diff --git a/pkgs/development/python-modules/python-u2flib-host/default.nix b/pkgs/development/python-modules/python-u2flib-host/default.nix
new file mode 100644
index 0000000000000..38785d813138f
--- /dev/null
+++ b/pkgs/development/python-modules/python-u2flib-host/default.nix
@@ -0,0 +1,23 @@
+{ stdenv, fetchPypi, buildPythonPackage, requests, hidapi }:
+
+buildPythonPackage rec {
+  pname = "python-u2flib-host";
+  version = "3.0.3";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "02pwafd5kyjpc310ys0pgnd0adff1laz18naxxwsfrllqafqnrxb";
+  };
+
+  propagatedBuildInputs = [ requests hidapi ];
+
+  # Tests fail: "ValueError: underlying buffer has been detached"
+  doCheck = false;
+
+  meta = with stdenv.lib; {
+    description = "Python based U2F host library";
+    homepage = https://github.com/Yubico/python-u2flib-host;
+    license = licenses.bsd2;
+    maintainers = with maintainers; [ jluttine ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 7cd7cc865667e..3a5114dca1cbc 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -16279,6 +16279,8 @@ EOF
 
   potr = callPackage ../development/python-modules/potr {};
 
+  python-u2flib-host = callPackage ../development/python-modules/python-u2flib-host { };
+
   pluggy = callPackage ../development/python-modules/pluggy {};
 
   xcffib = callPackage ../development/python-modules/xcffib {};