diff --git a/packages/middleware-sdk-s3/src/bucket-endpoint-middleware.ts b/packages/middleware-sdk-s3/src/bucket-endpoint-middleware.ts
new file mode 100644
index 0000000000000..58d19d0eec305
--- /dev/null
+++ b/packages/middleware-sdk-s3/src/bucket-endpoint-middleware.ts
@@ -0,0 +1,56 @@
+import {
+  HandlerExecutionContext,
+  MetadataBearer,
+  RelativeMiddlewareOptions,
+  SerializeHandler,
+  SerializeHandlerArguments,
+  SerializeHandlerOutput,
+  SerializeMiddleware,
+} from "@smithy/types";
+
+interface PreviouslyResolved {
+  bucketEndpoint?: boolean;
+}
+
+/**
+ * @internal
+ */
+export function bucketEndpointMiddleware(options: PreviouslyResolved): SerializeMiddleware<any, any> {
+  return <Output extends MetadataBearer>(
+      next: SerializeHandler<any, Output>,
+      context: HandlerExecutionContext
+    ): SerializeHandler<any, Output> =>
+    async (args: SerializeHandlerArguments<any>): Promise<SerializeHandlerOutput<Output>> => {
+      if (options.bucketEndpoint) {
+        const endpoint = context.endpointV2;
+        if (endpoint) {
+          const bucket: string | undefined = args.input.Bucket;
+          if (typeof bucket === "string") {
+            try {
+              const bucketEndpointUrl = new URL(bucket);
+              endpoint.url = bucketEndpointUrl;
+            } catch (e) {
+              const warning = `@aws-sdk/middleware-sdk-s3: bucketEndpoint=true was set but Bucket=${bucket} could not be parsed as URL.`;
+              if (context.logger?.constructor?.name === "NoOpLogger") {
+                console.warn(warning);
+              } else {
+                context.logger?.warn?.(warning);
+              }
+              throw e;
+            }
+          }
+        }
+      }
+      return next(args);
+    };
+}
+
+/**
+ * @internal
+ */
+export const bucketEndpointMiddlewareOptions: RelativeMiddlewareOptions = {
+  name: "bucketEndpointMiddleware",
+  override: true,
+  relation: "after",
+  toMiddleware: "endpointV2Middleware",
+};
diff --git a/packages/middleware-sdk-s3/src/middleware-sdk-s3.integ.spec.ts b/packages/middleware-sdk-s3/src/middleware-sdk-s3.integ.spec.ts
index 742c6348a4bbf..b94232466f6f0 100644
--- a/packages/middleware-sdk-s3/src/middleware-sdk-s3.integ.spec.ts
+++ b/packages/middleware-sdk-s3/src/middleware-sdk-s3.integ.spec.ts
@@ -57,5 +57,31 @@ describe("middleware-sdk-s3", () => {
 
       expect.hasAssertions();
     });
+
+    it("allows using a bucket input value as the endpoint", async () => {
+      const client = new S3({
+        region: "us-west-2",
+        bucketEndpoint: true,
+      });
+
+      requireRequestsFrom(client).toMatch({
+        query: { "x-id": "PutObject" },
+        protocol: "https:",
+        hostname: "mybucket.com",
+        port: 8888,
+        path: "/my-bucket-path/my-key",
+        headers: {
+          host: "mybucket.com:8888",
+        },
+      });
+
+      await client.putObject({
+        Bucket: "https://mybucket.com:8888/my-bucket-path",
+        Key: "my-key",
+        Body: "abcd",
+      });
+
+      expect.hasAssertions();
+    });
   });
 });
diff --git a/packages/middleware-sdk-s3/src/s3Configuration.ts b/packages/middleware-sdk-s3/src/s3Configuration.ts
index 5d79857a19f4d..4072a01dcaa4c 100644
--- a/packages/middleware-sdk-s3/src/s3Configuration.ts
+++ b/packages/middleware-sdk-s3/src/s3Configuration.ts
@@ -32,6 +32,10 @@ export interface S3InputConfig {
    * Identity provider for an S3 feature.
    */
   s3ExpressIdentityProvider?: S3ExpressIdentityProvider;
+  /**
+   * Whether to use the bucket name as the endpoint for this client.
+   */
+  bucketEndpoint?: boolean;
 }
 
 /**
@@ -54,6 +58,7 @@ export interface S3ResolvedConfig {
   disableMultiregionAccessPoints: boolean;
   followRegionRedirects: boolean;
   s3ExpressIdentityProvider: S3ExpressIdentityProvider;
+  bucketEndpoint: boolean;
 }
 
 export const resolveS3Config = <T>(
@@ -81,5 +86,6 @@ export const resolveS3Config = <T>(
           })
         )
       ),
+    bucketEndpoint: input.bucketEndpoint ?? false,
   };
 };
diff --git a/packages/middleware-sdk-s3/src/validate-bucket-name.spec.ts b/packages/middleware-sdk-s3/src/validate-bucket-name.spec.ts
index 0f70e83b80dce..b0864379f8814 100644
--- a/packages/middleware-sdk-s3/src/validate-bucket-name.spec.ts
+++ b/packages/middleware-sdk-s3/src/validate-bucket-name.spec.ts
@@ -11,7 +11,7 @@ describe("validateBucketNameMiddleware", () => {
   });
 
   it("throws error if Bucket parameter contains '/'", async () => {
-    const handler = validateBucketNameMiddleware()(mockNextHandler, {} as any);
+    const handler = validateBucketNameMiddleware({} as any)(mockNextHandler, {} as any);
     const bucket = "bucket/part/of/key";
     let error;
     try {
@@ -29,7 +29,7 @@ describe("validateBucketNameMiddleware", () => {
   });
 
   it("doesn't throw error if Bucket parameter has no '/'", async () => {
-    const handler = validateBucketNameMiddleware()(mockNextHandler, {} as any);
+    const handler = validateBucketNameMiddleware({} as any)(mockNextHandler, {} as any);
     const args = {
       input: {
         Bucket: "bucket",
@@ -42,7 +42,7 @@ describe("validateBucketNameMiddleware", () => {
 
   it("should not validate bucket name if the bucket name is an ARN", async () => {
     mockValidateArn.mockReturnValue(true);
-    const handler = validateBucketNameMiddleware()(mockNextHandler, {} as any);
+    const handler = validateBucketNameMiddleware({} as any)(mockNextHandler, {} as any);
     const args = {
       input: {
         Bucket: "arn:aws:s3:us-east-1:123456789012:accesspoint/myendpoint",
diff --git a/packages/middleware-sdk-s3/src/validate-bucket-name.ts b/packages/middleware-sdk-s3/src/validate-bucket-name.ts
index 85b8dfa144b6c..23fd863887c7b 100644
--- a/packages/middleware-sdk-s3/src/validate-bucket-name.ts
+++ b/packages/middleware-sdk-s3/src/validate-bucket-name.ts
@@ -9,16 +9,19 @@ import {
   Pluggable,
 } from "@smithy/types";
 
+import { bucketEndpointMiddleware, bucketEndpointMiddlewareOptions } from "./bucket-endpoint-middleware";
+import { S3ResolvedConfig } from "./s3Configuration";
+
 /**
  * @internal
  */
-export function validateBucketNameMiddleware(): InitializeMiddleware<any, any> {
+export function validateBucketNameMiddleware({ bucketEndpoint }: S3ResolvedConfig): InitializeMiddleware<any, any> {
   return <Output extends MetadataBearer>(next: InitializeHandler<any, Output>): InitializeHandler<any, Output> =>
     async (args: InitializeHandlerArguments<any>): Promise<InitializeHandlerOutput<Output>> => {
       const {
         input: { Bucket },
       } = args;
-      if (typeof Bucket === "string" && !validateArn(Bucket) && Bucket.indexOf("/") >= 0) {
+      if (!bucketEndpoint && typeof Bucket === "string" && !validateArn(Bucket) && Bucket.indexOf("/") >= 0) {
         const err = new Error(`Bucket name shouldn't contain '/', received '${Bucket}'`);
         err.name = "InvalidBucketName";
         throw err;
@@ -40,9 +43,9 @@ export const validateBucketNameMiddlewareOptions: InitializeHandlerOptions = {
 /**
  * @internal
  */
-// eslint-disable-next-line @typescript-eslint/no-unused-vars
-export const getValidateBucketNamePlugin = (unused: any): Pluggable<any, any> => ({
+export const getValidateBucketNamePlugin = (options: S3ResolvedConfig): Pluggable<any, any> => ({
   applyToStack: (clientStack) => {
-    clientStack.add(validateBucketNameMiddleware(), validateBucketNameMiddlewareOptions);
+    clientStack.add(validateBucketNameMiddleware(options), validateBucketNameMiddlewareOptions);
+    clientStack.addRelativeTo(bucketEndpointMiddleware(options), bucketEndpointMiddlewareOptions);
   },
 });
diff --git a/private/aws-client-api-test/src/client-interface-tests/client-s3/impl/initializeWithMaximalConfiguration.ts b/private/aws-client-api-test/src/client-interface-tests/client-s3/impl/initializeWithMaximalConfiguration.ts
index 7e9a37d9d0c4f..0944609ae18d8 100644
--- a/private/aws-client-api-test/src/client-interface-tests/client-s3/impl/initializeWithMaximalConfiguration.ts
+++ b/private/aws-client-api-test/src/client-interface-tests/client-s3/impl/initializeWithMaximalConfiguration.ts
@@ -116,6 +116,7 @@ export const initializeWithMaximalConfiguration = () => {
     disableS3ExpressSessionAuth: false,
     useGlobalEndpoint: false,
     signingEscapePath: false,
+    bucketEndpoint: false,
   };
 
   const s3 = new S3Client(config);