diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 27d4205e71b9..d381145ad7dd 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -423,11 +423,12 @@
 
   //#define AUTO_POWER_CONTROL      // Enable automatic control of the PS_ON pin
   #if ENABLED(AUTO_POWER_CONTROL)
-    #define AUTO_POWER_FANS         // Turn on PSU if fans need power
-    #define AUTO_POWER_E_FANS
-    #define AUTO_POWER_CONTROLLERFAN
-    #define AUTO_POWER_CHAMBER_FAN
-    #define AUTO_POWER_COOLER_FAN
+    #define AUTO_POWER_FANS           // Turn on PSU for fans
+    #define AUTO_POWER_E_FANS         // Turn on PSU for E Fans
+    #define AUTO_POWER_CONTROLLERFAN  // Turn on PSU for Controller Fan
+    #define AUTO_POWER_CHAMBER_FAN    // Turn on PSU for Chamber Fan
+    #define AUTO_POWER_COOLER_FAN     // Turn on PSU for Cooler Fan
+    #define AUTO_POWER_SPINDLE_LASER  // Turn on PSU for Spindle/Laser
     #define POWER_TIMEOUT              30 // (s) Turn off power if the machine is idle for this duration
     //#define POWER_OFF_DELAY          60 // (s) Delay of poweroff after M81 command. Useful to let fans run for extra time.
   #endif
diff --git a/Marlin/src/feature/power.cpp b/Marlin/src/feature/power.cpp
index d0f8a66fec36..e908c8292fd6 100644
--- a/Marlin/src/feature/power.cpp
+++ b/Marlin/src/feature/power.cpp
@@ -53,6 +53,10 @@ bool Power::psu_on;
     #include "controllerfan.h"
   #endif
 
+  #if ANY(LASER_FEATURE, SPINDLE_FEATURE)
+    #include "spindle_laser.h"
+  #endif
+
   millis_t Power::lastPowerOn;
 #endif
 
@@ -196,6 +200,10 @@ void Power::power_off() {
       if (controllerFan.state()) return true;
     #endif
 
+    #if ANY(LASER_FEATURE, SPINDLE_FEATURE)
+      if (TERN0(AUTO_POWER_SPINDLE_LASER, cutter.enabled())) return true;
+    #endif
+
     if (TERN0(AUTO_POWER_CHAMBER_FAN, thermalManager.chamberfan_speed))
       return true;
 
diff --git a/Marlin/src/inc/Conditionals_post.h b/Marlin/src/inc/Conditionals_post.h
index 13f20114e509..8f3a2eee27b9 100644
--- a/Marlin/src/inc/Conditionals_post.h
+++ b/Marlin/src/inc/Conditionals_post.h
@@ -2623,6 +2623,9 @@
 #if !HAS_AUTO_COOLER_FAN || AUTO_COOLER_IS_E
   #undef AUTO_POWER_COOLER_FAN
 #endif
+#if !HAS_CUTTER
+  #undef AUTO_POWER_SPINDLE_LASER
+#endif
 
 /**
  * Controller Fan Settings