diff --git a/packaging/rpm/patches/03ae30013de3fde03719c9b1c9c53b39c389b599.patch b/packaging/rpm/patches/03ae30013de3fde03719c9b1c9c53b39c389b599.patch
new file mode 100644
index 0000000000..0a68ffdcde
--- /dev/null
+++ b/packaging/rpm/patches/03ae30013de3fde03719c9b1c9c53b39c389b599.patch
@@ -0,0 +1,27 @@
+From 03ae30013de3fde03719c9b1c9c53b39c389b599 Mon Sep 17 00:00:00 2001
+From: Daniele Nicolodi <daniele@grinta.net>
+Date: Mon, 27 Mar 2023 21:41:56 +0200
+Subject: [PATCH] Fix compilation with CPython 3.12a6
+
+CPython 3.12a6 made PyThreadState an opaque structure thus the fast
+thread state optimization cannot be employed anymore.
+
+Fixes #5286.
+---
+ Cython/Utility/ModuleSetupCode.c | 3 ++-
+ 1 file changed, 2 insertions(+), 1 deletion(-)
+
+diff --git a/Cython/Utility/ModuleSetupCode.c b/Cython/Utility/ModuleSetupCode.c
+index e461cda1e7..950d89a679 100644
+--- a/Cython/Utility/ModuleSetupCode.c
++++ b/Cython/Utility/ModuleSetupCode.c
+@@ -331,7 +331,8 @@
+     #define CYTHON_UNPACK_METHODS 1
+   #endif
+   #ifndef CYTHON_FAST_THREAD_STATE
+-    #define CYTHON_FAST_THREAD_STATE 1
++    // CPython 3.12a6 made PyThreadState an opaque struct.
++    #define CYTHON_FAST_THREAD_STATE (PY_VERSION_HEX < 0x030C00A6)
+   #endif
+   #ifndef CYTHON_FAST_GIL
+     // Py3<3.5.2 does not support _PyThreadState_UncheckedGet().