diff --git a/pkgs/stdenv/generic/setup.sh b/pkgs/stdenv/generic/setup.sh
index 734abb890c24f..1861b044a394b 100644
--- a/pkgs/stdenv/generic/setup.sh
+++ b/pkgs/stdenv/generic/setup.sh
@@ -311,12 +311,6 @@ _accumFlagsArray() {
 _addRpathPrefix() {
     if [ "${NIX_NO_SELF_RPATH:-0}" != 1 ]; then
         export NIX_LDFLAGS="-rpath $1/lib ${NIX_LDFLAGS-}"
-        if [ -n "${NIX_LIB64_IN_SELF_RPATH:-}" ]; then
-            export NIX_LDFLAGS="-rpath $1/lib64 ${NIX_LDFLAGS-}"
-        fi
-        if [ -n "${NIX_LIB32_IN_SELF_RPATH:-}" ]; then
-            export NIX_LDFLAGS="-rpath $1/lib32 ${NIX_LDFLAGS-}"
-        fi
     fi
 }
 
diff --git a/pkgs/stdenv/linux/default.nix b/pkgs/stdenv/linux/default.nix
index 51f217f03b276..10a374a213a00 100644
--- a/pkgs/stdenv/linux/default.nix
+++ b/pkgs/stdenv/linux/default.nix
@@ -115,8 +115,6 @@ let
     ''
       export NIX_ENFORCE_PURITY="''${NIX_ENFORCE_PURITY-1}"
       export NIX_ENFORCE_NO_NATIVE="''${NIX_ENFORCE_NO_NATIVE-1}"
-      ${lib.optionalString (system == "x86_64-linux") "NIX_LIB64_IN_SELF_RPATH=1"}
-      ${lib.optionalString (system == "mipsel-linux") "NIX_LIB32_IN_SELF_RPATH=1"}
     '';