diff --git a/pkgs/development/python-modules/uamqp/default.nix b/pkgs/development/python-modules/uamqp/default.nix
index 61979da58d4c31..261e50b9afab67 100644
--- a/pkgs/development/python-modules/uamqp/default.nix
+++ b/pkgs/development/python-modules/uamqp/default.nix
@@ -27,6 +27,19 @@ buildPythonPackage rec {
     ./darwin-azure-c-shared-utility-corefoundation.patch
   ];
 
+  postPatch = lib.optionalString (stdenv.isDarwin && !stdenv.isx86_64) ''
+    # force darwin aarch64 to use openssl instead of applessl, removing
+    # some quirks upstream thinks they need to use openssl on macos
+    sed -i \
+      -e '/^use_openssl =/cuse_openssl = True' \
+      -e 's/\bazssl\b/ssl/' \
+      -e 's/\bazcrypto\b/crypto/' \
+      setup.py
+    sed -i \
+      -e '/#define EVP_PKEY_id/d' \
+      src/vendor/azure-uamqp-c/deps/azure-c-shared-utility/adapters/x509_openssl.c
+  '';
+
   nativeBuildInputs = [
     cmake
   ];