diff --git a/packages/@aws-cdk/aws-route53-targets/README.md b/packages/@aws-cdk/aws-route53-targets/README.md
index 3bd36f68ba46f..06d7dd6568255 100644
--- a/packages/@aws-cdk/aws-route53-targets/README.md
+++ b/packages/@aws-cdk/aws-route53-targets/README.md
@@ -16,6 +16,13 @@ This library contains Route53 Alias Record targets for:
     // or - route53.RecordTarget.fromAlias(new alias.ApiGatewayDomain(domainName)),
   });
   ```
+* API Gateway V2 custom domains
+  ```ts
+  new route53.ARecord(this, 'AliasRecord', {
+    zone,
+    target: route53.RecordTarget.fromAlias(new alias.ApiGatewayv2Domain(domainName)),
+  });
+  ```
 * CloudFront distributions
   ```ts
   new route53.ARecord(this, 'AliasRecord', {
@@ -55,17 +62,17 @@ For example, if the Amazon-provided DNS for the load balancer is `ALB-xxxxxxx.us
   ```
 * S3 Bucket Website:
 
-**Important:** The Bucket name must strictly match the full DNS name. 
-See [the Developer Guide](https://docs.aws.amazon.com/Route53/latest/DeveloperGuide/getting-started.html) for more info. 
+**Important:** The Bucket name must strictly match the full DNS name.
+See [the Developer Guide](https://docs.aws.amazon.com/Route53/latest/DeveloperGuide/getting-started.html) for more info.
   ```ts
   const [recordName, domainName] = ['www', 'example.com'];
-  
+
   const bucketWebsite = new Bucket(this, 'BucketWebsite', {
     bucketName: [recordName, domainName].join('.'), // www.example.com
     publicReadAccess: true,
     websiteIndexDocument: 'index.html',
   });
-  
+
   const zone = HostedZone.fromLookup(this, 'Zone', {domainName}); // example.com
 
   new route53.ARecord(this, 'AliasRecord', {
diff --git a/packages/@aws-cdk/aws-route53-targets/lib/api-gateway-domain-name.ts b/packages/@aws-cdk/aws-route53-targets/lib/api-gateway-domain-name.ts
index 3668a4858ac59..5aa40d5a52f10 100644
--- a/packages/@aws-cdk/aws-route53-targets/lib/api-gateway-domain-name.ts
+++ b/packages/@aws-cdk/aws-route53-targets/lib/api-gateway-domain-name.ts
@@ -5,7 +5,7 @@ import * as route53 from '@aws-cdk/aws-route53';
  * Defines an API Gateway domain name as the alias target.
  *
  * Use the `ApiGateway` class if you wish to map the alias to an REST API with a
- * domain name defined throug the `RestApiProps.domainName` prop.
+ * domain name defined through the `RestApiProps.domainName` prop.
  */
 export class ApiGatewayDomain implements route53.IAliasRecordTarget {
   constructor(private readonly domainName: apig.IDomainName) { }
diff --git a/packages/@aws-cdk/aws-route53-targets/lib/api-gatewayv2-domain-name.ts b/packages/@aws-cdk/aws-route53-targets/lib/api-gatewayv2-domain-name.ts
new file mode 100644
index 0000000000000..b78078fca525a
--- /dev/null
+++ b/packages/@aws-cdk/aws-route53-targets/lib/api-gatewayv2-domain-name.ts
@@ -0,0 +1,16 @@
+import * as apigv2 from '@aws-cdk/aws-apigatewayv2';
+import * as route53 from '@aws-cdk/aws-route53';
+
+/**
+ * Defines an API Gateway V2 domain name as the alias target.
+ */
+export class ApiGatewayv2Domain implements route53.IAliasRecordTarget {
+  constructor(private readonly domainName: apigv2.IDomainName) { }
+
+  public bind(_record: route53.IRecordSet): route53.AliasRecordTargetConfig {
+    return {
+      dnsName: this.domainName.regionalDomainName,
+      hostedZoneId: this.domainName.regionalHostedZoneId,
+    };
+  }
+}
diff --git a/packages/@aws-cdk/aws-route53-targets/lib/index.ts b/packages/@aws-cdk/aws-route53-targets/lib/index.ts
index 6df1bd67d6037..af574aa599519 100644
--- a/packages/@aws-cdk/aws-route53-targets/lib/index.ts
+++ b/packages/@aws-cdk/aws-route53-targets/lib/index.ts
@@ -1,4 +1,5 @@
 export * from './api-gateway-domain-name';
+export * from './api-gatewayv2-domain-name';
 export * from './bucket-website-target';
 export * from './classic-load-balancer-target';
 export * from './cloudfront-target';
diff --git a/packages/@aws-cdk/aws-route53-targets/package.json b/packages/@aws-cdk/aws-route53-targets/package.json
index 1d069b61487a8..3d34a41c6fcfa 100644
--- a/packages/@aws-cdk/aws-route53-targets/package.json
+++ b/packages/@aws-cdk/aws-route53-targets/package.json
@@ -74,6 +74,7 @@
   },
   "dependencies": {
     "@aws-cdk/aws-apigateway": "0.0.0",
+    "@aws-cdk/aws-apigatewayv2": "0.0.0",
     "@aws-cdk/aws-cloudfront": "0.0.0",
     "@aws-cdk/aws-cognito": "0.0.0",
     "@aws-cdk/aws-ec2": "0.0.0",
@@ -89,6 +90,7 @@
   "homepage": "https://github.com/aws/aws-cdk",
   "peerDependencies": {
     "@aws-cdk/aws-apigateway": "0.0.0",
+    "@aws-cdk/aws-apigatewayv2": "0.0.0",
     "@aws-cdk/aws-cloudfront": "0.0.0",
     "@aws-cdk/aws-cognito": "0.0.0",
     "@aws-cdk/aws-ec2": "0.0.0",
diff --git a/packages/@aws-cdk/aws-route53-targets/test/apigatewayv2-target.test.ts b/packages/@aws-cdk/aws-route53-targets/test/apigatewayv2-target.test.ts
new file mode 100644
index 0000000000000..66a504f630157
--- /dev/null
+++ b/packages/@aws-cdk/aws-route53-targets/test/apigatewayv2-target.test.ts
@@ -0,0 +1,49 @@
+import { expect as expectStack, haveResource } from '@aws-cdk/assert';
+import * as apigwv2 from '@aws-cdk/aws-apigatewayv2';
+import * as acm from '@aws-cdk/aws-certificatemanager';
+import * as route53 from '@aws-cdk/aws-route53';
+import { Stack } from '@aws-cdk/core';
+import * as targets from '../lib';
+
+test('targets.ApiGatewayv2Domain can be used to directly reference a domain', () => {
+  // GIVEN
+  const stack = new Stack();
+  const domainName = 'example.com';
+  const cert = new acm.Certificate(stack, 'cert', { domainName });
+  const dn = new apigwv2.DomainName(stack, 'DN', {
+    domainName,
+    certificate: cert,
+  });
+  const zone = new route53.HostedZone(stack, 'zone', {
+    zoneName: 'example.com',
+  });
+
+  // WHEN
+  new route53.ARecord(stack, 'A', {
+    zone,
+    target: route53.RecordTarget.fromAlias(new targets.ApiGatewayv2Domain(dn)),
+  });
+
+  // THEN
+  expectStack(stack).to(haveResource('AWS::Route53::RecordSet', {
+    Name: 'example.com.',
+    Type: 'A',
+    AliasTarget: {
+      DNSName: {
+        'Fn::GetAtt': [
+          'DNFDC76583',
+          'RegionalDomainName',
+        ],
+      },
+      HostedZoneId: {
+        'Fn::GetAtt': [
+          'DNFDC76583',
+          'RegionalHostedZoneId',
+        ],
+      },
+    },
+    HostedZoneId: {
+      Ref: 'zoneEB40FF1E',
+    },
+  }));
+});
diff --git a/packages/@aws-cdk/aws-route53-targets/test/integ.api-gatewayv2-domain-name.expected.json b/packages/@aws-cdk/aws-route53-targets/test/integ.api-gatewayv2-domain-name.expected.json
new file mode 100644
index 0000000000000..c65606784a1ac
--- /dev/null
+++ b/packages/@aws-cdk/aws-route53-targets/test/integ.api-gatewayv2-domain-name.expected.json
@@ -0,0 +1,47 @@
+{
+  "Resources": {
+    "DNFDC76583": {
+      "Type": "AWS::ApiGatewayV2::DomainName",
+      "Properties": {
+        "DomainName": "example.com",
+        "DomainNameConfigurations": [
+          {
+            "CertificateArn": "arn:aws:acm:us-east-1:111111111111:certificate",
+            "EndpointType": "REGIONAL"
+          }
+        ]
+      }
+    },
+    "zoneEB40FF1E": {
+      "Type": "AWS::Route53::HostedZone",
+      "Properties": {
+        "Name": "example.com."
+      }
+    },
+    "ACCC8ACD5": {
+      "Type": "AWS::Route53::RecordSet",
+      "Properties": {
+        "Name": "example.com.",
+        "Type": "A",
+        "AliasTarget": {
+          "DNSName": {
+            "Fn::GetAtt": [
+              "DNFDC76583",
+              "RegionalDomainName"
+            ]
+          },
+          "HostedZoneId": {
+            "Fn::GetAtt": [
+              "DNFDC76583",
+              "RegionalHostedZoneId"
+            ]
+          }
+        },
+        "HostedZoneId": {
+          "Ref": "zoneEB40FF1E"
+        }
+      }
+    }
+  },
+  "Outputs": {}
+}