diff --git a/deps/zlib/zlib.gyp b/deps/zlib/zlib.gyp
index 49de2a6c6de903..26ceed9fbe6825 100644
--- a/deps/zlib/zlib.gyp
+++ b/deps/zlib/zlib.gyp
@@ -107,33 +107,33 @@
             }],
           ],
         }, # zlib_arm_crc32
-        {
-          'target_name': 'zlib_crc32_simd',
-          'type': 'static_library',
-          'conditions': [
-            ['OS!="win" or llvm_version!="0.0"', {
-              'cflags': [
-                '-msse4.2',
-                '-mpclmul',
-              ],
-              'xcode_settings': {
-                'OTHER_CFLAGS': [
-                  '-msse4.2',
-                  '-mpclmul',
-                ],
-              },
-            }]
-          ],
-          'defines': [ 'CRC32_SIMD_SSE42_PCLMUL' ],
-          'include_dirs': [ '<(ZLIB_ROOT)' ],
-          'direct_dependent_settings': {
-            'defines': [ 'CRC32_SIMD_SSE42_PCLMUL' ],
-            'include_dirs': [ '<(ZLIB_ROOT)' ],
-          },
-          'sources': [
-            '<!@pymod_do_main(GN-scraper "<(ZLIB_ROOT)/BUILD.gn" "\\"zlib_crc32_simd\\".*?sources = ")',
-          ],
-        }, # zlib_crc32_simd
+        # {
+        #   'target_name': 'zlib_crc32_simd',
+        #   'type': 'static_library',
+        #   'conditions': [
+        #     ['OS!="win" or llvm_version!="0.0"', {
+        #       'cflags': [
+        #         '-msse4.2',
+        #         '-mpclmul',
+        #       ],
+        #       'xcode_settings': {
+        #         'OTHER_CFLAGS': [
+        #           '-msse4.2',
+        #           '-mpclmul',
+        #         ],
+        #       },
+        #     }]
+        #   ],
+        #   'defines': [ 'CRC32_SIMD_SSE42_PCLMUL' ],
+        #   'include_dirs': [ '<(ZLIB_ROOT)' ],
+        #   'direct_dependent_settings': {
+        #     'defines': [ 'CRC32_SIMD_SSE42_PCLMUL' ],
+        #     'include_dirs': [ '<(ZLIB_ROOT)' ],
+        #   },
+        #   'sources': [
+        #     '<!@pymod_do_main(GN-scraper "<(ZLIB_ROOT)/BUILD.gn" "\\"zlib_crc32_simd\\".*?sources = ")',
+        #   ],
+        # }, # zlib_crc32_simd
         {
           'target_name': 'zlib_inflate_chunk_simd',
           'type': 'static_library',
@@ -208,7 +208,9 @@
             ['target_arch in "ia32 x64" and OS!="ios"', {
               'dependencies': [
                 'zlib_adler32_simd',
-                'zlib_crc32_simd',
+                # Disabled due to memory corruption.
+                # See https://github.com/nodejs/node/issues/45268.
+                # 'zlib_crc32_simd',
               ],
               'defines': [ 'DEFLATE_SLIDE_HASH_SSE2' ],
               'conditions': [