diff --git a/cross/c-ares/Makefile b/cross/c-ares/Makefile
index 415a045d51e..3c4abc02af3 100644
--- a/cross/c-ares/Makefile
+++ b/cross/c-ares/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = c-ares
-PKG_VERS = 1.17.1
+PKG_VERS = 1.18.1
 PKG_EXT = tar.gz
 PKG_DIST_NAME = $(PKG_NAME)-$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_SITE = https://c-ares.haxx.se/download
diff --git a/cross/c-ares/PLIST b/cross/c-ares/PLIST
index 1cfb1c480fc..38646773edd 100644
--- a/cross/c-ares/PLIST
+++ b/cross/c-ares/PLIST
@@ -1,3 +1,3 @@
 lnk:lib/libcares.so
 lnk:lib/libcares.so.2
-lib:lib/libcares.so.2.4.2
+lib:lib/libcares.so.2.5.1
diff --git a/cross/c-ares/digests b/cross/c-ares/digests
index 9f1c730f80b..f469c3a26c7 100644
--- a/cross/c-ares/digests
+++ b/cross/c-ares/digests
@@ -1,3 +1,3 @@
-c-ares-1.17.1.tar.gz SHA1 431d5ff705db752f5d25e610827b7cb3653fc7ff
-c-ares-1.17.1.tar.gz SHA256 d73dd0f6de824afd407ce10750ea081af47eba52b8a6cb307d220131ad93fc40
-c-ares-1.17.1.tar.gz MD5 28f65c8ee6c097986bd902fd4f0804e2
+c-ares-1.18.1.tar.gz SHA1 9e2a99af58d163d084db6fcebb2165a960bdd1af
+c-ares-1.18.1.tar.gz SHA256 1a7d52a8a84a9fbffb1be9133c0f6e17217d91ea5a6fa61f6b4729cda78ebbcf
+c-ares-1.18.1.tar.gz MD5 bf770c0d3131ec0dd0575a0d2dcab226
diff --git a/cross/curl/Makefile b/cross/curl/Makefile
index 4aeb6dd5cbd..c6e081e3d9f 100644
--- a/cross/curl/Makefile
+++ b/cross/curl/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = curl
-PKG_VERS = 7.80.0
+PKG_VERS = 7.82.0
 PKG_EXT = tar.xz
 PKG_DIST_NAME = $(PKG_NAME)-$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_SITE = https://curl.se/download
diff --git a/cross/curl/digests b/cross/curl/digests
index d42424ba94b..01b22b66393 100644
--- a/cross/curl/digests
+++ b/cross/curl/digests
@@ -1,3 +1,3 @@
-curl-7.80.0.tar.xz SHA1 5bc5332d0a7f68747d685b3c8681f69447c3498d
-curl-7.80.0.tar.xz SHA256 a132bd93188b938771135ac7c1f3ac1d3ce507c1fcbef8c471397639214ae2ab
-curl-7.80.0.tar.xz MD5 cf9f8553762150ef0ebcd5ee412737f5
+curl-7.82.0.tar.xz SHA1 1da2b0a398a40b1b7e950940de21bc5e6dd8d622
+curl-7.82.0.tar.xz SHA256 0aaa12d7bd04b0966254f2703ce80dd5c38dbbd76af0297d3d690cdce58a583c
+curl-7.82.0.tar.xz MD5 ce05eb61ef7c398feb7dbe23122d0bd9
diff --git a/cross/libxml2/Makefile b/cross/libxml2/Makefile
index b169f89a368..0d83a40d52b 100644
--- a/cross/libxml2/Makefile
+++ b/cross/libxml2/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = libxml2
-PKG_VERS = 2.9.11
+PKG_VERS = 2.9.12
 PKG_EXT = tar.gz
 PKG_DIST_NAME = $(PKG_NAME)-$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_SITE = ftp://xmlsoft.org/libxml2
diff --git a/cross/libxml2/PLIST b/cross/libxml2/PLIST
index 77cde552143..ffc40da9d79 100644
--- a/cross/libxml2/PLIST
+++ b/cross/libxml2/PLIST
@@ -3,4 +3,4 @@ bin:bin/xmlcatalog
 bin:bin/xmllint
 lnk:lib/libxml2.so
 lnk:lib/libxml2.so.2
-lib:lib/libxml2.so.2.9.11
+lib:lib/libxml2.so.2.9.12
diff --git a/cross/libxml2/digests b/cross/libxml2/digests
index 2fd8e965e77..7e3a3d35a51 100644
--- a/cross/libxml2/digests
+++ b/cross/libxml2/digests
@@ -1,3 +1,3 @@
-libxml2-2.9.11.tar.gz SHA1 7902b9cc7a549c09f8fb227fc4aa1d0275d4282c
-libxml2-2.9.11.tar.gz SHA256 886f696d5d5b45d780b2880645edf9e0c62a4fd6841b853e824ada4e02b4d331
-libxml2-2.9.11.tar.gz MD5 bce2745076131c8127da9aeac126223e
+libxml2-2.9.12.tar.gz SHA1 339fe5bb2a7d0c13f068c26d8f7cd194c13f9a2a
+libxml2-2.9.12.tar.gz SHA256 c8d6681e38c56f172892c85ddc0852e1fd4b53b4209e7f4ebf17f7e2eae71d92
+libxml2-2.9.12.tar.gz MD5 f433a39be087a9f0b197eb2307ad9f75
diff --git a/cross/mariadb-connector-c/Makefile b/cross/mariadb-connector-c/Makefile
index 06132de51fc..c5ec9c49ca9 100644
--- a/cross/mariadb-connector-c/Makefile
+++ b/cross/mariadb-connector-c/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = mariadb-connector-c
-PKG_VERS = 3.2.5
+PKG_VERS = 3.2.6
 PKG_EXT = tar.gz
 PKG_DIST_NAME = v$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_FILE = $(PKG_NAME)-$(PKG_VERS).$(PKG_EXT)
diff --git a/cross/mariadb-connector-c/digests b/cross/mariadb-connector-c/digests
index d6f284c8a1f..ef4dc72bd80 100644
--- a/cross/mariadb-connector-c/digests
+++ b/cross/mariadb-connector-c/digests
@@ -1,3 +1,3 @@
-mariadb-connector-c-3.2.5.tar.gz SHA1 2054b8a6dbe51ad82d23f5c83e212e8411a91a2c
-mariadb-connector-c-3.2.5.tar.gz SHA256 edf1e1035c020c23874561cab3f97fd1d8ed11221c47177a1bc178eb971fd351
-mariadb-connector-c-3.2.5.tar.gz MD5 9ab9205418a933b0a7920e7cf424cc36
+mariadb-connector-c-3.2.6.tar.gz SHA1 7b542d0f27fbf92cf17da38b07a7e052bec0b105
+mariadb-connector-c-3.2.6.tar.gz SHA256 d9aee070e1d954074a70eff1cfd2d6c6bc5d190dc00075975a55d4f3e1ac20c5
+mariadb-connector-c-3.2.6.tar.gz MD5 5690599dd143758c029291bffa625069
diff --git a/cross/pip/Makefile b/cross/pip/Makefile
index da29a576948..65f0a21f096 100644
--- a/cross/pip/Makefile
+++ b/cross/pip/Makefile
@@ -1,6 +1,6 @@
 PKG_NAME = pip
 # use the same version in native/python3/Makefile (python3_native_post_install)
-PKG_VERS = 21.3.1
+PKG_VERS = 22.0.4
 PKG_EXT = tar.gz
 PKG_DIST_NAME = $(PKG_NAME)-$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_SITE = https://files.pythonhosted.org/packages/source/p/$(PKG_NAME)
diff --git a/cross/pip/digests b/cross/pip/digests
index e56f342323d..b4a24cf89a9 100644
--- a/cross/pip/digests
+++ b/cross/pip/digests
@@ -1,3 +1,3 @@
-pip-21.3.1.tar.gz SHA1 a243525070cf70f22a185447ebd3e1435dabb218
-pip-21.3.1.tar.gz SHA256 fd11ba3d0fdb4c07fbc5ecbba0b1b719809420f25038f8ee3cd913d3faa3033a
-pip-21.3.1.tar.gz MD5 0d3f27f4b7fecb33fd573e4f46cc6788
+pip-22.0.4.tar.gz SHA1 fa775332fc5dfbc0f8cb4aced2f50c5ccae9f361
+pip-22.0.4.tar.gz SHA256 b3a9de2c6ef801e9247d1527a4b16f92f2cc141cd1489f3fffaf6a9e96729764
+pip-22.0.4.tar.gz MD5 ffb2a7aa43004601409b3318777b75a8
diff --git a/cross/python310/Makefile b/cross/python310/Makefile
index 459d38f23a4..927ddd30d0d 100644
--- a/cross/python310/Makefile
+++ b/cross/python310/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = python310
-PKG_VERS = 3.10.2
+PKG_VERS = 3.10.4
 PKG_VERS_MAJOR_MINOR = $(word 1,$(subst ., ,$(PKG_VERS))).$(word 2,$(subst ., ,$(PKG_VERS)))
 PKG_EXT = tar.xz
 PKG_DIST_NAME = Python-$(PKG_VERS).$(PKG_EXT)
@@ -133,10 +133,10 @@ python310_post_install: $(WORK_DIR)/python-cc.mk
 	cp -R $(HOSTPYTHON_LIB_NATIVE) $(PYTHON_LIB_CROSS)/../
 	@$(RUN) $(PYTHON_NATIVE) -m crossenv $(STAGING_INSTALL_PREFIX)/bin/python$(PKG_VERS_MAJOR_MINOR) $(WORK_DIR)/crossenv/
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) wget https://bootstrap.pypa.io/get-pip.py
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-python get-pip.py "pip==21.3.1"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) python get-pip.py "pip==21.3.1"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "setuptools==60.7.1"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "setuptools==60.7.1"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-python get-pip.py "pip==22.0.4"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) python get-pip.py "pip==22.0.4"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "setuptools==60.10.0"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "setuptools==60.10.0"
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "setuptools-scm==6.4.2"
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "setuptools-scm==6.4.2"
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "wheel==0.37.1"
@@ -145,12 +145,12 @@ python310_post_install: $(WORK_DIR)/python-cc.mk
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "cffi==1.15.0"
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "cryptography==3.3.2"
 	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "cryptography==3.3.2"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "poetry==1.1.12"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "poetry==1.1.12"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "Cython==0.29.26"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "Cython==0.29.26"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "flit==3.6.0"
-	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "flit==3.6.0"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "poetry==1.1.13"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "poetry==1.1.13"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "Cython==0.29.28"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "Cython==0.29.28"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) build-pip install "flit==3.7.1"
+	. $(WORK_DIR)/crossenv/bin/activate && $(RUN) pip install "flit==3.7.1"
 ifneq ($(PYTHON_LIB_NATIVE),$(PYTHON_LIB_CROSS))
 	cp $(PYTHON_LIB_CROSS)/_sysconfigdata_*.py $(PYTHON_LIB_NATIVE)/_sysconfigdata.py
 endif
diff --git a/cross/python310/digests b/cross/python310/digests
index 5de4c57a488..32b51aa005e 100644
--- a/cross/python310/digests
+++ b/cross/python310/digests
@@ -1,3 +1,3 @@
-Python-3.10.2.tar.xz SHA1 e618946549cca1eb0d6d4cdf516003fec3975003
-Python-3.10.2.tar.xz SHA256 17de3ac7da9f2519aa9d64378c603a73a0e9ad58dffa8812e45160c086de64c7
-Python-3.10.2.tar.xz MD5 14e8c22458ed7779a1957b26cde01db9
+Python-3.10.4.tar.xz SHA1 8f684863b92bf43936b16dbb867e392f10e8ffc7
+Python-3.10.4.tar.xz SHA256 80bf925f571da436b35210886cf79f6eb5fa5d6c571316b73568343451f77a19
+Python-3.10.4.tar.xz MD5 21f2e113e087083a1e8cf10553d93599
diff --git a/native/python310/Makefile b/native/python310/Makefile
index edc147270f6..0f66d67ecb9 100644
--- a/native/python310/Makefile
+++ b/native/python310/Makefile
@@ -1,5 +1,5 @@
 PKG_NAME = python310
-PKG_VERS = 3.10.2
+PKG_VERS = 3.10.4
 PKG_EXT = tar.xz
 PKG_DIST_NAME = Python-$(PKG_VERS).$(PKG_EXT)
 PKG_DIST_SITE = https://www.python.org/ftp/python/$(PKG_VERS)
@@ -30,8 +30,8 @@ PIP_NATIVE = $(WORK_DIR)/../../../native/$(PKG_NAME)/work-native/install/usr/loc
 python310_native_post_install: $(WORK_DIR)/python-native.mk
 	@$(MSG) Installing pip, setuptools and crossenv
 	@$(RUN) wget https://bootstrap.pypa.io/get-pip.py
-	@$(RUN) $(PYTHON) get-pip.py "pip==21.3.1"
-	@$(PIP) install "setuptools==60.7.1"
+	@$(RUN) $(PYTHON) get-pip.py "pip==22.0.4"
+	@$(PIP) install "setuptools==60.10.0"
 	@$(PIP) install "crossenv==1.2.0"
 	@$(PIP) install "cffi==1.15"
 
diff --git a/native/python310/digests b/native/python310/digests
index 5de4c57a488..32b51aa005e 100644
--- a/native/python310/digests
+++ b/native/python310/digests
@@ -1,3 +1,3 @@
-Python-3.10.2.tar.xz SHA1 e618946549cca1eb0d6d4cdf516003fec3975003
-Python-3.10.2.tar.xz SHA256 17de3ac7da9f2519aa9d64378c603a73a0e9ad58dffa8812e45160c086de64c7
-Python-3.10.2.tar.xz MD5 14e8c22458ed7779a1957b26cde01db9
+Python-3.10.4.tar.xz SHA1 8f684863b92bf43936b16dbb867e392f10e8ffc7
+Python-3.10.4.tar.xz SHA256 80bf925f571da436b35210886cf79f6eb5fa5d6c571316b73568343451f77a19
+Python-3.10.4.tar.xz MD5 21f2e113e087083a1e8cf10553d93599
diff --git a/spk/python310/Makefile b/spk/python310/Makefile
index 0bbf7e297a7..dde5456d41b 100644
--- a/spk/python310/Makefile
+++ b/spk/python310/Makefile
@@ -1,7 +1,7 @@
 SPK_NAME = python310
-SPK_VERS = 3.10.2
+SPK_VERS = 3.10.4
 SPK_VERS_MAJOR_MINOR = $(word 1,$(subst ., ,$(SPK_VERS))).$(word 2,$(subst ., ,$(SPK_VERS)))
-SPK_REV = 8
+SPK_REV = 9
 SPK_ICON = src/python3.png
 
 DEPENDS  = cross/$(SPK_NAME)
@@ -13,7 +13,7 @@ DESCRIPTION_FRE = Langage de programmation Python.
 DESCRIPTION_SPN = Lenguaje de programación Python.
 STARTABLE = no
 DISPLAY_NAME = Python 3.10
-CHANGELOG = "1. Update to python 3.10.2"
+CHANGELOG = "1. Update to python 3.10.4 <br/>2. Update to OpenSSL 1.1.1n"
 
 HOMEPAGE = https://www.python.org
 LICENSE  = PSF
@@ -30,7 +30,7 @@ SPK_USR_LOCAL_LINKS = bin:bin/python3.10
 WHEELS = src/requirements-crossenv.txt src/requirements-pure.txt src/requirements-abi3.txt
 
 # Force building pure-python wheels
-#WHEELS_PURE_PYTHON_PACKAGING_ENABLE = 1
+# WHEELS_PURE_PYTHON_PACKAGING_ENABLE = 1
 
 ##
 ## All configurations below are optional and
diff --git a/spk/python310/src/requirements-crossenv.txt b/spk/python310/src/requirements-crossenv.txt
index fe0216d4a00..b07b84d7689 100644
--- a/spk/python310/src/requirements-crossenv.txt
+++ b/spk/python310/src/requirements-crossenv.txt
@@ -17,12 +17,12 @@
 # bcrypt==3.2.0
 # greenlet==1.1.2
 # immutables==0.16
-# MarkupSafe==2.0.1
+# MarkupSafe==2.1.1
 # msgpack-python==0.5.6
 # netifaces==0.11.0
 # psutil==5.9.0
-# regex==2021.11.10
-# SQLAlchemy==1.4.29
+# regex==2022.3.15
+# SQLAlchemy==1.4.32
 # zope.interface==5.4.0
 
 # [gevent]
@@ -34,7 +34,7 @@
 
 # [lxml]
 # Depends: libxml2, libxslt
-# lxml==4.7.1
+# lxml==4.8.0
 
 # [mysqlclient]
 # Depends: mysql-connector-c, mariadb-connector-c
@@ -69,13 +69,13 @@
 # Depends: curl
 # Require environment variables
 #  PYCURL_CURL_CONFIG
-# pycurl==7.44.1
+# pycurl==7.45.1
 
 # [PyNaCl]
 # Depends: cross/libsodium
 # Require environment variables
 #  SODIUM_INSTALL=system
-# PyNaCl==1.4.0
+# PyNaCl==1.5.0
 
 # [PyYAML]
 # Depends: libyaml
diff --git a/spk/python310/src/requirements-pure.txt b/spk/python310/src/requirements-pure.txt
index 6ac39f1227d..14ba173cc82 100644
--- a/spk/python310/src/requirements-pure.txt
+++ b/spk/python310/src/requirements-pure.txt
@@ -1,6 +1,6 @@
 # basic default wheels
-#pip==21.3.1             ==> Always install latest version (service-setup.sh:install_python_virtualenv)
-setuptools==60.7.1
+#pip==22.0.4             ==> Always install latest version (service-setup.sh:install_python_virtualenv)
+setuptools==60.10.0
 wheel==0.37.1
 
 # Always use latest version available
@@ -11,4 +11,12 @@ certifi
 # to create their local virtualenv
 # in order to install wheels within
 # their running environment
-virtualenv==20.13.0
+virtualenv==20.13.4
+
+# Other mandatory wheels that
+# gets install by default as
+# basic dependencies of above
+distlib==0.3.4
+filelock==3.6.0
+platformdirs==2.5.1
+six==1.16.0