diff --git a/monai/inferers/inferer.py b/monai/inferers/inferer.py
index f9c04664be..5484970d82 100644
--- a/monai/inferers/inferer.py
+++ b/monai/inferers/inferer.py
@@ -22,6 +22,7 @@
 
 from monai.apps.utils import get_logger
 from monai.data.meta_tensor import MetaTensor
+from monai.data.thread_buffer import ThreadBuffer
 from monai.inferers.merger import AvgMerger, Merger
 from monai.inferers.splitter import Splitter
 from monai.inferers.utils import compute_importance_map, sliding_window_inference
@@ -103,6 +104,7 @@ class PatchInferer(Inferer):
             the output dictionary to be used for merging.
             Defaults to None, where all the keys are used.
         match_spatial_shape: whether to crop the output to match the input shape. Defaults to True.
+        buffer_size: number of patches to be held in the buffer with a separate thread for batch sampling. Defaults to 0.
         merger_kwargs: arguments to be passed to `merger_cls` for instantiation.
             `merged_shape` is calculated automatically based on the input shape and
             the output patch shape unless it is passed here.
@@ -117,6 +119,7 @@ def __init__(
         postprocessing: Callable | None = None,
         output_keys: Sequence | None = None,
         match_spatial_shape: bool = True,
+        buffer_size: int = 0,
         **merger_kwargs: Any,
     ) -> None:
         Inferer.__init__(self)
@@ -157,6 +160,8 @@ def __init__(
         self.postprocessing = postprocessing
 
         # batch size for patches
+        if batch_size < 1:
+            raise ValueError(f"`batch_size` must be a positive number, {batch_size} is given.")
         self.batch_size = batch_size
 
         # model output keys
@@ -165,6 +170,9 @@ def __init__(
         # whether to crop the output to match the input shape
         self.match_spatial_shape = match_spatial_shape
 
+        # buffer size for multithreaded batch sampling
+        self.buffer_size = buffer_size
+
     def _batch_sampler(
         self, patches: Iterable[tuple[torch.Tensor, Sequence[int]]] | MetaTensor
     ) -> Iterator[tuple[torch.Tensor, Sequence, int]]:
@@ -182,10 +190,16 @@ def _batch_sampler(
                 batch_size = min(self.batch_size, total_size - i)
                 yield patches[i : i + batch_size], patches[i : i + batch_size].meta[PatchKeys.LOCATION], batch_size  # type: ignore
         else:
+            buffer: Iterable | ThreadBuffer
+            if self.buffer_size > 0:
+                # Use multi-threading to sample patches with a buffer
+                buffer = ThreadBuffer(patches, buffer_size=self.buffer_size, timeout=0.1)
+            else:
+                buffer = patches
             patch_batch: list[Any] = [None] * self.batch_size
             location_batch: list[Any] = [None] * self.batch_size
             idx_in_batch = 0
-            for sample in patches:
+            for sample in buffer:
                 patch_batch[idx_in_batch] = sample[0]
                 location_batch[idx_in_batch] = sample[1]
                 idx_in_batch += 1
diff --git a/tests/test_patch_inferer.py b/tests/test_patch_inferer.py
index b0d25a98b9..bc6fc30a88 100644
--- a/tests/test_patch_inferer.py
+++ b/tests/test_patch_inferer.py
@@ -127,6 +127,7 @@
     TENSOR_4x4,
 ]
 
+
 # non-divisible patch_size leading to larger image (without matching spatial shape)
 TEST_CASE_11_PADDING = [
     TENSOR_4x4,
@@ -155,6 +156,23 @@
     TENSOR_4x4,
 ]
 
+# multi-threading
+TEST_CASE_14_MULTITHREAD_BUFFER = [
+    TENSOR_4x4,
+    dict(splitter=SlidingWindowSplitter(patch_size=(2, 2)), merger_cls=AvgMerger, buffer_size=2),
+    lambda x: x,
+    TENSOR_4x4,
+]
+
+# multi-threading with batch
+TEST_CASE_15_MULTITHREADD_BUFFER = [
+    TENSOR_4x4,
+    dict(splitter=SlidingWindowSplitter(patch_size=(2, 2)), merger_cls=AvgMerger, buffer_size=4, batch_size=4),
+    lambda x: x,
+    TENSOR_4x4,
+]
+
+
 # list of tensor output
 TEST_CASE_0_LIST_TENSOR = [
     TENSOR_4x4,
@@ -245,6 +263,8 @@ class PatchInfererTests(unittest.TestCase):
             TEST_CASE_11_PADDING,
             TEST_CASE_12_MATCHING,
             TEST_CASE_13_PADDING_MATCHING,
+            TEST_CASE_14_MULTITHREAD_BUFFER,
+            TEST_CASE_15_MULTITHREADD_BUFFER,
         ]
     )
     def test_patch_inferer_tensor(self, inputs, arguments, network, expected):