diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index 72edad0df4e10e..8dd8d4b552d9d8 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -6,6 +6,10 @@
 
 -   Migrate `Divider` from `reakit` to `ariakit` ([#55622](https://github.com/WordPress/gutenberg/pull/55622))
 
+### Experimental
+
+-   `Tabs`: Add `focusable` prop to the `Tabs.TabPanel` sub-component ([#55287](https://github.com/WordPress/gutenberg/pull/55287))
+
 ### Enhancements
 
 -   `ToggleGroupControl`: Add opt-in prop for 40px default size ([#55789](https://github.com/WordPress/gutenberg/pull/55789)).
diff --git a/packages/components/src/tabs/README.md b/packages/components/src/tabs/README.md
index 6907f385fda371..8fb4e0e73caec2 100644
--- a/packages/components/src/tabs/README.md
+++ b/packages/components/src/tabs/README.md
@@ -240,3 +240,10 @@ The class name to apply to the tabpanel.
 Custom CSS styles for the tab.
 
 - Required: No
+
+###### `focusable`: `boolean`
+
+Determines whether or not the tabpanel element should be focusable. If `false`, pressing the tab key will skip over the tabpanel, and instead focus on the first focusable element in the panel (if there is one).
+
+- Required: No
+- Default: `true`
diff --git a/packages/components/src/tabs/stories/index.story.tsx b/packages/components/src/tabs/stories/index.story.tsx
index 3b6ba022f6d91b..08e29589881707 100644
--- a/packages/components/src/tabs/stories/index.story.tsx
+++ b/packages/components/src/tabs/stories/index.story.tsx
@@ -42,8 +42,16 @@ const Template: StoryFn< typeof Tabs > = ( props ) => {
 			<Tabs.TabPanel id={ 'tab2' }>
 				<p>Selected tab: Tab 2</p>
 			</Tabs.TabPanel>
-			<Tabs.TabPanel id={ 'tab3' }>
+			<Tabs.TabPanel id={ 'tab3' } focusable={ false }>
 				<p>Selected tab: Tab 3</p>
+				<p>
+					This tabpanel has its <code>focusable</code> prop set to
+					<code> false</code>, so it won&apos;t get a tab stop.
+					<br />
+					Instead, the [Tab] key will move focus to the first
+					focusable element within the panel.
+				</p>
+				<Button variant="primary">I&apos;m a button!</Button>
 			</Tabs.TabPanel>
 		</Tabs>
 	);
diff --git a/packages/components/src/tabs/styles.ts b/packages/components/src/tabs/styles.ts
index 091ba608fb6ecd..cb735f3177662a 100644
--- a/packages/components/src/tabs/styles.ts
+++ b/packages/components/src/tabs/styles.ts
@@ -101,3 +101,19 @@ export const Tab = styled( Ariakit.Tab )`
 		}
 	}
 `;
+
+export const TabPanel = styled( Ariakit.TabPanel )`
+	&:focus {
+		box-shadow: none;
+		outline: none;
+	}
+
+	&:focus-visible {
+		border-radius: 2px;
+		box-shadow: 0 0 0 var( --wp-admin-border-width-focus )
+			${ COLORS.theme.accent };
+		// Windows high contrast mode.
+		outline: 2px solid transparent;
+		outline-offset: 0;
+	}
+`;
diff --git a/packages/components/src/tabs/tabpanel.tsx b/packages/components/src/tabs/tabpanel.tsx
index fb62fc91912331..b5339141a56eca 100644
--- a/packages/components/src/tabs/tabpanel.tsx
+++ b/packages/components/src/tabs/tabpanel.tsx
@@ -1,8 +1,6 @@
 /**
  * External dependencies
  */
-// eslint-disable-next-line no-restricted-imports
-import * as Ariakit from '@ariakit/react';
 
 /**
  * WordPress dependencies
@@ -14,12 +12,16 @@ import { forwardRef, useContext } from '@wordpress/element';
  * Internal dependencies
  */
 import type { TabPanelProps } from './types';
+import { TabPanel as StyledTabPanel } from './styles';
 
 import warning from '@wordpress/warning';
 import { TabsContext } from './context';
 
 export const TabPanel = forwardRef< HTMLDivElement, TabPanelProps >(
-	function TabPanel( { children, id, className, style }, ref ) {
+	function TabPanel(
+		{ children, id, className, style, focusable = true },
+		ref
+	) {
 		const context = useContext( TabsContext );
 		if ( ! context ) {
 			warning( '`Tabs.TabPanel` must be wrapped in a `Tabs` component.' );
@@ -28,7 +30,8 @@ export const TabPanel = forwardRef< HTMLDivElement, TabPanelProps >(
 		const { store, instanceId } = context;
 
 		return (
-			<Ariakit.TabPanel
+			<StyledTabPanel
+				focusable={ focusable }
 				ref={ ref }
 				style={ style }
 				store={ store }
@@ -36,7 +39,7 @@ export const TabPanel = forwardRef< HTMLDivElement, TabPanelProps >(
 				className={ className }
 			>
 				{ children }
-			</Ariakit.TabPanel>
+			</StyledTabPanel>
 		);
 	}
 );
diff --git a/packages/components/src/tabs/test/index.tsx b/packages/components/src/tabs/test/index.tsx
index a89e680e244d8c..67b7bf588e74e8 100644
--- a/packages/components/src/tabs/test/index.tsx
+++ b/packages/components/src/tabs/test/index.tsx
@@ -26,6 +26,9 @@ type Tab = {
 		icon?: IconType;
 		disabled?: boolean;
 	};
+	tabpanel?: {
+		focusable?: boolean;
+	};
 };
 
 const TABS: Tab[] = [
@@ -83,7 +86,11 @@ const UncontrolledTabs = ( {
 				) ) }
 			</Tabs.TabList>
 			{ tabs.map( ( tabObj ) => (
-				<Tabs.TabPanel key={ tabObj.id } id={ tabObj.id }>
+				<Tabs.TabPanel
+					key={ tabObj.id }
+					id={ tabObj.id }
+					focusable={ tabObj.tabpanel?.focusable }
+				>
 					{ tabObj.content }
 				</Tabs.TabPanel>
 			) ) }
@@ -184,6 +191,63 @@ describe( 'Tabs', () => {
 			);
 		} );
 	} );
+	describe( 'Focus Behavior', () => {
+		it( 'should focus on the related TabPanel when pressing the Tab key', async () => {
+			const user = userEvent.setup();
+
+			render( <UncontrolledTabs tabs={ TABS } /> );
+
+			const selectedTabPanel = await screen.findByRole( 'tabpanel' );
+
+			// Tab should initially focus the first tab in the tablist, which
+			// is Alpha.
+			await user.keyboard( '[Tab]' );
+			expect(
+				await screen.findByRole( 'tab', { name: 'Alpha' } )
+			).toHaveFocus();
+
+			// By default the tabpanel should receive focus
+			await user.keyboard( '[Tab]' );
+			expect( selectedTabPanel ).toHaveFocus();
+		} );
+		it( 'should not focus on the related TabPanel when pressing the Tab key if `focusable: false` is set', async () => {
+			const user = userEvent.setup();
+
+			const TABS_WITH_ALPHA_FOCUSABLE_FALSE = TABS.map( ( tabObj ) =>
+				tabObj.id === 'alpha'
+					? {
+							...tabObj,
+							content: (
+								<>
+									Selected Tab: Alpha
+									<button>Alpha Button</button>
+								</>
+							),
+							tabpanel: { focusable: false },
+					  }
+					: tabObj
+			);
+
+			render(
+				<UncontrolledTabs tabs={ TABS_WITH_ALPHA_FOCUSABLE_FALSE } />
+			);
+
+			const alphaButton = await screen.findByRole( 'button', {
+				name: /alpha button/i,
+			} );
+
+			// Tab should initially focus the first tab in the tablist, which
+			// is Alpha.
+			await user.keyboard( '[Tab]' );
+			expect(
+				await screen.findByRole( 'tab', { name: 'Alpha' } )
+			).toHaveFocus();
+			// Because the alpha tabpanel is set to `focusable: false`, pressing
+			// the Tab key should focus the button, not the tabpanel
+			await user.keyboard( '[Tab]' );
+			expect( alphaButton ).toHaveFocus();
+		} );
+	} );
 
 	describe( 'Tab Attributes', () => {
 		it( "should apply the tab's `className` to the tab button", async () => {
diff --git a/packages/components/src/tabs/types.ts b/packages/components/src/tabs/types.ts
index 88e25eb5a3863c..9874fe6cb6ccfa 100644
--- a/packages/components/src/tabs/types.ts
+++ b/packages/components/src/tabs/types.ts
@@ -128,7 +128,7 @@ export type TabPanelProps = {
 	 */
 	children?: React.ReactNode;
 	/**
-	 * A unique identifier for the TabPanel, which is used to generate a unique `id` for the underlying element.
+	 * A unique identifier for the tabpanel, which is used to generate a unique `id` for the underlying element.
 	 */
 	id: string;
 	/**
@@ -139,4 +139,12 @@ export type TabPanelProps = {
 	 * Custom CSS styles for the rendered `TabPanel` component.
 	 */
 	style?: React.CSSProperties;
+	/**
+	 * Determines whether or not the tabpanel element should be focusable.
+	 * If `false`, pressing the tab key will skip over the tabpanel, and instead
+	 * focus on the first focusable element in the panel (if there is one).
+	 *
+	 * @default true
+	 */
+	focusable?: boolean;
 };