diff --git a/Cargo.lock b/Cargo.lock
index a116c570a..4d98b8d11 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -213,6 +213,20 @@ dependencies = [
  "serde",
 ]
 
+[[package]]
+name = "cargo-config2"
+version = "0.1.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "59a3dbc2202646fb5a83a0f0f45259be618f006862edc0d20938f247f2678706"
+dependencies = [
+ "cfg-expr",
+ "home",
+ "once_cell",
+ "serde",
+ "shell-escape",
+ "toml_edit",
+]
+
 [[package]]
 name = "cargo-options"
 version = "0.5.3"
@@ -233,19 +247,18 @@ dependencies = [
 
 [[package]]
 name = "cargo-xwin"
-version = "0.13.5"
+version = "0.13.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "570ef9c57470aa820aae02ec06456a9e2148149598c9927943ae8afba56ba322"
+checksum = "ce9653c9f9630bbdb6c3566f9e77ad568e38eeb4c4849b0913a65aa5c43c12df"
 dependencies = [
  "anyhow",
+ "cargo-config2",
  "cargo-options",
  "clap",
  "dirs",
  "fs-err",
  "indicatif",
  "path-slash",
- "serde",
- "serde_json",
  "which",
  "xwin",
 ]
@@ -320,6 +333,15 @@ dependencies = [
  "uuid",
 ]
 
+[[package]]
+name = "cfg-expr"
+version = "0.13.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a327683d7499ecc47369531a679fe38acdd300e09bf8c852d08b1e10558622bd"
+dependencies = [
+ "smallvec",
+]
+
 [[package]]
 name = "cfg-if"
 version = "1.0.0"
@@ -1107,6 +1129,15 @@ dependencies = [
  "digest 0.9.0",
 ]
 
+[[package]]
+name = "home"
+version = "0.5.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "747309b4b440c06d57b0b25f2aee03ee9b5e5397d288c60e21fc709bb98a7408"
+dependencies = [
+ "winapi",
+]
+
 [[package]]
 name = "humantime"
 version = "2.1.0"
@@ -1327,6 +1358,7 @@ dependencies = [
  "anyhow",
  "base64",
  "bytesize",
+ "cargo-config2",
  "cargo-options",
  "cargo-xwin",
  "cargo-zigbuild",
@@ -1823,9 +1855,9 @@ checksum = "b4596b6d070b27117e987119b4dac604f3c58cfb0b191112e24771b2faeac1a6"
 
 [[package]]
 name = "platform-info"
-version = "1.0.1"
+version = "1.0.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4278b2b54a23c9a91d5bae9b09e21d566f8b23890491951160b05d64f29d1d8b"
+checksum = "4e7c23cfae725ae06d9e43010153fa77bdfa8c827bf08fe4beeb2a3514e6be12"
 dependencies = [
  "libc",
  "winapi",
@@ -2042,9 +2074,9 @@ dependencies = [
 
 [[package]]
 name = "regex"
-version = "1.7.0"
+version = "1.7.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e076559ef8e241f2ae3479e36f97bd5741c0330689e217ad51ce2c76808b868a"
+checksum = "48aaa5748ba571fb95cd2c85c09f629215d3a6ece942baa100950af03a34f733"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -2338,6 +2370,12 @@ dependencies = [
  "lazy_static",
 ]
 
+[[package]]
+name = "shell-escape"
+version = "0.1.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "45bb67a18fa91266cc7807181f62f9178a6873bfad7dc788c42e6430db40184f"
+
 [[package]]
 name = "shlex"
 version = "1.1.0"
diff --git a/Cargo.toml b/Cargo.toml
index d0bc3c69b..a9d4f10a3 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -23,6 +23,7 @@ name = "maturin"
 anyhow = "1.0.63"
 base64 = "0.13.0"
 glob = "0.3.0"
+cargo-config2 = "0.1.1"
 cargo_metadata = "0.15.2"
 cargo-options = "0.5.2"
 cbindgen = { version = "0.24.2", default-features = false }
diff --git a/src/compile.rs b/src/compile.rs
index 05d43151c..6cec59d33 100644
--- a/src/compile.rs
+++ b/src/compile.rs
@@ -173,7 +173,10 @@ fn compile_target(
         }
     }
 
-    let mut rust_flags = env::var_os("RUSTFLAGS");
+    let target_triple = target.target_triple();
+
+    let manifest_dir = context.manifest_path.parent().unwrap();
+    let mut rust_flags = get_rustflags(manifest_dir, target_triple)?;
 
     // We need to pass --bin / --lib
     match bridge_model {
@@ -189,10 +192,11 @@ fn compile_target(
             // We must only do this for libraries as it breaks binaries
             // For some reason this value is ignored when passed as rustc argument
             if context.target.is_musl_target() {
-                debug!("Setting `-C target-features=-crt-static` for musl dylib");
-                rust_flags
-                    .get_or_insert_with(Default::default)
-                    .push(" -C target-feature=-crt-static");
+                let flags = rust_flags.get_or_insert_with(Default::default);
+                if !flags.contains("target-feature=-crt-static") {
+                    debug!("Setting `-C target-features=-crt-static` for musl dylib");
+                    flags.push_str(" -C target-feature=-crt-static");
+                }
             }
         }
     }
@@ -226,8 +230,9 @@ fn compile_target(
     } else if target.is_emscripten() {
         let flags = rust_flags.get_or_insert_with(Default::default);
         // Allow user to override these default flags
-        if !flags.to_string_lossy().contains("link-native-libraries") {
-            flags.push(" -Z link-native-libraries=no");
+        if !flags.contains("link-native-libraries") {
+            debug!("Setting `-Z link-native-libraries=no` for Emscripten");
+            flags.push_str(" -Z link-native-libraries=no");
         }
         let mut emscripten_args = Vec::new();
         // Allow user to override these default settings
@@ -260,7 +265,6 @@ fn compile_target(
             .extend(["-C".to_string(), "link-arg=-s".to_string()]);
     }
 
-    let target_triple = target.target_triple();
     let mut build_command = if target.is_msvc() && target.cross_compiling() {
         #[cfg(feature = "xwin")]
         {
@@ -505,6 +509,24 @@ fn compile_target(
     Ok(artifacts)
 }
 
+/// Get `RUSTFLAGS` in the following order:
+///
+/// 1. `RUSTFLAGS` environment variable
+/// 2. `rustflags` cargo configuration
+fn get_rustflags(workdir: &Path, target: &str) -> Result<Option<String>> {
+    match env::var("RUSTFLAGS") {
+        Ok(flags) => Ok(Some(flags)),
+        Err(_) => {
+            let cargo_config = cargo_config2::Config::load_with_cwd(workdir)?;
+            let rustflags = cargo_config.rustflags(target)?;
+            match rustflags {
+                Some(rustflags) => Ok(Some(rustflags.encode_space_separated()?)),
+                None => Ok(None),
+            }
+        }
+    }
+}
+
 /// Checks that the native library contains a function called `PyInit_<module name>` and warns
 /// if it's missing.
 ///