diff --git a/src/components/Tooltip/Tooltip.tsx b/src/components/Tooltip/Tooltip.tsx
index 844f3ca2..5413a652 100644
--- a/src/components/Tooltip/Tooltip.tsx
+++ b/src/components/Tooltip/Tooltip.tsx
@@ -314,6 +314,10 @@ const Tooltip = ({
       return
     }
 
+    if (!activeAnchor?.isConnected) {
+      return
+    }
+
     computeTooltipPosition({
       place,
       offset,
@@ -486,6 +490,7 @@ const Tooltip = ({
     }
     const documentObserverCallback: MutationCallback = (mutationList) => {
       const newAnchors: HTMLElement[] = []
+      const removedAnchors: HTMLElement[] = []
       mutationList.forEach((mutation) => {
         if (mutation.type === 'attributes' && mutation.attributeName === 'data-tooltip-id') {
           const newId = (mutation.target as HTMLElement).getAttribute('data-tooltip-id')
@@ -497,7 +502,30 @@ const Tooltip = ({
           return
         }
         if (activeAnchor) {
-          ;[...mutation.removedNodes].some((node) => {
+          const elements = [...mutation.removedNodes].filter((node) => node.nodeType === 1)
+          if (selector) {
+            try {
+              removedAnchors.push(
+                // the element itself is an anchor
+                ...(elements.filter((element) =>
+                  (element as HTMLElement).matches(selector),
+                ) as HTMLElement[]),
+              )
+              removedAnchors.push(
+                // the element has children which are anchors
+                ...elements.flatMap(
+                  (element) =>
+                    [...(element as HTMLElement).querySelectorAll(selector)] as HTMLElement[],
+                ),
+              )
+            } catch {
+              /**
+               * invalid CSS selector.
+               * already warned on tooltip controller
+               */
+            }
+          }
+          elements.some((node) => {
             if (node?.contains?.(activeAnchor)) {
               setRendered(false)
               handleShow(false)
@@ -538,8 +566,11 @@ const Tooltip = ({
            */
         }
       })
-      if (newAnchors.length) {
-        setAnchorsBySelect((anchors) => [...anchors, ...newAnchors])
+      if (newAnchors.length || removedAnchors.length) {
+        setAnchorsBySelect((anchors) => [
+          ...anchors.filter((anchor) => removedAnchors.includes(anchor)),
+          ...newAnchors,
+        ])
       }
     }
     const documentObserver = new MutationObserver(documentObserverCallback)