diff --git a/src/AsmResolver.DotNet/DefaultMetadataResolver.cs b/src/AsmResolver.DotNet/DefaultMetadataResolver.cs
index 30bab5716..18e57b9e5 100644
--- a/src/AsmResolver.DotNet/DefaultMetadataResolver.cs
+++ b/src/AsmResolver.DotNet/DefaultMetadataResolver.cs
@@ -15,7 +15,7 @@ public class DefaultMetadataResolver : IMetadataResolver
         private readonly ConcurrentDictionary<ITypeDescriptor, TypeDefinition> _typeCache;
         private readonly SignatureComparer _comparer = new()
         {
-            AcceptNewerAssemblyVersionNumbers = true
+            IgnoreAssemblyVersionNumbers = true
         };
 
         /// <summary>
diff --git a/test/AsmResolver.DotNet.Tests/MetadataResolverTest.cs b/test/AsmResolver.DotNet.Tests/MetadataResolverTest.cs
index d3bc6ecac..94298169e 100644
--- a/test/AsmResolver.DotNet.Tests/MetadataResolverTest.cs
+++ b/test/AsmResolver.DotNet.Tests/MetadataResolverTest.cs
@@ -225,6 +225,28 @@ public void MaliciousExportedTypeLoop()
         }
 
         [Fact]
+        public void ResolveToOlderNetVersion()
+        {
+            // https://github.com/Washi1337/AsmResolver/issues/321
+
+            var mainApp = ModuleDefinition.FromBytes(Properties.Resources.DifferentNetVersion_MainApp);
+            var library = ModuleDefinition.FromBytes(Properties.Resources.DifferentNetVersion_Library);
+
+            mainApp.MetadataResolver.AssemblyResolver.AddToCache(library.Assembly!, library.Assembly!);
+
+            var definition = library
+                .TopLevelTypes.First(t => t.Name == "MyClass")
+                .Methods.First(m => m.Name == "ThrowMe");
+
+            var reference = (IMethodDescriptor) mainApp.ManagedEntrypointMethod!.CilMethodBody!.Instructions.First(
+                    i => i.OpCode == CilOpCodes.Callvirt && ((IMethodDescriptor) i.Operand)?.Name == "ThrowMe")
+                .Operand!;
+
+            var resolved = reference.Resolve();
+            Assert.NotNull(resolved);
+            Assert.Equal(definition, resolved);
+        }
+        
         public void ResolveMethodWithoutHideBySig()
         {
             // https://github.com/Washi1337/AsmResolver/issues/241
diff --git a/test/AsmResolver.DotNet.Tests/Properties/Resources.Designer.cs b/test/AsmResolver.DotNet.Tests/Properties/Resources.Designer.cs
index 413f1fa55..fbf27fbcb 100644
--- a/test/AsmResolver.DotNet.Tests/Properties/Resources.Designer.cs
+++ b/test/AsmResolver.DotNet.Tests/Properties/Resources.Designer.cs
@@ -234,6 +234,20 @@ public static byte[] FieldRvaTest {
             }
         }
 
+        public static byte[] DifferentNetVersion_MainApp {
+            get {
+                object obj = ResourceManager.GetObject("DifferentNetVersion_MainApp", resourceCulture);
+                return ((byte[])(obj));
+            }
+        }
+
+        public static byte[] DifferentNetVersion_Library {
+            get {
+                object obj = ResourceManager.GetObject("DifferentNetVersion_Library", resourceCulture);
+                return ((byte[])(obj));
+            }
+        }
+
         public static byte[] CallManagedExport_X86 {
             get {
                 object obj = ResourceManager.GetObject("CallManagedExport_X86", resourceCulture);
diff --git a/test/AsmResolver.DotNet.Tests/Properties/Resources.resx b/test/AsmResolver.DotNet.Tests/Properties/Resources.resx
index ecc3273dd..e919e0c39 100644
--- a/test/AsmResolver.DotNet.Tests/Properties/Resources.resx
+++ b/test/AsmResolver.DotNet.Tests/Properties/Resources.resx
@@ -99,6 +99,12 @@
     <data name="FieldRvaTest" type="System.Resources.ResXFileRef, System.Windows.Forms">
         <value>..\Resources\FieldRvaTest.exe;System.Byte[], mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
     </data>
+    <data name="DifferentNetVersion_MainApp" type="System.Resources.ResXFileRef, System.Windows.Forms">
+        <value>..\Resources\DifferentNetVersion.MainApp.dll;System.Byte[], mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
+    </data>
+    <data name="DifferentNetVersion_Library" type="System.Resources.ResXFileRef, System.Windows.Forms">
+        <value>..\Resources\DifferentNetVersion.Library.dll;System.Byte[], mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
+    </data>
     <data name="CallManagedExport_X86" type="System.Resources.ResXFileRef, System.Windows.Forms">
         <value>..\Resources\CallManagedExport.x86.exe;System.Byte[], mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089</value>
     </data>
diff --git a/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.Library.dll b/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.Library.dll
new file mode 100644
index 000000000..b1e05392b
Binary files /dev/null and b/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.Library.dll differ
diff --git a/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.MainApp.dll b/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.MainApp.dll
new file mode 100644
index 000000000..e484ca0fd
Binary files /dev/null and b/test/AsmResolver.DotNet.Tests/Resources/DifferentNetVersion.MainApp.dll differ