diff --git a/Core/Kernel/elxTransformixMain.cxx b/Core/Kernel/elxTransformixMain.cxx
index 913c69648..516e22a85 100644
--- a/Core/Kernel/elxTransformixMain.cxx
+++ b/Core/Kernel/elxTransformixMain.cxx
@@ -311,6 +311,15 @@ TransformixMain::EnterCommandLineArgumentsWithTransformParameterMaps(
 
     if ((i + 1) == numberOfTransformParameterMaps)
     {
+      // Remember the transform parameter file name from the argument map (if any).
+      if (const auto foundTransformParameterFileName = argmap.find("-tp");
+          foundTransformParameterFileName != argmap.end())
+      {
+        // The path of the transform parameter file may be used later by TransformBase::ReadFromFile(), when it has an
+        // initial transform parameter file whose file name is specified relative to this path.
+        configuration->SetParameterFileName(foundTransformParameterFileName->second);
+      }
+
       /** Copy last configuration object to m_Configuration. */
       MainBase::SetConfiguration(configuration);
     }
diff --git a/Core/Main/itkTransformixFilter.h b/Core/Main/itkTransformixFilter.h
index b59abcb97..6158e54cd 100644
--- a/Core/Main/itkTransformixFilter.h
+++ b/Core/Main/itkTransformixFilter.h
@@ -129,6 +129,9 @@ class ITK_TEMPLATE_EXPORT TransformixFilter : public ImageSource<TImage>
   const DataObject *
   GetInput(DataObjectPointerArraySizeType index) const;
 
+  void SetTransformParameterFileName(std::string);
+  itkGetConstMacro(TransformParameterFileName, std::string);
+
   /** Set/Get/Remove fixed point set filename. */
   itkSetMacro(FixedPointSetFileName, std::string);
   itkGetConstMacro(FixedPointSetFileName, std::string);
@@ -280,6 +283,7 @@ class ITK_TEMPLATE_EXPORT TransformixFilter : public ImageSource<TImage>
 
   SmartPointer<const elx::TransformixMain> m_TransformixMain{ nullptr };
 
+  std::string m_TransformParameterFileName{};
   std::string m_FixedPointSetFileName{};
   bool        m_ComputeSpatialJacobian{ false };
   bool        m_ComputeDeterminantOfSpatialJacobian{ false };
diff --git a/Core/Main/itkTransformixFilter.hxx b/Core/Main/itkTransformixFilter.hxx
index 46f610386..411d0eef3 100644
--- a/Core/Main/itkTransformixFilter.hxx
+++ b/Core/Main/itkTransformixFilter.hxx
@@ -107,6 +107,11 @@ TransformixFilter<TImage>::GenerateData()
     argumentMap.insert(ArgumentMapEntryType("-def", m_FixedPointSetFileName));
   }
 
+  if (!m_TransformParameterFileName.empty())
+  {
+    argumentMap.insert(ArgumentMapEntryType("-tp", m_TransformParameterFileName));
+  }
+
   // Setup output directory
   // Only the input "MovingImage" does not require an output directory
   if ((m_ComputeSpatialJacobian || m_ComputeDeterminantOfSpatialJacobian || m_ComputeDeformationField ||
@@ -512,6 +517,20 @@ TransformixFilter<TImage>::GetTransformParameterObject() const -> const Paramete
 }
 
 
+template <typename TImage>
+void
+TransformixFilter<TImage>::SetTransformParameterFileName(std::string fileName)
+{
+  if (m_TransformParameterFileName != fileName)
+  {
+    const auto parameterObject = elx::ParameterObject::New();
+    parameterObject->AddParameterFile(fileName);
+    SetTransformParameterObject(parameterObject);
+    m_TransformParameterFileName = std::move(fileName);
+    this->Modified();
+  }
+}
+
 template <typename TImage>
 auto
 TransformixFilter<TImage>::GetOutputDeformationField() -> OutputDeformationFieldType *