diff --git a/pkg/frontend/transport/roundtripper.go b/pkg/frontend/transport/roundtripper.go
index 45cfb22225..d9ba57ccba 100644
--- a/pkg/frontend/transport/roundtripper.go
+++ b/pkg/frontend/transport/roundtripper.go
@@ -3,6 +3,7 @@ package transport
 import (
 	"bytes"
 	"context"
+	"io"
 	"io/ioutil"
 	"net/http"
 
@@ -24,6 +25,15 @@ type grpcRoundTripperAdapter struct {
 	roundTripper GrpcRoundTripper
 }
 
+type buffer struct {
+	buff []byte
+	io.ReadCloser
+}
+
+func (b *buffer) Bytes() []byte {
+	return b.buff
+}
+
 func (a *grpcRoundTripperAdapter) RoundTrip(r *http.Request) (*http.Response, error) {
 	req, err := server.HTTPRequest(r)
 	if err != nil {
@@ -37,7 +47,7 @@ func (a *grpcRoundTripperAdapter) RoundTrip(r *http.Request) (*http.Response, er
 
 	httpResp := &http.Response{
 		StatusCode:    int(resp.Code),
-		Body:          ioutil.NopCloser(bytes.NewReader(resp.Body)),
+		Body:          &buffer{buff: resp.Body, ReadCloser: ioutil.NopCloser(bytes.NewReader(resp.Body))},
 		Header:        http.Header{},
 		ContentLength: int64(len(resp.Body)),
 	}
diff --git a/pkg/querier/queryrange/query_range.go b/pkg/querier/queryrange/query_range.go
index 7506d4f507..32962db908 100644
--- a/pkg/querier/queryrange/query_range.go
+++ b/pkg/querier/queryrange/query_range.go
@@ -266,20 +266,15 @@ func (prometheusCodec) DecodeResponse(ctx context.Context, r *http.Response, _ R
 	log, ctx := spanlogger.New(ctx, "ParseQueryRangeResponse") //nolint:ineffassign,staticcheck
 	defer log.Finish()
 
-	// Preallocate the buffer with the exact size so we don't waste allocations
-	// while progressively growing an initial small buffer. The buffer capacity
-	// is increased by MinRead to avoid extra allocations due to how ReadFrom()
-	// internally works.
-	buf := bytes.NewBuffer(make([]byte, 0, r.ContentLength+bytes.MinRead))
-	if _, err := buf.ReadFrom(r.Body); err != nil {
+	buf, err := bodyBuffer(r)
+	if err != nil {
 		log.Error(err)
-		return nil, httpgrpc.Errorf(http.StatusInternalServerError, "error decoding response: %v", err)
+		return nil, err
 	}
-
-	log.LogFields(otlog.Int("bytes", buf.Len()))
+	log.LogFields(otlog.Int("bytes", len(buf)))
 
 	var resp PrometheusResponse
-	if err := json.Unmarshal(buf.Bytes(), &resp); err != nil {
+	if err := json.Unmarshal(buf, &resp); err != nil {
 		return nil, httpgrpc.Errorf(http.StatusInternalServerError, "error decoding response: %v", err)
 	}
 
@@ -289,6 +284,29 @@ func (prometheusCodec) DecodeResponse(ctx context.Context, r *http.Response, _ R
 	return &resp, nil
 }
 
+// Buffer can be used to read a response body.
+// This allows to avoid reading the body multiple times from the `http.Response.Body`.
+type Buffer interface {
+	Bytes() []byte
+}
+
+func bodyBuffer(res *http.Response) ([]byte, error) {
+	// Attempt to cast the response body to a Buffer and use it if possible.
+	// This is because the frontend may have already read the body and buffered it.
+	if buffer, ok := res.Body.(Buffer); ok {
+		return buffer.Bytes(), nil
+	}
+	// Preallocate the buffer with the exact size so we don't waste allocations
+	// while progressively growing an initial small buffer. The buffer capacity
+	// is increased by MinRead to avoid extra allocations due to how ReadFrom()
+	// internally works.
+	buf := bytes.NewBuffer(make([]byte, 0, res.ContentLength+bytes.MinRead))
+	if _, err := buf.ReadFrom(res.Body); err != nil {
+		return nil, httpgrpc.Errorf(http.StatusInternalServerError, "error decoding response: %v", err)
+	}
+	return buf.Bytes(), nil
+}
+
 func (prometheusCodec) EncodeResponse(ctx context.Context, res Response) (*http.Response, error) {
 	sp, _ := opentracing.StartSpanFromContext(ctx, "APIResponse.ToHTTPResponse")
 	defer sp.Finish()
@@ -392,7 +410,6 @@ func matrixMerge(resps []*PrometheusResponse) []SampleStream {
 // bigger than the given minTs. Empty slice is returned if minTs is bigger than all the
 // timestamps in samples.
 func sliceSamples(samples []cortexpb.Sample, minTs int64) []cortexpb.Sample {
-
 	if len(samples) <= 0 || minTs < samples[0].TimestampMs {
 		return samples
 	}