diff --git a/packages/components/src/button/style.scss b/packages/components/src/button/style.scss
index ae242c38634180..3bc99f3a7975c1 100644
--- a/packages/components/src/button/style.scss
+++ b/packages/components/src/button/style.scss
@@ -23,16 +23,10 @@
 	}
 
 	&[aria-expanded="true"],
-	&:hover {
+	&:hover:not(:disabled, [aria-disabled="true"]) {
 		color: $components-color-accent;
 	}
 
-	// Unset some hovers, instead of adding :not specificity.
-	&:disabled:hover,
-	&[aria-disabled="true"]:hover {
-		color: initial;
-	}
-
 	// Focus.
 	// See https://github.com/WordPress/gutenberg/issues/13267 for more context on these selectors.
 	&:focus:not(:disabled) {
@@ -80,7 +74,6 @@
 			color: rgba($white, 0.4);
 			background: $components-color-accent;
 			border-color: $components-color-accent;
-			opacity: 1;
 			outline: none;
 
 			&:focus:enabled {
@@ -125,7 +118,6 @@
 			color: $gray-600;
 			background: transparent;
 			transform: none;
-			opacity: 1;
 		}
 	}
 
@@ -199,17 +191,22 @@
 		&:not(.is-primary):not(.is-secondary):not(.is-tertiary):not(.is-link) {
 			color: $alert-red;
 
-			&:hover:not(:disabled) {
+			&:hover:not(:disabled, [aria-disabled="true"]) {
 				color: darken($alert-red, 20%);
 			}
 
-			&:focus:not(:disabled) {
+			&:focus {
 				box-shadow: 0 0 0 var(--wp-admin-border-width-focus) $alert-red;
 			}
 
-			&:active:not(:disabled) {
+			&:active:not(:disabled, [aria-disabled="true"]) {
 				background: $gray-400;
 			}
+
+			&:disabled,
+			&[aria-disabled="true"] {
+				color: lighten($alert-red, 40%);
+			}
 		}
 	}
 
@@ -237,6 +234,11 @@
 		&:focus {
 			border-radius: $radius-block-ui;
 		}
+
+		&:disabled,
+		&[aria-disabled="true"] {
+			color: $gray-600;
+		}
 	}
 
 	&:not(:disabled, [aria-disabled="true"]):active {
@@ -246,7 +248,11 @@
 	&:disabled,
 	&[aria-disabled="true"] {
 		cursor: default;
-		opacity: 0.3;
+		color: $gray-600;
+
+		svg {
+			opacity: 0.66;
+		}
 	}
 
 	&.is-busy,
@@ -259,7 +265,6 @@
 		@media (prefers-reduced-motion: reduce) {
 			animation-duration: 0s;
 		}
-		opacity: 1;
 		background-size: 100px 100%;
 		/* stylelint-disable -- Disable reason: This function call looks nicer when each argument is on its own line. */
 		background-image: linear-gradient(