diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index fd602e43..1e4b78b4 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -2,6 +2,19 @@
 Changelog
 *********
 
+2.1.1 -- 2022-12-19
+===================
+
+Deprecation Announcement
+------------------------
+The AWS DynamoDB Encryption Client for Python Major Version 2 is End of Support.
+It will no longer receive security updates or bug fixes.
+Consider updating to the latest version of the AWS DynamoDB Encryption Client for Python.
+
+Maintenance
+------------------------
+* Emit Deprecation Warning on library initialization
+
 2.1.0 -- 2021-07-15
 ===================
 
diff --git a/SUPPORT_POLICY.rst b/SUPPORT_POLICY.rst
index 26667e42..2f779801 100644
--- a/SUPPORT_POLICY.rst
+++ b/SUPPORT_POLICY.rst
@@ -22,16 +22,13 @@ This table describes the current support status of each major version of the AWS
       - Next status
       - Next status date
     * - 1.x
-      - Maintenance
       - End of Support
-      - 2022-07-08
     * - 2.x
-      - Generally Available
-      - Maintenance
-      - 2021-07-13
+      - End of Support
+      -
+      -
     * - 3.x
       -
       - Generally Available
-      - 2021-07-13
 
 .. _AWS SDKs and Tools Maintenance Policy: https://docs.aws.amazon.com/sdkref/latest/guide/maint-policy.html#version-life-cycle
diff --git a/ci-requirements.txt b/ci-requirements.txt
index 053148f8..87aaac6e 100644
--- a/ci-requirements.txt
+++ b/ci-requirements.txt
@@ -1 +1 @@
-tox
+tox < 4.0
diff --git a/codebuild/coverage/coverage.yml b/codebuild/coverage/coverage.yml
index f82a3a98..51d8b0a6 100644
--- a/codebuild/coverage/coverage.yml
+++ b/codebuild/coverage/coverage.yml
@@ -10,5 +10,5 @@ phases:
       python: latest
   build:
     commands:
-      - pip install tox
+      - pip install "tox < 4.0"
       - tox
diff --git a/codebuild/python3.7.yml b/codebuild/python3.7.yml
index 1ac0daa6..dcb6b944 100644
--- a/codebuild/python3.7.yml
+++ b/codebuild/python3.7.yml
@@ -28,5 +28,5 @@ phases:
       # The choice of versions should be reviewed.
       - pyenv install 3.7.9
       - pyenv local 3.7.9
-      - pip install tox tox-pyenv
+      - pip install "tox < 4.0"
       - tox
diff --git a/codebuild/python3.8.yml b/codebuild/python3.8.yml
index c0170f2a..cc7a821d 100644
--- a/codebuild/python3.8.yml
+++ b/codebuild/python3.8.yml
@@ -16,5 +16,5 @@ phases:
     commands:
       - pyenv install 3.8.12
       - pyenv local 3.8.12
-      - pip install tox tox-pyenv
+      - pip install "tox < 4.0"
       - tox
diff --git a/codebuild/python3.9.yml b/codebuild/python3.9.yml
index 62868c80..f8ed9616 100644
--- a/codebuild/python3.9.yml
+++ b/codebuild/python3.9.yml
@@ -16,5 +16,5 @@ phases:
     commands:
       - pyenv install 3.9.0
       - pyenv local 3.9.0
-      - pip install tox tox-pyenv
+      - pip install "tox < 4.0"
       - tox
diff --git a/codebuild/release/prod-release.yml b/codebuild/release/prod-release.yml
index c729c96c..c8639c61 100644
--- a/codebuild/release/prod-release.yml
+++ b/codebuild/release/prod-release.yml
@@ -10,7 +10,7 @@ env:
 phases:
   install:
     commands:
-      - pip install tox
+      - pip install "tox < 4.0"
       - pip install --upgrade pip
     runtime-versions:
       python: latest
diff --git a/codebuild/release/test-release.yml b/codebuild/release/test-release.yml
index 1dc9feae..9d8fbed2 100644
--- a/codebuild/release/test-release.yml
+++ b/codebuild/release/test-release.yml
@@ -10,7 +10,7 @@ env:
 phases:
   install:
     commands:
-      - pip install tox
+      - pip install "tox < 4.0"
       - pip install --upgrade pip
     runtime-versions:
       python: latest
diff --git a/codebuild/release/validate.yml b/codebuild/release/validate.yml
index eacf49ae..e72def0c 100644
--- a/codebuild/release/validate.yml
+++ b/codebuild/release/validate.yml
@@ -15,7 +15,7 @@ env:
 phases:
   install:
     commands:
-      - pip install tox
+      - pip install "tox < 4.0"
     runtime-versions:
       python: latest
   pre_build:
diff --git a/src/dynamodb_encryption_sdk/__init__.py b/src/dynamodb_encryption_sdk/__init__.py
index 7b5dba80..cc47c5c9 100644
--- a/src/dynamodb_encryption_sdk/__init__.py
+++ b/src/dynamodb_encryption_sdk/__init__.py
@@ -11,6 +11,8 @@
 # ANY KIND, either express or implied. See the License for the specific
 # language governing permissions and limitations under the License.
 """DynamoDB Encryption Client."""
+import warnings
+
 from dynamodb_encryption_sdk.encrypted.client import EncryptedClient
 from dynamodb_encryption_sdk.encrypted.item import (
     decrypt_dynamodb_item,
@@ -32,3 +34,10 @@
     "EncryptedTable",
     "__version__",
 )
+
+warnings.warn(
+    "This major version (2.x) of the AWS Encryption SDK for Python has reached End-of-Support.\n"
+    + "It will no longer receive security updates or bug fixes.\n"
+    + "Consider updating to the latest version of the AWS Encryption SDK.",
+    DeprecationWarning,
+)
diff --git a/src/dynamodb_encryption_sdk/identifiers.py b/src/dynamodb_encryption_sdk/identifiers.py
index e7a0fcfd..61cc9568 100644
--- a/src/dynamodb_encryption_sdk/identifiers.py
+++ b/src/dynamodb_encryption_sdk/identifiers.py
@@ -14,7 +14,7 @@
 from enum import Enum
 
 __all__ = ("LOGGER_NAME", "CryptoAction", "EncryptionKeyType", "KeyEncodingType")
-__version__ = "2.1.0"
+__version__ = "2.1.1"
 
 LOGGER_NAME = "dynamodb_encryption_sdk"
 USER_AGENT_SUFFIX = "DynamodbEncryptionSdkPython/{}".format(__version__)