diff --git a/build/crypto.m4 b/build/crypto.m4
index a5d68af3117..ce91ea60e88 100644
--- a/build/crypto.m4
+++ b/build/crypto.m4
@@ -74,7 +74,7 @@ int main() {
   return 1;
 }
   ])],
-  [AC_MSG_RESULT(yes) TS_ADDTO(CPPFLAGS, -DOPENSSL_API_COMPAT=10002)], [AC_MSG_RESULT(no)]
+  [AC_MSG_RESULT(yes) TS_ADDTO(CPPFLAGS, -DOPENSSL_API_COMPAT=10002 -DOPENSSL_IS_OPENSSL3) openssl_is_openssl3=1], [AC_MSG_RESULT(no)]
   )
 ])
 
diff --git a/configure.ac b/configure.ac
index 1ffcc319681..dd5cb62d340 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1253,6 +1253,7 @@ TS_CHECK_CRYPTO_VERSION
 
 # Check for OpenSSL Version 3 and add compatiblity define if needed
 TS_CHECK_OPENSSL3
+AM_CONDITIONAL([OPENSSL_IS_OPENSSL3], [test -n "$openssl_is_openssl3"])
 
 # Check for openssl ASYNC jobs
 TS_CHECK_CRYPTO_ASYNC
diff --git a/include/tscore/HKDF.h b/include/tscore/HKDF.h
index 78ad0f2e753..f405b616447 100644
--- a/include/tscore/HKDF.h
+++ b/include/tscore/HKDF.h
@@ -30,16 +30,25 @@
 #include <openssl/evp.h>
 #endif
 
+#ifdef OPENSSL_IS_OPENSSL3
+#include <openssl/core.h>
+#endif
+
 class HKDF
 {
 public:
-  HKDF(const EVP_MD *digest);
+  HKDF(const char *digest);
   ~HKDF();
   int extract(uint8_t *dst, size_t *dst_len, const uint8_t *salt, size_t salt_len, const uint8_t *ikm, size_t ikm_len);
   int expand(uint8_t *dst, size_t *dst_len, const uint8_t *prk, size_t prk_len, const uint8_t *info, size_t info_len,
              uint16_t length);
 
 protected:
-  const EVP_MD *_digest = nullptr;
-  EVP_PKEY_CTX *_pctx   = nullptr;
+#ifdef OPENSSL_IS_OPENSSL3
+  EVP_KDF_CTX *_kctx = nullptr;
+  OSSL_PARAM params[5];
+#else
+  EVP_PKEY_CTX *_pctx      = nullptr;
+  const EVP_MD *_digest_md = nullptr;
+#endif
 };
diff --git a/iocore/net/quic/QUICHKDF.h b/iocore/net/quic/QUICHKDF.h
index 4bb0ffb003a..6b7a316379e 100644
--- a/iocore/net/quic/QUICHKDF.h
+++ b/iocore/net/quic/QUICHKDF.h
@@ -28,7 +28,7 @@
 class QUICHKDF : public HKDF
 {
 public:
-  QUICHKDF(const EVP_MD *digest) : HKDF(digest) {}
+  QUICHKDF(const char *digest) : HKDF(digest) {}
   int expand(uint8_t *dst, size_t *dst_len, const uint8_t *secret, size_t secret_len, const char *label, size_t label_len,
              uint16_t length);
 };
diff --git a/iocore/net/quic/QUICKeyGenerator.cc b/iocore/net/quic/QUICKeyGenerator.cc
index 7ac32baf653..09ed9eda3ce 100644
--- a/iocore/net/quic/QUICKeyGenerator.cc
+++ b/iocore/net/quic/QUICKeyGenerator.cc
@@ -49,7 +49,7 @@ void
 QUICKeyGenerator::generate(QUICVersion version, uint8_t *hp_key, uint8_t *pp_key, uint8_t *iv, size_t *iv_len, QUICConnectionId cid)
 {
   const EVP_CIPHER *cipher = this->_get_cipher_for_initial();
-  const EVP_MD *md         = EVP_sha256();
+  const char *md           = "SHA256";
   uint8_t secret[512];
   size_t secret_len = sizeof(secret);
   QUICHKDF hkdf(md);
@@ -57,7 +57,7 @@ QUICKeyGenerator::generate(QUICVersion version, uint8_t *hp_key, uint8_t *pp_key
   switch (this->_ctx) {
   case Context::CLIENT:
     this->_generate_initial_secret(version, secret, &secret_len, hkdf, cid, LABEL_FOR_CLIENT_INITIAL_SECRET.data(),
-                                   LABEL_FOR_CLIENT_INITIAL_SECRET.length(), EVP_MD_size(md));
+                                   LABEL_FOR_CLIENT_INITIAL_SECRET.length(), EVP_MD_size(EVP_get_digestbyname(md)));
     if (is_debug_tag_set("vv_quic_crypto")) {
       uint8_t print_buf[1024 + 1];
       QUICDebug::to_hex(print_buf, secret, secret_len);
@@ -67,7 +67,7 @@ QUICKeyGenerator::generate(QUICVersion version, uint8_t *hp_key, uint8_t *pp_key
     break;
   case Context::SERVER:
     this->_generate_initial_secret(version, secret, &secret_len, hkdf, cid, LABEL_FOR_SERVER_INITIAL_SECRET.data(),
-                                   LABEL_FOR_SERVER_INITIAL_SECRET.length(), EVP_MD_size(md));
+                                   LABEL_FOR_SERVER_INITIAL_SECRET.length(), EVP_MD_size(EVP_get_digestbyname(md)));
     if (is_debug_tag_set("vv_quic_crypto")) {
       uint8_t print_buf[1024 + 1];
       QUICDebug::to_hex(print_buf, secret, secret_len);
diff --git a/iocore/net/quic/QUICTLS.h b/iocore/net/quic/QUICTLS.h
index 9a488c4fffe..a1ca8bc6807 100644
--- a/iocore/net/quic/QUICTLS.h
+++ b/iocore/net/quic/QUICTLS.h
@@ -89,7 +89,7 @@ class QUICTLS : public QUICHandshakeProtocol
 private:
   QUICKeyGenerator _keygen_for_client = QUICKeyGenerator(QUICKeyGenerator::Context::CLIENT);
   QUICKeyGenerator _keygen_for_server = QUICKeyGenerator(QUICKeyGenerator::Context::SERVER);
-  const EVP_MD *_get_handshake_digest() const;
+  const char *_get_handshake_digest() const;
 
   int _read_early_data();
   int _write_early_data();
diff --git a/iocore/net/quic/QUICTLS_boringssl.cc b/iocore/net/quic/QUICTLS_boringssl.cc
index 091b186e071..dbd808f66f0 100644
--- a/iocore/net/quic/QUICTLS_boringssl.cc
+++ b/iocore/net/quic/QUICTLS_boringssl.cc
@@ -348,15 +348,15 @@ QUICTLS::_pass_quic_data_to_ssl_impl(const QUICHandshakeMsgs &in)
   }
 }
 
-const EVP_MD *
+const char *
 QUICTLS::_get_handshake_digest() const
 {
   switch (SSL_CIPHER_get_id(SSL_get_current_cipher(this->_ssl))) {
   case TLS1_CK_AES_128_GCM_SHA256:
   case TLS1_CK_CHACHA20_POLY1305_SHA256:
-    return EVP_sha256();
+    return "SHA256";
   case TLS1_CK_AES_256_GCM_SHA384:
-    return EVP_sha384();
+    return "SHA384";
   default:
     ink_assert(false);
     return nullptr;
diff --git a/iocore/net/quic/QUICTLS_openssl.cc b/iocore/net/quic/QUICTLS_openssl.cc
index 5a5d3a9da1d..23bcfcc1087 100644
--- a/iocore/net/quic/QUICTLS_openssl.cc
+++ b/iocore/net/quic/QUICTLS_openssl.cc
@@ -312,7 +312,7 @@ QUICTLS::_pass_quic_data_to_ssl_impl(const QUICHandshakeMsgs &in)
   }
 }
 
-const EVP_MD *
+const char *
 QUICTLS::_get_handshake_digest() const
 {
   switch (SSL_CIPHER_get_id(SSL_get_current_cipher(this->_ssl))) {
@@ -320,9 +320,9 @@ QUICTLS::_get_handshake_digest() const
   case TLS1_3_CK_CHACHA20_POLY1305_SHA256:
   case TLS1_3_CK_AES_128_CCM_SHA256:
   case TLS1_3_CK_AES_128_CCM_8_SHA256:
-    return EVP_sha256();
+    return "SHA256";
   case TLS1_3_CK_AES_256_GCM_SHA384:
-    return EVP_sha384();
+    return "SHA384";
   default:
     ink_assert(false);
     return nullptr;
diff --git a/plugins/experimental/access_control/unit_tests/test_utils.cc b/plugins/experimental/access_control/unit_tests/test_utils.cc
index 5040964aa1f..228f526dcff 100644
--- a/plugins/experimental/access_control/unit_tests/test_utils.cc
+++ b/plugins/experimental/access_control/unit_tests/test_utils.cc
@@ -21,6 +21,7 @@
  * @brief Unit tests for functions used in utils.cc
  */
 
+#include <openssl/opensslv.h>
 #include <catch.hpp> /* catch unit-test framework */
 #include "../utils.h"
 #include "../common.h"
@@ -253,6 +254,13 @@ TEST_CASE("HMAC Digest: test various supported/unsupported types", "[MAC][access
   digests.push_back("ccf3230972bcf229fb3b16741495c74a72bbdd14");
 #endif
 
+#ifdef OPENSSL_IS_OPENSSL3 // MD4, RIPEMD160 are deprecated in OpenSSL 3
+  types.pop_front();
+  digests.pop_front();
+  types.pop_back();
+  digests.pop_back();
+#endif
+
   StringList::iterator digestIter = digests.begin();
   for (String digestType : types) {
     size_t outLen = cryptoMessageDigestGet(digestType.c_str(), data.c_str(), data.length(), key.c_str(), key.length(), out,
diff --git a/src/tscore/HKDF_boringssl.cc b/src/tscore/HKDF_boringssl.cc
index 9fa84cdbdde..7df0bc322a9 100644
--- a/src/tscore/HKDF_boringssl.cc
+++ b/src/tscore/HKDF_boringssl.cc
@@ -22,14 +22,18 @@
  */
 #include "tscore/HKDF.h"
 #include <openssl/hkdf.h>
+#include <openssl/digest.h>
 
-HKDF::HKDF(const EVP_MD *digest) : _digest(digest) {}
+HKDF::HKDF(const char *digest)
+{
+  this->_digest_md = EVP_get_digestbyname(digest);
+}
 HKDF::~HKDF() {}
 
 int
 HKDF::extract(uint8_t *dst, size_t *dst_len, const uint8_t *salt, size_t salt_len, const uint8_t *ikm, size_t ikm_len)
 {
-  return HKDF_extract(dst, dst_len, this->_digest, ikm, ikm_len, salt, salt_len);
+  return HKDF_extract(dst, dst_len, this->_digest_md, ikm, ikm_len, salt, salt_len);
 }
 
 int
@@ -37,5 +41,5 @@ HKDF::expand(uint8_t *dst, size_t *dst_len, const uint8_t *prk, size_t prk_len,
              uint16_t length)
 {
   *dst_len = length;
-  return HKDF_expand(dst, length, this->_digest, prk, prk_len, info, info_len);
+  return HKDF_expand(dst, length, this->_digest_md, prk, prk_len, info, info_len);
 }
diff --git a/src/tscore/HKDF_openssl.cc b/src/tscore/HKDF_openssl.cc
index ac8d69051e1..9c18cb07f86 100644
--- a/src/tscore/HKDF_openssl.cc
+++ b/src/tscore/HKDF_openssl.cc
@@ -23,8 +23,9 @@
 #include "tscore/HKDF.h"
 #include <openssl/kdf.h>
 
-HKDF::HKDF(const EVP_MD *digest) : _digest(digest)
+HKDF::HKDF(const char *digest)
 {
+  this->_digest_md = EVP_get_digestbyname(digest);
   // XXX We cannot reuse pctx now due to a bug in OpenSSL
   // this->_pctx = EVP_PKEY_CTX_new_id(EVP_PKEY_HKDF, nullptr);
 }
@@ -51,7 +52,7 @@ HKDF::extract(uint8_t *dst, size_t *dst_len, const uint8_t *salt, size_t salt_le
   if (EVP_PKEY_CTX_hkdf_mode(this->_pctx, EVP_PKEY_HKDEF_MODE_EXTRACT_ONLY) != 1) {
     return -2;
   }
-  if (EVP_PKEY_CTX_set_hkdf_md(this->_pctx, this->_digest) != 1) {
+  if (EVP_PKEY_CTX_set_hkdf_md(this->_pctx, this->_digest_md) != 1) {
     return -3;
   }
   if (EVP_PKEY_CTX_set1_hkdf_salt(this->_pctx, salt, salt_len) != 1) {
@@ -84,7 +85,7 @@ HKDF::expand(uint8_t *dst, size_t *dst_len, const uint8_t *prk, size_t prk_len,
   if (EVP_PKEY_CTX_hkdf_mode(this->_pctx, EVP_PKEY_HKDEF_MODE_EXPAND_ONLY) != 1) {
     return -2;
   }
-  if (EVP_PKEY_CTX_set_hkdf_md(this->_pctx, this->_digest) != 1) {
+  if (EVP_PKEY_CTX_set_hkdf_md(this->_pctx, this->_digest_md) != 1) {
     return -3;
   }
   if (EVP_PKEY_CTX_set1_hkdf_key(this->_pctx, prk, prk_len) != 1) {
diff --git a/src/tscore/HKDF_openssl3.cc b/src/tscore/HKDF_openssl3.cc
new file mode 100644
index 00000000000..30c190dc804
--- /dev/null
+++ b/src/tscore/HKDF_openssl3.cc
@@ -0,0 +1,85 @@
+/** @file
+ *
+ *  HKDF utility (OpenSSL version)
+ *
+ *  @section license License
+ *
+ *  Licensed to the Apache Software Foundation (ASF) under one
+ *  or more contributor license agreements.  See the NOTICE file
+ *  distributed with this work for additional information
+ *  regarding copyright ownership.  The ASF licenses this file
+ *  to you under the Apache License, Version 2.0 (the
+ *  "License"); you may not use this file except in compliance
+ *  with the License.  You may obtain a copy of the License at
+ *
+ *      http://www.apache.org/licenses/LICENSE-2.0
+ *
+ *  Unless required by applicable law or agreed to in writing, software
+ *  distributed under the License is distributed on an "AS IS" BASIS,
+ *  WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ *  See the License for the specific language governing permissions and
+ *  limitations under the License.
+ */
+#include "tscore/HKDF.h"
+#include <openssl/kdf.h>
+#include <cstring>
+#include <openssl/core_names.h>
+
+HKDF::HKDF(const char *digest)
+{
+  EVP_KDF *kdf = EVP_KDF_fetch(NULL, "HKDF", NULL);
+  this->_kctx  = EVP_KDF_CTX_new(kdf);
+  EVP_KDF_free(kdf);
+  *params = OSSL_PARAM_construct_utf8_string(OSSL_KDF_PARAM_DIGEST, (char *)digest, strlen(digest));
+}
+
+HKDF::~HKDF()
+{
+  EVP_KDF_CTX_free(this->_kctx);
+  this->_kctx = nullptr;
+}
+
+int
+HKDF::extract(uint8_t *dst, size_t *dst_len, const uint8_t *salt, size_t salt_len, const uint8_t *ikm, size_t ikm_len)
+{
+  size_t keysize;
+  int mode      = EVP_KDF_HKDF_MODE_EXTRACT_ONLY;
+  OSSL_PARAM *p = params + 1;
+  *p++          = OSSL_PARAM_construct_octet_string(OSSL_KDF_PARAM_KEY, (uint8_t *)ikm, ikm_len);
+  *p++          = OSSL_PARAM_construct_octet_string(OSSL_KDF_PARAM_SALT, (uint8_t *)salt, salt_len);
+  *p++          = OSSL_PARAM_construct_int(OSSL_KDF_PARAM_MODE, &mode);
+  *p            = OSSL_PARAM_construct_end();
+
+  EVP_KDF_CTX_set_params(_kctx, params);
+  keysize = EVP_KDF_CTX_get_kdf_size(this->_kctx);
+  if (*dst_len < keysize) {
+    return -1;
+  }
+  if (EVP_KDF_derive(_kctx, dst, keysize, params) <= 0) {
+    EVP_KDF_CTX_reset(this->_kctx);
+    return -2;
+  }
+  *dst_len = keysize;
+  EVP_KDF_CTX_reset(this->_kctx);
+
+  return 1;
+}
+
+int
+HKDF::expand(uint8_t *dst, size_t *dst_len, const uint8_t *prk, size_t prk_len, const uint8_t *info, size_t info_len,
+             uint16_t length)
+{
+  int mode      = EVP_KDF_HKDF_MODE_EXPAND_ONLY;
+  OSSL_PARAM *p = params + 1;
+  *p++          = OSSL_PARAM_construct_octet_string(OSSL_KDF_PARAM_KEY, (uint8_t *)prk, prk_len);
+  *p++          = OSSL_PARAM_construct_octet_string(OSSL_KDF_PARAM_INFO, (uint8_t *)info, info_len);
+  *p++          = OSSL_PARAM_construct_int(OSSL_KDF_PARAM_MODE, &mode);
+  *p            = OSSL_PARAM_construct_end();
+  if (EVP_KDF_derive(_kctx, dst, length, params) <= 0) {
+    return -1;
+  }
+  *dst_len = length;
+  EVP_KDF_CTX_reset(this->_kctx);
+
+  return 1;
+}
diff --git a/src/tscore/Makefile.am b/src/tscore/Makefile.am
index 80fbb8f7785..e96104f7fa8 100644
--- a/src/tscore/Makefile.am
+++ b/src/tscore/Makefile.am
@@ -130,8 +130,12 @@ if HAS_HKDF
 if OPENSSL_IS_BORINGSSL
 HKDF_impl = HKDF_boringssl.cc
 else
+if OPENSSL_IS_OPENSSL3
+HKDF_impl = HKDF_openssl3.cc
+else
 HKDF_impl = HKDF_openssl.cc
 endif
+endif
 libtscore_la_SOURCES += \
   $(HKDF_impl)
 endif
diff --git a/src/tscore/unit_tests/test_HKDF.cc b/src/tscore/unit_tests/test_HKDF.cc
index 59d2a3540c3..2c6404b578a 100644
--- a/src/tscore/unit_tests/test_HKDF.cc
+++ b/src/tscore/unit_tests/test_HKDF.cc
@@ -54,7 +54,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha256());
+    HKDF hkdf("SHA256");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -104,7 +104,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha256());
+    HKDF hkdf("SHA256");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -140,7 +140,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha256());
+    HKDF hkdf("SHA256");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -178,7 +178,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha1());
+    HKDF hkdf("SHA1");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -226,7 +226,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha1());
+    HKDF hkdf("SHA1");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -261,7 +261,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha1());
+    HKDF hkdf("SHA1");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);
@@ -296,7 +296,7 @@ TEST_CASE("HKDF tests", "[hkdf]")
     uint8_t okm[256] = {0};
     size_t okm_len   = sizeof(okm);
 
-    HKDF hkdf(EVP_sha1());
+    HKDF hkdf("SHA1");
 
     // Extract
     CHECK(hkdf.extract(prk, &prk_len, salt, sizeof(salt), ikm, sizeof(ikm)) == 1);