diff --git a/README.rst b/README.rst
index 72d76e8..8515934 100644
--- a/README.rst
+++ b/README.rst
@@ -142,7 +142,6 @@ Example
 
 .. code:: python
 
-    from __future__ import print_function
     import pandas as pd
     from gspread_pandas import Spread, Client
 
@@ -174,28 +173,6 @@ Example
 Troubleshooting
 ===============
 
-SSL Error
----------
-
-If you're getting an SSL related error or can't seem to be able to open existing
-spreadsheets that you have access to, you might be running into an issue caused by
-``certifi``. This has mainly been experienced on RHEL and CentOS running Python 2.7.
-You can read more about it in `issue 223
-<https://github.com/burnash/gspread/issues/223>`_
-and `issue 354 <https://github.com/burnash/gspread/issues/354>`_ but, in short, the
-solution is to either install a specific version of ``certifi`` that works for you,
-or remove it altogether.
-
-.. code-block:: console
-
-   pip install certifi==2015.4.28
-
-or
-
-.. code-block:: console
-
-   pip uninstall certifi
-
 EOFError in Rodeo
 -----------------
 
diff --git a/gspread_pandas/client.py b/gspread_pandas/client.py
index 3659a6e..5147644 100644
--- a/gspread_pandas/client.py
+++ b/gspread_pandas/client.py
@@ -1,9 +1,4 @@
-from __future__ import print_function
-
-from builtins import super
-
 import requests
-import six
 from google.auth.credentials import Credentials
 from google.auth.transport.requests import AuthorizedSession
 from gspread.client import Client as ClientV4
@@ -86,7 +81,7 @@ def __init__(
                 credentials = creds
             elif creds is not None and "oauth2client" in creds.__module__:
                 credentials = convert_credentials(creds)
-            elif isinstance(user, six.string_types):
+            elif isinstance(user, str):
                 credentials = get_creds(user, config, self.scope)
             else:
                 raise TypeError(
diff --git a/gspread_pandas/conf.py b/gspread_pandas/conf.py
index 4c79c3b..d928cfe 100644
--- a/gspread_pandas/conf.py
+++ b/gspread_pandas/conf.py
@@ -1,8 +1,8 @@
 import json
 import sys
 from os import environ, name
+from pathlib import Path
 
-import six
 from google.oauth2.credentials import Credentials as OAuthCredentials
 from google.oauth2.service_account import Credentials as SACredentials
 from google_auth_oauthlib.flow import InstalledAppFlow
@@ -10,12 +10,6 @@
 from gspread_pandas.exceptions import ConfigException
 from gspread_pandas.util import decode
 
-try:
-    from pathlib import Path
-except ImportError:
-    from pathlib2 import Path
-
-
 __all__ = ["default_scope", "get_config", "get_creds"]
 if name == "nt":
     _default_dir = Path(environ.get("APPDATA")) / "gspread_pandas"
@@ -144,7 +138,7 @@ def get_creds(
         if "private_key_id" in config:
             return SACredentials.from_service_account_info(config, scopes=scope)
 
-        if not isinstance(user, six.string_types):
+        if not isinstance(user, str):
             raise ConfigException(
                 "Need to provide a user key as a string if not using a service account"
             )
@@ -178,6 +172,4 @@ def get_creds(
         return creds
     except Exception:
         exc_info = sys.exc_info()
-
-    if "exc_info" in locals():
-        six.reraise(ConfigException, *exc_info[1:])
+        raise ConfigException(*exc_info[1:])
diff --git a/gspread_pandas/spread.py b/gspread_pandas/spread.py
index 882499a..a90cae7 100644
--- a/gspread_pandas/spread.py
+++ b/gspread_pandas/spread.py
@@ -1,11 +1,8 @@
-from __future__ import print_function
-
 from builtins import range, str
 from re import match
 
 import numpy as np
 import pandas as pd
-import six
 from gspread.exceptions import (
     APIError,
     NoValidUrlKeyFound,
@@ -543,10 +540,7 @@ def _find_sheet(self, sheet):
             Tuple like (index, worksheet)
         """
         for ix, worksheet in enumerate(self.sheets):
-            if (
-                isinstance(sheet, six.string_types)
-                and sheet.lower() == worksheet.title.lower()
-            ):
+            if isinstance(sheet, str) and sheet.lower() == worksheet.title.lower():
                 return ix, worksheet
             if isinstance(sheet, Worksheet) and sheet.id == worksheet.id:
                 return ix, worksheet
diff --git a/gspread_pandas/util.py b/gspread_pandas/util.py
index 81fc298..86fd8b4 100644
--- a/gspread_pandas/util.py
+++ b/gspread_pandas/util.py
@@ -5,7 +5,6 @@
 
 import numpy as np
 import pandas as pd
-import six
 from google.oauth2 import credentials as oauth2, service_account
 from gspread.client import Client as ClientV4
 from gspread.exceptions import APIError
@@ -51,7 +50,7 @@ def parse_df_col_names(df, include_index, index_size=1, flatten_sep=None):
     # handle multi-index headers
     if len(headers) > 0 and type(headers[0]) == tuple:
 
-        if isinstance(flatten_sep, six.string_types):
+        if isinstance(flatten_sep, str):
             headers = [
                 [
                     # Remove blank elements and join using sep
@@ -238,7 +237,7 @@ def get_cell_as_tuple(cell):
         ):
             raise TypeError("{0} is not a valid cell tuple".format(cell))
         return cell
-    elif isinstance(cell, six.string_types):
+    elif isinstance(cell, str):
         if not match("[a-zA-Z]+[0-9]+", cell):
             raise TypeError("{0} is not a valid address".format(cell))
         return a1_to_rowcol(cell)
@@ -454,7 +453,7 @@ def parse_permission(perm):
 
 def remove_keys(dct, keys=[]):
     """Remove keys from a dict."""
-    return {key: val for key, val in six.iteritems(dct) if key not in keys}
+    return {key: val for key, val in dct.items() if key not in keys}
 
 
 def remove_keys_from_list(lst, keys=[]):
diff --git a/pyproject.toml b/pyproject.toml
index 98e46c5..77aeab1 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -7,4 +7,4 @@ include_trailing_comma = true
 force_grid_wrap = 0
 combine_as_imports = true
 line_length = 88
-known_third_party = ["Crypto", "betamax", "betamax_serializers", "google", "google_auth_oauthlib", "gspread", "numpy", "oauth2client", "pandas", "pytest", "requests", "setuptools", "six"]
+known_third_party = ["Crypto", "betamax", "betamax_serializers", "google", "google_auth_oauthlib", "gspread", "numpy", "oauth2client", "pandas", "pytest", "requests", "setuptools"]
diff --git a/requirements.txt b/requirements.txt
index 1a2b1f9..5896180 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -2,7 +2,5 @@
 gspread<5.0.0
 pandas>=0.20.0
 decorator
-six
-pathlib2;python_version=="2.7"
 google-auth
 google-auth-oauthlib
diff --git a/requirements_dev.txt b/requirements_dev.txt
index e881f7c..efb58ef 100644
--- a/requirements_dev.txt
+++ b/requirements_dev.txt
@@ -9,7 +9,7 @@ flake8
 pytest
 pre-commit
 isort
-black;python_version>="3.6"
+black
 pycryptodome
 betamax
 betamax_serializers
diff --git a/setup.cfg b/setup.cfg
index d32ce26..13d3bbe 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -19,14 +19,16 @@ max-complexity = 18
 select = B,C,E,F,W,T4,B9
 
 [tox:tox]
-envlist = py27, py35, py36, py37, flake8
+envlist = py35, py36, py37, py38, py39, py310, flake8
 
 [travis]
-python = 
+python =
+        3.10: py310
+        3.9: py39
+        3.8: py38
 	3.7: py37
 	3.6: py36
 	3.5: py35
-	2.7: py27
 
 [testenv:flake8]
 basepython = python
@@ -34,7 +36,7 @@ deps = flake8
 commands = flake8 gspread_pandas
 
 [testenv]
-setenv = 
+setenv =
 	PYTHONPATH = {toxinidir}
 deps = -r requirements_dev.txt
 commands = python setup.py test
diff --git a/setup.py b/setup.py
index 8fb8bac..fa1e4c5 100644
--- a/setup.py
+++ b/setup.py
@@ -40,7 +40,6 @@
         "Development Status :: 4 - Beta",
         "Intended Audience :: Developers",
         "Intended Audience :: Science/Research",
-        "Programming Language :: Python :: 2.7",
         "Programming Language :: Python :: 3",
     ],
     keywords="gspread pandas google spreadsheets",
diff --git a/tests/client_test.py b/tests/client_test.py
index c77d5a3..5e0a85d 100644
--- a/tests/client_test.py
+++ b/tests/client_test.py
@@ -1,5 +1,4 @@
 import pytest
-import six
 
 from gspread_pandas import Client
 
@@ -22,7 +21,7 @@ def test_directories(self):
             assert {"name", "id", "path"} == set(d.keys())
 
     def test_email(self):
-        assert isinstance(self.client.auth.service_account_email, six.string_types)
+        assert isinstance(self.client.auth.service_account_email, str)
 
     def test_email_no_perm(self, betamax_client_bad_scope, capsys):
         betamax_client_bad_scope.email
diff --git a/tests/conf_test.py b/tests/conf_test.py
index 9bfd3c6..e9bfab7 100644
--- a/tests/conf_test.py
+++ b/tests/conf_test.py
@@ -1,4 +1,5 @@
 import os
+from pathlib import PosixPath, WindowsPath
 
 import pytest
 from google.oauth2.credentials import Credentials as OAuth2Credentials
@@ -6,11 +7,6 @@
 
 from gspread_pandas import conf, exceptions
 
-try:
-    from pathlib import PosixPath, WindowsPath
-except ImportError:
-    from pathlib2 import PosixPath, WindowsPath
-
 
 def test_get_config_dir():
     conf_dir = conf.get_config_dir()
diff --git a/tests/conftest.py b/tests/conftest.py
index 1265acf..8384a63 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -1,5 +1,6 @@
 import json
 import os
+from pathlib import Path
 
 import pytest
 from betamax import Betamax
@@ -10,12 +11,6 @@
 from gspread_pandas import Client, Spread, conf
 from gspread_pandas.util import decode
 
-# from betamax_json_body_serializer import JSONBodySerializer
-try:
-    from pathlib import Path
-except ImportError:
-    from pathlib2 import Path
-
 pytest.RECORD = os.environ.get("GSPREAD_RECORD") is not None
 pytest.DUMMY_TOKEN = "<ACCESS_TOKEN>"