diff --git a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/objects/objects.scala b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/objects/objects.scala
index 12e73f2e9fe1a..a644b90a96ff6 100644
--- a/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/objects/objects.scala
+++ b/sql/catalyst/src/main/scala/org/apache/spark/sql/catalyst/expressions/objects/objects.scala
@@ -50,7 +50,8 @@ trait InvokeLike extends Expression with NonSQLExpression with ImplicitCastInput
 
   def propagateNull: Boolean
 
-  override def foldable: Boolean = children.forall(_.foldable) && deterministic
+  override def foldable: Boolean =
+    children.forall(_.foldable) && deterministic && trustedSerializable(dataType)
   protected lazy val needNullCheck: Boolean = needNullCheckForIndex.contains(true)
   protected lazy val needNullCheckForIndex: Array[Boolean] =
     arguments.map(a => a.nullable && (propagateNull ||
@@ -62,6 +63,14 @@ trait InvokeLike extends Expression with NonSQLExpression with ImplicitCastInput
       .map(cls => v => cls.cast(v))
       .getOrElse(identity)
 
+  // Returns true if we can trust all values of the given DataType can be serialized.
+  private def trustedSerializable(dt: DataType): Boolean = {
+    // Right now we conservatively block all ObjectType (Java objects) regardless of
+    // serializability, because the type-level info with java.io.Serializable and
+    // java.io.Externalizable marker interfaces are not strong guarantees.
+    // This restriction can be relaxed in the future to expose more optimizations.
+    !dt.existsRecursively(_.isInstanceOf[ObjectType])
+  }
 
   /**
    * Prepares codes for arguments.
diff --git a/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/optimizer/ConstantFoldingSuite.scala b/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/optimizer/ConstantFoldingSuite.scala
index e6605b496972b..90882da0cab3b 100644
--- a/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/optimizer/ConstantFoldingSuite.scala
+++ b/sql/catalyst/src/test/scala/org/apache/spark/sql/catalyst/optimizer/ConstantFoldingSuite.scala
@@ -336,6 +336,51 @@ class ConstantFoldingSuite extends PlanTest {
     comparePlans(optimized, correctAnswer)
   }
 
+  test("SPARK-40380: InvokeLike should only constant-fold to serializable types") {
+    val serializableObjType = ObjectType(classOf[SerializableBoxedInt])
+    val notSerializableObjType = ObjectType(classOf[NotSerializableBoxedInt])
+
+    val originalQuery =
+      testRelation
+        .select(
+          // SerializableBoxedInt(42).add(1).toNotSerializable().addAsInt($"a")
+          Invoke(
+            Invoke(
+              Invoke(
+                Literal.fromObject(SerializableBoxedInt(42), serializableObjType),
+                "add",
+                serializableObjType,
+                Literal(1) :: Nil
+              ),
+              "toNotSerializable",
+              notSerializableObjType),
+            "addAsInt",
+            IntegerType,
+            $"a" :: Nil).as("c1"))
+
+    val optimized = Optimize.execute(originalQuery.analyze)
+
+    val correctAnswer = originalQuery.analyze
+
+    // If serializable ObjectType is allowed to be constant-folded in the future, this chain can
+    // be optimized into:
+    // val correctAnswer =
+    //   testRelation
+    //     .select(
+    //       // SerializableBoxedInt(43).toNotSerializable().addAsInt($"a")
+    //       Invoke(
+    //         Invoke(
+    //           Literal.fromObject(SerializableBoxedInt(43), serializableObjType),
+    //           "toNotSerializable",
+    //           notSerializableObjType),
+    //         "addAsInt",
+    //         IntegerType,
+    //         $"a" :: Nil).as("c1"))
+    //     .analyze
+
+    comparePlans(optimized, correctAnswer)
+  }
+
   test("SPARK-39106: Correct conditional expression constant folding") {
     val t = LocalRelation.fromExternalRows(
       $"c".double :: Nil,
@@ -371,3 +416,12 @@ class ConstantFoldingSuite extends PlanTest {
     }
   }
 }
+
+case class SerializableBoxedInt(intVal: Int) {
+  def add(other: Int): SerializableBoxedInt = SerializableBoxedInt(intVal + other)
+  def toNotSerializable(): NotSerializableBoxedInt = new NotSerializableBoxedInt(intVal)
+}
+
+class NotSerializableBoxedInt(intVal: Int) {
+  def addAsInt(other: Int): Int = intVal + other
+}