPTION>"),
+    Florence2Prompt(encoder_prompt="<DETAILED_CAPTION>"),
+    Florence2Prompt(encoder_prompt="<MORE_DETAILED_CAPTION>"),
+    Florence2Prompt(encoder_prompt="<CAPTION_TO_PHRASE_GROUNDING>"),
+    Florence2Prompt(encoder_prompt="<DENSE_REGION_CAPTION>"),
+    Florence2Prompt(encoder_prompt="<REGION_PROPOSAL>"),
+    Florence2Prompt(encoder_prompt="<OCR_WITH_REGION>"),
+    Florence2Prompt(encoder_prompt="<OCR>"),
+    Florence2Prompt(encoder_prompt="<OD>"),
+]
+
+
+def vllm_to_hf_output(vllm_output: Tuple[List[int], str,
+                                         Optional[SampleLogprobs]], ):
+    """Sanitize vllm output to be comparable with hf output."""
+    output_ids, output_str, out_logprobs = vllm_output
+
+    hf_output_str = "</s><s>" + output_str + "</s>"
+
+    return output_ids, hf_output_str, out_logprobs
+
+
+def run_test(
+    hf_runner: Type[HfRunner],
+    vllm_runner: Type[VllmRunner],
+    prompts: List[ExplicitEncoderDecoderPrompt],
+    model: str,
+    *,
+    dtype: str,
+    max_tokens: int,
+    num_logprobs: int,
+    tensor_parallel_size: int,
+    distributed_executor_backend: Optional[str] = None,
+) -> None:
+    with vllm_runner(model,
+                     tokenizer_name=TOKENIZER,
+                     dtype=dtype,
+                     tensor_parallel_size=tensor_parallel_size,
+                     distributed_executor_backend=distributed_executor_backend,
+                     enforce_eager=True) as vllm_model:
+        vllm_outputs = vllm_model.generate_encoder_decoder_greedy_logprobs(
+            prompts, max_tokens, num_logprobs)
+
+    # Florence-2 processors require image inputs
+    dummy_image = Image.new(mode="RGB", size=(2, 2))
+    with hf_runner(model, dtype=dtype, skip_tokenizer_init=True) as hf_model:
+        hf_model.model.get_output_embeddings = lambda: \
+            hf_model.model.language_model.lm_head
+        hf_outputs = (hf_model.generate_encoder_decoder_greedy_logprobs_limit(
+            prompts,
+            max_tokens,
+            num_logprobs,
+            images=[dummy_image] * len(prompts),
+        ))
+
+    check_logprobs_close(
+        outputs_0_lst=hf_outputs,
+        outputs_1_lst=[
+            vllm_to_hf_output(vllm_output) for vllm_output in vllm_outputs
+        ],
+        name_0="hf",
+        name_1="vllm",
+    )
+
+
+@pytest.mark.parametrize("model", MODELS)
+@pytest.mark.parametrize("dtype", ["float"])
+@pytest.mark.parametrize("max_tokens", [64])
+@pytest.mark.parametrize("num_logprobs", [5])
+def test_models(hf_runner, vllm_runner, model, dtype, max_tokens,
+                num_logprobs) -> None:
+    run_test(
+        hf_runner,
+        vllm_runner,
+        PROMPTS,
+        model,
+        dtype=dtype,
+        max_tokens=max_tokens,
+        num_logprobs=num_logprobs,
+        tensor_parallel_size=1,
+    )
diff --git a/vllm/model_executor/models/florence2.py b/vllm/model_executor/models/florence2.py
new file mode 100644
index 0000000000000..6840ac8b9e303
--- /dev/null
+++ b/vllm/model_executor/models/florence2.py
@@ -0,0 +1,261 @@
+import math
+from typing import Iterable, List, Optional, Tuple
+
+import torch
+import torch.nn as nn
+from transformers import PretrainedConfig
+
+from vllm.attention import AttentionMetadata
+from vllm.config import CacheConfig
+from vllm.model_executor.layers.logits_processor import LogitsProcessor
+from vllm.model_executor.layers.quantization.base_config import (
+    QuantizationConfig)
+from vllm.model_executor.layers.sampler import Sampler, SamplerOutput
+from vllm.model_executor.model_loader.weight_utils import default_weight_loader
+from vllm.model_executor.models.bart import (BartDecoder, BartEncoder,
+                                             BartParallelLMHead,
+                                             BartScaledWordEmbedding)
+from vllm.model_executor.sampling_metadata import SamplingMetadata
+from vllm.sequence import IntermediateTensors
+
+from .utils import AutoWeightsLoader
+
+
+class Florence2LanguageModel(nn.Module):
+
+    def __init__(self,
+                 config: PretrainedConfig,
+                 cache_config: Optional[CacheConfig] = None,
+                 quant_config: Optional[QuantizationConfig] = None):
+        super().__init__()
+        self.config = config
+
+        self.padding_idx = config.pad_token_id
+        self.vocab_size = config.vocab_size
+
+        self.shared = BartScaledWordEmbedding(self.vocab_size, config.d_model)
+        self.encoder = BartEncoder(config,
+                                   cache_config=cache_config,
+                                   quant_config=quant_config)
+        self.decoder = BartDecoder(config,
+                                   cache_config=cache_config,
+                                   quant_config=quant_config)
+
+        if self.config.tie_word_embeddings:
+            self.encoder.embed_tokens.weight = self.shared.weight
+            self.decoder.embed_tokens.weight = self.shared.weight
+
+    def forward(self, input_ids: torch.Tensor, positions: torch.Tensor,
+                encoder_input_ids: torch.Tensor,
+                encoder_positions: torch.Tensor, kv_caches: List[torch.Tensor],
+                attn_metadata: AttentionMetadata) -> torch.Tensor:
+        r"""
+        Args:
+            input_ids
+                Indices of *decoder* input sequence tokens in the vocabulary.
+                Padding will be ignored by default should you
+                provide it.
+            positions
+                Positions of *decoder* input sequence tokens.
+            encoder_input_ids
+                Indices of *encoder* input sequence tokens in the vocabulary.
+            encoder_positions:
+                Positions of *encoder* input sequence tokens.
+            kv_caches:
+                Layer-wise list of KV cache tensors
+            attn_metadata:
+                vLLM Attention metadata structure
+        Returns:
+            Model output torch.Tensor
+        """
+
+        encoder_hidden_states = None
+
+        if encoder_input_ids.numel() > 0:
+            # Run encoder attention if a non-zero number of encoder tokens
+            # are provided as input
+            encoder_hidden_states = self.encoder(input_ids=encoder_input_ids,
+                                                 positions=encoder_positions,
+                                                 kv_caches=kv_caches,
+                                                 attn_metadata=attn_metadata)
+
+        # decoder outputs consists of
+        # (dec_features, past_key_value, dec_hidden, dec_attn)
+        decoder_outputs = self.decoder(
+            decoder_input_ids=input_ids,
+            decoder_positions=positions,
+            encoder_hidden_states=encoder_hidden_states,
+            kv_caches=kv_caches,
+            attn_metadata=attn_metadata)
+
+        return decoder_outputs
+
+
+class Florence2LanguageForConditionalGeneration(nn.Module):
+
+    def __init__(self,
+                 config: PretrainedConfig,
+                 cache_config: Optional[CacheConfig] = None,
+                 quant_config: Optional[QuantizationConfig] = None):
+        super().__init__()
+        self.config = config
+        self.model = Florence2LanguageModel(config,
+                                            cache_config=cache_config,
+                                            quant_config=quant_config)
+        embed_scale = math.sqrt(
+            config.d_model) if config.scale_embedding else 1.0
+
+        self.vocab_size = config.vocab_size
+        self.lm_head = BartParallelLMHead(self.vocab_size,
+                                          config.d_model,
+                                          embed_scale=embed_scale)
+
+        self.logits_processor = LogitsProcessor(self.vocab_size,
+                                                config.vocab_size)
+        self.sampler = Sampler()
+
+    def forward(
+        self,
+        input_ids: torch.Tensor,
+        positions: torch.Tensor,
+        encoder_input_ids: torch.Tensor,
+        encoder_positions: torch.Tensor,
+        kv_caches: List[torch.Tensor],
+        attn_metadata: AttentionMetadata,
+        **kwargs,
+    ) -> torch.Tensor:
+        r"""
+        Args:
+            input_ids
+                torch.Tensor of *decoder* input token ids.
+            positions
+                torch.Tensor of *decoder* position indices.
+            encoder_input_ids
+                torch.Tensor of *encoder* input token ids.
+            encoder_positions
+                torch.Tensor of *encoder* position indices
+            kv_caches:
+                Layer-wise list of KV cache tensors
+            attn_metadata:
+                vLLM Attention metadata structure
+        Returns:
+            Output torch.Tensor
+        """
+        return self.model(input_ids, positions, encoder_input_ids,
+                          encoder_positions, kv_caches, attn_metadata)
+
+    def compute_logits(
+        self,
+        hidden_states: torch.Tensor,
+        sampling_metadata: SamplingMetadata,
+    ) -> Optional[torch.Tensor]:
+        logits = self.logits_processor(self.lm_head, hidden_states,
+                                       sampling_metadata)
+        return logits
+
+    def sample(self, logits: torch.Tensor,
+               sampling_metadata: SamplingMetadata) -> SamplerOutput:
+        next_tokens = self.sampler(logits, sampling_metadata)
+        return next_tokens
+
+    def load_weights(self, weights: Iterable[Tuple[str, torch.Tensor]]):
+        stacked_params_mapping = [
+            # (param_name, shard_name, shard_id)
+            ("qkv_proj", "q_proj", "q"),
+            ("qkv_proj", "k_proj", "k"),
+            ("qkv_proj", "v_proj", "v"),
+        ]
+
+        params_dict = dict(self.named_parameters())
+        for name, loaded_weight in weights:
+            for (param_name, weight_name, shard_id) in stacked_params_mapping:
+                if weight_name not in name:
+                    continue
+
+                param = params_dict[name.replace(weight_name, param_name)]
+                weight_loader = param.weight_loader
+                weight_loader(param, loaded_weight, shard_id)
+                break
+            else:
+                if "final_logits_bias" in name:
+                    continue
+                if self.config.tie_word_embeddings and "embed_tokens" in name:
+                    continue
+                param = params_dict[name]
+                weight_loader = getattr(param, "weight_loader",
+                                        default_weight_loader)
+                weight_loader(param, loaded_weight)
+
+
+class Florence2ForConditionalGeneration(nn.Module):
+
+    def __init__(self,
+                 config: PretrainedConfig,
+                 cache_config: Optional[CacheConfig] = None,
+                 quant_config: Optional[QuantizationConfig] = None):
+        super().__init__()
+
+        # TODO(Isotr0py): Add vision backbone
+        self.language_model = Florence2LanguageForConditionalGeneration(
+            config=config.text_config,
+            cache_config=cache_config,
+            quant_config=quant_config)
+
+    @property
+    def sampler(self):
+        return self.language_model.sampler
+
+    def forward(
+        self,
+        input_ids: torch.Tensor,
+        positions: torch.Tensor,
+        kv_caches: List[torch.Tensor],
+        attn_metadata: AttentionMetadata,
+        intermediate_tensors: Optional[IntermediateTensors] = None,
+        *,
+        encoder_input_ids: torch.Tensor,
+        encoder_positions: torch.Tensor,
+        **kwargs,
+    ) -> torch.Tensor:
+        r"""
+        Args:
+            input_ids
+                torch.Tensor of *decoder* input token ids.
+            positions
+                torch.Tensor of *decoder* position indices.
+            encoder_input_ids
+                torch.Tensor of *encoder* input token ids.
+            encoder_positions
+                torch.Tensor of *encoder* position indices
+            kv_caches:
+                Layer-wise list of KV cache tensors
+            attn_metadata:
+                vLLM Attention metadata structure
+        Returns:
+            Output torch.Tensor
+        """
+        return self.language_model(input_ids, positions, encoder_input_ids,
+                                   encoder_positions, kv_caches, attn_metadata)
+
+    def compute_logits(
+        self,
+        hidden_states: torch.Tensor,
+        sampling_metadata: SamplingMetadata,
+    ) -> Optional[torch.Tensor]:
+        return self.language_model.compute_logits(hidden_states,
+                                                  sampling_metadata)
+
+    def sample(
+        self,
+        logits: torch.Tensor,
+        sampling_metadata: SamplingMetadata,
+    ) -> SamplerOutput:
+        return self.language_model.sample(logits, sampling_metadata)
+
+    def load_weights(self, weights: Iterable[Tuple[str, torch.Tensor]]):
+        skip_prefixes = [
+            'image_projection', "vision_tower", "image_proj_norm",
+            "image_pos_embed", "visual_temporal_embed"
+        ]
+        loader = AutoWeightsLoader(self, skip_prefixes=skip_prefixes)
+        loader.load_weights(weights)
diff --git a/vllm/model_executor/models/registry.py b/vllm/model_executor/models/registry.py
index a255b2a2f3982..787c65743e894 100644
--- a/vllm/model_executor/models/registry.py
+++ b/vllm/model_executor/models/registry.py
@@ -85,6 +85,7 @@
     # [Encoder-decoder]
     "BartModel": ("bart", "BartForConditionalGeneration"),
     "BartForConditionalGeneration": ("bart", "BartForConditionalGeneration"),
+    "Florence2ForConditionalGeneration": ("florence2", "Florence2ForConditionalGeneration"),  # noqa: E501
 }
 
 _EMBEDDING_MODELS = {