diff --git a/.github/workflows/apply-clang-format.yml b/.github/workflows/apply-clang-format.yml
deleted file mode 100644
index 5d0389b7e..000000000
--- a/.github/workflows/apply-clang-format.yml
+++ /dev/null
@@ -1,15 +0,0 @@
-name: Apply clang-format to PR
-
-on:
-  pull_request:
-    types: [labeled]
-
-jobs:
-  clang-format:
-    runs-on: ubuntu-latest
-
-    steps:
-    - uses: actions/checkout@v1
-    - uses: InsightSoftwareConsortium/ITKApplyClangFormatAction@testing
-      with:
-        github-token: ${{ secrets.GITHUB_TOKEN }}
\ No newline at end of file
diff --git a/.github/workflows/build-test-cxx-cuda.yml b/.github/workflows/build-test-cxx-cuda.yml
deleted file mode 100644
index cb88feba4..000000000
--- a/.github/workflows/build-test-cxx-cuda.yml
+++ /dev/null
@@ -1,165 +0,0 @@
-name: 'Build, Test RTK with CUDA'
-
-on: [push,pull_request]
-
-env:
-  itk-git-tag: "v5.4.0"
-  itk-module-deps: "CudaCommon@v1.1.0"
-
-jobs:
-  build-test-cxx:
-    runs-on: ${{ matrix.os }}
-    strategy:
-      max-parallel: 3
-      matrix:
-        os: [self-hosted-linux, self-hosted-windows]
-        include:
-          - os: self-hosted-linux
-            c-compiler: "gcc"
-            cxx-compiler: "g++"
-            cmake-build-type: "MinSizeRel"
-          - os: self-hosted-windows
-            c-compiler: "cl.exe"
-            cxx-compiler: "cl.exe"
-            cmake-build-type: "Release"
-
-    steps:
-    - uses: actions/checkout@v3
-
-    - name: Install build dependencies
-      run: |
-        python -m pip install --upgrade pip
-        python -m pip install ninja
-
-    - name: Get specific version of CMake, Ninja
-      uses: lukka/get-cmake@v3.24.2
-
-    - name: self-hosted cleanup
-      shell: bash
-      run: |
-        rm -fr ../ITK
-        rm -fr ../ITK-build
-        rm -fr ../build
-
-    - name: Download ITK
-      run: |
-        cd ..
-        git clone https://github.com/InsightSoftwareConsortium/ITK.git
-        cd ITK
-        git checkout ${{ env.itk-git-tag }}
-
-    - name: Build ITK
-      if: matrix.os != 'self-hosted-windows'
-      shell: bash
-      run: |
-        cd ..
-        mkdir ITK-build
-        cd ITK-build
-        MODULE_ARGS=""
-        MODULE_DEPS=${{ env.itk-module-deps }}
-        for MODULE_INFO in ${MODULE_DEPS//:/ }; do
-          MODULE_NAME=`(echo ${MODULE_INFO} | cut -d'@' -f 1)`
-          MODULE_ARGS="${MODULE_ARGS} -DModule_${MODULE_NAME}:BOOL=ON"
-          MODULE_TAG=`(echo ${MODULE_INFO} | cut -d'@' -f 2)`
-          if [[ -n ${MODULE_TAG} ]]; then
-            MODULE_ARGS+=" -DModule_${MODULE_NAME}_GIT_TAG:STRING=${MODULE_TAG}"
-          fi
-        done
-        if [[ -n $MODULE_ARGS ]]; then
-          echo "Building with modules: $MODULE_ARGS"
-        fi
-
-        cmake -DCMAKE_C_COMPILER:FILEPATH="${{ matrix.c-compiler }}" -DBUILD_SHARED_LIBS:BOOL=ON -DCMAKE_CXX_COMPILER="${{ matrix.cxx-compiler }}" -DCMAKE_BUILD_TYPE:STRING=${{ matrix.cmake-build-type }} -DBUILD_TESTING:BOOL=OFF ${{ env.itk-cmake-options }} ${MODULE_ARGS} -GNinja ../ITK
-        ninja
-
-    - name: Build ITK
-      if: matrix.os == 'self-hosted-windows'
-      shell: pwsh
-      run: |
-        Set-PSDebug -Trace 1
-        cd ..
-        & "C:\Program Files\Microsoft Visual Studio\2022\Community\Common7\Tools\Launch-VsDevShell.ps1" -Arch amd64 -SkipAutomaticLocation
-        mkdir ITK-build
-        cd ITK-build
-
-        $MODULE_ARGS=""
-        $MODULE_DEPS="${{ env.itk-module-deps }}"
-        $MODULES_LIST = $MODULE_DEPS.split(":")
-        foreach($MODULE_INFO in $MODULES_LIST) {
-          if($MODULE_ARGS) { $MODULE_ARGS += " " }
-          $MODULE_NAME = $MODULE_INFO.split("@")[0]
-          $MODULE_ARGS += "-DModule_$MODULE_NAME`:BOOL=ON"
-          $MODULE_TAG = $MODULE_INFO.split("@")[1]
-          if($MODULE_TAG) {
-            $MODULE_ARGS += " -DModule_$MODULE_NAME`_GIT_TAG:STRING=$MODULE_TAG"
-          }
-        }
-
-        if($MODULE_ARGS) {
-          echo "Building with parameters: ${{ env.itk-cmake-options }} $MODULE_ARGS"
-        }
-
-        cmake -DCMAKE_C_COMPILER:FILEPATH="${{ matrix.c-compiler }}" -DBUILD_SHARED_LIBS:BOOL=ON -DCMAKE_CXX_COMPILER="${{ matrix.cxx-compiler }}" -DCMAKE_BUILD_TYPE:STRING=${{ matrix.cmake-build-type }} -DBUILD_TESTING:BOOL=OFF ${{ env.itk-cmake-options }} $MODULE_ARGS.split(" ") -GNinja ../ITK
-        ninja
-
-    - name: Fetch CTest driver script
-      run: |
-        curl -L https://raw.githubusercontent.com/InsightSoftwareConsortium/ITK/dashboard/itk_common.cmake -O
-
-    - name: Configure CTest script
-      shell: bash
-      run: |
-        operating_system="${{ matrix.os }}"
-        cat > dashboard.cmake << EOF
-        set(CTEST_SITE "GitHubActions")
-        file(TO_CMAKE_PATH "\$ENV{GITHUB_WORKSPACE}/.." CTEST_DASHBOARD_ROOT)
-        file(TO_CMAKE_PATH "\$ENV{GITHUB_WORKSPACE}/" CTEST_SOURCE_DIRECTORY)
-        file(TO_CMAKE_PATH "\$ENV{GITHUB_WORKSPACE}/../build" CTEST_BINARY_DIRECTORY)
-        set(dashboard_source_name "${GITHUB_REPOSITORY}")
-        if((ENV{GITHUB_REF_NAME} MATCHES "master" OR ENV{GITHUB_REF_NAME} MATCHES "main"))
-          set(branch "-master")
-          set(dashboard_model "Continuous")
-        else()
-          set(branch "-${GITHUB_REF}")
-          set(dashboard_model "Experimental")
-        endif()
-        set(CTEST_BUILD_NAME "${GITHUB_REPOSITORY}-${operating_system}-\${branch}")
-        set(CTEST_UPDATE_VERSION_ONLY 1)
-        set(CTEST_TEST_ARGS \${CTEST_TEST_ARGS} PARALLEL_LEVEL \${PARALLEL_LEVEL})
-        set(CTEST_BUILD_CONFIGURATION "Release")
-        set(CTEST_CMAKE_GENERATOR "Ninja")
-        set(CTEST_CUSTOM_WARNING_EXCEPTION
-          \${CTEST_CUSTOM_WARNING_EXCEPTION}
-          # macOS Azure VM Warning
-          "ld: warning: text-based stub file"
-          ${{ env.warnings-to-ignore }}
-          )
-        set(dashboard_no_clean 1)
-        set(ENV{CC} ${{ matrix.c-compiler }})
-        set(ENV{CXX} ${{ matrix.cxx-compiler }})
-        if(WIN32)
-          set(ENV{PATH} "\${CTEST_DASHBOARD_ROOT}/ITK-build/bin;\$ENV{PATH}")
-        endif()
-        set(dashboard_cache "
-        ITK_DIR:PATH=\${CTEST_DASHBOARD_ROOT}/ITK-build
-        BUILD_TESTING:BOOL=ON
-        ${{ env.cmake-options }}
-        ")
-        string(TIMESTAMP build_date "%Y-%m-%d")
-        message("CDash Build Identifier: \${build_date} \${CTEST_BUILD_NAME}")
-        message("CTEST_SITE = \${CTEST_SITE}")
-        include(\${CTEST_SCRIPT_DIRECTORY}/itk_common.cmake)
-        EOF
-        cat dashboard.cmake
-
-    - name: Build and test
-      if: matrix.os != 'self-hosted-windows'
-      run: |
-        ctest --output-on-failure -j 2 -V -S dashboard.cmake ${{ env.ctest-options }}
-
-    - name: Build and test
-      if: matrix.os == 'self-hosted-windows'
-      shell: pwsh
-      run: |
-        & "C:\Program Files\Microsoft Visual Studio\2022\Community\Common7\Tools\Launch-VsDevShell.ps1" -Arch amd64 -SkipAutomaticLocation
-        ctest --output-on-failure -j 2 -V -S dashboard.cmake ${{ env.ctest-options }}
diff --git a/.github/workflows/build-test-package-python-cuda.yml b/.github/workflows/build-test-package-python-cuda.yml
index ea42b1356..c81667240 100644
--- a/.github/workflows/build-test-package-python-cuda.yml
+++ b/.github/workflows/build-test-package-python-cuda.yml
@@ -4,7 +4,7 @@ on: [push,pull_request]
 
 env:
   itk-wheel-tag: 'v5.4.0'
-  itk-python-package-tag: 'v5.4.0'
+  itk-python-package-tag: 'f38e8b0f38580807809b0412235fb2ba0946deba'
   itk-python-package-org: 'InsightSoftwareConsortium'
   itk-module-deps: "RTKConsortium/ITKCudaCommon@v1.1.0"
 
@@ -14,9 +14,9 @@ jobs:
     strategy:
       max-parallel: 2
       matrix:
-        python3-minor-version: ["8","9","10","11"]
-        manylinux-platform: ["_2_28-x64","2014-x64"]
-        cuda-version: ["116","121"]
+        python3-minor-version: ["11"]
+        manylinux-platform: ["_2_28-x64"]
+        cuda-version: ["121"]
 
     steps:
     - uses: actions/checkout@v3
@@ -68,6 +68,8 @@ jobs:
         LIBCUBLAS=`basename /home/srit/Downloads/cuda${CUDA_VERSION}/targets/x86_64-linux/lib/libcublas.so.${CUDA_VERSION_MAJOR}*`
         LIBCUBLASLT=`basename /home/srit/Downloads/cuda${CUDA_VERSION}/targets/x86_64-linux/lib/libcublasLt.so.${CUDA_VERSION_MAJOR}*`
         LIBCUFFT=`basename /home/srit/Downloads/cuda${CUDA_VERSION}/targets/x86_64-linux/lib/libcufft.so.$((${CUDA_VERSION_MAJOR}-1))*`
+        sed -i "s/dependencies = \[/dependencies = [ \"itk-cudacommon-cuda${CUDA_VERSION}  == 1.1.*\",/g" pyproject.toml
+        sed -i "s/itk-rtk/itk-rtk-cuda${CUDA_VERSION}/g" pyproject.toml
 
         ./dockcross-manylinux-download-cache-and-build-module-wheels.sh "${CMAKE_OPTIONS[@]}" -x "libcuda.so.1;${LIBCUDART};${LIBCUBLAS};${LIBCUBLASLT};${LIBCUFFT}" cp3${{ matrix.python3-minor-version }}
         mv *zst ../..
@@ -95,89 +97,9 @@ jobs:
         name: LinuxWheel3${{ matrix.python3-minor-version }}${{ matrix.manylinux-platform }}-cuda${{ matrix.cuda-version }}
         path: dist/*.whl
 
-  build-windows-cuda-python-packages:
-    runs-on: self-hosted-windows
-    strategy:
-      max-parallel: 2
-      matrix:
-        python3-minor-version: ["8","9","10","11"]
-        cuda-version: ["116","121"]
-
-    steps:
-    - uses: actions/checkout@v4
-      with:
-        path: "im"
-
-    - name: 'Reduce source path length'
-      shell: bash
-      run: |
-        # Move ITKPythonBuilds archive to the checked-out source
-        if test -f ../../im/ITKPythonBuilds-windows.zip; then
-           mv ../../im/*.zip im
-        fi
-        rm -fr ../../im
-
-        # Move checked-out source to a shorter path to avoid Windows path length issues
-        mv im ../../
-
-    - name: 'Fetch build script'
-      shell: pwsh
-      run: |
-        cd ../../im
-        $ITKPYTHONPACKAGE_TAG = "${{ env.itk-python-package-tag }}"
-        $ITKPYTHONPACKAGE_ORG = "${{ env.itk-python-package-org }}"
-        $SCRIPT_UPSTREAM = "https://raw.githubusercontent.com/$ITKPYTHONPACKAGE_ORG/ITKPythonPackage/$ITKPYTHONPACKAGE_TAG/scripts/windows-download-cache-and-build-module-wheels.ps1"
-        echo "Fetching $SCRIPT_UPSTREAM"
-        (new-object net.webclient).DownloadString($SCRIPT_UPSTREAM) > windows-download-cache-and-build-module-wheels.ps1
-
-    - name: 'Build 🐍 Python 📦 package'
-      shell: pwsh
-      run: |
-        if (Test-Path dist) { rm dist -r -fo }
-
-        cd ../../im
-        & "C:\Program Files\Microsoft Visual Studio\2022\Community\Common7\Tools\Launch-VsDevShell.ps1" -Arch amd64 -SkipAutomaticLocation
-        $env:CC="cl.exe"
-        $env:CXX="cl.exe"
-        $env:ITK_PACKAGE_VERSION = "${{ env.itk-wheel-tag }}"
-        $env:ITKPYTHONPACKAGE_TAG = "${{ env.itk-python-package-tag }}"
-        $env:ITKPYTHONPACKAGE_ORG = "${{ env.itk-python-package-org }}"
-        $env:ITK_MODULE_PREQ = "${{ env.itk-module-deps }}"
-        $CUDA_VERSION = "${{ matrix.cuda-version }}"
-        $CUDA_VERSION_MAJOR=$CUDA_VERSION.substring(0,2)
-        $CUDA_VERSION_MINOR=$CUDA_VERSION.substring(2,$CUDA_VERSION.Length-2)
-        $env:CUDA_PATH = "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}"
-        $env:Path = "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}\bin;" + $env:Path
-        $LIBCUDART= (Get-Item "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}\bin\cudart64*dll" ).Name
-        $LIBCUBLAS= (Get-Item "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}\bin\cublas64*dll" ).Name
-        $LIBCUBLASLT= (Get-Item "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}\bin\cublasLt64*dll" ).Name
-        $LIBCUFFT= (Get-Item "C:\Program Files\NVIDIA GPU Computing Toolkit\CUDA\v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}\bin\cufft64*dll" ).Name
-        ./windows-download-cache-and-build-module-wheels.ps1 "${{ matrix.python3-minor-version }}" -setup_options "--lib-paths ""C:/Program\ Files/NVIDIA\ GPU\ Computing\ Toolkit/CUDA/v${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}/bin"" --exclude-libs ""nvcuda.dll;concrt140.dll;${LIBCUDART};${LIBCUBLAS};${LIBCUBLASLT};${LIBCUFFT}""" -cmake_options "-DRTK_CUDA_VERSION=${CUDA_VERSION_MAJOR}.${CUDA_VERSION_MINOR}"
-
-        mkdir -p '${{ github.workspace }}\dist'
-        cp 'dist\*.whl' '${{ github.workspace }}\dist'
-
-    - name: Validate build output
-      shell: pwsh
-      run: |
-        python -m pip install twine
-        ls dist/
-
-        $WHEEL_PATTERN = "dist/itk_*cp3${{ matrix.python3-minor-version }}*win*.whl"
-        echo "Searching for wheels matching pattern ${WHEEL_PATTERN}"
-
-        python -m twine check ${WHEEL_PATTERN}
-
-    - name: Publish Python package as GitHub Artifact
-      uses: actions/upload-artifact@v4
-      with:
-        name: WindowsWheel3${{ matrix.python3-minor-version }}-cuda${{ matrix.cuda-version }}
-        path: dist/*.whl
-
   publish-python-packages-to-pypi:
     needs:
       - build-linux-cuda-python-packages
-      - build-windows-cuda-python-packages
     runs-on: ubuntu-22.04
 
     steps:
diff --git a/.github/workflows/build-test-package.yml b/.github/workflows/build-test-package.yml
index d3143cea5..03fa97c04 100644
--- a/.github/workflows/build-test-package.yml
+++ b/.github/workflows/build-test-package.yml
@@ -7,11 +7,10 @@ jobs:
     uses: InsightSoftwareConsortium/ITKRemoteModuleBuildTestPackageAction/.github/workflows/build-test-cxx.yml@main
 
   python-build-workflow:
-    uses: InsightSoftwareConsortium/ITKRemoteModuleBuildTestPackageAction/.github/workflows/build-test-package-python.yml@main
+    uses: SimonRit/ITKRemoteModuleBuildTestPackageAction/.github/workflows/build-test-package-python.yml@4ead98d367e8d7065c93672abfaec553360db86f
     with:
       cmake-options: '-DRTK_BUILD_APPLICATIONS:BOOL=OFF'
-      itk-wheel-tag: 'v5.4.0'
-      itk-python-package-tag: 'v5.4.0'
+      itk-python-package-tag: 'f38e8b0f38580807809b0412235fb2ba0946deba'
       itk-module-deps: "RTKConsortium/ITKCudaCommon@v1.1.0"
     secrets:
       pypi_password: ${{ secrets.pypi_password }}
diff --git a/.github/workflows/clang-format-linter.yml b/.github/workflows/clang-format-linter.yml
deleted file mode 100644
index 899d579ef..000000000
--- a/.github/workflows/clang-format-linter.yml
+++ /dev/null
@@ -1,12 +0,0 @@
-name: clang-format linter
-
-on: [push,pull_request]
-
-jobs:
-  lint:
-    runs-on: ubuntu-latest
-
-    steps:
-    - uses: actions/checkout@v3
-
-    - uses: InsightSoftwareConsortium/ITKClangFormatLinterAction@master
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 855649401..415c1e3fc 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -280,16 +280,6 @@ option(RTK_BUILD_APPLICATIONS "Build RTK applications" ON)
 if(RTK_BUILD_APPLICATIONS)
   add_subdirectory(applications)
 endif()
-if(ITK_WRAP_PYTHON)
-  # Install Python application
-  install(FILES applications/rtkconjugategradient/rtkconjugategradient.py
-                applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py
-                applications/rtkorageometry/rtkorageometry.py
-                applications/rtksimulatedgeometry/rtksimulatedgeometry.py
-                applications/rtkvarianobigeometry/rtkvarianobigeometry.py
-          DESTINATION ${RTK_INSTALL_LIB_DIR}
-          COMPONENT PythonWheelRuntimeLibraries)
-endif()
 
 # --------------------------------------------------------
 # Setup KWStyle from ITK
diff --git a/applications/rtkconjugategradient/rtkconjugategradient.py b/applications/rtkconjugategradient/rtkconjugategradient.py
index c9511edff..8d05eadfa 100755
--- a/applications/rtkconjugategradient/rtkconjugategradient.py
+++ b/applications/rtkconjugategradient/rtkconjugategradient.py
@@ -17,7 +17,7 @@ def GetCudaImageFromImage(img):
   else:
     return img
 
-if __name__ == '__main__':
+def main():
   # argument parsing
   parser = argparse.ArgumentParser(description=
     'Reconstructs a 3D volume from a sequence of projections with a conjugate gradient technique',
@@ -131,3 +131,6 @@ def GetCudaImageFromImage(img):
   writer.SetFileName(args_info.output)
   writer.SetInput(conjugategradient.GetOutput())
   writer.Update()
+
+if __name__ == '__main__':
+  main()
diff --git a/applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py b/applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py
index 607d91123..b9a919f79 100755
--- a/applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py
+++ b/applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py
@@ -4,7 +4,7 @@
 import itk
 from itk import RTK as rtk
 
-if __name__ == '__main__':
+def main():
   # Argument parsing
   parser = argparse.ArgumentParser(description=
     "Creates an RTK geometry file from an Elekta Synergy acquisition.")
@@ -27,3 +27,6 @@
   xmlWriter.SetFilename(args.output)
   xmlWriter.SetObject(reader.GetGeometry())
   xmlWriter.WriteFile()
+
+if __name__ == '__main__':
+  main()
diff --git a/applications/rtkorageometry/rtkorageometry.py b/applications/rtkorageometry/rtkorageometry.py
index 914f8a7d3..f50618860 100644
--- a/applications/rtkorageometry/rtkorageometry.py
+++ b/applications/rtkorageometry/rtkorageometry.py
@@ -3,7 +3,7 @@
 import itk
 from itk import RTK as rtk
 
-if __name__ == '__main__':
+def main():
   # Argument parsing
   parser = argparse.ArgumentParser(description=
     "Creates an RTK geometry file from a Varian OBI acquisition.")
@@ -37,3 +37,6 @@
   xmlWriter.SetFilename(args.output)
   xmlWriter.SetObject(reader.GetGeometry())
   xmlWriter.WriteFile()
+
+if __name__ == '__main__':
+  main()
diff --git a/applications/rtksimulatedgeometry/rtksimulatedgeometry.py b/applications/rtksimulatedgeometry/rtksimulatedgeometry.py
index 313723626..b3c3a249d 100644
--- a/applications/rtksimulatedgeometry/rtksimulatedgeometry.py
+++ b/applications/rtksimulatedgeometry/rtksimulatedgeometry.py
@@ -3,7 +3,7 @@
 import sys
 from itk import RTK as rtk
 
-if __name__ == '__main__':
+def main():
   # Argument parsing
   parser = argparse.ArgumentParser(description=
     "Creates an RTK geometry file from simulated/regular trajectory. See https://www.openrtk.org/Doxygen/DocGeo3D.html for more information.")
@@ -51,3 +51,6 @@
   writer.SetFilename(args.output)
   writer.SetObject(geometry)
   writer.WriteFile()
+
+if __name__ == '__main__':
+  main()
diff --git a/applications/rtkvarianobigeometry/rtkvarianobigeometry.py b/applications/rtkvarianobigeometry/rtkvarianobigeometry.py
index 02fd74882..fc34b5267 100644
--- a/applications/rtkvarianobigeometry/rtkvarianobigeometry.py
+++ b/applications/rtkvarianobigeometry/rtkvarianobigeometry.py
@@ -4,7 +4,7 @@
 import itk
 from itk import RTK as rtk
 
-if __name__ == '__main__':
+def main():
   # Argument parsing
   parser = argparse.ArgumentParser(description=
     "Creates an RTK geometry file from a Varian OBI acquisition.")
@@ -34,3 +34,6 @@
   xmlWriter.SetFilename(args.output)
   xmlWriter.SetObject(reader.GetGeometry())
   xmlWriter.WriteFile()
+
+if __name__ == '__main__':
+  main()
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 000000000..9e06a93da
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,116 @@
+[build-system]
+requires = ["scikit-build-core"]
+build-backend = "scikit_build_core.build"
+
+[project]
+name = "itk-rtk"
+version = "2.5.0"
+description = "The Reconstruction Toolkit (RTK) for fast circular cone-beam CT reconstruction"
+readme = "README.md"
+license = {file = "LICENSE.TXT"}
+authors = [
+    { name = "RTK Consortium", email = "simon.rit@creatis.insa-lyon.fr" },
+]
+keywords = [
+    "itk",
+    "rtk",
+]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Intended Audience :: Developers",
+    "Intended Audience :: Education",
+    "Intended Audience :: Healthcare Industry",
+    "Intended Audience :: Science/Research",
+    "License :: OSI Approved :: Apache Software License",
+    "Operating System :: Android",
+    "Operating System :: MacOS",
+    "Operating System :: Microsoft :: Windows",
+    "Operating System :: POSIX",
+    "Operating System :: Unix",
+    "Programming Language :: C++",
+    "Programming Language :: Python",
+    "Topic :: Scientific/Engineering",
+    "Topic :: Scientific/Engineering :: Information Analysis",
+    "Topic :: Scientific/Engineering :: Medical Science Apps.",
+    "Topic :: Software Development :: Libraries",
+]
+requires-python = ">=3.8"
+dependencies = [
+    "itk == 5.4.*",
+]
+
+[project.scripts]
+rtkconjugategradient = "itk.rtkconjugategradient:main"
+rtkelektasynergygeometry = "itk.rtkelektasynergygeometry:main"
+rtkorageometry = "itk.rtkorageometry:main"
+rtksimulatedgeometry = "itk.rtksimulatedgeometry:main"
+rtkvarianobigeometry = "itk.rtkvarianobigeometry:main"
+
+[project.urls]
+Download = "https://github.com/RTKConsortium/RTK"
+Homepage = "https://www.openrtk.org"
+
+[tool.scikit-build]
+# The versions of CMake to allow. If CMake is not present on the system or does
+# not pass this specifier, it will be downloaded via PyPI if possible. An empty
+# string will disable this check.
+cmake.version = ">=3.16.3"
+
+# A list of args to pass to CMake when configuring the project. Setting this in
+# config or envvar will override toml. See also ``cmake.define``.
+cmake.args = []
+
+# A table of defines to pass to CMake when configuring the project. Additive.
+cmake.define = {}
+
+# Verbose printout when building.
+cmake.verbose = true
+
+# The build type to use when building the project. Valid options are: "Debug",
+# "Release", "RelWithDebInfo", "MinSizeRel", "", etc.
+cmake.build-type = "Release"
+
+# The source directory to use when building the project. Currently only affects
+# the native builder (not the setuptools plugin).
+cmake.source-dir = "."
+
+# The versions of Ninja to allow. If Ninja is not present on the system or does
+# not pass this specifier, it will be downloaded via PyPI if possible. An empty
+# string will disable this check.
+ninja.version = ">=1.11"
+
+# The logging level to display, "DEBUG", "INFO", "WARNING", and "ERROR" are
+# possible options.
+logging.level = "INFO"
+
+# Files to include in the SDist even if they are skipped by default. Supports
+# gitignore syntax.
+sdist.include = []
+
+# Files to exclude from the SDist even if they are included by default. Supports
+# gitignore syntax.
+sdist.exclude = []
+
+# A list of license files to include in the wheel. Supports glob patterns.
+wheel.license-files = ["LICEN[CS]E*",]
+
+# Target the platlib or the purelib. If not set, the default is to target the
+# platlib if wheel.cmake is true, and the purelib otherwise.
+wheel.platlib = "false"
+
+# If CMake is less than this value, backport a copy of FindPython. Set to 0
+# disable this, or the empty string.
+backport.find-python = "3.26.1"
+
+# Select the editable mode to use. Can be "redirect" (default) or "inplace".
+editable.mode = "redirect"
+
+# Rebuild the project when the package is imported. The build-directory must be
+# set.
+editable.rebuild = false
+
+# If set, this will provide a method for scikit-build-core backward compatibility.
+minimum-version = "0.8.2"
+
+# The build directory. Defaults to a temporary directory, but can be set.
+build-dir = "build/{wheel_tag}"
diff --git a/setup.py b/setup.py
deleted file mode 100755
index dbea42bf0..000000000
--- a/setup.py
+++ /dev/null
@@ -1,65 +0,0 @@
-# -*- coding: utf-8 -*-
-from os import sys
-
-try:
-    from skbuild import setup
-except ImportError:
-    print('scikit-build is required to build from source.', file=sys.stderr)
-    print('Please run:', file=sys.stderr)
-    print('', file=sys.stderr)
-    print('  python -m pip install scikit-build')
-    sys.exit(1)
-
-# Configure wheel name if CUDA is used
-wheel_name='itk-rtk'
-wheel_requirements=[r'itk==5.4.*']
-
-# Extract cuda version from the RTK_CUDA_VERSION cmake option
-for arg in sys.argv:
-  if "RTK_CUDA_VERSION" in str(arg):
-    cuda_version = arg.rsplit('RTK_CUDA_VERSION=', 1)[-1]
-    wheel_name += '-cuda' + cuda_version.replace('.', '')
-    cudacommon_wheel_name = wheel_name.replace('rtk', 'cudacommon')
-    wheel_requirements.append(fr'{cudacommon_wheel_name}')
-
-setup(
-    name=wheel_name,
-    version='2.5.0',
-    author='RTK Consortium',
-    author_email='rtk-users@openrtk.org',
-    packages=['itk'],
-    package_dir={'itk': 'itk'},
-    download_url=r'https://github.com/RTKConsortium/RTK',
-    description=r'The Reconstruction Toolkit (RTK) for fast circular cone-beam CT reconstruction.',
-    long_description='Based on the Insight Toolkit ITK, RTK provides: basic operators for reconstruction (e.g. filtering, forward, projection and backprojection), multithreaded CPU and GPU versions, tools for respiratory motion correction, I/O for several scanners, preprocessing of raw data for scatter correction.',
-    classifiers=[
-        "License :: OSI Approved :: Apache Software License",
-        "Programming Language :: Python",
-        "Programming Language :: C++",
-        "Development Status :: 4 - Beta",
-        "Intended Audience :: Developers",
-        "Intended Audience :: Education",
-        "Intended Audience :: Healthcare Industry",
-        "Intended Audience :: Science/Research",
-        "Topic :: Scientific/Engineering",
-        "Topic :: Scientific/Engineering :: Medical Science Apps.",
-        "Topic :: Scientific/Engineering :: Information Analysis",
-        "Topic :: Software Development :: Libraries",
-        "Operating System :: Android",
-        "Operating System :: Microsoft :: Windows",
-        "Operating System :: POSIX",
-        "Operating System :: Unix",
-        "Operating System :: MacOS"
-        ],
-    scripts=[
-        "lib/rtkconjugategradient.py",
-        "lib/rtkelektasynergygeometry.py",
-        "lib/rtkorageometry.py",
-        "lib/rtksimulatedgeometry.py",
-        "lib/rtkvarianobigeometry.py"
-        ],
-    license='Apache',
-    keywords='RTK Reconstruction Toolkit',
-    url=r'https://www.openrtk.org/',
-    install_requires=wheel_requirements
-    )
diff --git a/wrapping/CMakeLists.txt b/wrapping/CMakeLists.txt
index 44ad3bc7a..83afdc330 100644
--- a/wrapping/CMakeLists.txt
+++ b/wrapping/CMakeLists.txt
@@ -32,4 +32,10 @@ wrap_itk_python_bindings_install(/itk "RTK"
     ${RTK_SOURCE_DIR}/applications/rtk3Doutputimage_group.py
     ${RTK_SOURCE_DIR}/applications/rtkinputprojections_group.py
     ${RTK_SOURCE_DIR}/applications/rtkiterations_group.py
-    ${RTK_SOURCE_DIR}/applications/rtkprojectors_group.py)
+    ${RTK_SOURCE_DIR}/applications/rtkprojectors_group.py
+    ${RTK_SOURCE_DIR}/applications/rtkconjugategradient/rtkconjugategradient.py
+    ${RTK_SOURCE_DIR}/applications/rtkelektasynergygeometry/rtkelektasynergygeometry.py
+    ${RTK_SOURCE_DIR}/applications/rtkorageometry/rtkorageometry.py
+    ${RTK_SOURCE_DIR}/applications/rtksimulatedgeometry/rtksimulatedgeometry.py
+    ${RTK_SOURCE_DIR}/applications/rtkvarianobigeometry/rtkvarianobigeometry.py
+)