diff --git a/pkgs/development/python-modules/re-wx/default.nix b/pkgs/development/python-modules/re-wx/default.nix
new file mode 100644
index 0000000000000..1c9f402c78862
--- /dev/null
+++ b/pkgs/development/python-modules/re-wx/default.nix
@@ -0,0 +1,54 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, wxPython_4_2
+, pytest
+}:
+
+buildPythonPackage rec {
+    pname = "re-wx";
+    version = "0.0.10";
+
+    src = fetchPypi {
+        inherit pname version;
+        sha256 = "750d28e1987cb58ea580bee3b63178f5a1ee483a32682f95455628fe7429117e";
+    };
+
+    buildInputs = [ wxPython_4_2 ];
+
+    doCheck = true;
+    checkInputs = [ pytest ];
+    checkPhase = ''
+      # py.test tests/test_components/test_gauge.py # ModuleNotFoundError: No module named 'pip._vendor.contextlib2'
+      # py.test tests/test_components/test_staticbitmap.py # ModuleNotFoundError: No module named 'pip._vendor.contextlib2'
+      # py.test tests/test_components/test_textctrl.py # SystemExit: Unable to access the X Display
+      py.test tests/test_create_element.py
+      # py.test tests/test_nested_components.py # SystemExit: Unable to access the X Display
+      # py.test tests/test_widgets.py # SystemExit: Unable to access the X Display
+    '';
+
+    pythonImportsCheck = [
+    "rewx"
+    "rewx.components"
+    "rewx.widgets"
+    ];
+
+  meta = with lib; {
+    # for python v3.10.6, re-wx fails during linking with
+    #
+    #     python3.10-wxPython-4.1.1/lib/python3.10/site-packages/wx/svg/_nanosvg.cpython-310-x86_64-linux-gnu.so: undefined symbol: _PyGen_Send
+    #
+    # https://github.com/wxWidgets/Phoenix/issues/2016
+    # https://github.com/cython/cython/issues/3876
+    #
+    # This is fixed in wxPython v4.2.0.
+    # https://github.com/wxWidgets/Phoenix/issues/2016
+    #
+    # So Python v3.10 requires wxPython v4.2.0
+    description = "Modern declarative desktop applications with a wxPython virtualdom";
+    homepage = "https://github.com/chriskiehl/re-wx";
+    license = licenses.mit;
+    maintainers = with maintainers; [ ];
+  };
+}
+
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 405b9de1c9db8..0fbc414924a04 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -9815,6 +9815,8 @@ self: super: with self; {
 
   retworkx = callPackage ../development/python-modules/retworkx { };
 
+  re-wx = callPackage ../development/python-modules/re-wx { };
+
   rfc3339 = callPackage ../development/python-modules/rfc3339 { };
 
   rfc3339-validator = callPackage ../development/python-modules/rfc3339-validator { };