diff --git a/pulsar-broker/src/main/java/org/apache/pulsar/broker/PulsarService.java b/pulsar-broker/src/main/java/org/apache/pulsar/broker/PulsarService.java
index 1934bcca9eceb..84395a0f138a5 100644
--- a/pulsar-broker/src/main/java/org/apache/pulsar/broker/PulsarService.java
+++ b/pulsar-broker/src/main/java/org/apache/pulsar/broker/PulsarService.java
@@ -96,6 +96,7 @@
 import org.apache.pulsar.broker.resourcegroup.ResourceGroupService;
 import org.apache.pulsar.broker.resourcegroup.ResourceUsageTopicTransportManager;
 import org.apache.pulsar.broker.resourcegroup.ResourceUsageTransportManager;
+import org.apache.pulsar.broker.resources.ClusterResources;
 import org.apache.pulsar.broker.resources.PulsarResources;
 import org.apache.pulsar.broker.service.BrokerService;
 import org.apache.pulsar.broker.service.GracefulExecutorServicesShutdown;
@@ -141,6 +142,8 @@
 import org.apache.pulsar.functions.worker.WorkerService;
 import org.apache.pulsar.metadata.api.MetadataStoreConfig;
 import org.apache.pulsar.metadata.api.MetadataStoreException;
+import org.apache.pulsar.metadata.api.Notification;
+import org.apache.pulsar.metadata.api.NotificationType;
 import org.apache.pulsar.metadata.api.coordination.CoordinationService;
 import org.apache.pulsar.metadata.api.coordination.LeaderElectionState;
 import org.apache.pulsar.metadata.api.extended.MetadataStoreExtended;
@@ -603,6 +606,8 @@ public void start() throws PulsarServerException {
             pulsarResources = new PulsarResources(localMetadataStore, configurationMetadataStore,
                     config.getZooKeeperOperationTimeoutSeconds());
 
+            pulsarResources.getClusterResources().getStore().registerListener(this::handleDeleteCluster);
+
             orderedExecutor = OrderedExecutor.newBuilder()
                     .numThreads(config.getNumOrderedExecutorThreads())
                     .name("pulsar-ordered")
@@ -834,6 +839,14 @@ config, localMetadataStore, getZkClient(), bkClientFactory, ioEventLoopGroup
         }
     }
 
+    private void handleDeleteCluster(Notification notification) {
+        if (notification.getPath().startsWith(ClusterResources.CLUSTERS_ROOT)
+                && notification.getType() == NotificationType.Deleted) {
+            final String clusterName = notification.getPath().substring(ClusterResources.CLUSTERS_ROOT.length() + 1);
+            getBrokerService().closeAndRemoveReplicationClient(clusterName);
+        }
+    }
+
     public MetadataStoreExtended createLocalMetadataStore() throws MetadataStoreException {
         return MetadataStoreExtended.create(config.getZookeeperServers(),
                 MetadataStoreConfig.builder()
diff --git a/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/BrokerService.java b/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/BrokerService.java
index 04815d21de81a..110975df19511 100644
--- a/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/BrokerService.java
+++ b/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/BrokerService.java
@@ -637,6 +637,32 @@ public void close() throws IOException {
         }
     }
 
+    public CompletableFuture<Void> closeAndRemoveReplicationClient(String clusterName) {
+        List<CompletableFuture<Void>> futures = new ArrayList<>((int) topics.size());
+        topics.forEach((__, future) -> {
+            CompletableFuture<Void> f = new CompletableFuture<>();
+            futures.add(f);
+            future.whenComplete((ot, ex) -> {
+                if (ot.isPresent()) {
+                    Replicator r = ot.get().getReplicators().get(clusterName);
+                    if (r != null && r.isConnected()) {
+                        r.disconnect(false).whenComplete((v, e) -> f.complete(null));
+                        return;
+                    }
+                }
+                f.complete(null);
+            });
+        });
+
+        return FutureUtil.waitForAll(futures).thenCompose(__ -> {
+            PulsarClient client = replicationClients.remove(clusterName);
+            if (client == null) {
+                return CompletableFuture.completedFuture(null);
+            }
+            return client.closeAsync();
+        });
+    }
+
     public CompletableFuture<Void> closeAsync() {
         try {
             log.info("Shutting down Pulsar Broker service");
diff --git a/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java b/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
index 825d800459677..1d85cb47cce48 100644
--- a/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
+++ b/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
@@ -83,6 +83,7 @@
 import org.apache.pulsar.common.policies.data.BacklogQuota.RetentionPolicy;
 import org.apache.pulsar.common.policies.data.ClusterData;
 import org.apache.pulsar.common.policies.data.ReplicatorStats;
+import org.apache.pulsar.common.policies.data.TenantInfoImpl;
 import org.apache.pulsar.common.protocol.Commands;
 import org.apache.pulsar.common.util.collections.ConcurrentOpenHashMap;
 import org.awaitility.Awaitility;
@@ -1168,6 +1169,55 @@ public void createPartitionedTopicTest() throws Exception {
         checkListContainExpectedTopic(admin3, namespace, expectedTopicList);
     }
 
+    @Test
+    public void testRemoveClusterFromNamespace() throws Exception {
+        final String cluster4 = "r4";
+        admin1.clusters().createCluster(cluster4, ClusterData.builder()
+                .serviceUrl(url3.toString())
+                .serviceUrlTls(urlTls3.toString())
+                .brokerServiceUrl(pulsar3.getSafeBrokerServiceUrl())
+                .brokerServiceUrlTls(pulsar3.getBrokerServiceUrlTls())
+                .build());
+
+        admin1.tenants().createTenant("pulsar1",
+                new TenantInfoImpl(Sets.newHashSet("appid1", "appid2", "appid3"),
+                        Sets.newHashSet("r1", "r3", cluster4)));
+
+        admin1.namespaces().createNamespace("pulsar1/ns1", Sets.newHashSet("r1", "r3", cluster4));
+
+        PulsarClient repClient1 = pulsar1.getBrokerService().getReplicationClient(cluster4);
+        Assert.assertNotNull(repClient1);
+        Assert.assertFalse(repClient1.isClosed());
+
+        PulsarClient client = PulsarClient.builder()
+                .serviceUrl(url1.toString()).statsInterval(0, TimeUnit.SECONDS)
+                .build();
+
+        final String topicName = "persistent://pulsar1/ns1/testRemoveClusterFromNamespace-" + UUID.randomUUID();
+
+        Producer<byte[]> producer = client.newProducer()
+                .topic(topicName)
+                .create();
+
+        producer.send("Pulsar".getBytes());
+
+        producer.close();
+        client.close();
+
+        Replicator replicator = pulsar1.getBrokerService().getTopicReference(topicName)
+                .get().getReplicators().get(cluster4);
+
+        Awaitility.await().untilAsserted(() -> Assert.assertTrue(replicator.isConnected()));
+
+        admin1.clusters().deleteCluster(cluster4);
+
+        Awaitility.await().untilAsserted(() -> Assert.assertFalse(replicator.isConnected()));
+        Awaitility.await().untilAsserted(() -> Assert.assertTrue(repClient1.isClosed()));
+
+        Awaitility.await().untilAsserted(() -> Assert.assertNull(
+                pulsar1.getBrokerService().getReplicationClients().get(cluster4)));
+    }
+
     private void checkListContainExpectedTopic(PulsarAdmin admin, String namespace, List<String> expectedTopicList) {
         // wait non-partitioned topics replicators created finished
         final List<String> list = new ArrayList<>();