diff --git a/.all-contributorsrc b/.all-contributorsrc index 81c78a73..0d92c5b6 100644 --- a/.all-contributorsrc +++ b/.all-contributorsrc @@ -336,6 +336,15 @@ "contributions": [ "bug" ] + }, + { + "login": "Christoff1993", + "name": "Christoff1993", + "avatar_url": "https://avatars.githubusercontent.com/u/95428150?v=4", + "profile": "https://github.com/Christoff1993", + "contributions": [ + "bug" + ] } ], "repoType": "github", diff --git a/.github/workflows/yaml-validation.yml b/.github/workflows/yaml-validation.yml index d76314c8..46cc286a 100644 --- a/.github/workflows/yaml-validation.yml +++ b/.github/workflows/yaml-validation.yml @@ -16,7 +16,7 @@ jobs: uses: actions/checkout@v3 - name: YAML Lint - uses: ibiqlik/action-yamllint@v1.0.0 + uses: metabolicatlas/action-yamllint@v3 with: ## File(s) or Directory, separate by space if multiple files or folder are specified file_or_dir: model/ diff --git a/README.md b/README.md index 243e2e2e..bb50e833 100644 --- a/README.md +++ b/README.md @@ -2,7 +2,7 @@ [![Join the chat at https://gitter.im/SysBioChalmers/Human-GEM](https://badges.gitter.im/SysBioChalmers/Human-GEM.svg)](https://gitter.im/SysBioChalmers/Human-GEM?utm_source=badge&utm_medium=badge&utm_campaign=pr-badge&utm_content=badge) [![GitHub version](https://badge.fury.io/gh/sysbiochalmers%2FHuman-GEM.svg)](https://badge.fury.io/gh/sysbiochalmers%2FHuman-GEM) [![DOI](https://zenodo.org/badge/105752644.svg)](https://zenodo.org/badge/latestdoi/105752644) -[![All Contributors](https://img.shields.io/badge/all_contributors-29-success.svg)](#contributors) +[![All Contributors](https://img.shields.io/badge/all_contributors-31-success.svg)](#contributors) ### Brief Model Description @@ -125,40 +125,42 @@ A collection of manually curated 2D metabolic maps associated with Human-GEM are Anne Niknejad
Anne Niknejad
πŸ› πŸ–‹ πŸ”¬ - Avlant
Avlant
πŸ› πŸ–‹ - BenjamΓ­n SΓ‘nchez
BenjamΓ­n SΓ‘nchez
πŸ’¬ - Daniel Weindl
Daniel Weindl
πŸ› - Devlin Moyer
Devlin Moyer
πŸ› πŸ”¬ πŸ‘€ - Eduard Kerkhoven
Eduard Kerkhoven
πŸ’¬ + Avlant
Avlant
πŸ› πŸ–‹ + BenjamΓ­n SΓ‘nchez
BenjamΓ­n SΓ‘nchez
πŸ’¬ + Christoff1993
Christoff1993
πŸ› + Daniel Weindl
Daniel Weindl
πŸ› + Devlin Moyer
Devlin Moyer
πŸ› πŸ–‹ πŸ”¬ πŸ‘€ + Eduard Kerkhoven
Eduard Kerkhoven
πŸ› πŸ’» πŸ’¬ πŸ‘€ Hao Wang
Hao Wang
πŸ› πŸ’» πŸ”£ πŸ“– πŸ€” πŸš‡ 🚧 πŸ“¦ πŸ“† πŸ’¬ πŸ”¬ πŸ‘€ ⚠️ πŸ“’ - Jonathan Robinson
Jonathan Robinson
πŸ› πŸ’» πŸ”£ πŸ“– πŸ€” πŸš‡ 🚧 πŸ“¦ πŸ“† πŸ’¬ πŸ”¬ πŸ‘€ βœ… πŸ“’ + Jiahao Luo
Jiahao Luo
πŸ› πŸ–‹ + Jonathan Robinson
Jonathan Robinson
πŸ› πŸ’» πŸ”£ πŸ“– πŸ€” πŸš‡ 🚧 πŸ“¦ πŸ“† πŸ’¬ πŸ”¬ πŸ‘€ βœ… πŸ“’ Jorge Ferreira
Jorge Ferreira
πŸ› - Jose L. Cadavid
Jose L. Cadavid
πŸ› πŸ”¬ - Juliette
Juliette
πŸ› - Justin Reimertz
Justin Reimertz
πŸ› - Marco Pagni
Marco Pagni
πŸ› πŸ”¬ + Jose L. Cadavid
Jose L. Cadavid
πŸ› πŸ”¬ + Juliette
Juliette
πŸ› πŸ–‹ + Justin Reimertz
Justin Reimertz
πŸ› πŸ–‹ πŸ‘€ + Marco Pagni
Marco Pagni
πŸ› πŸ”¬ Mihail Anton
Mihail Anton
πŸ› πŸ’» πŸ€” πŸš‡ πŸ‘€ ⚠️ πŸ“’ - Pierre-Etienne Cholley
Pierre-Etienne Cholley
πŸ› πŸ’» πŸ–‹ πŸ”¬ πŸ‘€ - Pierre-Etienne Cholley
Pierre-Etienne Cholley
πŸ› - PkiwiBird
PkiwiBird
πŸ› πŸ”¬ πŸ’» - Pranas Grigaitis
Pranas Grigaitis
πŸ› πŸ–‹ πŸ’» πŸ”¬ - PΔ±nar Kocabaş
Pınar Kocabaş
πŸ› πŸ”¬ πŸ‘€ - Rasool Saghaleyni
Rasool Saghaleyni
πŸ€” πŸ”¬ - Sarah Cherkaoui
Sarah Cherkaoui
πŸ› πŸ–‹ πŸ’» πŸ”¬ + Pierre-Etienne Cholley
Pierre-Etienne Cholley
πŸ› πŸ’» πŸ–‹ πŸ”¬ πŸ‘€ + Pierre-Etienne Cholley
Pierre-Etienne Cholley
πŸ› + PkiwiBird
PkiwiBird
πŸ› πŸ”¬ πŸ’» + Pranas Grigaitis
Pranas Grigaitis
πŸ› πŸ–‹ πŸ’» πŸ”¬ + PΔ±nar Kocabaş
Pınar Kocabaş
πŸ› πŸ”¬ πŸ‘€ + Rasool Saghaleyni
Rasool Saghaleyni
πŸ€” πŸ”¬ + Sarah Cherkaoui
Sarah Cherkaoui
πŸ› πŸ–‹ πŸ’» πŸ”¬ Simonas MarciΕ‘auskas
Simonas MarciΕ‘auskas
πŸ’¬ - TunahanCakir
TunahanCakir
πŸ› - Xuhang Li
Xuhang Li
πŸ› - feiranl
feiranl
πŸ› πŸ’» πŸ”£ πŸ“– πŸ€” πŸš‡ 🚧 πŸ“¦ πŸ“† πŸ”¬ πŸ‘€ - johan-gson
johan-gson
πŸ› πŸ–‹ πŸ”¬ + TunahanCakir
TunahanCakir
πŸ› + Xuhang Li
Xuhang Li
πŸ› + feiranl
feiranl
πŸ› πŸ’» πŸ”£ πŸ“– πŸ€” πŸš‡ 🚧 πŸ“¦ πŸ“† πŸ”¬ πŸ‘€ + johan-gson
johan-gson
πŸ› πŸ–‹ πŸ”¬ manas-kohli
manas-kohli
πŸ› smoretti
smoretti
πŸ› πŸ”¬ - stairs
stairs
πŸ› πŸ–‹ + stairs
stairs
πŸ› πŸ–‹ diff --git a/code/test/sanityCheck.py b/code/test/sanityCheck.py index 12e8d035..e3e7e9fe 100644 --- a/code/test/sanityCheck.py +++ b/code/test/sanityCheck.py @@ -4,6 +4,7 @@ import pandas as pd import cobra +from collections import Counter def get_column_from_tsv(tsv_file, column_id, to_list=True): @@ -106,6 +107,22 @@ def checkUnusedEntities(model, entity_type): assert len(unused_entities) == 0, f"Found unused {entity_type}: {unused_entities}" +def checkDupRxn(model): + """ + Check for duplicate reactions in the model + """ + + reaction_equations = [rxn.build_reaction_string(use_metabolite_names=False) for rxn in model.reactions] + duplicate_reactions = [reaction for reaction, count in Counter(reaction_equations).items() if count > 1] + dup_list = [model.reactions[idx].id for idx, val in enumerate(reaction_equations) if val in duplicate_reactions] + + if duplicate_reactions: + output = f"The following {len(dup_list)} reactions are duplicates, please check: " + ';'.join(dup_list) + print(output) + + assert len(duplicate_reactions) == 0, "Found duplicated reactions!" + + if __name__ == "__main__": rxns, mets, genes, model = load_yml("model/Human-GEM.yml") checkRxnAnnotation(rxns) @@ -113,4 +130,5 @@ def checkUnusedEntities(model, entity_type): checkGeneAnnotation(genes) checkUnusedEntities(model, "metabolites") checkUnusedEntities(model, "genes") + checkDupRxn(model) print("All checks have passed.") diff --git a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv index 193acd1e..6f646a4c 100644 --- a/data/deprecatedIdentifiers/deprecatedMetabolites.tsv +++ b/data/deprecatedIdentifiers/deprecatedMetabolites.tsv @@ -2237,6 +2237,7 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM01445m" "MAM01445" "cholate" "C00695" "HMDB0000619" "CHEBI:16359" "221493" "LMST04010001" "" "HC00502" "cholate" "MNXM450" "m01445m" "m01445m" "MAM01514m" "MAM01514" "cholcoa" "C01794" "HMDB0001374" "CHEBI:15519" "439573" "" "" "HC00844" "cholcoa" "MNXM162468;MNXM431" "m01514m" "m01514m" "MAM00759c" "MAM00759" "" "C13712" "" "" "" "LMST02030130" "" "" "M00759" "MNXM3494" "m00759c" "m00759c" +"MAM02397c" "MAM02397" "" "C16239" "" "" "" "" "" "" "M02397" "MNXM19093" "m02397c" "m02397c" "MAM01268c" "MAM01268" "" "" "" "" "" "PROTEIN" "" "" "M01268" "" "m01268c" "m01268c" "MAM01268m" "MAM01268" "" "" "" "" "" "PROTEIN" "" "" "M01268" "" "m01268m" "m01268m" "MAM01268n" "MAM01268" "" "" "" "" "" "PROTEIN" "" "" "M01268" "" "m01268n" "m01268n" @@ -2247,3 +2248,13 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM02757l" "MAM02757" "" "" "" "" "" "" "" "" "M02757" "" "m02757l" "m02757l" "MAM02757n" "MAM02757" "" "" "" "" "" "" "" "" "M02757" "" "m02757n" "m02757n" "MAM01816n" "MAM01816" "" "" "" "" "" "PROTEIN" "" "" "M01816" "" "m01816n" "m01816n" +"MAM00926c" "MAM00926" "4aphdob" "C01252" "HMDB0000978" "CHEBI:17442" "472" "" "" "" "4aphdob" "MNXM163204" "m00926c" "m00926c" +"MAM20020r" "MAM20020" "C00061" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "" +"MAM20022i" "MAM20022" "C01847" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "" +"MAM20023i" "MAM20023" "C00061" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "" +"MAM02398c" "MAM02398" "" "C16238" "" "" "23724672" "" "CE5656" "" "CE5656" "MNXM2392" "m02398c" "m02398c" +"MAM01701c" "MAM01701" "dhlam" "C00579" "HMDB0000985" "CHEBI:17694" "663" "" "" "HC00437" "dhlam" "MNXM1277" "m01701c" "m01701c" +"MAM03684c" "MAM03684" "hxa" "" "" "CHEBI:17120" "" "" "" "" "hxa" "MNXM1653" "" "hxa_c" +"MAM03684m" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_m" +"MAM03684e" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_s" +"MAM03684x" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_p" diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv index 1938f667..c726bad6 100644 --- a/data/deprecatedIdentifiers/deprecatedReactions.tsv +++ b/data/deprecatedIdentifiers/deprecatedReactions.tsv @@ -230,3 +230,35 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR00096" "" "BUP2" "" "" "" "BUP2" "MNXR96346" "" "" "" 0 "" "" "BUP2" "MAR02027" "" "r0193" "" "" "" "r0193" "MNXR105313" "" "" "" 0 "" "" "r0193" "MAR02006" "" "CPS_m" "" "" "" "r0034" "" "" "" "" 0 "" "" "r0034" +"MAR06400" "R07768" "" "R07768C" "" "" "HMR_6400" "MNXR111356" "HMR_6400" "RCR11944" "" 0 "" "" "HMR_6400" +"MAR06401" "R07769" "" "R07769C" "" "" "HMR_6401" "MNXR111357" "HMR_6401" "RCR11945" "" 0 "" "" "HMR_6401" +"MAR03940" "R01795" "PHETHPTOX" "R01795C" "r0399" "" "r0399" "MNXR102632;MNXR107174" "HMR_3940" "RCR11388" "" 0 "" "RHEA:30787" "HMR_3940" +"MAR07785" "" "ATPtx" "" "" "" "ATPtx" "MNXR96140" "HMR_7785" "RCR20040" "" 0 "" "" "HMR_7785" +"MAR07775" "" "NADHtpu" "" "" "" "NADHtpu;NADtpu" "MNXR101881" "HMR_7775" "RCR20024" "" 0 "" "" "HMR_7775" +"MAR07788" "" "FADH2tx" "" "" "" "FADH2tx" "MNXR99212" "HMR_7788" "RCR20202" "" 0 "" "" "HMR_7788" +"MAR04915" "" "COAtp" "" "r0864" "" "COAtp" "MNXR96815" "HMR_4915" "RCR20004" "" 0 "" "" "HMR_4915" +"MAR07771" "" "NADtpu" "" "" "" "NADtx" "MNXR101881" "HMR_7771" "RCR20023" "" 0 "" "" "HMR_7771" +"MAR07782" "" "ADPtx" "" "" "" "ADPtx" "MNXR95484" "HMR_7782" "RCR20201" "" 0 "" "" "HMR_7782" +"MAR07783" "" "AMPtp" "" "" "" "AMPtp" "MNXR95830" "HMR_7783" "RCR20046" "" 0 "" "" "HMR_7783" +"MAR07790" "" "FADtx" "" "" "" "FADtx" "MNXR99217" "HMR_7790" "RCR20203" "" 0 "" "" "HMR_7790" +"MAR08564" "" "KYNAKGAT" "" "" "" "KYNAKGAT" "MNXR100948" "HMR_8564" "RCR11356" "" 0 "" "" "HMR_8564" +"MAR08565" "R03445" "KYNATESYN" "" "" "" "KYNATESYN" "MNXR100949" "HMR_8565" "RCR11357" "" 0 "" "RHEA:42452" "HMR_8565" +"MAR04843" "" "" "" "r0801" "" "r0801" "MNXR105390" "HMR_4843" "RCR20168" "" 0 "" "" "HMR_4843" +"MAR09019" "" "" "" "" "" "HMR_9019" "" "HMR_9019" "RCR20242" "" 0 "" "" "HMR_9019" +"MAR07823" "" "DNDPt51m" "" "" "" "DCTPtm" "MNXR97204" "" "" "" 0 "" "" "DCTPtm" +"MAR07926" "" "DGTPtm" "" "" "" "DGTPtm" "MNXR97327" "" "" "" 0 "" "" "DGTPtm" +"MAR01483" "" "LIPOti" "" "" "" "LIPOti" "MNXR101093" "" "" "" 0 "" "" "LIPOti" +"MAR06406" "" "LIPOti" "RT1089" "" "" "" "MNXR101093" "HMR_6406" "RCR41534" "" 0 "" "" "HMR_6406" +"MAR00478" "R00844" "" "" "" "R-HSA-75889" "HMR_0478" "MNXR99876" "HMR_0478" "RCR14575" "" 0 "RHEA:11098" "RHEA:11096" "HMR_0478" +"MAR00482" "R00848;R00849" "G3PD2m" "R00848C" "r0205" "" "HMR_0482;r0205" "MNXR99875;MNXR106713" "HMR_0482;HMR_0483" "RCR14578;RCR21050" "" 0 "" "RHEA:31283;RHEA:18977" "HMR_0482;HMR_0483;MAR00483" +"MAR20012" "R02123" "HMR_6647;RADH;R_HMR_6647;R_RADH" "" "" "" "" "MNXR146215" "" "" "" 0 "RHEA:42080" "" "" +"MAR20089" "R02701" "" "" "" "" "" "MNXR151808" "" "" "" 0 "RHEA:18533" "" "" +"MAR06398" "R07770" "" "R07770C" "" "" "RE1944C" "MNXR101081" "HMR_6398" "RCR14489" "" 0 "" "RHEA:12913" "HMR_6398" +"MAR06399" "R07771" "" "R07771C" "" "" "HMR_6399" "MNXR111358" "HMR_6399" "RCR14490" "" 0 "" "RHEA:20473" "HMR_6399" +"MAR06408" "" "" "RT0295" "" "" "HMR_6408" "" "HMR_6408" "RCR21069" "" 0 "" "" "HMR_6408" +"MAR11292" "" "HXAt3" "" "" "" "HXAt3" "" "" "" "" 0 "" "" "HXAt3" +"MAR11293" "" "EX_hxa_e" "" "" "" "EX_hxa[e]" "MNXR98664" "" "" "" 0 "" "" "EX_hxa[e]" +"MAR09949" "" "FACOAE60" "" "" "" "HXCOAc" "MNXR99139" "" "" "" 0 "" "" "HXCOAc" +"MAR04239" "R01933" "2OXOADOXm" "R01933M" "r0448" "" "2OXOADOXm" "MNXR94818" "HMR_4239" "RCR11332" "" 0 "RHEA:30796" "RHEA:30795" "HMR_4239" +"MAR04940" "" "" "" "r0885" "" "r0885" "MNXR105402" "HMR_4940" "RCR20265" "2.A.29.2.7" 0 "" "" "HMR_4940" +"MAR06391" "" "" "" "r2520" "" "r2520" "MNXR106328" "HMR_6391" "RCR20063" "" 0 "" "" "HMR_6391" diff --git a/data/metabolicTasks/metabolicTasks_CellfieConsensus.txt b/data/metabolicTasks/metabolicTasks_CellfieConsensus.txt index 2a43215d..778b9177 100644 --- a/data/metabolicTasks/metabolicTasks_CellfieConsensus.txt +++ b/data/metabolicTasks/metabolicTasks_CellfieConsensus.txt @@ -220,12 +220,12 @@ 36 Synthesis of lactose glucose[g] 1 1 lactose[g] 1 1 UDP-galactose[g] 1 1 UDP[g] 1 1 H+[g] 1 1 - 37 Glycogen biosynthesis NA[c] 1 1 glycogenin G4G7[c] 1 1 - UDP-glucose[c] 11 H+[c] 11 - UDP[c] 11 - 38 Glycogen degradation glycogenin G4G7[c] 1 1 glucose[c] 8 - Pi[c] 3 NA[c] 1 1 - H2O[c] 8 glucose-1-phosphate[c] 3 +# 37 Glycogen biosynthesis NA[c] 1 1 glycogenin G4G7[c] 1 1 The metabolite NA[c] in this task is conflicting with HumanGEM +# UDP-glucose[c] 11 H+[c] 11 +# UDP[c] 11 +# 38 Glycogen degradation glycogenin G4G7[c] 1 1 glucose[c] 8 The metabolite NA[c] in this task is conflicting with HumanGEM +# Pi[c] 3 NA[c] 1 1 +# H2O[c] 8 glucose-1-phosphate[c] 3 39 Fructose degradation (to glucose-3-phosphate) fructose[c] 1 1 D-glyceraldehyde 3-phosphate[c] 2 2 ATP[c] 2 2 ADP[c] 2 2 H+[c] 2 2 @@ -1130,14 +1130,14 @@ 180 Pyridoxal-phosphate synthesis pyridoxal[c] 1 1 pyridoxal-phosphate[c] 1 1 ATP[c] 1 1 ADP[c] 1 1 H+[c] 1 1 - 181 Synthesis of bilirubin heme[c] 1 1 bilirubin[c] 1 1 - NADPH[c] 0 4 H2O[c] 0 3 - H+[c] 0 6 Fe2+[c] 0 1 - O2[c] 0 3 Fe3+[c] 0 1 - FADH2[c] 0 1 NADP+[c] 0 4 - FAD[c] 0 1 - CO[c] 1 1 - NA[c] 0 1 +# 181 Synthesis of bilirubin heme[c] 1 1 bilirubin[c] 1 1 The metabolite NA[c] in this task is conflicting with HumanGEM +# NADPH[c] 0 4 H2O[c] 0 3 +# H+[c] 0 6 Fe2+[c] 0 1 +# O2[c] 0 3 Fe3+[c] 0 1 +# FADH2[c] 0 1 NADP+[c] 0 4 +# FAD[c] 0 1 +# CO[c] 1 1 +# NA[c] 0 1 182 Heme synthesis glycine[m] 16 16 heme[m] 2 2 succinyl-CoA[m] 16 18 H2O[m] 26 26 Fe2+[m] 2 2 CoA[m] 16 18 diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml index a41283bd..460f88a5 100644 --- a/model/Human-GEM.yml +++ b/model/Human-GEM.yml @@ -11729,14 +11729,6 @@ - charge: -1 - inchis: "" - metFrom: "HMRdatabase" - - !!omap - - id: "MAM00926c" - - name: "4-(2-aminophenyl)-2,4-dioxobutanoate" - - compartment: "c" - - formula: "C10H8NO4" - - charge: -1 - - inchis: "" - - metFrom: "HMRdatabase" - !!omap - id: "MAM00927c" - name: "4-(methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone" @@ -22857,14 +22849,6 @@ - charge: -2 - inchis: "" - metFrom: "HMRdatabase" - - !!omap - - id: "MAM01701c" - - name: "dihydrolipoamide" - - compartment: "c" - - formula: "C8H17NOS2" - - charge: 0 - - inchis: "" - - metFrom: "HMRdatabase" - !!omap - id: "MAM01701m" - name: "dihydrolipoamide" @@ -24961,6 +24945,14 @@ - charge: -2 - inchis: "" - metFrom: "HMRdatabase" + - !!omap + - id: "MAM01828x" + - name: "FMN" + - compartment: "x" + - formula: "C17H19N4O9P" + - charge: -2 + - inchis: "" + - metFrom: "" - !!omap - id: "MAM01829g" - name: "fn2m2masn" @@ -29249,6 +29241,22 @@ - charge: -1 - inchis: "" - metFrom: "HMRdatabase" + - !!omap + - id: "MAM02120x" + - name: "hexanoic acid" + - compartment: "x" + - formula: "C6H11O2" + - charge: -1 + - inchis: "" + - metFrom: "HMRdatabase" + - !!omap + - id: "MAM02120m" + - name: "hexanoic acid" + - compartment: "m" + - formula: "C6H11O2" + - charge: -1 + - inchis: "" + - metFrom: "HMRdatabase" - !!omap - id: "MAM02121c" - name: "hexanoyl-[ACP]" @@ -32657,22 +32665,6 @@ - charge: -1 - inchis: "" - metFrom: "HMRdatabase" - - !!omap - - id: "MAM02397c" - - name: "lipoyl-[ACP]" - - compartment: "c" - - formula: "C19H33N2O8PRS3" - - charge: -1 - - inchis: "" - - metFrom: "HMRdatabase" - - !!omap - - id: "MAM02398c" - - name: "lipoyl-AMP" - - compartment: "c" - - formula: "C18H25N5O8PS2" - - charge: -1 - - inchis: "" - - metFrom: "HMRdatabase" - !!omap - id: "MAM02399c" - name: "lipoyllysine" @@ -53233,14 +53225,6 @@ - charge: -1 - inchis: "" - metFrom: "Recon3D" - - !!omap - - id: "MAM03684c" - - name: "Hexanoate (N-C6:0)" - - compartment: "c" - - formula: "C6H11O2" - - charge: -1 - - inchis: "" - - metFrom: "Recon3D" - !!omap - id: "MAM03976c" - name: "Cia-5,8, Tetradecadienoic Acid" @@ -54377,22 +54361,6 @@ - charge: -1 - inchis: "" - metFrom: "Recon3D" - - !!omap - - id: "MAM03684m" - - name: "Hexanoate (N-C6:0)" - - compartment: "m" - - formula: "C6H11O2" - - charge: -1 - - inchis: "" - - metFrom: "Recon3D" - - !!omap - - id: "MAM03684x" - - name: "Hexanoate (N-C6:0)" - - compartment: "x" - - formula: "C6H11O2" - - charge: -1 - - inchis: "" - - metFrom: "Recon3D" - !!omap - id: "MAM02169e" - name: "indoleacetate" @@ -58657,14 +58625,6 @@ - charge: 0 - inchis: "" - metFrom: "Recon3D" - - !!omap - - id: "MAM03684e" - - name: "Hexanoate (N-C6:0)" - - compartment: "e" - - formula: "C6H11O2" - - charge: -1 - - inchis: "" - - metFrom: "Recon3D" - !!omap - id: "MAM01954c" - name: "glcnac-alpha-1,4-core 1" @@ -66665,6 +66625,14 @@ - charge: 0 - inchis: "" - metFrom: "" + - !!omap + - id: "MAM20019c" + - name: "FMNH2" + - compartment: "c" + - formula: "C17H21N4O9P" + - charge: -2 + - inchis: "" + - metFrom: "" - !!omap - id: "MAM20019r" - name: "FMNH2" @@ -66674,10 +66642,10 @@ - inchis: "" - metFrom: "" - !!omap - - id: "MAM20020r" + - id: "MAM01828r" - name: "FMN" - compartment: "r" - - formula: "C17H18N4O9P" + - formula: "C17H19N4O9P" - charge: -2 - inchis: "" - metFrom: "" @@ -66706,7 +66674,7 @@ - inchis: "" - metFrom: "" - !!omap - - id: "MAM20022i" + - id: "MAM20019i" - name: "FMNH2" - compartment: "i" - formula: "C17H21N4O9P" @@ -66714,10 +66682,10 @@ - inchis: "" - metFrom: "" - !!omap - - id: "MAM20023i" + - id: "MAM01828i" - name: "FMN" - compartment: "i" - - formula: "C17H18N4O9P" + - formula: "C17H19N4O9P" - charge: -2 - inchis: "" - metFrom: "" @@ -70640,7 +70608,7 @@ - MAM02774m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000111271 or ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303" + - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.99.3;1.3.8.7" @@ -71018,7 +70986,7 @@ - MAM01803m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000111271 or ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303" + - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.3.99.3" @@ -74296,9 +74264,9 @@ - name: "(S)-dihydroorotate:NAD+ oxidoreductase" - metabolites: !!omap - MAM00180c: -1 + - MAM01828c: -1 - MAM02659c: 1 - - MAM03102m: 1 - - MAM03103m: -1 + - MAM20019c: 1 - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "ENSG00000102967" @@ -80479,7 +80447,7 @@ - MAM01596m: 1 - MAM01986m: -1 - MAM02039m: -1 - - MAM02393m: -1 + - MAM00209c: -1 - MAM02878m: 1 - lower_bound: 0 - upper_bound: 1000 @@ -80496,7 +80464,7 @@ - name: "" - metabolites: !!omap - MAM01045m: 1 - - MAM01701m: 1 + - MAM00208c: 1 - MAM02039m: 1 - MAM02578m: 1 - MAM02878m: -1 @@ -80947,26 +80915,6 @@ - subsystem: - "Histidine metabolism" - confidence_score: 0 - - !!omap - - id: "MAR04239" - - name: "2-oxoadipate dehydrogenase complex" - - metabolites: !!omap - - MAM00670m: -1 - - MAM01596m: 1 - - MAM01597m: -1 - - MAM01977m: 1 - - MAM02552m: -1 - - MAM02553m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000091140 and ENSG00000105953 and ENSG00000119689" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.2.4.2" - - references: "PMID:10676873" - - subsystem: - - "Lysine metabolism" - - confidence_score: 0 - !!omap - id: "MAR04241" - name: "S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase" @@ -81054,11 +81002,11 @@ - MAM02899m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192 or ENSG00000197444" + - gene_reaction_rule: "(ENSG00000105953 and ENSG00000119689) or (ENSG00000181192 and ENSG00000119689)" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.2" - - references: "PMID:10676873" + - references: "PMID:28757203;PMID:32160276" - subsystem: - "Lysine metabolism" - confidence_score: 0 @@ -81176,7 +81124,7 @@ - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.3.1.61" - - references: "PMID:9620315" + - references: "PMID:9620315;PMID:28757203;PMID:32160276" - subsystem: - "Lysine metabolism" - confidence_score: 0 @@ -81691,41 +81639,6 @@ - subsystem: - "Tryptophan metabolism" - confidence_score: 0 - - !!omap - - id: "MAR08564" - - name: "" - - metabolites: !!omap - - MAM00926c: 1 - - MAM01306c: -1 - - MAM01974c: 1 - - MAM02319c: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000109576 or ENSG00000137944 or ENSG00000171097" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "2.6.1.7" - - references: "" - - subsystem: - - "Tryptophan metabolism" - - confidence_score: 0 - - !!omap - - id: "MAR08565" - - name: "" - - metabolites: !!omap - - MAM00926c: -1 - - MAM00990c: 1 - - MAM02040c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Tryptophan metabolism" - - confidence_score: 0 - !!omap - id: "MAR08566" - name: "" @@ -82727,26 +82640,6 @@ - subsystem: - "Phenylalanine, tyrosine and tryptophan biosynthesis" - confidence_score: 0 - - !!omap - - id: "MAR03940" - - name: "L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" - - metabolites: !!omap - - MAM01698c: 1 - - MAM02040c: 1 - - MAM02630c: -1 - - MAM02724c: -1 - - MAM02978c: -1 - - MAM03101c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000171759" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.14.16.1" - - references: "PMID:3298976;PMID:4074362" - - subsystem: - - "Phenylalanine, tyrosine and tryptophan biosynthesis" - - confidence_score: 0 - !!omap - id: "MAR04214" - name: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" @@ -82846,14 +82739,14 @@ - id: "MAR04222" - name: "" - metabolites: !!omap - - MAM00990c: -1 - - MAM01306c: 1 - - MAM01974c: -1 - - MAM02040c: -1 - - MAM02319c: 1 - - lower_bound: -1000 + - MAM00990c: 1 + - MAM01306c: -1 + - MAM01974c: 1 + - MAM02040c: 1 + - MAM02319c: -1 + - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000109576 or ENSG00000137944 or ENSG00000171097" + - gene_reaction_rule: "ENSG00000137944 or ENSG00000171097" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.6.1.7" @@ -86763,20 +86656,15 @@ - id: "MAR08771" - name: "" - metabolites: !!omap - - MAM01285c: 1 - - MAM01371c: -1 - MAM02026c: -1 - MAM02026m: 1 - - MAM02039c: 1 - - MAM02040c: -1 - - MAM02751c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "" + - gene_reaction_rule: "ENSG00000013306 or ENSG00000075303" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "" - - references: "" + - references: "PMID:25637873;PMID:34707288;PMID:35513392" - subsystem: - "Transport reactions" - confidence_score: 0 @@ -94176,11 +94064,11 @@ - MAM02984m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192 or ENSG00000197444" + - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.2" - - references: "PMID:10676873;PMID:3207422" + - references: "PMID:10676873;PMID:3207422;PMID:32160276" - subsystem: - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism" - confidence_score: 0 @@ -94315,11 +94203,11 @@ - MAM02984m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192 or ENSG00000197444" + - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.4.2" - - references: "PMID:10676873" + - references: "PMID:10676873;PMID:32160276" - subsystem: - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism" - confidence_score: 0 @@ -94337,7 +94225,7 @@ - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.3.1.61" - - references: "PMID:8076640;PMID:9620315" + - references: "PMID:8076640;PMID:9620315;PMID:32160276" - subsystem: - "Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism" - confidence_score: 0 @@ -100730,87 +100618,6 @@ - subsystem: - "Lipoic acid metabolism" - confidence_score: 0 - - !!omap - - id: "MAR06398" - - name: "" - - metabolites: !!omap - - MAM01371c: -1 - - MAM02039c: -1 - - MAM02394c: -1 - - MAM02398c: 1 - - MAM02759c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000144182" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "2.7.7.63" - - references: "PMID:10103005" - - subsystem: - - "Lipoic acid metabolism" - - confidence_score: 0 - - !!omap - - id: "MAR06399" - - name: "" - - metabolites: !!omap - - MAM00209c: 1 - - MAM01334c: 1 - - MAM01350c: -1 - - MAM02039c: 1 - - MAM02398c: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000144182" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "2.7.7.63" - - references: "" - - subsystem: - - "Lipoic acid metabolism" - - confidence_score: 0 - - !!omap - - id: "MAR06400" - - name: "" - - metabolites: !!omap - - MAM01098c: 2 - - MAM02039c: -5 - - MAM02040c: 6 - - MAM02397c: 1 - - MAM02471c: 2 - - MAM02554c: 7 - - MAM02555c: -7 - - MAM02643c: -1 - - MAM02681c: 2 - - MAM02682c: -2 - - MAM02877c: -2 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000121897 or ENSG00000175536" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "2.8.1.8;2.3.1.181" - - references: "" - - subsystem: - - "Lipoic acid metabolism" - - confidence_score: 0 - - !!omap - - id: "MAR06401" - - name: "lipoyl-[acp]:protein N6-lipoyltransferase" - - metabolites: !!omap - - MAM00184c: 1 - - MAM00209c: 1 - - MAM01350c: -1 - - MAM02397c: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000175536" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "2.3.1.181" - - references: "" - - subsystem: - - "Lipoic acid metabolism" - - confidence_score: 0 - !!omap - id: "MAR06402" - name: "octanoyl-[acp]:protein N6-octanoyltransferase" @@ -105630,7 +105437,7 @@ - MAM02538c: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000144182 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477" + - gene_reaction_rule: "ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.3.1.-" @@ -105649,7 +105456,7 @@ - MAM02538n: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000144182 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477" + - gene_reaction_rule: "ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.3.1.-" @@ -109041,7 +108848,7 @@ - confidence_score: 0 - !!omap - id: "MAR00154" - - name: "" + - name: "Propanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109050,7 +108857,7 @@ - MAM02774c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000123130 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000097021" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109060,7 +108867,7 @@ - confidence_score: 0 - !!omap - id: "MAR00189" - - name: "" + - name: "Lauroyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109069,7 +108876,7 @@ - MAM02345c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109079,7 +108886,7 @@ - confidence_score: 0 - !!omap - id: "MAR00193" - - name: "" + - name: "Tridecanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109088,7 +108895,7 @@ - MAM03051c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109098,7 +108905,7 @@ - confidence_score: 0 - !!omap - id: "MAR00197" - - name: "" + - name: "Myristoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109107,7 +108914,7 @@ - MAM02495c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109117,7 +108924,7 @@ - confidence_score: 0 - !!omap - id: "MAR00201" - - name: "" + - name: "(9E)-tetradecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00128c: 1 - MAM00129c: -1 @@ -109126,7 +108933,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109136,7 +108943,7 @@ - confidence_score: 0 - !!omap - id: "MAR00206" - - name: "" + - name: "(7Z)-tetradecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00117c: 1 - MAM00118c: -1 @@ -109145,7 +108952,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109155,7 +108962,7 @@ - confidence_score: 0 - !!omap - id: "MAR00210" - - name: "" + - name: "5-tetradecenoyl-CoA hydrolase" - metabolites: !!omap - MAM01141c: -1 - MAM01597c: 1 @@ -109164,7 +108971,7 @@ - MAM02745c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109174,7 +108981,7 @@ - confidence_score: 0 - !!omap - id: "MAR00214" - - name: "" + - name: "Pentadecanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109183,7 +108990,7 @@ - MAM02690c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109193,7 +109000,7 @@ - confidence_score: 0 - !!omap - id: "MAR00223" - - name: "palmitoyl-CoA hydrolase" + - name: "Palmitoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109202,7 +109009,7 @@ - MAM02678c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109212,7 +109019,7 @@ - confidence_score: 0 - !!omap - id: "MAR00230" - - name: "" + - name: "Palmitoleoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109221,7 +109028,7 @@ - MAM02677c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109231,7 +109038,7 @@ - confidence_score: 0 - !!omap - id: "MAR00234" - - name: "" + - name: "7-hexadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM01191c: -1 - MAM01197c: 1 @@ -109240,7 +109047,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109250,7 +109057,7 @@ - confidence_score: 0 - !!omap - id: "MAR00238" - - name: "" + - name: "Heptadecanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109259,7 +109066,7 @@ - MAM02456c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109269,7 +109076,7 @@ - confidence_score: 0 - !!omap - id: "MAR00242" - - name: "" + - name: "(10Z)-heptadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00003c: 1 - MAM00004c: -1 @@ -109278,7 +109085,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109288,7 +109095,7 @@ - confidence_score: 0 - !!omap - id: "MAR00246" - - name: "" + - name: "9-heptadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM01237c: -1 - MAM01238c: 1 @@ -109297,7 +109104,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109307,7 +109114,7 @@ - confidence_score: 0 - !!omap - id: "MAR00250" - - name: "stearoyl-CoA hydrolase" + - name: "Stearoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109316,7 +109123,7 @@ - MAM02941c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109326,7 +109133,7 @@ - confidence_score: 0 - !!omap - id: "MAR00256" - - name: "" + - name: "(13Z)-octadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00019c: 1 - MAM00020c: -1 @@ -109335,7 +109142,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109345,7 +109152,7 @@ - confidence_score: 0 - !!omap - id: "MAR00260" - - name: "" + - name: "Cis-vaccenoyl-CoA hydrolase" - metabolites: !!omap - MAM01585c: 1 - MAM01586c: -1 @@ -109354,7 +109161,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109364,7 +109171,7 @@ - confidence_score: 0 - !!omap - id: "MAR00264" - - name: "" + - name: "Oleoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109373,7 +109180,7 @@ - MAM02647c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109383,7 +109190,7 @@ - confidence_score: 0 - !!omap - id: "MAR00268" - - name: "" + - name: "(9E)-octadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00127c: -1 - MAM01597c: 1 @@ -109392,7 +109199,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109402,7 +109209,7 @@ - confidence_score: 0 - !!omap - id: "MAR00272" - - name: "" + - name: "(7Z)-octadecenoyl-CoA hydrolase" - metabolites: !!omap - MAM00115c: 1 - MAM00116c: -1 @@ -109411,7 +109218,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109421,7 +109228,7 @@ - confidence_score: 0 - !!omap - id: "MAR00276" - - name: "" + - name: "(6Z,9Z)-octadecadienoyl-CoA hydrolase" - metabolites: !!omap - MAM00104c: 1 - MAM00106c: -1 @@ -109430,7 +109237,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109440,7 +109247,7 @@ - confidence_score: 0 - !!omap - id: "MAR00280" - - name: "" + - name: "Nonadecanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109449,7 +109256,7 @@ - MAM02613c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109459,7 +109266,7 @@ - confidence_score: 0 - !!omap - id: "MAR00284" - - name: "Icosanoyl-CoA hydrolase" + - name: "Eicosanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM01771c: 1 @@ -109468,7 +109275,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109478,7 +109285,7 @@ - confidence_score: 0 - !!omap - id: "MAR00290" - - name: "" + - name: "(13Z)-eicosenoyl-CoA hydrolase" - metabolites: !!omap - MAM00017c: 1 - MAM00018c: -1 @@ -109487,7 +109294,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109497,7 +109304,7 @@ - confidence_score: 0 - !!omap - id: "MAR00294" - - name: "" + - name: "(11Z)-eicosenoyl-CoA hydrolase" - metabolites: !!omap - MAM00007c: -1 - MAM01584c: 1 @@ -109506,7 +109313,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109516,7 +109323,7 @@ - confidence_score: 0 - !!omap - id: "MAR00298" - - name: "" + - name: "9-eicosenoyl-CoA hydrolase" - metabolites: !!omap - MAM01235c: 1 - MAM01236c: -1 @@ -109525,7 +109332,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109535,7 +109342,7 @@ - confidence_score: 0 - !!omap - id: "MAR00302" - - name: "" + - name: "(8Z,11Z)-eicosadienoyl-CoA hydrolase" - metabolites: !!omap - MAM00123c: -1 - MAM01207c: 1 @@ -109544,7 +109351,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109554,7 +109361,7 @@ - confidence_score: 0 - !!omap - id: "MAR00306" - - name: "" + - name: "(5Z,8Z,11Z)-eicosatrienoyl-CoA hydrolase" - metabolites: !!omap - MAM00101c: -1 - MAM01597c: 1 @@ -109563,7 +109370,7 @@ - MAM02457c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109573,7 +109380,7 @@ - confidence_score: 0 - !!omap - id: "MAR00310" - - name: "" + - name: "Heneicosanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109582,7 +109389,7 @@ - MAM02053c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109592,7 +109399,7 @@ - confidence_score: 0 - !!omap - id: "MAR00314" - - name: "" + - name: "Docosanoyl-CoA hydrolase" - metabolites: !!omap - MAM01373c: 1 - MAM01597c: 1 @@ -109601,7 +109408,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109611,7 +109418,7 @@ - confidence_score: 0 - !!omap - id: "MAR00320" - - name: "" + - name: "(13Z)-docosenoyl-CoA hydrolase" - metabolites: !!omap - MAM00016c: -1 - MAM01583c: 1 @@ -109620,7 +109427,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109630,7 +109437,7 @@ - confidence_score: 0 - !!omap - id: "MAR00324" - - name: "" + - name: "(11Z)-docosenoyl-CoA hydrolase" - metabolites: !!omap - MAM00006c: -1 - MAM01582c: 1 @@ -109639,7 +109446,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109649,7 +109456,7 @@ - confidence_score: 0 - !!omap - id: "MAR00328" - - name: "" + - name: "Tricosanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109658,7 +109465,7 @@ - MAM03047c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109668,7 +109475,7 @@ - confidence_score: 0 - !!omap - id: "MAR00332" - - name: "" + - name: "Tetracosenoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109677,7 +109484,7 @@ - MAM02971c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109687,7 +109494,7 @@ - confidence_score: 0 - !!omap - id: "MAR00338" - - name: "" + - name: "(15Z)-tetracosenoyl-CoA hydrolase" - metabolites: !!omap - MAM00025c: -1 - MAM01597c: 1 @@ -109696,7 +109503,7 @@ - MAM02564c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109706,7 +109513,7 @@ - confidence_score: 0 - !!omap - id: "MAR00342" - - name: "" + - name: "Hexacosanoyl-CoA hydrolase" - metabolites: !!omap - MAM01432c: 1 - MAM01597c: 1 @@ -109715,7 +109522,7 @@ - MAM02110c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109725,7 +109532,7 @@ - confidence_score: 0 - !!omap - id: "MAR00346" - - name: "" + - name: "Hexacosenoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109734,7 +109541,7 @@ - MAM03153c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109744,7 +109551,7 @@ - confidence_score: 0 - !!omap - id: "MAR00350" - - name: "" + - name: "Linolenoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -109753,7 +109560,7 @@ - MAM02390c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109763,7 +109570,7 @@ - confidence_score: 0 - !!omap - id: "MAR00354" - - name: "" + - name: "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00108c: -1 - MAM01597c: 1 @@ -109772,7 +109579,7 @@ - MAM02939c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109782,7 +109589,7 @@ - confidence_score: 0 - !!omap - id: "MAR00358" - - name: "" + - name: "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00125c: -1 - MAM01597c: 1 @@ -109791,7 +109598,7 @@ - MAM02648c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109801,7 +109608,7 @@ - confidence_score: 0 - !!omap - id: "MAR00362" - - name: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA hydrolase" + - name: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00103c: -1 - MAM01597c: 1 @@ -109810,7 +109617,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109820,7 +109627,7 @@ - confidence_score: 0 - !!omap - id: "MAR00366" - - name: "" + - name: "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00121c: -1 - MAM01597c: 1 @@ -109829,7 +109636,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109839,7 +109646,7 @@ - confidence_score: 0 - !!omap - id: "MAR00370" - - name: "" + - name: "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00134c: -1 - MAM00135c: 1 @@ -109848,7 +109655,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109858,7 +109665,7 @@ - confidence_score: 0 - !!omap - id: "MAR00374" - - name: "" + - name: "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00113c: -1 - MAM00114c: 1 @@ -109867,7 +109674,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109877,7 +109684,7 @@ - confidence_score: 0 - !!omap - id: "MAR00378" - - name: "" + - name: "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00095c: -1 - MAM01597c: 1 @@ -109886,7 +109693,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109896,7 +109703,7 @@ - confidence_score: 0 - !!omap - id: "MAR00382" - - name: "" + - name: "(11Z,14Z,17Z)-eicosatrienoyl-CoA hydrolase" - metabolites: !!omap - MAM00010c: 1 - MAM00012c: -1 @@ -109905,7 +109712,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109915,7 +109722,7 @@ - confidence_score: 0 - !!omap - id: "MAR00386" - - name: "" + - name: "13,16,19-docosatrienoyl-CoA hydrolase" - metabolites: !!omap - MAM00341c: 1 - MAM00343c: -1 @@ -109924,7 +109731,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109934,7 +109741,7 @@ - confidence_score: 0 - !!omap - id: "MAR00390" - - name: "" + - name: "10,13,16,19-docosatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00260c: 1 - MAM00262c: -1 @@ -109943,7 +109750,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109953,7 +109760,7 @@ - confidence_score: 0 - !!omap - id: "MAR00394" - - name: "" + - name: "12,15,18,21-tetracosatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00315c: 1 - MAM00317c: -1 @@ -109962,7 +109769,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109981,7 +109788,7 @@ - MAM02391c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -109991,7 +109798,7 @@ - confidence_score: 0 - !!omap - id: "MAR00402" - - name: "" + - name: "Gamma-linolenoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM01932c: 1 @@ -110000,7 +109807,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110010,7 +109817,7 @@ - confidence_score: 0 - !!omap - id: "MAR00406" - - name: "" + - name: "Dihomo-gamma-linolenoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM01696c: 1 @@ -110019,7 +109826,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110029,7 +109836,7 @@ - confidence_score: 0 - !!omap - id: "MAR00410" - - name: "" + - name: "Arachidonyl-CoA hydrolase" - metabolites: !!omap - MAM01362c: 1 - MAM01364c: -1 @@ -110038,7 +109845,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000097021 or ENSG00000136881 or ENSG00000112304 or ENSG00000159445" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110048,7 +109855,7 @@ - confidence_score: 0 - !!omap - id: "MAR00414" - - name: "" + - name: "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00119c: -1 - MAM01291c: 1 @@ -110057,7 +109864,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110067,7 +109874,7 @@ - confidence_score: 0 - !!omap - id: "MAR00418" - - name: "" + - name: "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA hydrolase" - metabolites: !!omap - MAM00131c: -1 - MAM00132c: 1 @@ -110076,7 +109883,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110086,7 +109893,7 @@ - confidence_score: 0 - !!omap - id: "MAR00422" - - name: "" + - name: "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00110c: -1 - MAM00111c: 1 @@ -110095,7 +109902,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110105,7 +109912,7 @@ - confidence_score: 0 - !!omap - id: "MAR00426" - - name: "" + - name: "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA hydrolase" - metabolites: !!omap - MAM00093c: -1 - MAM00094c: 1 @@ -110114,7 +109921,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110124,7 +109931,7 @@ - confidence_score: 0 - !!omap - id: "MAR00430" - - name: "" + - name: "(11Z,14Z)-eicosadienoyl-CoA hydrolase" - metabolites: !!omap - MAM00008c: 1 - MAM00009c: -1 @@ -110133,7 +109940,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000184227 or ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110143,7 +109950,7 @@ - confidence_score: 0 - !!omap - id: "MAR00434" - - name: "" + - name: "(13Z,16Z)-docosadienoyl-CoA hydrolase" - metabolites: !!omap - MAM00021c: 1 - MAM00023c: -1 @@ -110152,7 +109959,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110162,7 +109969,7 @@ - confidence_score: 0 - !!omap - id: "MAR00438" - - name: "" + - name: "10,13,16-docosatrienoyl-CoA hydrolase" - metabolites: !!omap - MAM00264c: -1 - MAM00265c: 1 @@ -110171,7 +109978,7 @@ - MAM02040c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000136881 or ENSG00000205669" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110181,7 +109988,7 @@ - confidence_score: 0 - !!omap - id: "MAR03009" - - name: "" + - name: "Propanoyl-CoA hydrolase (peroxisomal)" - metabolites: !!omap - MAM01597x: 1 - MAM02039x: 1 @@ -110190,7 +109997,7 @@ - MAM02774x: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000101473 or ENSG00000177465" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -110200,7 +110007,7 @@ - confidence_score: 0 - !!omap - id: "MAR03475" - - name: "Acetyl-CoA hydrolase" + - name: "Acetyl-CoA hydrolase (peroxisomal)" - metabolites: !!omap - MAM01252x: 1 - MAM01261x: -1 @@ -110209,7 +110016,7 @@ - MAM02040x: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000101473" + - gene_reaction_rule: "ENSG00000101473 or ENSG00000177465" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.27" @@ -133552,25 +133359,6 @@ - subsystem: - "Glycerophospholipid metabolism" - confidence_score: 0 - - !!omap - - id: "MAR00478" - - name: "sn-Glycerol-3-phosphate:NADP+ 2-oxidoreductase" - - metabolites: !!omap - - MAM01690c: -1 - - MAM02039c: -1 - - MAM02554c: 1 - - MAM02555c: -1 - - MAM02914c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000167588" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.1.1.94" - - references: "PMID:16460752" - - subsystem: - - "Glycerophospholipid metabolism" - - confidence_score: 0 - !!omap - id: "MAR00479" - name: "sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase" @@ -133586,7 +133374,7 @@ - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.1.1.8" - - references: "PMID:17045662;PMID:7772607" + - references: "PMID:16460752;PMID:17045662;PMID:7772607" - subsystem: - "Glycerophospholipid metabolism" - confidence_score: 0 @@ -133609,24 +133397,6 @@ - subsystem: - "Glycerophospholipid metabolism" - confidence_score: 0 - - !!omap - - id: "MAR00482" - - name: "sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase" - - metabolites: !!omap - - MAM01690c: 1 - - MAM01802c: -1 - - MAM01803c: 1 - - MAM02914c: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000115159" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "1.1.5.3" - - references: "PMID:11955283;PMID:2115809;PMID:2923620;PMID:3338458;PMID:340460;PMID:8401296;PMID:8549872;PMID:8579375;PMID:9171333;PMID:9244403;PMID:9559543" - - subsystem: - - "Glycerophospholipid metabolism" - - confidence_score: 0 - !!omap - id: "MAR00484" - name: "CDPglycerol phosphoglycerohydrolase" @@ -147372,7 +147142,7 @@ - MAM02774m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669" + - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000136881 or ENSG00000177465 or ENSG00000184227 or ENSG00000205669 or ENSG00000123130" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "3.1.2.2" @@ -152855,7 +152625,7 @@ - confidence_score: 0 - !!omap - id: "MAR04665" - - name: "S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)" + - name: "" - metabolites: !!omap - MAM01044m: -1 - MAM01100m: 1 @@ -152863,11 +152633,11 @@ - MAM02040m: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000091140 and ENSG00000140905 and ENSG00000145020 and ENSG00000178445" + - gene_reaction_rule: "ENSG00000182199" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "2.1.2.10" - - references: "PMID:7916605" + - references: "PMID:11087421" - subsystem: - "Folate metabolism" - confidence_score: 0 @@ -155324,7 +155094,7 @@ - MAM02833c: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000128918 or ENSG00000165092" + - gene_reaction_rule: "ENSG00000128918 or ENSG00000165092 or ENSG00000184254" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "1.2.1.36" @@ -188444,29 +188214,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR06406" - - name: "" - - metabolites: !!omap - - MAM01285c: 1 - - MAM01371c: -1 - - MAM02039c: 1 - - MAM02040c: -1 - - MAM02394c: 1 - - MAM02394e: -1 - - MAM02519c: 2 - - MAM02519e: -2 - - MAM02751c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000138074" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "PMID:16415531" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR06424" - name: "" @@ -194227,7 +193974,7 @@ - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "" - - references: "" + - references: "PMID:9516450;PMID:10329687;PMID:15561972" - subsystem: - "Transport reactions" - confidence_score: 0 @@ -195167,22 +194914,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR09019" - - name: "" - - metabolites: !!omap - - MAM01424c: -1 - - MAM01424m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR09020" - name: "" @@ -196292,24 +196023,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR04843" - - name: "" - - metabolites: !!omap - - MAM01948c: -1 - - MAM01948m: 1 - - MAM02034c: 1 - - MAM02034m: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000108602 or ENSG00000132746 or ENSG00000184254" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "PMID:11078702" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR04850" - name: "" @@ -196676,24 +196389,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR04940" - - name: "" - - metabolites: !!omap - - MAM02026c: -1 - - MAM02026m: 1 - - MAM02751c: 1 - - MAM02751m: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000183048" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "PMID:15845418;PMID:16600197;PMID:9639574" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR04944" - name: "" @@ -198678,42 +198373,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR06391" - - name: "" - - metabolites: !!omap - - MAM01306c: -1 - - MAM01306m: 1 - - MAM02026c: 1 - - MAM02026m: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000108528" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "PMID:15845418" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR06408" - - name: "" - - metabolites: !!omap - - MAM01701c: -1 - - MAM01701m: 1 - - MAM02039i: -1 - - MAM02039m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR06431" - name: "" @@ -201299,17 +200958,17 @@ - id: "MAR03473" - name: "" - metabolites: !!omap + - MAM01285c: -1 + - MAM01285x: 1 - MAM01334c: 1 - MAM01334x: -1 - - MAM01371c: -1 - - MAM01371x: 1 - - lower_bound: 0 + - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "ENSG00000100372" - rxnNotes: "" - rxnFrom: "HMRdatabase" - eccodes: "" - - references: "PMID:16756494;PMID:9874197;PMID:12445829;PMID:14598172;PMID:18406340;PMID:9759482" + - references: "PMID:12445829;PMID:16756494;PMID:22185573" - subsystem: - "Transport reactions" - confidence_score: 0 @@ -201523,22 +201182,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR04915" - - name: "" - - metabolites: !!omap - - MAM01597c: -1 - - MAM01597x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "PMID:14598172" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR04924" - name: "" @@ -201865,38 +201508,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR07771" - - name: "" - - metabolites: !!omap - - MAM02552c: 1 - - MAM02552x: -1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07775" - - name: "" - - metabolites: !!omap - - MAM02553c: -1 - - MAM02553x: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR07777" - name: "" @@ -201929,86 +201540,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR07782" - - name: "" - - metabolites: !!omap - - MAM01285c: -1 - - MAM01285x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07783" - - name: "" - - metabolites: !!omap - - MAM01334c: -1 - - MAM01334x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07785" - - name: "" - - metabolites: !!omap - - MAM01371c: -1 - - MAM01371x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07788" - - name: "" - - metabolites: !!omap - - MAM01803c: -1 - - MAM01803x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07790" - - name: "" - - metabolites: !!omap - - MAM01802c: -1 - - MAM01802x: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "HMRdatabase" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR07797" - name: "" @@ -218368,7 +217899,7 @@ - MAM02553m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000111275 or ENSG00000137124 or ENSG00000159423" + - gene_reaction_rule: "ENSG00000111275 or ENSG00000137124" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "1.5.1.12" @@ -223095,7 +222626,6 @@ - eccodes: "4.99.1.1" - references: "PMID:7983009;PMID:11175906;PMID:11215517;PMID:11853551;PMID:11947230;PMID:1624416;PMID:182145;PMID:2310748;PMID:3196293;PMID:3702737;PMID:406931;PMID:6425295;PMID:7309736;PMID:8818224;PMID:9712849;PMID:9808757" - subsystem: - - "Heme synthesis" - "Porphyrin metabolism" - confidence_score: 0 - !!omap @@ -224194,29 +223724,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR01483" - - name: "Transport of Lipoate via Sodium Symport" - - metabolites: !!omap - - MAM01285c: 1 - - MAM01371c: -1 - - MAM02039c: 1 - - MAM02040c: -1 - - MAM02394c: 1 - - MAM02394e: -1 - - MAM02519c: 1 - - MAM02519e: -1 - - MAM02751c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000138074" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:10329687;PMID:10334869;PMID:12646417;PMID:15561972;PMID:9516450" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR01485" - name: "Transport of L-Lactate via Diffusion, Mitochondrial" @@ -225634,7 +225141,7 @@ - eccodes: "1.3.3.4" - references: "PMID:8771201" - subsystem: - - "Heme synthesis" + - "Porphyrin metabolism" - confidence_score: 0 - !!omap - id: "MAR01645" @@ -229477,7 +228984,7 @@ - MAM02941m: -1 - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673" + - gene_reaction_rule: "ENSG00000097021 or ENSG00000119673 or ENSG00000196407" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "3.1.2.2" @@ -230485,7 +229992,7 @@ - MAM01974m: 1 - MAM02040m: 1 - MAM02319m: -1 - - lower_bound: -1000 + - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: "ENSG00000109576 or ENSG00000137944" - rxnNotes: "" @@ -245085,38 +244592,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR07823" - - name: "Transport of dCTP into Mitochondria" - - metabolites: !!omap - - MAM01645c: -1 - - MAM01645m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:16816105;PMID:17403938" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR07926" - - name: "Transport of dGTP into Mitochondria" - - metabolites: !!omap - - MAM01688c: -1 - - MAM01688m: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "PMID:16816105;PMID:17403938" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - !!omap - id: "MAR08111" - name: "Transport of Dihydroxyacetone Phosphate into Cytosol" @@ -245195,13 +244670,13 @@ - metabolites: !!omap - MAM01753c: -1 - MAM01753m: 1 - - lower_bound: 0 + - lower_bound: -1000 - upper_bound: 1000 - - gene_reaction_rule: "" + - gene_reaction_rule: "ENSG00000171612" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "" - - references: "PMID:16816105;PMID:17403938" + - references: "PMID:25320081" - subsystem: - "Transport reactions" - confidence_score: 0 @@ -249147,25 +248622,6 @@ - subsystem: - "Fatty acid oxidation" - confidence_score: 0 - - !!omap - - id: "MAR09949" - - name: "Acylcoa Hydrolase, Cytosolic" - - metabolites: !!omap - - MAM01597c: 1 - - MAM02039c: 1 - - MAM02040c: -1 - - MAM02122c: -1 - - MAM03684c: 1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "3.1.2.2" - - references: "" - - subsystem: - - "Fatty acid oxidation" - - confidence_score: 0 - !!omap - id: "MAR09950" - name: "Hydrolysis of Tetradecadienoyl Coenzyme A to Cis-5, 8-Tetradecadienoic Acid" @@ -254260,16 +253716,16 @@ - confidence_score: 0 - !!omap - id: "MAR10374" - - name: "Acyl-Coenzyme A Hydrolase, Mitochondrial" + - name: "Hexanoyl-CoA hydrolase, Mitochondrial" - metabolites: !!omap - MAM01597m: 1 - MAM02039m: 1 - MAM02040m: -1 - MAM02122m: -1 - - MAM03684m: 1 + - MAM02120m: 1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "" + - gene_reaction_rule: "ENSG00000123130" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "" @@ -254311,16 +253767,16 @@ - confidence_score: 0 - !!omap - id: "MAR10377" - - name: "Acylcoa Hydrolase, Peroxisome" + - name: "Hexanoyl-CoA hydrolase, Peroxisome" - metabolites: !!omap - MAM01597x: 1 - MAM02039x: 1 - MAM02040x: -1 - MAM02122x: -1 - - MAM03684x: 1 - - lower_bound: -1000 + - MAM02120x: 1 + - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "" + - gene_reaction_rule: "ENSG00000101473" - rxnNotes: "" - rxnFrom: "Recon3D" - eccodes: "" @@ -254548,7 +254004,7 @@ - eccodes: "" - references: "PMID:8145081" - subsystem: - - "Exchange/demand reactions" + - "Transport reactions" - confidence_score: 0 - !!omap - id: "MAR10390" @@ -269787,8 +269243,8 @@ - id: "MAR11290" - name: "Transport of Hexanoate (N-C6:0), Mitochondrial" - metabolites: !!omap - - MAM03684c: 1 - - MAM03684m: -1 + - MAM02120c: 1 + - MAM02120m: -1 - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "" @@ -269803,24 +269259,8 @@ - id: "MAR11291" - name: "Transport of Hexanoate (N-C6:0), Peroxisome" - metabolites: !!omap - - MAM03684c: 1 - - MAM03684x: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "" - - subsystem: - - "Transport reactions" - - confidence_score: 0 - - !!omap - - id: "MAR11292" - - name: "Transport of Hexanoate (N-C6:0), Extracellular" - - metabolites: !!omap - - MAM03684c: -1 - - MAM03684e: 1 + - MAM02120c: 1 + - MAM02120x: -1 - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "" @@ -269831,21 +269271,6 @@ - subsystem: - "Transport reactions" - confidence_score: 0 - - !!omap - - id: "MAR11293" - - name: "Exchange of Hexanoate (N-C6:0)" - - metabolites: !!omap - - MAM03684e: -1 - - lower_bound: -1000 - - upper_bound: 1000 - - gene_reaction_rule: "" - - rxnNotes: "" - - rxnFrom: "Recon3D" - - eccodes: "" - - references: "" - - subsystem: - - "Exchange/demand reactions" - - confidence_score: 0 - !!omap - id: "MAR11294" - name: "Hydrolysis of Fatty Acyl Coenzyme A (14:1)" @@ -270241,7 +269666,7 @@ - eccodes: "" - references: "PMID:21749716" - subsystem: - - "Heme synthesis" + - "Porphyrin metabolism" - confidence_score: 0 - !!omap - id: "MAR11317" @@ -270705,8 +270130,6 @@ - id: "MAR11346" - name: "Lipoamide Transport" - metabolites: !!omap - - MAM02039c: 1 - - MAM02039e: -1 - MAM02393c: 1 - MAM02393e: -1 - lower_bound: -1000 @@ -270942,11 +270365,9 @@ - id: "MAR11361" - name: "Transport of Lipoamide, Mitochondrial" - metabolites: !!omap - - MAM02039i: -1 - - MAM02039m: 1 - MAM02393c: -1 - MAM02393m: 1 - - lower_bound: 0 + - lower_bound: -1000 - upper_bound: 1000 - gene_reaction_rule: "" - rxnNotes: "" @@ -271723,7 +271144,7 @@ - eccodes: "" - references: "PMID:21749716" - subsystem: - - "Heme synthesis" + - "Porphyrin metabolism" - confidence_score: 0 - !!omap - id: "MAR11407" @@ -273995,7 +273416,7 @@ - confidence_score: 0 - !!omap - id: "MAR11544" - - name: "Formation of Hexanoic Acid" + - name: "Hexanoyl-CoA hydrolase" - metabolites: !!omap - MAM01597c: 1 - MAM02039c: 1 @@ -274004,10 +273425,10 @@ - MAM02122c: -1 - lower_bound: 0 - upper_bound: 1000 - - gene_reaction_rule: "" + - gene_reaction_rule: "ENSG00000172497" - rxnNotes: "https://www.springer.com/gp/book/9789400957800" - rxnFrom: "Recon3D" - - eccodes: "" + - eccodes: "3.1.2.2" - references: "PMID:8371066" - subsystem: - "Fatty acid oxidation" @@ -302974,26 +302395,6 @@ - subsystem: - "Retinol metabolism" - confidence_score: 0 - - !!omap - - id: "MAR20012" - - name: "MAR20012" - - metabolites: !!omap - - MAM02039c: 2 - - MAM02040c: -1 - - MAM02552c: -1 - - MAM02553c: 1 - - MAM02832c: -1 - - MAM02833c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000184254" - - rxnNotes: "" - - rxnFrom: "" - - eccodes: "1.2.1.36" - - references: "" - - subsystem: - - "Retinol metabolism" - - confidence_score: 0 - !!omap - id: "MAR20013" - name: "MAR20013" @@ -303100,7 +302501,7 @@ - MAM02630r: -1 - MAM20018r: 1 - MAM20019r: -1 - - MAM20020r: 1 + - MAM01828r: 1 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: "ENSG00000130649" @@ -303120,8 +302521,8 @@ - MAM02457i: -1 - MAM02630i: -1 - MAM20021i: 1 - - MAM20022i: -1 - - MAM20023i: 1 + - MAM20019i: -1 + - MAM01828i: 1 - lower_bound: 0 - upper_bound: 1000 - gene_reaction_rule: "ENSG00000130649" @@ -303141,7 +302542,7 @@ - MAM02040r: 1 - MAM02630r: -1 - MAM20019r: -1 - - MAM20020r: 1 + - MAM01828r: 1 - MAM20024r: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303161,8 +302562,8 @@ - MAM02039i: 1 - MAM02040i: 1 - MAM02630i: -1 - - MAM20022i: -1 - - MAM20023i: 1 + - MAM20019i: -1 + - MAM01828i: 1 - MAM20025i: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303183,7 +302584,7 @@ - MAM02040r: 1 - MAM02630r: -1 - MAM20019r: -1 - - MAM20020r: 1 + - MAM01828r: 1 - MAM20026r: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303203,8 +302604,8 @@ - MAM02039i: 1 - MAM02040i: 1 - MAM02630i: -1 - - MAM20022i: -1 - - MAM20023i: 1 + - MAM20019i: -1 + - MAM01828i: 1 - MAM20027i: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303225,7 +302626,7 @@ - MAM02344r: -1 - MAM02630r: -1 - MAM20019r: -1 - - MAM20020r: 1 + - MAM01828r: 1 - MAM20028r: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303245,8 +302646,8 @@ - MAM02040i: 1 - MAM02344i: -1 - MAM02630i: -1 - - MAM20022i: -1 - - MAM20023i: 1 + - MAM20019i: -1 + - MAM01828i: 1 - MAM20029i: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303267,7 +302668,7 @@ - MAM02494r: -1 - MAM02630r: -1 - MAM20019r: -1 - - MAM20020r: 1 + - MAM01828r: 1 - MAM20030r: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303287,8 +302688,8 @@ - MAM02040i: 1 - MAM02494i: -1 - MAM02630i: -1 - - MAM20022i: -1 - - MAM20023i: 1 + - MAM20019i: -1 + - MAM01828i: 1 - MAM20031i: 1 - lower_bound: 0 - upper_bound: 1000 @@ -303474,7 +302875,7 @@ - MAM02040c: -1 - MAM02554c: -1 - MAM02555c: 1 - - MAM03684c: 1 + - MAM02120c: 1 - MAM20037c: -1 - lower_bound: 0 - upper_bound: 1000 @@ -304341,24 +303742,6 @@ - subsystem: - "Fatty acid metabolism" - confidence_score: 0 - - !!omap - - id: "MAR20089" - - name: "MAR20089" - - metabolites: !!omap - - MAM01107c: -1 - - MAM01596c: 1 - - MAM02039c: -1 - - MAM02897c: 1 - - lower_bound: 0 - - upper_bound: 1000 - - gene_reaction_rule: "ENSG00000132437" - - rxnNotes: "" - - rxnFrom: "" - - eccodes: "4.1.1.28" - - references: "" - - subsystem: - - "Tryptophan metabolism" - - confidence_score: 0 - !!omap - id: "MAR20090" - name: "MAR20090" @@ -304816,6 +304199,1043 @@ - subsystem: - "Miscellaneous" - confidence_score: 0 + - !!omap + - id: "MAR20115" + - name: "MAR20115" + - metabolites: !!omap + - MAM01334c: -1 + - MAM01334x: 1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000100372" + - 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"MAR20163" + - name: "MAR20163" + - metabolites: !!omap + - MAM01756c: -1 + - MAM01756m: 1 + - MAM03130c: 1 + - MAM03130m: -1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000171612" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:25320081" + - subsystem: + - "Transport reactions" + - confidence_score: 0 + - !!omap + - id: "MAR20164" + - name: "MAR20164" + - metabolites: !!omap + - MAM01623c: -1 + - MAM01623m: 1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000114120 or ENSG00000171612" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:25320081" + - subsystem: + - "Transport reactions" + - confidence_score: 0 + - !!omap + - id: "MAR20165" + - name: "MAR20165" + - metabolites: !!omap + - MAM02034c: -1 + - MAM02034m: 1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000114120 or ENSG00000171612" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:25320081" + - subsystem: + - "Transport reactions" + - confidence_score: 0 + - !!omap + - id: "MAR20166" + - name: "MAR20166" + - metabolites: !!omap + - MAM03130c: -1 + - MAM03130m: 1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000114120 or ENSG00000171612" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:25320081" + - subsystem: + - "Transport reactions" + - confidence_score: 0 + - !!omap + - id: "MAR20167" + - name: "MAR20167" + - metabolites: !!omap + - MAM01828c: 1 + - MAM03102m: 1 + - MAM03103m: -1 + - MAM20019c: -1 + - lower_bound: -1000 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000102967" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:34428349" + - subsystem: + - "Miscellaneous" + - confidence_score: 0 + - !!omap + - id: "MAR20168" + - name: "MAR20168" + - metabolites: !!omap + - MAM00209c: -1 + - MAM02393m: 1 + - lower_bound: 0 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000144182" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "" + - references: "PMID:29987032" + - subsystem: + - "Miscellaneous" + - confidence_score: 0 + - !!omap + - id: "MAR20169" + - name: "Butyryl-CoA hydrolase" + - metabolites: !!omap + - MAM01412c: -1 + - MAM02040c: -1 + - MAM01410c: 1 + - MAM01597c: 1 + - MAM02039c: 1 + - lower_bound: 0 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000172497" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "3.1.2.2" + - references: "" + - subsystem: + - "Acyl-CoA hydrolysis" + - confidence_score: 0 + - !!omap + - id: "MAR20170" + - name: "Octanoyl-CoA hydrolase" + - metabolites: !!omap + - MAM02644c: -1 + - MAM02040c: -1 + - MAM02642c: 1 + - MAM01597c: 1 + - MAM02039c: 1 + - lower_bound: 0 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000097021" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "3.1.2.2" + - references: "" + - subsystem: + - "Acyl-CoA hydrolysis" + - confidence_score: 0 + - !!omap + - id: "MAR20171" + - name: "Decanoyl-CoA hydrolase" + - metabolites: !!omap + - MAM01650c: -1 + - MAM02040c: -1 + - MAM01648c: 1 + - MAM01597c: 1 + - MAM02039c: 1 + - lower_bound: 0 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000097021" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "3.1.2.2" + - references: "" + - subsystem: + - "Acyl-CoA hydrolysis" + - confidence_score: 0 + - !!omap + - id: "MAR20172" + - name: "Undecanoyl-CoA hydrolase" + - metabolites: !!omap + - MAM03116c: -1 + - MAM02040c: -1 + - MAM03117c: 1 + - MAM01597c: 1 + - MAM02039c: 1 + - lower_bound: 0 + - upper_bound: 1000 + - gene_reaction_rule: "ENSG00000097021" + - rxnNotes: "" + - rxnFrom: "" + - eccodes: "3.1.2.2" + - references: "" + - subsystem: + - "Acyl-CoA hydrolysis" + - confidence_score: 0 - genes: - !!omap - id: "ENSG00000000419" @@ -305024,6 +305444,9 @@ - !!omap - id: "ENSG00000013288" - name: "MAN2B2" + - !!omap + - id: "ENSG00000013306" + - name: "SLC25A39" - !!omap - id: "ENSG00000013375" - name: "PGM3" @@ -305618,6 +306041,9 @@ - !!omap - id: "ENSG00000075239" - name: "ACAT1" + - !!omap + - id: "ENSG00000075303" + - name: "SLC25A40" - !!omap - id: "ENSG00000075415" - name: "SLC25A3" @@ -307037,9 +307463,6 @@ - !!omap - id: "ENSG00000111261" - name: "MANSC1" - - !!omap - - id: "ENSG00000111271" - - name: "ACAD10" - !!omap - id: "ENSG00000111275" - name: "ALDH2" @@ -307271,6 +307694,9 @@ - !!omap - id: "ENSG00000114115" - name: "RBP1" + - !!omap + - id: "ENSG00000114120" + - name: "SLC25A36" - !!omap - id: "ENSG00000114124" - name: "GRK7" @@ -311468,6 +311894,9 @@ - !!omap - id: "ENSG00000171608" - name: "PIK3CD" + - !!omap + - id: "ENSG00000171612" + - name: "SLC25A33" - !!omap - id: "ENSG00000171723" - name: "GPHN" @@ -312698,9 +313127,6 @@ - !!omap - id: "ENSG00000197417" - name: "SHPK" - - !!omap - - id: "ENSG00000197444" - - name: "OGDHL" - !!omap - id: "ENSG00000197446" - name: "CYP2F1" @@ -313472,6 +313898,12 @@ - !!omap - id: "ENSG00000288705" - name: "UGT1A5" + - !!omap + - id: "ENSG00000159445" + - name: "THEM4" + - !!omap + - id: "ENSG00000196407" + - name: "THEM5" - compartments: !!omap - e: "Extracellular" - x: "Peroxisome" diff --git a/model/genes.tsv b/model/genes.tsv index 4b17c98d..cdd14823 100644 --- a/model/genes.tsv +++ b/model/genes.tsv @@ -737,7 +737,6 @@ genes geneENSTID geneENSPID geneUniProtID geneSymbols geneEntrezID geneNames gen "ENSG00000111224" "ENST00000416739;ENST00000427057;ENST00000458162;ENST00000228820;ENST00000476985;ENST00000453942;ENST00000450737;ENST00000447133" "ENSP00000392392;ENSP00000397058;ENSP00000399665;ENSP00000228820;ENSP00000395062;ENSP00000387481;ENSP00000405385" "Q9NR21" "PARP11" "57097" "poly(ADP-ribose) polymerase family member 11" "ARTD11;C12orf6" "Nucleus;Cytosol" "SwissProt;CellAtlas" "ENSG00000111237" "ENST00000549578;ENST00000360579;ENST00000621131;ENST00000552130;ENST00000447578;ENST00000546588;ENST00000548539;ENST00000549970;ENST00000548259;ENST00000553128;ENST00000551655;ENST00000550267" "ENSP00000447058;ENSP00000353786;ENSP00000480853;ENSP00000449954;ENSP00000400048;ENSP00000449044;ENSP00000447634" "Q9UBQ0" "VPS29" "51699" "VPS29 retromer complex component" "DC15;DC7;PEP11" "Cytosol" "SwissProt;CellAtlas" "ENSG00000111261" "ENST00000535902;ENST00000396349;ENST00000545735;ENST00000543314" "ENSP00000438205;ENSP00000379638;ENSP00000445303;ENSP00000437624" "Q9H8J5" "MANSC1" "54682" "MANSC domain containing 1" "FLJ10298;LOH12CR3" "Golgi apparatus" "CellAtlas" -"ENSG00000111271" "ENST00000511915;ENST00000514615;ENST00000509936;ENST00000413681;ENST00000549590;ENST00000455480;ENST00000552965;ENST00000507135;ENST00000515283;ENST00000313698;ENST00000502746;ENST00000552706;ENST00000514847;ENST00000507683;ENST00000503490;ENST00000508303;ENST00000552177;ENST00000504803;ENST00000546647;ENST00000505487;ENST00000550198;ENST00000507688;ENST00000547491;ENST00000512792" "ENSP00000421527;ENSP00000446959;ENSP00000389813;ENSP00000446998;ENSP00000449097;ENSP00000325137;ENSP00000447561;ENSP00000446711" "Q6JQN1" "ACAD10" "80724" "acyl-CoA dehydrogenase family member 10" "MGC5601" "Mitochondria" "DeepLoc2" "ENSG00000111275" "ENST00000416293;ENST00000261733;ENST00000548536;ENST00000549106;ENST00000551450" "ENSP00000403349;ENSP00000261733;ENSP00000448179;ENSP00000474669" "P05091" "ALDH2" "217" "aldehyde dehydrogenase 2 family member" "" "Mitochondria" "SwissProt" "ENSG00000111339" "ENST00000228936;ENST00000430129;ENST00000544616;ENST00000420600" "ENSP00000228936;ENSP00000412735;ENSP00000442877;ENSP00000405689" "Q93070" "ART4" "420" "ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)" "ARTC4;CD297;DO;DOK1" "Cytosol" "CellAtlas" "ENSG00000111371" "ENST00000398637;ENST00000549049;ENST00000439706;ENST00000546893;ENST00000552197;ENST00000548979;ENST00000549633;ENST00000551506;ENST00000550173;ENST00000546519;ENST00000612161" "ENSP00000381634;ENSP00000449607;ENSP00000398142;ENSP00000447853;ENSP00000449756;ENSP00000449744;ENSP00000478907" "Q9H2H9" "SLC38A1" "81539" "solute carrier family 38 member 1" "ATA1;NAT2;SAT1" "Cell membrane;Lysosome" "DeepLoc2" @@ -2607,7 +2606,6 @@ genes geneENSTID geneENSPID geneUniProtID geneSymbols geneEntrezID geneNames gen "ENSG00000197408" "ENST00000324071;ENST00000598834;ENST00000593831;ENST00000594187;ENST00000597612" "ENSP00000324648;ENSP00000496294;ENSP00000470582" "P20813" "CYP2B6" "1555" "cytochrome P450 family 2 subfamily B member 6" "CPB6;CYP2B;CYPIIB6" "Endoplasmic reticulum;Nucleus;Cytosol" "SwissProt;CellAtlas" "ENSG00000197416" "ENST00000519696;ENST00000360464" "ENSP00000427973;ENSP00000353650" "A6NFH5" "FABP12" "646486" "fatty acid binding protein 12" "" "Cytosol" "DeepLoc2" "ENSG00000197417" "ENST00000225519" "ENSP00000225519" "Q9UHJ6" "SHPK" "23729" "sedoheptulokinase" "CARKL;SHK" "Nucleus;Cytosol" "SwissProt;CellAtlas" -"ENSG00000197444" "ENST00000374103;ENST00000419399;ENST00000432695;ENST00000490844;ENST00000496884;ENST00000471460" "ENSP00000363216;ENSP00000401356;ENSP00000390240" "Q9ULD0" "OGDHL" "55753" "oxoglutarate dehydrogenase L" "FLJ10851" "Mitochondria;Nucleus" "SwissProt;CellAtlas" "ENSG00000197446" "ENST00000526093;ENST00000531409;ENST00000331105;ENST00000532164;ENST00000534009;ENST00000439903" "ENSP00000333534;ENSP00000471416;ENSP00000470136;ENSP00000443424" "P24903" "CYP2F1" "1572" "cytochrome P450 family 2 subfamily F member 1" "CYP2F" "Endoplasmic reticulum" "SwissProt" "ENSG00000197448" "ENST00000436038;ENST00000409500;ENST00000443571;ENST00000358406;ENST00000442394;ENST00000479303;ENST00000494735;ENST00000473649;ENST00000489654" "ENSP00000408341;ENSP00000386944;ENSP00000415813;ENSP00000351181;ENSP00000406802;ENSP00000431049" "Q9Y2Q3" "GSTK1" "373156" "glutathione S-transferase kappa 1" "GST13" "Peroxisome" "SwissProt;CellAtlas" "ENSG00000197496" "ENST00000359271;ENST00000486000;ENST00000611837" "ENSP00000352216;ENSP00000478679" "O95528" "SLC2A10" "81031" "solute carrier family 2 member 10" "GLUT10" "Cytosol" "SwissProt;CellAtlas" @@ -2884,3 +2882,9 @@ genes geneENSTID geneENSPID geneUniProtID geneSymbols geneEntrezID geneNames gen "ENSG00000111319" "ENST00000228916;ENST00000360168;ENST00000540037;ENST00000543768;ENST00000396966;ENST00000536788" "ENSP00000228916;ENSP00000353292;ENSP00000440876;ENSP00000438739;ENSP00000380166;ENSP00000443434" "P37088" "SCNN1A" "6337" "sodium channel epithelial 1 subunit alpha" "" "" "" "ENSG00000162572" "ENST00000379116;ENST00000338555;ENST00000400928;ENST00000325425;ENST00000379099;ENST00000470022" "ENSP00000368411;ENSP00000339504;ENSP00000383717;ENSP00000321594;ENSP00000368393;ENSP00000420548" "P51172" "SCNN1D" "6339" "sodium channel epithelial 1 subunit delta" "" "" "" "ENSG00000153253" "ENST00000283254;ENST00000706067;ENST00000639244;ENST00000409101;ENST00000668657;ENST00000440431;ENST00000453007" "ENSP00000283254;ENSP00000516211;ENSP00000492251;ENSP00000386726;ENSP00000499420;ENSP00000403348;ENSP00000391569" "Q9NY46" "SCN3A" "6328" "sodium voltage-gated channel alpha subunit 3" "" "" "" +"ENSG00000171612" "ENST00000302692" "ENSP00000306328" "Q9BSK2" "SLC25A33" "84275" "solute carrier family 25 member 33" "" "" "" +"ENSG00000114120" "ENST00000324194;ENST00000446041;ENST00000507429;ENST00000453248;ENST00000513887;ENST00000648615;ENST00000502594;ENST00000512023;ENST00000512506;ENST00000631654" "ENSP00000320688;ENSP00000401938;ENSP00000421470;ENSP00000391521;ENSP00000422265;ENSP00000497436;ENSP00000423319;ENSP00000424505;ENSP00000423711;ENSP00000487839" "Q96CQ1" "SLC25A36" "55186" "solute carrier family 25 member 36" "" "" "" +"ENSG00000159445" "ENST00000368814.8;ENST00000489410.1;ENST00000471464.5;ENST00000477437.1;ENST00000483207.5" "ENSP00000357804.3;ENSP00000433304.1;ENSP00000431288.1" "Q5T1C6" "THEM4" "117145" "thioesterase superfamily member 4" "CTMP" "Cytosol;Inner mitochondria" "SwissProt" +"ENSG00000196407" "ENST00000368817.10;ENST00000453881.2" "ENSP00000357807.4;ENSP00000406809.2" "Q8N1Q8" "THEM5" "284486" "thioesterase superfamily member 5" "ACOT15" "Inner mitochondria" "SwissProt" +"ENSG00000013306" "ENST00000377095;ENST00000225308;ENST00000590194;ENST00000537904;ENST00000586016;ENST00000588049;ENST00000592857;ENST00000588767;ENST00000585523;ENST00000586633;ENST00000585636;ENST00000593166;ENST00000591006;ENST00000588315;ENST00000585695;ENST00000592372;ENST00000591151" "ENSP00000366299;ENSP00000225308;ENSP00000467681;ENSP00000444540;ENSP00000466676;ENSP00000465182;ENSP00000467956;ENSP00000466615;ENSP00000466144;ENSP00000465594;ENSP00000465554" "Q9BZJ4" "SLC25A39" "51629" "solute carrier family 25 member 39" "" "" "" +"ENSG00000075303" "ENST00000341119;ENST00000429674;ENST00000444363;ENST00000446236;ENST00000470328;ENST00000483810;ENST00000491499;ENST00000496348" "ENSP00000344831;ENSP00000401473;ENSP00000405566;ENSP00000407780" "Q8TBP6" "SLC25A40" "55972" "solute carrier family 25 member 40" "MCFP" "" "" diff --git a/model/metabolites.tsv b/model/metabolites.tsv index b7d4e67f..6e52173c 100644 --- a/model/metabolites.tsv +++ b/model/metabolites.tsv @@ -1464,7 +1464,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM00923c" "MAM00923" "cala" "C02642" "HMDB0000026" "CHEBI:18261" "111" "" "" "HC00975" "cala" "MNXM802" "m00923c" "m00923c" "MAM00924c" "MAM00924" "42A3HP24DB" "C05645" "" "" "440741" "" "" "HC01547" "42A3HP24DB" "MNXM163203;MNXM4997" "m00924c" "m00924c" "MAM00925c" "MAM00925" "" "" "" "" "10948689" "" "CE3086" "" "CE3086" "MNXM166294" "m00925c" "m00925c" -"MAM00926c" "MAM00926" "4aphdob" "C01252" "HMDB0000978" "CHEBI:17442" "472" "" "" "" "4aphdob" "MNXM163204" "m00926c" "m00926c" "MAM00927c" "MAM00927" "" "C19602" "" "" "" "" "" "" "M00927" "MNXM14691" "m00927c" "m00927c" "MAM00928c" "MAM00928" "" "C19605" "" "" "" "" "" "" "M00928" "MNXM14692" "m00928c" "m00928c" "MAM00929c" "MAM00929" "" "C19574" "" "" "" "" "" "" "M00929" "MNXM4356" "m00929c" "m00929c" @@ -2855,7 +2854,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM01700l" "MAM01700" "dhf" "C00415" "" "CHEBI:15633" "98792" "" "" "HC00340" "dhf" "MNXM281" "m01700l" "m01700l" "MAM01700m" "MAM01700" "dhf" "C00415" "" "CHEBI:15633" "98792" "" "" "HC00340" "dhf" "MNXM281" "m01700m" "m01700m" "MAM01700e" "MAM01700" "dhf" "C00415" "" "CHEBI:15633" "98792" "" "" "HC00340" "dhf" "MNXM281" "m01700s" "m01700s" -"MAM01701c" "MAM01701" "dhlam" "C00579" "HMDB0000985" "CHEBI:17694" "663" "" "" "HC00437" "dhlam" "MNXM1277" "m01701c" "m01701c" "MAM01701m" "MAM01701" "dhlam" "C00579" "HMDB0000985" "CHEBI:17694" "663" "" "" "HC00437" "dhlam" "MNXM1277" "m01701m" "m01701m" "MAM01702c" "MAM01702" "" "C02147" "HMDB0012210" "CHEBI:18047" "421" "LMFA01130003" "" "" "C02147" "MNXM3585" "m01702c" "m01702c" "MAM01704c" "MAM01704" "" "C04874" "" "CHEBI:17001" "65074" "" "" "HC01361" "HC01361" "MNXM993" "m01704c" "m01704c" @@ -3118,6 +3116,7 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM01827l" "MAM01827" "" "C00393" "" "" "" "PROTEIN" "" "HC01852" "HC01852" "MNXM5157" "m01827l" "m01827l" "MAM01827e" "MAM01827" "" "C00393" "" "" "" "PROTEIN" "" "HC01852" "HC01852" "MNXM5157" "m01827s" "m01827s" "MAM01828c" "MAM01828" "fmn" "C00061" "HMDB0001520" "CHEBI:17621" "643976" "" "" "HC00064" "fmn" "MNXM119" "m01828c" "m01828c" +"MAM01828x" "MAM01828" "fmn" "C00061" "HMDB0001520" "CHEBI:17621" "643976" "" "" "" "" "MNXM119" "" "" "MAM01829g" "MAM01829" "fn2m2masn" "G00016" "" "CHEBI:32984" "" "" "" "" "fn2m2masn" "MNXM12419" "m01829g" "m01829g" "MAM01830c" "MAM01830" "fol" "C00504" "HMDB0000121" "CHEBI:27470" "6037" "" "" "HC00396" "fol" "MNXM617" "m01830c" "m01830c" "MAM01830m" "MAM01830" "fol" "C00504" "HMDB0000121" "CHEBI:27470" "6037" "" "" "HC00396" "fol" "MNXM617" "m01830m" "m01830m" @@ -3652,8 +3651,10 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM02119l" "MAM02119" "6thf" "" "" "" "169691" "" "" "" "6thf" "MNXM3616" "m02119l" "m02119l" "MAM02119m" "MAM02119" "6thf" "" "" "" "169691" "" "" "" "6thf" "MNXM3616" "m02119m" "m02119m" "MAM02119e" "MAM02119" "6thf" "" "" "" "169691" "" "" "" "6thf" "MNXM3616" "m02119s" "m02119s" -"MAM02120c" "MAM02120" "" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" "m02120c" "m02120c" -"MAM02120e" "MAM02120" "" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" "m02120s" "m02120s" +"MAM02120c" "MAM02120" "hxa" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" "m02120c" "m02120c" +"MAM02120e" "MAM02120" "hxa" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" "m02120s" "m02120s" +"MAM02120x" "MAM02120" "hxa" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" +"MAM02120m" "MAM02120" "hxa" "C01585" "HMDB0000535" "CHEBI:17120;CHEBI:30776" "" "LMFA01010006" "" "" "caproic" "MNXM1653" "MAM02121c" "MAM02121" "" "C05749" "" "" "" "" "" "HC01592" "HC01592" "MNXM23683" "m02121c" "m02121c" "MAM02122c" "MAM02122" "" "C05270" "HMDB0002845" "CHEBI:27540" "440611" "LMFA07050001" "" "HC01409" "hxcoa" "MNXM162502;MNXM553" "m02122c" "m02122c" "MAM02122m" "MAM02122" "" "C05270" "HMDB0002845" "CHEBI:27540" "440611" "LMFA07050001" "" "HC01409" "hxcoa" "MNXM162502;MNXM553" "m02122m" "m02122m" @@ -4080,8 +4081,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM02396n" "MAM02396" "" "C06315" "HMDB0005082" "CHEBI:6499" "5280915" "LMFA03040002" "" "" "C06315" "MNXM12130" "m02396n" "m02396n" "MAM02396x" "MAM02396" "" "C06315" "HMDB0005082" "CHEBI:6499" "5280915" "LMFA03040002" "" "" "C06315" "MNXM12130" "m02396p" "m02396p" "MAM02396r" "MAM02396" "" "C06315" "HMDB0005082" "CHEBI:6499" "5280915" "LMFA03040002" "" "" "C06315" "MNXM12130" "m02396r" "m02396r" -"MAM02397c" "MAM02397" "" "C16239" "" "" "" "" "" "" "M02397" "MNXM19093" "m02397c" "m02397c" -"MAM02398c" "MAM02398" "" "C16238" "" "" "23724672" "" "CE5656" "" "CE5656" "MNXM2392" "m02398c" "m02398c" "MAM02399c" "MAM02399" "" "" "" "" "53481572" "" "CE2102" "" "CE2102" "MNXM60228" "m02399c" "m02399c" "MAM02401c" "MAM02401" "" "C03127" "" "CHEBI:29160" "" "" "" "" "M02401" "MNXM89832" "m02401c" "m02401c" "MAM02402c" "MAM02402" "" "C03990" "HMDB0000761" "CHEBI:16325" "11740284" "LMST04010003" "" "HC02191" "HC02191" "MNXM886" "m02402c" "m02402c" @@ -6652,7 +6651,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM03814c" "MAM03814" "pchollinl_hs" "" "" "CHEBI:28733" "" "" "" "" "pchollinl_hs" "" "" "pchollinl_hs_c" "MAM03856c" "MAM03856" "pelinl_hs" "" "" "CHEBI:83058" "" "" "" "" "pelinl_hs" "" "" "pelinl_hs_c" "MAM03569c" "MAM03569" "eidi1114ac" "C16525" "HMDB0005060" "CHEBI:603631" "6439848" "" "" "" "eidi1114ac" "" "" "eidi1114ac_c" -"MAM03684c" "MAM03684" "hxa" "" "" "CHEBI:17120" "" "" "" "" "hxa" "MNXM1653" "" "hxa_c" "MAM03976c" "MAM03976" "tetdeca511ac" "" "" "" "" "" "" "" "tetdeca511ac" "" "" "tetdeca511ac_c" "MAM03619c" "MAM03619" "glyc2p" "" "" "CHEBI:58083" "" "" "" "" "glyc2p" "MNXM2527" "" "glyc2p_c" "MAM03401c" "MAM03401" "aclys" "" "" "" "" "" "" "" "aclys" "" "" "aclys_c" @@ -6795,8 +6793,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM03619e" "MAM03619" "glyc2p" "" "" "" "" "" "" "" "glyc2p" "MNXM2527" "" "glyc2p_s" "MAM01998e" "MAM01998" "glyclt" "C00160" "HMDB0000115" "CHEBI:17497" "757" "" "" "" "glyclt" "MNXM222" "" "m01998s" "MAM03232e" "MAM03232" "3hpppn" "" "" "" "" "" "" "" "3hpppn" "MNXM1634" "" "3hpppn_s" -"MAM03684m" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_m" -"MAM03684x" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_p" "MAM02169e" "MAM02169" "ind3ac" "C00954" "HMDB0000197" "CHEBI:16411" "802" "" "" "" "ind3ac" "MNXM383" "" "m02169s" "MAM02350e" "MAM02350" "Lcyst" "C00506" "HMDB0002757" "CHEBI:21260" "25701" "" "" "" "Lcyst" "MNXM713" "" "m02350s" "MAM02413c" "MAM02413" "Lpipecol" "C00408" "HMDB0000716" "CHEBI:30913" "439227" "" "" "" "Lpipecol" "MNXM684" "" "m02413c" @@ -7330,7 +7326,6 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM04078c" "MAM04078" "" "" "" "" "" "" "" "" "xolest204_hs" "" "" "xolest204_hs_c" "MAM04080c" "MAM04080" "xolest226_hs" "" "" "" "" "" "" "" "xolest226_hs" "" "" "xolest226_hs_c" "MAM02908e" "MAM02908" "sphmyln_hs" "C00550" "" "CHEBI:17636" "" "LMSP03010000" "" "HC02007" "sphmyln_hs" "MNXM5930" "" "m02908s" -"MAM03684e" "MAM03684" "hxa" "" "" "" "" "" "" "" "hxa" "MNXM1653" "" "hxa_s" "MAM01954c" "MAM01954" "gncore1" "" "" "" "" "" "" "" "gncore1" "MNXM18091" "" "m01954c" "MAM01954e" "MAM01954" "gncore1" "" "" "" "" "" "" "" "gncore1" "MNXM18091" "" "m01954s" "MAM03394c" "MAM03394" "Lhcystin" "" "" "" "" "" "" "" "Lhcystin" "" "" "Lhcystin_c" @@ -8331,13 +8326,14 @@ mets metsNoComp metBiGGID metKEGGID metHMDBID metChEBIID metPubChemID metLipidMa "MAM20016n" "MAM20016" "" "" "" "CHEBI:57400" "" "" "" "" "" "MNXM1619" "" "" "MAM20017n" "MAM20017" "" "" "" "CHEBI:57402" "" "" "" "" "" "MNXM733372" "" "" "MAM20018r" "MAM20018" "" "" "" "CHEBI:132024" "" "" "" "" "" "MNXM163133" "" "" -"MAM20019r" "MAM20019" "" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "" -"MAM20020r" "MAM20020" "" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "" +"MAM20019r" "MAM20019" "C01847" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "" +"MAM01828r" "MAM01828" "C00061" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "MAM20020r" "MAM20021i" "MAM20021" "" "" "" "CHEBI:132024" "" "" "" "" "" "MNXM163133" "" "" "MAM02040i" "MAM02040" "" "" "" "CHEBI:15377" "" "" "" "" "" "WATER" "" "" "MAM02630i" "MAM02630" "" "" "" "CHEBI:15379" "" "" "" "" "" "MNXM735438" "" "" -"MAM20022i" "MAM20022" "" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "" -"MAM20023i" "MAM20023" "" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "" +"MAM20019c" "MAM20019" "C01847" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "" +"MAM20019i" "MAM20019" "C01847" "" "" "CHEBI:57618" "" "" "" "" "" "MNXM1107623" "" "MAM20022i" +"MAM01828i" "MAM01828" "C00061" "" "" "CHEBI:58210" "" "" "" "" "" "MNXM1105928" "" "MAM20023i" "MAM02457i" "MAM02457" "" "" "" "CHEBI:78043" "" "" "" "" "" "MNXM735122" "" "" "MAM20024r" "MAM20024" "" "" "" "CHEBI:76636" "" "" "" "" "" "MNXM146872" "" "" "MAM01784i" "MAM01784" "" "" "" "CHEBI:58562" "" "" "" "" "" "MNXM727959" "" "" diff --git a/model/reactions.tsv b/model/reactions.tsv index c79c8937..7c808f4e 100644 --- a/model/reactions.tsv +++ b/model/reactions.tsv @@ -709,18 +709,17 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR08783" "R02150" "HISTASE" "" "" "" "HISTASE" "MNXR95850" "HMR_8783" "RCR11329" "" 0 "" "RHEA:25625" "HMR_8783" "MAR08784" "R04065" "IMACTD" "" "" "" "IMACTD" "MNXR95745" "HMR_8784" "RCR11330" "" 0 "RHEA:31060" "RHEA:31059" "HMR_8784" "MAR08786" "R04065" "IMACTD_m" "" "" "" "IMACTD_m" "MNXR95745" "HMR_8786" "RCR11331" "" 0 "RHEA:31060" "RHEA:31059" "HMR_8786" -"MAR04239" "R01933" "2OXOADOXm" "R01933M" "r0448" "" "2OXOADOXm" "MNXR94818" "HMR_4239" "RCR11332" "" 0 "RHEA:30796" "RHEA:30795" "HMR_4239" "MAR04241" "R03938" "" "" "" "" "HMR_4241" "MNXR108541" "HMR_4241" "RCR14332" "" 0 "" "RHEA:10024" "HMR_4241" "MAR04288" "R00716" "SACCD3m" "R00716M" "r0180" "" "SACCD3m" "MNXR104238" "HMR_4288" "RCR11333" "" 0 "" "RHEA:19373" "HMR_4288" "MAR04596" "R01939" "" "R01939C" "r0450" "" "AATAi" "MNXR95160" "HMR_4596" "RCR10526" "" 0 "" "RHEA:12601" "HMR_4596" "MAR04597" "R01939" "" "R01939M" "r0450" "" "r0450" "MNXR95160" "HMR_4597" "RCR11334" "" 0 "" "RHEA:12601" "HMR_4597" -"MAR04599" "R01940" "" "R01940M" "r0451" "" "r0451" "MNXR102246;MNXR107241" "HMR_4599" "RCR10318" "" 0 "" "RHEA:12188" "HMR_4599" +"MAR04599" "R01940" "2OXOADOXm" "R01940M;R01933M" "r0451;r0448" "" "r0451;2OXOADOXm" "MNXR102246;MNXR107241" "HMR_4599;HMR_4239" "RCR10318;RCR11332" "" 0 "RHEA:12189" "RHEA:12188" "HMR_4599;MAR04239;HMR_4239" "MAR04667" "R02313" "r0525" "R02313C" "r0525" "" "r0525" "MNXR105347" "HMR_4667" "RCR11335" "" 0 "" "RHEA:24520" "HMR_4667" "MAR04668" "R02315" "SACCD4m" "" "r0526" "" "SACCD4m" "MNXR104236" "HMR_4668" "RCR11336" "" 0 "" "RHEA:10020" "HMR_4668" "MAR04737" "R03102" "" "R03102M" "r0594" "" "r0594" "MNXR95158" "HMR_4737" "RCR10319" "" 0 "" "RHEA:12308" "HMR_4737" "MAR04739" "R03102" "AASAD3m" "R03102M" "" "" "AASAD3m" "MNXR95158" "HMR_4739" "RCR10527" "" 0 "" "RHEA:12308" "HMR_4739" "MAR04740" "R02317" "" "RE1254C" "" "" "RE1254C" "MNXR95152" "HMR_4740" "RCR11337" "" 1 "" "RHEA:25121" "HMR_4740" -"MAR06415" "R02571" "" "R02571C" "r0557" "" "r0557" "MNXR100213;MNXR107586" "HMR_6415" "RCR14333" "" 0 "" "" "HMR_6415" +"MAR06415" "R02571" "2OXOADOXm" "R02571C;R01933M" "r0557;r0448" "" "r0557;2OXOADOXm" "MNXR100213;MNXR107586" "HMR_6415;HMR_4239" "RCR14333;RCR11332" "" 0 "" "" "HMR_6415;MAR04239;HMR_4239" "MAR06974" "" "" "" "r1386" "" "" "" "HMR_6974" "RCR10159" "" 0 "" "" "HMR_6974" "MAR06975" "R03875" "" "" "" "" "HMR_6975" "MNXR108494" "HMR_6975" "RCR11338" "" 0 "" "RHEA:51736" "HMR_6975" "MAR06976" "R04866" "" "" "" "" "HMR_6976" "MNXR109175" "HMR_6976" "RCR11339" "" 0 "" "RHEA:54196" "HMR_6976" @@ -748,8 +747,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR08091" "" "3HXKYNDCL" "" "" "" "3HXKYNDCL" "MNXR94906" "HMR_8091" "RCR11354" "" 0 "" "" "HMR_8091" "MAR08092" "R04907" "3HXKYNOXDA" "" "" "" "3HXKYNOXDA" "MNXR94907" "HMR_8092" "RCR11355" "" 0 "" "" "HMR_8092" "MAR08563" "R02678" "ALDD20xm" "" "" "" "ALDD20xm" "MNXR95744" "HMR_8563" "RCR10320" "" 0 "" "RHEA:30867" "HMR_8563" -"MAR08564" "" "KYNAKGAT" "" "" "" "KYNAKGAT" "MNXR100948" "HMR_8564" "RCR11356" "" 0 "" "" "HMR_8564" -"MAR08565" "R03445" "KYNATESYN" "" "" "" "KYNATESYN" "MNXR100949" "HMR_8565" "RCR11357" "" 0 "" "RHEA:42452" "HMR_8565" "MAR08566" "" "MELATNOX" "" "" "" "MELATNOX" "MNXR101458" "HMR_8566" "RCR11358" "" 0 "" "" "HMR_8566" "MAR03935" "R06982" "r1377" "" "r1377" "" "r1377" "MNXR105462;MNXR99239" "HMR_3935" "RCR11359" "" 0 "" "RHEA:22488" "HMR_3935" "MAR04681" "R00699" "" "" "" "" "PHYCBOXL" "MNXR102650" "HMR_4681" "RCR10321" "" 0 "" "RHEA:19717" "HMR_4681" @@ -803,13 +800,12 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR08088" "R04188" "3AIBTm" "" "" "" "3AIBTm" "MNXR108721;MNXR94851" "HMR_8088" "RCR11385" "" 0 "" "RHEA:13993" "HMR_8088" "MAR08787" "R00923" "MMCDm" "" "" "" "MMCDm" "MNXR101656" "HMR_8787" "RCR11386" "" 0 "" "RHEA:21396" "HMR_8787" "MAR03743" "" "" "RE2117M" "" "" "RE2117M" "MNXR103611" "HMR_3743" "RCR11387" "" 0 "" "" "HMR_3743" -"MAR03940" "R01795" "PHETHPTOX" "R01795C" "r0399" "" "r0399" "MNXR102632;MNXR107174" "HMR_3940" "RCR11388" "" 0 "" "RHEA:30787" "HMR_3940" "MAR04214" "R00678" "TRPO2" "R00678C" "r0169" "" "TRPO2" "MNXR104944" "HMR_4214" "RCR11389" "" 0 "" "RHEA:24536" "HMR_4214" "MAR04216" "R01958" "FKYNH" "R01958C" "r0454" "" "FKYNH" "MNXR99596" "HMR_4216" "RCR11390" "" 0 "" "" "HMR_4216" "MAR04218" "R03936" "LFORKYNHYD" "R03936C" "r0646" "" "LFORKYNHYD" "MNXR101060;MNXR108539" "HMR_4218" "RCR11391" "" 0 "" "" "HMR_4218" "MAR04219" "R00988" "" "R00988C" "r0239" "" "r0239" "MNXR105316;MNXR106774" "HMR_4219" "RCR11392" "" 0 "" "" "HMR_4219" "MAR04220" "R01960" "KYN3OX" "R01960C" "r0455" "" "KYN3OX" "MNXR100947" "HMR_4220" "RCR11393" "" 0 "RHEA:20548" "RHEA:20545" "HMR_4220" -"MAR04222" "" "" "RE1233C" "" "" "RE1233C" "" "HMR_4222" "RCR11394" "" 0 "" "" "HMR_4222" +"MAR04222" "" "" "RE1233C" "" "" "RE1233C" "" "HMR_4222" "RCR11394" "" 0 "RHEA:65561" "RHEA:65560" "HMR_4222;MAR08564+MAR08565" "MAR04224" "R00987" "KYN" "R00987C" "r0238" "" "KYN" "MNXR100946" "HMR_4224" "RCR11395" "" 0 "" "RHEA:16813" "HMR_4224" "MAR04225" "R02668" "HKYNH" "R02668C" "r0563" "" "HKYNH" "MNXR100656" "HMR_4225" "RCR10534" "" 0 "" "RHEA:25143" "HMR_4225" "MAR04227" "R02670" "" "" "" "" "HMR_4227" "MNXR107655" "HMR_4227" "RCR14355" "" 0 "" "" "HMR_4227" @@ -956,7 +952,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR06889" "" "" "RE3201C" "" "" "RE3201C" "MNXR103829" "HMR_6889" "RCR11479" "" 0 "" "" "HMR_6889" "MAR07628" "R00690" "" "" "" "" "HMR_7628" "MNXR106645" "HMR_7628" "RCR11480" "" 0 "" "RHEA:10712" "HMR_7628" "MAR07756" "R02540" "" "" "" "" "HMR_7756" "MNXR95813" "HMR_7756" "RCR11481" "" 0 "" "RHEA:64820" "HMR_7756" -"MAR08539" "R07211" "PHETHPTOX2" "" "" "" "PHETHPTOX2" "MNXR102633" "HMR_8539" "RCR11482" "" 0 "" "RHEA:20273" "HMR_8539" +"MAR08539" "R07211" "PHETHPTOX2" "" "" "" "PHETHPTOX2" "MNXR102633" "HMR_8539" "RCR11482" "" 0 "" "RHEA:20273" "HMR_8539;MAR03940" "MAR08794" "R02539" "PACCOAL" "" "" "" "PACCOAL" "MNXR102315" "HMR_8794" "RCR11483" "" 0 "" "RHEA:20956" "HMR_8794" "MAR08795" "R02576" "PHACCOAGLNAC" "" "" "" "PHACCOAGLNAC" "MNXR102611" "HMR_8795" "RCR11484" "" 0 "" "RHEA:21844" "HMR_8795" "MAR08796" "R05841" "" "" "" "" "HMR_8796" "MNXR102612" "HMR_8796" "RCR11485" "" 0 "RHEA:27851" "RHEA:27850" "HMR_8796" @@ -1018,7 +1014,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04708" "R02743" "" "R02743C" "r0568" "" "r0568" "MNXR105350" "HMR_4708" "RCR14413" "" 0 "" "" "HMR_4708" "MAR08769" "" "GTMLTe" "" "" "" "GTMLTe" "MNXR100452" "HMR_8769" "RCR40314" "" 0 "" "" "HMR_8769" "MAR08770" "" "GGLUCT" "" "" "" "GGLUCT" "MNXR100126" "HMR_8770" "RCR40168" "" 0 "" "" "HMR_8770" -"MAR08771" "" "GTHRDt" "" "" "" "GTHRDt" "MNXR100447" "HMR_8771" "RCR20224" "" 0 "RHEA:29792" "RHEA:29791" "HMR_8771" +"MAR08771" "" "GTHRDt" "" "r0885;r2520" "" "GTHRDt;r0885;r2520" "MNXR100447;MNXR105402;MNXR106328" "HMR_8771;HMR_4940;HMR_6391" "RCR20224;RCR20265;RCR20063" "2.A.29.2.7" 0 "RHEA:74821" "RHEA:74819" "HMR_8771;MAR04940;HMR_4940;MAR06391;HMR_6391" "MAR04078" "R09076" "" "" "" "" "HMR_4078" "" "HMR_4078" "RCR10551" "" 0 "" "RHEA:25804" "HMR_4078" "MAR04079" "" "" "" "" "" "HMR_4079" "" "HMR_4079" "RCR11506" "" 0 "" "" "HMR_4079" "MAR04174" "R00489" "ASP1DC" "R00489C" "r0128" "" "ASP1DC" "MNXR96077" "HMR_4174" "RCR10095" "" 0 "" "RHEA:19497" "HMR_4174" @@ -1334,7 +1330,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04589" "R01900" "" "R01900C" "r0426" "" "r0426" "MNXR105342;MNXR95387" "HMR_4589" "RCR10352" "" 0 "" "RHEA:22144" "HMR_4589" "MAR04652" "R00408;R02164" "r0509;SUCD1m" "R02164C" "r0509" "" "r0509;SUCD1m" "MNXR107340;MNXR99636" "HMR_4652;HMR_8743" "RCR14481;RCR11674" "" 0 "" "RHEA:13713;RHEA:30343" "HMR_4652;HMR_8743;MAR08743" "MAR06413" "R03316" "" "R03316M" "r0620" "" "r0620" "MNXR105357;MNXR108089" "HMR_6413" "RCR11672" "" 0 "" "" "HMR_6413" -"MAR06414" "R02570" "" "R02570C" "r0556" "" "r0556" "MNXR107585;MNXR95656" "HMR_6414" "RCR14482" "" 0 "" "RHEA:15213" "HMR_6414" +"MAR06414" "R02570" "" "R02570C" "r0556" "" "r0556" "MNXR107585;MNXR95656" "HMR_6414" "RCR14482" "" 0 "RHEA:15216" "RHEA:15213" "HMR_6414" "MAR07704" "R00466" "GLXO2p" "" "" "" "GLXO2p" "MNXR100305" "HMR_7704" "RCR10605" "" 0 "" "RHEA:14837" "HMR_7704" "MAR07706" "R00475" "GLYCTO1p" "" "" "" "GLYCTO1p" "MNXR100338" "HMR_7706" "RCR11673" "" 0 "" "RHEA:25311" "HMR_7706" "MAR08772" "" "KHK2" "" "" "" "KHK2" "MNXR100937" "HMR_8772" "RCR11675" "" 0 "" "" "HMR_8772" @@ -1667,12 +1663,8 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR02469" "" "" "RE3264C" "" "" "RE3264C" "" "HMR_2469" "RCR11942" "" 0 "" "" "HMR_2469" "MAR02470" "" "" "RE3264R" "" "" "RE3264R" "MNXR103858" "HMR_2470" "RCR11943" "" 0 "" "" "HMR_2470" "MAR06397" "" "" "RE2882C" "" "" "HMR_6397" "" "HMR_6397" "RCR10619" "" 0 "" "" "HMR_6397" -"MAR06398" "R07770" "" "R07770C" "" "" "RE1944C" "MNXR101081" "HMR_6398" "RCR14489" "" 0 "" "RHEA:12913" "HMR_6398" -"MAR06399" "R07771" "" "R07771C" "" "" "HMR_6399" "MNXR111358" "HMR_6399" "RCR14490" "" 0 "" "RHEA:20473" "HMR_6399" -"MAR06400" "R07768" "" "R07768C" "" "" "HMR_6400" "MNXR111356" "HMR_6400" "RCR11944" "" 0 "" "" "HMR_6400" -"MAR06401" "R07769" "" "R07769C" "" "" "HMR_6401" "MNXR111357" "HMR_6401" "RCR11945" "" 0 "" "" "HMR_6401" -"MAR06402" "R07766" "" "R07766C" "" "" "HMR_6402" "MNXR111354" "HMR_6402" "RCR11946" "" 0 "" "RHEA:17665" "HMR_6402" -"MAR06403" "R07767" "" "R07767C" "" "" "HMR_6403" "MNXR111355" "HMR_6403" "RCR11947" "" 0 "" "RHEA:16585" "HMR_6403" +"MAR06402" "R07766;R07769" "" "R07766C;R07769C" "" "" "HMR_6402;HMR_6401" "MNXR111354" "HMR_6402;HMR_6401" "RCR11946;RCR11945" "" 0 "RHEA:17666" "RHEA:17665" "HMR_6402;HMR_6401;MAR06401" +"MAR06403" "R07767;R07768" "" "R07767C;R07768C" "" "" "HMR_6403;HMR_6400" "MNXR111355" "HMR_6403;HMR_6400" "RCR11947;RCR11948" "" 0 "RHEA:16586" "RHEA:16585" "HMR_6403;HMR_6400;MAR06400" "MAR06404" "R08550" "" "R08550C" "" "" "HMR_6404" "MNXR112089" "HMR_6404" "RCR14491" "" 0 "" "" "HMR_6404" "MAR02472" "" "HMR_2472" "RE3109C" "" "" "HMR_2472" "" "HMR_2472" "RCR11948" "" 0 "" "" "HMR_2472" "MAR02475" "" "RE3110C" "RE3110C" "" "" "RE3110C" "MNXR103792" "HMR_2475" "RCR11949" "" 0 "" "" "HMR_2475" @@ -3424,10 +3416,8 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR00448" "R00847" "GLYKm" "R00847C" "r0204" "" "GLYKm" "MNXR100348" "HMR_0448" "RCR13153" "" 0 "" "RHEA:21644" "HMR_0448" "MAR00450" "R00847" "GLYK" "R00847C" "r0203" "" "GLYK" "MNXR100348" "HMR_0450" "RCR10853" "" 0 "" "RHEA:21644" "HMR_0450" "MAR00468" "" "CEPTC" "" "r1288" "" "HMR_0468" "MNXR96592" "HMR_0468" "RCR13154" "" 0 "" "" "HMR_0468" -"MAR00478" "R00844" "" "" "" "R-HSA-75889" "HMR_0478" "MNXR99876" "HMR_0478" "RCR14575" "" 0 "RHEA:11098" "RHEA:11096" "HMR_0478" -"MAR00479" "R00842" "G3PD1" "R00842C" "r0201" "" "G3PD1" "MNXR99876" "HMR_0479" "RCR14576" "" 0 "" "RHEA:11092" "HMR_0479" +"MAR00479" "R00842;R00844" "G3PD1" "R00842C" "r0201" "R-HSA-75889" "G3PD1;HMR_0478" "MNXR99876" "HMR_0479;HMR_0478" "RCR14576;RCR14575" "" 0 "" "RHEA:11092" "HMR_0479;HMR_0478;MAR00478" "MAR00481" "R00842" "" "R00842C" "r0202" "" "r0202" "MNXR99876" "HMR_0481" "RCR14577" "" 0 "" "RHEA:11092" "HMR_0481" -"MAR00482" "R00848;R00849" "G3PD2m" "R00848C" "r0205" "" "HMR_0482;r0205" "MNXR99875;MNXR106713" "HMR_0482;HMR_0483" "RCR14578;RCR21050" "" 0 "" "RHEA:31283;RHEA:18977" "HMR_0482;HMR_0483" "MAR00484" "R00855" "" "" "" "" "HMR_0484" "MNXR106718" "HMR_0484" "RCR14579" "" 0 "" "RHEA:21692" "HMR_0484" "MAR00579" "R00851" "" "" "r1307" "" "HMR_0579" "" "HMR_0579" "RCR13155" "" 0 "" "RHEA:15325" "HMR_0579" "MAR00580" "R02241" "" "" "r1308" "" "HMR_0580" "" "HMR_0580" "RCR13156" "" 0 "" "RHEA:19709" "HMR_0580" @@ -4066,7 +4056,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR01702" "" "" "" "r1012" "" "" "MNXR105423" "HMR_1702" "RCR20518" "" 0 "" "" "HMR_1702" "MAR01703" "R08739" "" "" "" "R-HSA-193452" "HMR_1703" "MNXR124748" "HMR_1703" "RCR13627" "" 0 "" "" "HMR_1703" "MAR01704" "" "" "" "" "R-HSA-193369" "HMR_1704" "MNXR124227" "HMR_1704" "RCR13628" "" 0 "" "" "HMR_1704" -"MAR01706" "R04809" "" "" "" "R-HSA-193535" "HMR_1706" "MNXR123029" "HMR_1706" "RCR13629" "" 0 "" "" "HMR_1706" +"MAR01706" "R04809" "" "" "" "R-HSA-193535" "HMR_1706" "MNXR123029" "HMR_1706" "RCR13629" "" 0 "RHEA:47409" "RHEA:47408" "HMR_1706" "MAR01708" "R04810" "" "" "r1021" "R-HSA-193508" "HMR_1708" "MNXR124228" "HMR_1708" "RCR13630" "" 0 "" "" "HMR_1708" "MAR01710" "R04811" "" "" "" "R-HSA-193533" "HMR_1710" "MNXR109135" "HMR_1710" "RCR13631" "" 0 "" "" "HMR_1710" "MAR01716" "R03974" "" "RE1835X" "" "" "RE1835X" "MNXR103559" "HMR_1716" "RCR14626" "" 0 "" "RHEA:31511" "HMR_1716" @@ -4451,7 +4441,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04654" "R02235" "" "R02235C" "r0512" "" "r0512" "MNXR97399" "HMR_4654" "RCR13812" "" 0 "" "" "HMR_4654" "MAR04655" "R02236" "FOLR2" "R02236C" "r0513" "" "FOLR2" "MNXR97400" "HMR_4655" "RCR13813" "" 0 "" "RHEA:31103" "HMR_4655" "MAR04656" "R02236" "" "R02236C" "r0514" "" "r0514" "MNXR97400" "HMR_4656" "RCR13814" "" 0 "" "RHEA:31103" "HMR_4656" -"MAR04665" "R02300" "" "R02300G" "r0522" "" "r0522" "MNXR99614" "HMR_4665" "RCR13815" "" 0 "" "" "HMR_4665" +"MAR04665" "R02300" "" "R02300G" "r0522" "" "r0522" "MNXR99614" "HMR_4665" "RCR13815" "" 0 "RHEA:34768" "RHEA:34767" "HMR_4665" "MAR09726" "R03189" "" "" "" "" "HMR_9726" "MNXR100282" "HMR_9726" "RCR13816" "" 0 "" "RHEA:23240" "HMR_9726" "MAR04666" "R02301" "" "R02301C" "r0523" "" "r0523" "MNXR99668" "HMR_4666" "RCR13817" "" 0 "" "RHEA:10488" "HMR_4666" "MAR07145" "R09394" "" "" "" "" "HMR_7145" "MNXR112822" "HMR_7145" "RCR10270" "" 0 "" "RHEA:49576" "HMR_7145" @@ -4527,7 +4517,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04834" "R05046" "" "R05046C" "r0776" "" "r0776" "MNXR105382" "HMR_4834" "RCR14690" "" 0 "" "" "HMR_4834" "MAR04835" "R05048" "" "R05048C" "r0777" "" "r0777" "MNXR105383" "HMR_4835" "RCR13860" "" 0 "" "" "HMR_4835" "MAR04836" "R05048" "" "R05048C" "r0778" "" "r0778" "MNXR105383" "HMR_4836" "RCR13861" "" 0 "" "" "HMR_4836" -"MAR08538" "R04734" "THBPT4ACAMDASE" "" "" "" "THBPT4ACAMDASE" "MNXR104802" "HMR_8538" "RCR10142" "" 0 "" "RHEA:11920" "HMR_8538" +"MAR08538" "R04734" "THBPT4ACAMDASE" "" "" "" "THBPT4ACAMDASE" "MNXR104802" "HMR_8538" "RCR10142" "" 0 "" "RHEA:11920" "HMR_8538;MAR03940" "MAR08738" "R04286" "PTHPSn" "" "" "" "PTHPSn" "MNXR103331" "HMR_8738" "RCR14691" "" 0 "" "RHEA:22048" "HMR_8738" "MAR08739" "R08208" "SPRn" "" "" "" "SPRn" "MNXR104500" "HMR_8739" "RCR14692" "" 0 "" "RHEA:32627" "HMR_8739" "MAR08740" "" "DIGALSGALSIDEtg" "" "" "" "DHPR2" "MNXR97459" "HMR_8740" "RCR13862" "" 0 "" "" "HMR_8740" @@ -4583,7 +4573,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR06643" "" "" "RE2656C" "" "" "RETI2" "" "HMR_6643" "RCR10986" "" 0 "" "" "HMR_6643" "MAR06644" "R08382" "" "RE1900C" "" "" "RDH2" "" "HMR_6644" "RCR10987" "" 0 "RHEA:42055" "RHEA:42052" "HMR_6644" "MAR06645" "" "" "RE2657C" "" "" "RETI3" "" "HMR_6645" "RCR13889" "" 0 "" "" "HMR_6645" -"MAR06646" "R02123" "" "" "" "" "RADH" "MNXR103412" "HMR_6646" "RCR10227" "" 0 "RHEA:16178" "RHEA:16177" "HMR_6646" +"MAR06646" "R02123" "" "" "" "" "RADH" "MNXR103412" "HMR_6646" "RCR10227" "" 0 "RHEA:16178" "RHEA:16177" "HMR_6646;MAR20012" "MAR06647" "R02123" "" "" "" "" "HMR_6647" "MNXR103412" "HMR_6647" "RCR14700" "" 0 "RHEA:16178" "RHEA:16177" "HMR_6647" "MAR06648" "" "" "RE1906C" "" "" "HMR_6648" "MNXR103569" "HMR_6648" "RCR13890" "" 0 "" "" "HMR_6648" "MAR06649" "" "" "RE1906R" "" "" "RE1906R" "MNXR103570" "HMR_6649" "RCR13891" "" 0 "" "" "HMR_6649" @@ -4660,7 +4650,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR06510" "R09748" "" "RE3347C" "" "" "RE3347C" "MNXR99215" "HMR_6510" "RCR10228" "" 0 "" "RHEA:30147" "HMR_6510" "MAR06511" "R09520" "" "" "" "" "HMR_6511" "MNXR99216" "HMR_6511" "RCR13933" "" 0 "" "RHEA:30151" "HMR_6511" "MAR04537" "R07213" "" "R01814C" "r0403" "" "TRPHYDRO2" "MNXR107187" "HMR_4537" "RCR13934" "" 0 "" "RHEA:16709" "HMR_4537" -"MAR04545" "R02701" "5HLTDL" "R02701C" "r0564" "" "5HLTDL" "MNXR107676;MNXR95078" "HMR_4545" "RCR10427" "" 0 "RHEA:18534" "RHEA:18533" "HMR_4545" +"MAR04545" "R02701" "5HLTDL" "R02701C" "r0564" "" "5HLTDL" "MNXR107676;MNXR95078" "HMR_4545" "RCR10427" "" 0 "RHEA:18534" "RHEA:18533" "HMR_4545;MAR020089" "MAR04546" "R02911" "" "" "" "" "SRTNACT" "" "HMR_4546" "RCR14717" "" 0 "" "RHEA:25217" "HMR_4546" "MAR04547" "R03130" "" "" "" "" "ACSRTNMT" "" "HMR_4547" "RCR14718" "" 0 "" "RHEA:15573" "HMR_4547" "MAR04548" "R03629" "" "RE2426C" "" "" "" "MNXR103669;MNXR108309" "HMR_4548" "RCR13935" "" 0 "" "" "HMR_4548" @@ -6256,7 +6246,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR06383" "" "HOMt4" "" "r2480" "" "" "MNXR100677" "HMR_6383" "RCR41531" "2.A.18.6.8" 0 "" "" "HMR_6383" "MAR06384" "" "HISt4" "" "r2481" "" "HISSNAT5tc" "MNXR100646" "HMR_6384" "RCR41532" "2.A.18.6.2" 0 "" "" "HMR_6384" "MAR06392" "" "" "" "r2505" "" "r2505" "MNXR106316" "HMR_6392" "RCR41533" "3.A.1.208.8" 0 "" "" "HMR_6392" -"MAR06406" "" "LIPOti" "RT1089" "" "" "" "MNXR101093" "HMR_6406" "RCR41534" "" 0 "" "" "HMR_6406" "MAR06424" "" "AVITE2t" "RT1352" "" "" "AVITE2t" "MNXR96147" "HMR_6424" "RCR40703" "" 0 "" "" "HMR_6424" "MAR06439" "" "" "" "" "" "HMR_6439" "" "HMR_6439" "RCR40704" "" 0 "" "" "HMR_6439" "MAR06462" "" "" "" "" "" "YVITEt" "" "HMR_6462" "RCR40705" "" 0 "" "" "HMR_6462" @@ -6590,7 +6579,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR09605" "" "" "" "" "" "HMR_9605" "" "HMR_9605" "RCR41621" "" 0 "" "" "HMR_9605" "MAR09606" "" "" "" "" "" "GLYSNAT5tc" "" "HMR_9606" "RCR41622" "" 0 "" "" "HMR_9606" "MAR09607" "" "" "" "" "" "HMR_9607" "" "HMR_9607" "RCR41623" "" 0 "" "" "HMR_9607" -"MAR09608" "" "" "" "" "" "HMR_9608" "" "HMR_9608" "RCR41624" "" 0 "" "" "HMR_9608" +"MAR09608" "" "LIPOti" "RT1089" "" "" "HMR_9608;LIPOti" "MNXR101093" "HMR_9608;HMR_6406" "RCR41624;RCR41534" "" 0 "RHEA:73380" "RHEA:73379" "HMR_9608;LIPOti;HMR_6406;MAR01483;MAR06406" "MAR09609" "" "" "" "" "" "HMR_9609" "" "HMR_9609" "RCR41625" "" 0 "" "" "HMR_9609" "MAR09610" "" "" "" "" "" "HMR_9610" "" "HMR_9610" "RCR41626" "" 0 "" "" "HMR_9610" "MAR09611" "" "" "" "" "" "INSTt2r" "" "HMR_9611" "RCR40899" "" 0 "" "" "HMR_9611" @@ -6647,7 +6636,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR08022" "" "2AMADPTm" "" "" "" "2AMADPTm" "MNXR94780" "HMR_8022" "RCR20241" "" 0 "" "" "HMR_8022" "MAR08070" "" "" "" "" "" "SLDtm" "" "HMR_8070" "RCR20536" "" 0 "" "" "HMR_8070" "MAR09015" "" "" "" "" "" "AMETtd" "" "HMR_9015" "RCR20135" "" 0 "" "" "HMR_9015" -"MAR09019" "" "" "" "" "" "HMR_9019" "" "HMR_9019" "RCR20242" "" 0 "" "" "HMR_9019" "MAR09020" "" "" "" "" "" "FADtm" "" "HMR_9020" "RCR20537" "" 0 "" "" "HMR_9020" "MAR00157" "" "" "" "" "" "HMR_0157" "" "HMR_0157" "RCR20164" "" 0 "" "" "HMR_0157" "MAR00158" "" "" "" "r1401" "" "r1401" "MNXR105470" "HMR_0158" "RCR20165" "" 0 "" "" "HMR_0158" @@ -6715,7 +6703,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04754" "" "PPPG9tm" "" "r0976" "" "PPPG9tm" "MNXR103127" "HMR_4754" "RCR20570" "3.A.1.210" 0 "RHEA:27649" "RHEA:27646" "HMR_4754" "MAR04756" "" "HMR_4756" "" "" "" "HMR_4756" "" "HMR_4756" "RCR20262" "" 0 "" "" "HMR_4756" "MAR04760" "" "PHEMEtm" "" "r0880" "" "PHEMEtm" "MNXR102625" "HMR_4760" "RCR20571" "3.A.1.210" 0 "" "" "HMR_4760" -"MAR04843" "" "" "" "r0801" "" "r0801" "MNXR105390" "HMR_4843" "RCR20168" "" 0 "" "" "HMR_4843" "MAR04850" "" "" "" "r0818" "" "r0818" "MNXR97813" "HMR_4850" "RCR20572" "" 0 "" "" "HMR_4850" "MAR04851" "" "" "" "r0819" "" "r0819" "MNXR105393" "HMR_4851" "RCR20573" "2.A.29.2.2" 0 "" "" "HMR_4851" "MAR04852" "" "AKGMALtm" "" "r0820" "" "AKGMALtm" "MNXR95659" "HMR_4852" "RCR20169" "2.A.29.2.2" 0 "" "" "HMR_4852" @@ -6737,7 +6724,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04914" "" "COAtim" "" "r0863" "" "COAtm" "MNXR96815" "HMR_4914" "RCR20001" "" 0 "" "" "HMR_4914" "MAR04922" "" "CO2tm" "" "r0868" "" "CO2tm" "MNXR96810" "HMR_4922" "RCR20011" "" 0 "" "" "HMR_4922" "MAR04926" "" "PYRt2m" "" "r0872" "" "PYRt2m" "MNXR103385" "HMR_4926" "RCR20136" "" 0 "" "" "HMR_4926" -"MAR04940" "" "" "" "r0885" "" "r0885" "MNXR105402" "HMR_4940" "RCR20265" "2.A.29.2.7" 0 "" "" "HMR_4940" "MAR04944" "" "FORtm" "" "r0888" "" "FORt2m" "MNXR99620" "HMR_4944" "RCR20583" "" 0 "RHEA:29682" "RHEA:29679" "HMR_4944" "MAR04951" "" "UREAtm" "" "r0897" "" "UREAtm" "MNXR105156" "HMR_4951" "RCR20266" "" 0 "RHEA:32802" "RHEA:32799" "HMR_4951" "MAR04953" "" "BALAtmr" "" "r0900" "" "BALAtmr" "MNXR95682" "HMR_4953" "RCR20584" "" 0 "" "" "HMR_4953" @@ -6848,8 +6834,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR06342" "" "DNDPt58m" "" "r2431" "" "DNDPt58m" "MNXR97671" "HMR_6342" "RCR20140" "2.A.29.16.1" 0 "" "" "HMR_6342" "MAR06343" "" "DNDPt42m" "" "r2432" "" "DNDPt42m" "MNXR97655" "HMR_6343" "RCR20276" "2.A.29.16.1" 0 "" "" "HMR_6343" "MAR06389" "" "r2472" "" "r2472" "" "r2472" "MNXR100321" "HMR_6389" "RCR20616" "2.A.1.4.7" 0 "" "" "HMR_6389" -"MAR06391" "" "" "" "r2520" "" "r2520" "MNXR106328" "HMR_6391" "RCR20063" "" 0 "" "" "HMR_6391" -"MAR06408" "" "" "RT0295" "" "" "HMR_6408" "" "HMR_6408" "RCR21069" "" 0 "" "" "HMR_6408" "MAR06431" "" "" "" "" "" "HMR_6431" "" "HMR_6431" "RCR20617" "" 0 "" "" "HMR_6431" "MAR06438" "" "" "" "" "" "HMR_6438" "" "HMR_6438" "RCR20618" "" 0 "" "" "HMR_6438" "MAR06446" "" "" "" "" "" "HMR_6446" "" "HMR_6446" "RCR20619" "" 0 "" "" "HMR_6446" @@ -7016,7 +7000,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04890" "" "H2Otp" "" "r0852" "" "H2Otp" "MNXR98641" "HMR_4890" "RCR20016" "" 0 "RHEA:29670" "RHEA:29667" "HMR_4890" "MAR04900" "" "O2tp" "" "r0857" "" "O2tp" "MNXR102090" "HMR_4900" "RCR20059" "" 0 "" "" "HMR_4900" "MAR04908" "R00124" "r0860" "" "r0860" "" "r0860" "MNXR96123" "HMR_4908" "RCR20198" "" 0 "RHEA:35002" "RHEA:34999" "HMR_4908" -"MAR04915" "" "COAtp" "" "r0864" "" "COAtp" "MNXR96815" "HMR_4915" "RCR20004" "" 0 "" "" "HMR_4915" "MAR04924" "" "CO2tp" "" "r0869" "" "CO2tp" "MNXR96810" "HMR_4924" "RCR20149" "" 0 "" "" "HMR_4924" "MAR04930" "" "PYRt2p" "" "r0874" "" "PYRt2p" "MNXR103385" "HMR_4930" "RCR20123" "2.A.1.13.1;2.A.1.13.5" 0 "RHEA:64723" "RHEA:64720" "HMR_4930" "MAR04945" "" "" "RT0324" "" "" "FORMCOAtx" "" "HMR_4945" "RCR20306" "" 0 "" "" "HMR_4945" @@ -7037,15 +7020,8 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR07646" "" "DALAxt" "" "" "" "DALAxt" "MNXR95702" "HMR_7646" "RCR21081" "" 0 "" "" "HMR_7646" "MAR07705" "" "GLYCLTtp" "" "" "" "GLYCLTtp" "MNXR100333" "HMR_7705" "RCR20712" "" 0 "" "" "HMR_7705" "MAR07707" "" "GLXtp" "" "" "" "GLXtp" "MNXR100306" "HMR_7707" "RCR20200" "" 0 "" "" "HMR_7707" -"MAR07771" "" "NADtpu" "" "" "" "NADtx" "MNXR101881" "HMR_7771" "RCR20023" "" 0 "" "" "HMR_7771" -"MAR07775" "" "NADHtpu" "" "" "" "NADHtpu;NADtpu" "MNXR101881" "HMR_7775" "RCR20024" "" 0 "" "" "HMR_7775" "MAR07777" "" "NADPtxu" "" "" "" "NADPtxu" "MNXR101896" "HMR_7777" "RCR20713" "" 0 "" "" "HMR_7777" "MAR07779" "" "NADPHtxu" "" "" "" "NADPHtxu" "MNXR101894" "HMR_7779" "RCR20311" "" 0 "" "" "HMR_7779" -"MAR07782" "" "ADPtx" "" "" "" "ADPtx" "MNXR95484" "HMR_7782" "RCR20201" "" 0 "" "" "HMR_7782" -"MAR07783" "" "AMPtp" "" "" "" "AMPtp" "MNXR95830" "HMR_7783" "RCR20046" "" 0 "" "" "HMR_7783" -"MAR07785" "" "ATPtx" "" "" "" "ATPtx" "MNXR96140" "HMR_7785" "RCR20040" "" 0 "" "" "HMR_7785" -"MAR07788" "" "FADH2tx" "" "" "" "FADH2tx" "MNXR99212" "HMR_7788" "RCR20202" "" 0 "" "" "HMR_7788" -"MAR07790" "" "FADtx" "" "" "" "FADtx" "MNXR99217" "HMR_7790" "RCR20203" "" 0 "" "" "HMR_7790" "MAR07797" "" "AKGtp" "" "" "" "AKGtp" "MNXR95663" "HMR_7797" "RCR20150" "" 0 "" "" "HMR_7797" "MAR08016" "" "LYStip" "" "" "" "LYStip" "MNXR101269" "HMR_8016" "RCR20033" "" 0 "" "" "HMR_8016" "MAR08020" "" "THP2Ctp" "" "" "" "THP2Ctp" "MNXR104832" "HMR_8020" "RCR20714" "" 0 "" "" "HMR_8020" @@ -8335,7 +8311,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR01083" "" "FUT18g" "" "" "" "FUT18g" "MNXR99731" "" "" "" 0 "" "" "FUT18g" "MAR01118" "" "FUT34g" "" "" "" "FUT34g" "MNXR99739" "" "" "" 0 "" "" "FUT34g" "MAR01141" "" "FUT93g" "" "" "" "FUT93g" "MNXR99751" "" "" "" 0 "" "" "FUT93g" -"MAR01169" "R00849" "G3PD2m" "" "r0205" "" "G3PD2m;r0205" "MNXR99878;MNXR106713" "HMR_0483" "RCR21050" "" 0 "" "RHEA:18977" "G3PD2m;HMR_0483" +"MAR01169" "R00849;R00848" "G3PD2m" "R00848C" "r0205" "" "G3PD2m;r0205;HMR_0482" "MNXR99878;MNXR106713;MNXR192664" "HMR_0483;HMR_0482" "RCR21050;RCR14578" "" 0 "" "RHEA:18977" "G3PD2m;HMR_0483;HMR_0482;MAR00482;MAR00483" "MAR01314" "" "GABAVESSEC" "" "" "" "GABAVESSEC" "MNXR99916" "" "" "" 0 "" "" "GABAVESSEC" "MAR01340" "" "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg" "" "" "" "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg" "MNXR99968" "" "" "" 0 "" "" "GALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg" "MAR01348" "" "GALGLUSIDEtg" "" "" "" "GALGLUSIDEtg" "MNXR99974" "" "" "" 0 "" "" "GALGLUSIDEtg" @@ -8386,7 +8362,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR01480" "" "LEUt5m" "" "" "" "LEUt5m" "MNXR101057" "" "" "" 0 "" "" "LEUt5m" "MAR01481" "" "LGNCCPT2" "" "" "" "LGNCCPT2" "MNXR101063" "" "" "" 0 "" "" "LGNCCPT2" "MAR01482" "" "LGNCCRNt" "" "" "" "LGNCCRNt" "MNXR101064" "" "" "" 0 "" "" "LGNCCRNt" -"MAR01483" "" "LIPOti" "" "" "" "LIPOti" "MNXR101093" "" "" "" 0 "" "" "LIPOti" "MAR01485" "" "L_LACtcm" "" "" "" "L_LACtcm" "MNXR100999" "" "" "" 0 "" "" "L_LACtcm" "MAR01486" "" "LNELDCCRNt" "" "" "" "LNELDCCRNt" "MNXR101102" "" "" "" 0 "" "" "LNELDCCRNt" "MAR01487" "" "LNLCCRNt" "" "" "" "LNLCCRNt" "MNXR101106" "" "" "" 0 "" "" "LNLCCRNt" @@ -8735,7 +8710,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR02751" "" "RE1134M" "" "" "" "RE1134M" "MNXR102255" "" "" "" 0 "" "" "RE1134M" "MAR02756" "" "" "" "" "" "RE1135G" "" "" "" "" 0 "" "" "RE1135G" "MAR02763" "" "" "" "" "" "RE1135L" "" "" "" "" 0 "" "" "RE1135L" -"MAR02765" "" "" "" "" "" "RE1233M" "" "" "" "" 0 "" "" "RE1233M" +"MAR02765" "" "" "" "" "" "RE1233M" "" "" "" "" 0 "RHEA:65561" "RHEA:65560" "RE1233M" "MAR02767" "" "RE1309M" "" "" "" "RE1309M" "MNXR103507" "" "" "" 0 "" "" "RE1309M" "MAR02779" "" "RE1342C" "" "" "" "RE1342C" "MNXR103511" "" "" "" 0 "" "" "RE1342C" "MAR02781" "" "RE1447M" "" "" "" "RE1447M" "MNXR102717" "" "" "" 0 "" "" "RE1447M" @@ -9075,7 +9050,7 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR04092" "" "EX_prostgh2_e" "" "" "" "EX_prostgh2[e]" "MNXR98873" "" "" "" 0 "" "" "EX_prostgh2[e]" "MAR04094" "" "EX_prostgi2_e" "" "" "" "EX_prostgi2[e]" "MNXR98874" "" "" "" 0 "" "" "EX_prostgi2[e]" "MAR04096" "" "EX_cdp_e" "" "" "" "EX_cdp[e]" "MNXR98331" "" "" "" 0 "" "" "EX_cdp[e]" -"MAR04098" "" "EX_dtdp_e" "" "" "" "EX_dtdp[e]" "MNXR98432" "" "" "" 0 "" "" "EX_dtdp[e]" +"MAR04098" "" "EX_dtdp_e" "" "" "" "EX_dtdp[e]" "MNXR98432" "" "" "" 0 "" "" "EX_dtdp[e];MAR07785" "MAR04100" "" "EX_HC00955_e" "" "" "" "EX_HC00955[e]" "MNXR98138" "" "" "" 0 "" "" "EX_HC00955[e]" "MAR04102" "" "" "" "" "" "EX_HC00002[e]" "" "" "" "" 0 "" "" "EX_HC00002[e]" "MAR04104" "" "" "" "" "" "EX_HC00003[e]" "" "" "" "" 0 "" "" "EX_HC00003[e]" @@ -9527,8 +9502,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR07817" "" "CYSAMOe" "" "" "" "CYSAMOe" "MNXR96988" "" "" "" 0 "RHEA:14410" "RHEA:14409" "CYSAMOe" "MAR07819" "" "Coqe" "" "" "" "Coqe" "MNXR97066" "" "" "" 0 "" "" "Coqe" "MAR07821" "" "DATPtm_cho" "" "" "" "DATPtm" "MNXR97176" "" "" "" 0 "" "" "DATPtm" -"MAR07823" "" "DNDPt51m" "" "" "" "DCTPtm" "MNXR97204" "" "" "" 0 "" "" "DCTPtm" -"MAR07926" "" "DGTPtm" "" "" "" "DGTPtm" "MNXR97327" "" "" "" 0 "" "" "DGTPtm" "MAR08111" "" "DHAPtm" "" "" "" "DHAPtc" "MNXR97366" "" "" "" 0 "" "" "DHAPtc" "MAR08204" "" "DPCOAPPe" "" "" "" "DPCOAPPe" "MNXR97763" "" "" "" 0 "" "" "DPCOAPPe" "MAR08218" "" "DSREDUCr" "" "" "" "DSREDUCr" "" "" "" "" 0 "" "" "DSREDUCr" @@ -9764,7 +9737,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR09946" "" "" "" "" "" "XOLEST204CEH" "" "" "" "" 0 "" "" "XOLEST204CEH" "MAR09947" "" "XOLEST226CEH" "" "" "" "XOLEST226CEH" "" "" "" "" 0 "" "" "XOLEST226CEH" "MAR09948" "" "CE4843HYDc" "" "" "" "CE4843HYDc" "" "" "" "" 0 "" "" "CE4843HYDc" -"MAR09949" "" "FACOAE60" "" "" "" "HXCOAc" "MNXR99139" "" "" "" 0 "" "" "HXCOAc" "MAR09950" "" "TETDECA511ACc" "" "" "" "TETDECA511ACc" "" "" "" "" 0 "" "" "TETDECA511ACc" "MAR09951" "" "GPDDACHOL" "" "" "" "GPDDACHOL" "" "" "" "" 0 "" "" "GPDDACHOL" "MAR09952" "" "ACLYSHYc" "" "" "" "ACLYSHYc" "" "" "" "" 0 "" "" "ACLYSHYc" @@ -10988,8 +10960,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR11289" "" "PHEACGLYtm" "" "" "" "PHEACGLYtm" "MNXR157011" "" "" "" 0 "" "" "PHEACGLYtm" "MAR11290" "" "HXAt1" "" "" "" "HXAt1" "" "" "" "" 0 "" "" "HXAt1" "MAR11291" "" "HXAt2" "" "" "" "HXAt2" "" "" "" "" 0 "" "" "HXAt2" -"MAR11292" "" "HXAt3" "" "" "" "HXAt3" "" "" "" "" 0 "" "" "HXAt3" -"MAR11293" "" "EX_hxa_e" "" "" "" "EX_hxa[e]" "MNXR98664" "" "" "" 0 "" "" "EX_hxa[e]" "MAR11294" "" "TTDCEAc" "" "" "" "TTDCEAc" "" "" "" "" 0 "" "" "TTDCEAc" "MAR11295" "" "PACCOALm" "" "" "" "PACCOALm" "" "" "" "" 0 "" "" "PACCOALm" "MAR11296" "" "PACALDtm" "" "" "" "PACALDtm" "MNXR102312" "" "" "" 0 "" "" "PACALDtm" @@ -12871,7 +12841,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR20009" "" "" "" "" "" "" "MNXR133773" "" "" "" 0 "RHEA:60660" "" "" "MAR20010" "" "" "" "" "" "" "MNXR133773" "" "" "" 0 "RHEA:60660" "" "" "MAR20011" "R02123" "HMR_6647;RADH;R_HMR_6647;R_RADH" "" "" "" "" "MNXR146215" "" "" "" 0 "RHEA:42080" "" "" -"MAR20012" "R02123" "HMR_6647;RADH;R_HMR_6647;R_RADH" "" "" "" "" "MNXR146215" "" "" "" 0 "RHEA:42080" "" "" "MAR20013" "R03225" "" "" "" "" "" "MNXR108031" "" "" "" 0 "RHEA:23048" "" "" "MAR20016" "R01704" "ALDD16;R_ALDD16" "" "" "" "" "MNXR95739" "" "" "" 0 "RHEA:33739" "" "" "MAR20017" "" "ALDD8;R_ALDD8" "" "" "" "" "MNXR95760" "" "" "" 0 "RHEA:44100" "" "" @@ -12942,7 +12911,6 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR20086" "" "" "" "" "" "" "MNXR168657" "" "" "" 0 "RHEA:45372" "" "" "MAR20087" "" "" "" "" "" "" "MNXR168656" "" "" "" 0 "RHEA:45368" "" "" "MAR20088" "" "" "" "" "" "" "MNXR168656" "" "" "" 0 "RHEA:45368" "" "" -"MAR20089" "R02701" "" "" "" "" "" "MNXR151808" "" "" "" 0 "RHEA:18533" "" "" "MAR20090" "R07411" "HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1" "" "" "" "" "MNXR115959" "" "" "" 0 "RHEA:28070" "" "" "MAR20091" "R07411" "HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1" "" "" "" "" "MNXR115959" "" "" "" 0 "RHEA:28070" "" "" "MAR20092" "R07411" "HEMEOS;HEMEOS_1;HEMEOSm;HEMEOSm_1;R_HEMEOS;R_HEMEOS_1;R_HEMEOSm;R_HEMEOSm_1" "" "" "" "" "MNXR115959" "" "" "" 0 "RHEA:28070" "" "" @@ -12968,3 +12936,61 @@ rxns rxnKEGGID rxnBiGGID rxnEHMNID rxnHepatoNET1ID rxnREACTOMEID rxnRecon3DID rx "MAR20112" "R04385" "" "" "" "" "" "MNXR96330" "" "" "" 0 "" "RHEA:13501" "" "MAR20113" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" "MAR20114" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20115" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20116" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20117" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20118" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20119" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20120" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20121" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20122" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20123" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20124" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20125" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20126" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20127" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20128" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20129" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20130" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20131" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20132" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20133" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20134" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20135" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20136" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20137" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20138" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20139" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20140" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20141" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20142" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20143" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20144" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20145" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20146" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20147" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20148" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20149" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20150" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20151" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20152" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20153" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20154" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20155" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20156" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20157" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20158" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20159" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20160" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20161" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20162" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20163" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20164" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20165" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20166" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20167" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20168" "" "" "" "" "" "" "" "" "" "" 0 "" "" "" +"MAR20169" "" "" "" "" "" "" "" "" "" "" 0 "RHEA:40112" "RHEA:40111" "" +"MAR20170" "" "" "" "" "" "" "" "" "" "" 0 "RHEA:30144" "RHEA:30143" "" +"MAR20171" "" "" "" "" "" "" "" "" "" "" 0 "RHEA:40060" "RHEA:40059" "" +"MAR20172" "" "" "" "" "" "" "" "" "" "" 0 "" "" ""