diff --git a/py/selenium/common/__init__.py b/py/selenium/common/__init__.py
index 2ef6204d37070..88269940125d9 100644
--- a/py/selenium/common/__init__.py
+++ b/py/selenium/common/__init__.py
@@ -15,6 +15,7 @@
 # specific language governing permissions and limitations
 # under the License.
 
+from .exceptions import DetachedShadowRootException
 from .exceptions import ElementClickInterceptedException
 from .exceptions import ElementNotInteractableException
 from .exceptions import ElementNotSelectableException
@@ -83,4 +84,5 @@
     "InvalidSessionIdException",
     "SessionNotCreatedException",
     "UnknownMethodException",
+    "DetachedShadowRootException",
 ]
diff --git a/py/selenium/common/exceptions.py b/py/selenium/common/exceptions.py
index 931eb307f809f..d1d7efdd1f0bd 100644
--- a/py/selenium/common/exceptions.py
+++ b/py/selenium/common/exceptions.py
@@ -285,3 +285,7 @@ def __init__(
         with_support = f"{msg}; {SUPPORT_MSG} {ERROR_URL}/driver_location"
 
         super().__init__(with_support, screen, stacktrace)
+
+
+class DetachedShadowRootException(WebDriverException):
+    """Raised when referenced shadow root is no longer attached to the DOM."""
diff --git a/py/selenium/webdriver/remote/errorhandler.py b/py/selenium/webdriver/remote/errorhandler.py
index e9b30fe51dd3f..d2df3b1b8e241 100644
--- a/py/selenium/webdriver/remote/errorhandler.py
+++ b/py/selenium/webdriver/remote/errorhandler.py
@@ -19,6 +19,7 @@
 from typing import Dict
 from typing import Type
 
+from selenium.common.exceptions import DetachedShadowRootException
 from selenium.common.exceptions import ElementClickInterceptedException
 from selenium.common.exceptions import ElementNotInteractableException
 from selenium.common.exceptions import ElementNotSelectableException
@@ -88,6 +89,7 @@ class ExceptionMapping:
     UNABLE_TO_CAPTURE_SCREEN = ScreenshotException
     ELEMENT_CLICK_INTERCEPTED = ElementClickInterceptedException
     UNKNOWN_METHOD = UnknownMethodException
+    DETACHED_SHADOW_ROOT = DetachedShadowRootException
 
 
 class ErrorCode:
@@ -131,6 +133,7 @@ class ErrorCode:
     UNABLE_TO_CAPTURE_SCREEN = [63, "unable to capture screen"]
     ELEMENT_CLICK_INTERCEPTED = [64, "element click intercepted"]
     UNKNOWN_METHOD = ["unknown method exception"]
+    DETACHED_SHADOW_ROOT = [65, "detached shadow root"]
 
     METHOD_NOT_ALLOWED = [405, "unsupported operation"]
 
diff --git a/py/test/unit/selenium/webdriver/remote/error_handler_tests.py b/py/test/unit/selenium/webdriver/remote/error_handler_tests.py
index 809d64193387a..9f3098550efc8 100644
--- a/py/test/unit/selenium/webdriver/remote/error_handler_tests.py
+++ b/py/test/unit/selenium/webdriver/remote/error_handler_tests.py
@@ -242,6 +242,12 @@ def test_raises_exception_for_method_not_allowed(handler, code):
         handler.check_response({"status": code, "value": "foo"})
 
 
+@pytest.mark.parametrize("code", ErrorCode.DETACHED_SHADOW_ROOT)
+def test_raises_exception_for_detached_shadow_root(handler, code):
+    with pytest.raises(exceptions.DetachedShadowRootException):
+        handler.check_response({"status": code, "value": "foo"})
+
+
 @pytest.mark.parametrize("key", ["stackTrace", "stacktrace"])
 def test_relays_exception_stacktrace(handler, key):
     import json