diff --git a/crates/ruff_linter/resources/test/fixtures/perflint/PERF101.py b/crates/ruff_linter/resources/test/fixtures/perflint/PERF101.py
index 6123e6d6526bf..fbef6a7b2a709 100644
--- a/crates/ruff_linter/resources/test/fixtures/perflint/PERF101.py
+++ b/crates/ruff_linter/resources/test/fixtures/perflint/PERF101.py
@@ -50,3 +50,16 @@
 
 for i in itertools.product(foo_int):  # Ok
     pass
+
+for i in list(foo_list):  # Ok
+    foo_list.append(i + 1)
+
+for i in list(foo_list):  # PERF101
+    # Make sure we match the correct list
+    other_list.append(i + 1)
+
+for i in list(foo_tuple):  # Ok
+    foo_tuple.append(i + 1)
+
+for i in list(foo_set):  # Ok
+    foo_set.append(i + 1)
diff --git a/crates/ruff_linter/src/checkers/ast/analyze/statement.rs b/crates/ruff_linter/src/checkers/ast/analyze/statement.rs
index 0ad8dc16e5777..48343b3825c7c 100644
--- a/crates/ruff_linter/src/checkers/ast/analyze/statement.rs
+++ b/crates/ruff_linter/src/checkers/ast/analyze/statement.rs
@@ -1269,7 +1269,7 @@ pub(crate) fn statement(stmt: &Stmt, checker: &mut Checker) {
                 perflint::rules::manual_dict_comprehension(checker, target, body);
             }
             if checker.enabled(Rule::UnnecessaryListCast) {
-                perflint::rules::unnecessary_list_cast(checker, iter);
+                perflint::rules::unnecessary_list_cast(checker, iter, body);
             }
             if !is_async {
                 if checker.enabled(Rule::ReimplementedBuiltin) {
diff --git a/crates/ruff_linter/src/rules/perflint/rules/unnecessary_list_cast.rs b/crates/ruff_linter/src/rules/perflint/rules/unnecessary_list_cast.rs
index 9769eed8d71e3..93321cf6b070c 100644
--- a/crates/ruff_linter/src/rules/perflint/rules/unnecessary_list_cast.rs
+++ b/crates/ruff_linter/src/rules/perflint/rules/unnecessary_list_cast.rs
@@ -49,7 +49,7 @@ impl AlwaysFixableViolation for UnnecessaryListCast {
 }
 
 /// PERF101
-pub(crate) fn unnecessary_list_cast(checker: &mut Checker, iter: &Expr) {
+pub(crate) fn unnecessary_list_cast(checker: &mut Checker, iter: &Expr, body: &[Stmt]) {
     let Expr::Call(ast::ExprCall {
         func,
         arguments:
@@ -98,6 +98,18 @@ pub(crate) fn unnecessary_list_cast(checker: &mut Checker, iter: &Expr) {
             range: iterable_range,
             ..
         }) => {
+            // If the variable is being appended to, don't suggest removing the cast:
+            //
+            // ```python
+            // items = ["foo", "bar"]
+            // for item in list(items):
+            //    items.append("baz")
+            // ```
+            //
+            // Here, removing the `list()` cast would change the behavior of the code.
+            if body.iter().any(|stmt| match_append(stmt, id)) {
+                return;
+            }
             let scope = checker.semantic().current_scope();
             if let Some(binding_id) = scope.get(id) {
                 let binding = checker.semantic().binding(binding_id);
@@ -128,6 +140,28 @@ pub(crate) fn unnecessary_list_cast(checker: &mut Checker, iter: &Expr) {
     }
 }
 
+/// Check if a statement is an `append` call to a given identifier.
+///
+/// For example, `foo.append(bar)` would return `true` if `id` is `foo`.
+fn match_append(stmt: &Stmt, id: &str) -> bool {
+    let Some(ast::StmtExpr { value, .. }) = stmt.as_expr_stmt() else {
+        return false;
+    };
+    let Some(ast::ExprCall { func, .. }) = value.as_call_expr() else {
+        return false;
+    };
+    let Some(ast::ExprAttribute { value, attr, .. }) = func.as_attribute_expr() else {
+        return false;
+    };
+    if attr != "append" {
+        return false;
+    }
+    let Some(ast::ExprName { id: target_id, .. }) = value.as_name_expr() else {
+        return false;
+    };
+    target_id == id
+}
+
 /// Generate a [`Fix`] to remove a `list` cast from an expression.
 fn remove_cast(list_range: TextRange, iterable_range: TextRange) -> Fix {
     Fix::safe_edits(
diff --git a/crates/ruff_linter/src/rules/perflint/snapshots/ruff_linter__rules__perflint__tests__PERF101_PERF101.py.snap b/crates/ruff_linter/src/rules/perflint/snapshots/ruff_linter__rules__perflint__tests__PERF101_PERF101.py.snap
index 645b5e5177784..1b4b456af3f15 100644
--- a/crates/ruff_linter/src/rules/perflint/snapshots/ruff_linter__rules__perflint__tests__PERF101_PERF101.py.snap
+++ b/crates/ruff_linter/src/rules/perflint/snapshots/ruff_linter__rules__perflint__tests__PERF101_PERF101.py.snap
@@ -180,4 +180,25 @@ PERF101.py:34:10: PERF101 [*] Do not cast an iterable to `list` before iterating
 38 36 | 
 39 37 | for i in list(foo_dict):  # Ok
 
+PERF101.py:57:10: PERF101 [*] Do not cast an iterable to `list` before iterating over it
+   |
+55 |     foo_list.append(i + 1)
+56 | 
+57 | for i in list(foo_list):  # PERF101
+   |          ^^^^^^^^^^^^^^ PERF101
+58 |     # Make sure we match the correct list
+59 |     other_list.append(i + 1)
+   |
+   = help: Remove `list()` cast
+
+ℹ Safe fix
+54 54 | for i in list(foo_list):  # Ok
+55 55 |     foo_list.append(i + 1)
+56 56 | 
+57    |-for i in list(foo_list):  # PERF101
+   57 |+for i in foo_list:  # PERF101
+58 58 |     # Make sure we match the correct list
+59 59 |     other_list.append(i + 1)
+60 60 | 
+