diff --git a/packages/@aws-cdk/aws-dynamodb/lib/replica-handler/index.ts b/packages/@aws-cdk/aws-dynamodb/lib/replica-handler/index.ts
index 1554dcc84004d..38109b1a4a614 100644
--- a/packages/@aws-cdk/aws-dynamodb/lib/replica-handler/index.ts
+++ b/packages/@aws-cdk/aws-dynamodb/lib/replica-handler/index.ts
@@ -49,12 +49,13 @@ export async function isCompleteHandler(event: IsCompleteRequest): Promise<IsCom
   const replicas = data.Table?.Replicas ?? [];
   const regionReplica = replicas.find(r => r.RegionName === event.ResourceProperties.Region);
   const replicaActive = !!(regionReplica?.ReplicaStatus === 'ACTIVE');
+  const skipReplicationCompletedWait = event.ResourceProperties.SkipReplicationCompletedWait ?? false;
 
   switch (event.RequestType) {
     case 'Create':
     case 'Update':
       // Complete when replica is reported as ACTIVE
-      return { IsComplete: tableActive && replicaActive };
+      return { IsComplete: tableActive && (replicaActive || skipReplicationCompletedWait) };
     case 'Delete':
       // Complete when replica is gone
       return { IsComplete: tableActive && regionReplica === undefined };
diff --git a/packages/@aws-cdk/aws-dynamodb/lib/table.ts b/packages/@aws-cdk/aws-dynamodb/lib/table.ts
index a2b1aae5ee2eb..10a7472be3c0d 100644
--- a/packages/@aws-cdk/aws-dynamodb/lib/table.ts
+++ b/packages/@aws-cdk/aws-dynamodb/lib/table.ts
@@ -231,6 +231,22 @@ export interface TableOptions extends SchemaOptions {
    */
   readonly replicationTimeout?: Duration;
 
+  /**
+   * Indicates whether CloudFormation stack waits for replication to finish.
+   * If set to false, the CloudFormation resource will mark the resource as
+   * created and replication will be completed asynchronously. This property is
+   * ignored if replicationRegions property is not set.
+   *
+   * DO NOT UNSET this property if adding/removing multiple replicationRegions
+   * in one deployment, as CloudFormation only supports one region replication
+   * at a time. CDK overcomes this limitation by waiting for replication to
+   * finish before starting new replicationRegion.
+   *
+   * @see https://docs.aws.amazon.com/AWSCloudFormation/latest/UserGuide/aws-resource-dynamodb-globaltable.html#cfn-dynamodb-globaltable-replicas
+   * @default true
+   */
+  readonly waitForReplicationToFinish?: boolean;
+
   /**
    * Whether CloudWatch contributor insights is enabled.
    *
@@ -1152,7 +1168,7 @@ export class Table extends TableBase {
     }
 
     if (props.replicationRegions && props.replicationRegions.length > 0) {
-      this.createReplicaTables(props.replicationRegions, props.replicationTimeout);
+      this.createReplicaTables(props.replicationRegions, props.replicationTimeout, props.waitForReplicationToFinish);
     }
   }
 
@@ -1494,7 +1510,7 @@ export class Table extends TableBase {
    *
    * @param regions regions where to create tables
    */
-  private createReplicaTables(regions: string[], timeout?: Duration) {
+  private createReplicaTables(regions: string[], timeout?: Duration, waitForReplicationToFinish?: boolean) {
     const stack = Stack.of(this);
 
     if (!Token.isUnresolved(stack.region) && regions.includes(stack.region)) {
@@ -1524,6 +1540,7 @@ export class Table extends TableBase {
         properties: {
           TableName: this.tableName,
           Region: region,
+          SkipReplicationCompletedWait: waitForReplicationToFinish === undefined ? undefined : !waitForReplicationToFinish,
         },
       });
       currentRegion.node.addDependency(
diff --git a/packages/@aws-cdk/aws-dynamodb/test/dynamodb.test.ts b/packages/@aws-cdk/aws-dynamodb/test/dynamodb.test.ts
index 56ab48f19f501..a095bff84ca25 100644
--- a/packages/@aws-cdk/aws-dynamodb/test/dynamodb.test.ts
+++ b/packages/@aws-cdk/aws-dynamodb/test/dynamodb.test.ts
@@ -2438,6 +2438,60 @@ describe('global', () => {
     });
   });
 
+  test('create replicas without waiting to finish replication', () => {
+    // GIVEN
+    const stack = new Stack();
+
+    // WHEN
+    new Table(stack, 'Table', {
+      partitionKey: {
+        name: 'id',
+        type: AttributeType.STRING,
+      },
+      replicationRegions: [
+        'eu-west-2',
+        'eu-central-1',
+      ],
+      waitForReplicationToFinish: false,
+    });
+
+    // THEN
+    expect(stack).toHaveResource('Custom::DynamoDBReplica', {
+      Properties: {
+        TableName: {
+          Ref: 'TableCD117FA1',
+        },
+        Region: 'eu-west-2',
+        SkipReplicationCompletedWait: true,
+      },
+      Condition: 'TableStackRegionNotEqualseuwest2A03859E7',
+    }, ResourcePart.CompleteDefinition);
+
+    expect(stack).toHaveResource('Custom::DynamoDBReplica', {
+      Properties: {
+        TableName: {
+          Ref: 'TableCD117FA1',
+        },
+        Region: 'eu-central-1',
+        SkipReplicationCompletedWait: true,
+      },
+      Condition: 'TableStackRegionNotEqualseucentral199D46FC0',
+    }, ResourcePart.CompleteDefinition);
+
+    expect(SynthUtils.toCloudFormation(stack).Conditions).toEqual({
+      TableStackRegionNotEqualseuwest2A03859E7: {
+        'Fn::Not': [
+          { 'Fn::Equals': ['eu-west-2', { Ref: 'AWS::Region' }] },
+        ],
+      },
+      TableStackRegionNotEqualseucentral199D46FC0: {
+        'Fn::Not': [
+          { 'Fn::Equals': ['eu-central-1', { Ref: 'AWS::Region' }] },
+        ],
+      },
+    });
+  });
+
   test('grantReadData', () => {
     const stack = new Stack();
     const table = new Table(stack, 'Table', {