From 1296cddcd0665a45a4abc6279836e0ce8e3ba755 Mon Sep 17 00:00:00 2001
From: =?UTF-8?q?Sonia=20Garc=C3=ADa-Ruiz?=
 <43370296+SoniaRuiz@users.noreply.github.com>
Date: Wed, 20 Jul 2022 17:16:04 +0100
Subject: [PATCH] Create README.md

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+# IntroVerse
+
+IntroVerse is a database of introns and alternative splicing events across human tissues.
+
+IntroVerse is the first version of an effort to provide quality-controlled information of the splicing activity of 208,985 annotated introns from the reference transcriptome Ensembl v105, spanning 31,413 different genes across 18,826 RNA-seq samples and 54 human control tissues provided by the GTEx v8 project and processed by recount3. 
+
+IntroVerse has two unique features: 
+
+* it provides a complete and unfiltered catalogue of introns that have been carefully processed and quality-controlled
+* each novel intron has been assigned to a specific annotated intron, which provides a hierarchical structure allowing the user to start by browsing a gene or genomic position of interest and to end with an exploration of the complete catalogue of alternative events.
+
+In addition, IntroVerse allows users to browse, visualise, download and compare key genomic parameters either across introns of a particular gene and sample of interest or across multiple genes, samples and human tissues.
+
+IntroVerse also provides the visualisation of alternative splicing events by:
+
+* displaying the section of the gene’s MANE transcript predicted to be spliced out from the isoform after the excision of the novel event
+* the mis-splicing frequency of each one of the introns of the MANE transcript.
+
+## Software used:
+
+* [ggtranscript](https://github.com/dzhang32/ggtranscript)
+* [recount3](https://rna.recount.bio/)
+* [SQLite](https://www.sqlite.org/index.html)
+* [Shiny](https://shiny.rstudio.com/)
+* [Docker](https://shiny.rstudio.com/)