diff --git a/CHANGELOG.md b/CHANGELOG.md
index 029de8ae11..9e59564b94 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -28,6 +28,9 @@ A brief description of the categories of changes:
 * (gazelle): Update error messages when unable to resolve a dependency to be more human-friendly.
 
 ### Fixed
+* (whl_library): Remove `--no-index` and add `--no-build-isolation` to the
+  `pip install` command when installing a wheel from a local file, which happens
+  when `experimental_index_url` flag is used.
 * (bzlmod) get the path to the host python interpreter in a way that results in
   platform non-dependent hashes in the lock file when the requirement markers need
   to be evaluated.
diff --git a/examples/bzlmod/MODULE.bazel.lock b/examples/bzlmod/MODULE.bazel.lock
index e542f43b0a..4deef01be4 100644
--- a/examples/bzlmod/MODULE.bazel.lock
+++ b/examples/bzlmod/MODULE.bazel.lock
@@ -1231,7 +1231,7 @@
     },
     "@@rules_python~//python/extensions:pip.bzl%pip": {
       "general": {
-        "bzlTransitiveDigest": "iJtgc0fsxL6yWzjazyklge5csIWtbgQ8+wgW8P4jfL0=",
+        "bzlTransitiveDigest": "eWzi4IV0AzQ+cpVkMkdU/wOc7BUQdo0hAAQcCh8C4uU=",
         "usagesDigest": "MChlcSw99EuW3K7OOoMcXQIdcJnEh6YmfyjJm+9mxIg=",
         "recordedFileInputs": {
           "@@other_module~//requirements_lock_3_11.txt": "a7d0061366569043d5efcf80e34a32c732679367cb3c831c4cdc606adc36d314",
@@ -6140,7 +6140,7 @@
     },
     "@@rules_python~//python/private/pypi:pip.bzl%pip_internal": {
       "general": {
-        "bzlTransitiveDigest": "vTGpUAA3aBLYLx1iJ020kpJsuvO9GLbl11swsDXNKRI=",
+        "bzlTransitiveDigest": "RyEJxfGmNQVzqInjjGrR29yqfFPKe9DKgODI1mxd8wA=",
         "usagesDigest": "Y8ihY+R57BAFhalrVLVdJFrpwlbsiKz9JPJ99ljF7HA=",
         "recordedFileInputs": {
           "@@rules_python~//tools/publish/requirements.txt": "031e35d03dde03ae6305fe4b3d1f58ad7bdad857379752deede0f93649991b8a",
diff --git a/python/private/pypi/whl_library.bzl b/python/private/pypi/whl_library.bzl
index 2300eb3598..5b14151be6 100644
--- a/python/private/pypi/whl_library.bzl
+++ b/python/private/pypi/whl_library.bzl
@@ -227,8 +227,10 @@ def _whl_library_impl(rctx):
             whl_path = rctx.path(rctx.attr.filename)
         else:
             # It is an sdist and we need to tell PyPI to use a file in this directory
-            # and not use any indexes.
-            extra_pip_args.extend(["--no-index", "--find-links", "."])
+            # and, allow getting build dependencies from PYTHONPATH, which we
+            # setup in this repository rule, but still download any necessary
+            # build deps from PyPI (e.g. `flit_core`) if they are missing.
+            extra_pip_args.extend(["--no-build-isolation", "--find-links", "."])
 
     args = _parse_optional_attrs(rctx, args, extra_pip_args)
 
diff --git a/tests/pypi/evaluate_markers/BUILD.bazel b/tests/pypi/evaluate_markers/BUILD.bazel
deleted file mode 100644
index aba9264953..0000000000
--- a/tests/pypi/evaluate_markers/BUILD.bazel
+++ /dev/null
@@ -1,7 +0,0 @@
-load("@bazel_skylib//rules:build_test.bzl", "build_test")
-load("@dev_pip//:requirements.bzl", "all_whl_requirements")
-
-build_test(
-    name = "all_dev_wheels",
-    targets = all_whl_requirements,
-)
diff --git a/tests/pypi/integration/BUILD.bazel b/tests/pypi/integration/BUILD.bazel
new file mode 100644
index 0000000000..f846bfb124
--- /dev/null
+++ b/tests/pypi/integration/BUILD.bazel
@@ -0,0 +1,20 @@
+load("@bazel_skylib//rules:build_test.bzl", "build_test")
+load("@dev_pip//:requirements.bzl", "all_requirements")
+load(":transitions.bzl", "transition_rule")
+
+build_test(
+    name = "all_requirements_build_test",
+    targets = all_requirements,
+)
+
+# Rule that transitions dependencies to be built from sdist
+transition_rule(
+    name = "all_requirements_from_sdist",
+    testonly = True,
+    deps = all_requirements,
+)
+
+build_test(
+    name = "all_requirements_from_sdist_build_test",
+    targets = ["all_requirements_from_sdist"],
+)
diff --git a/tests/pypi/integration/transitions.bzl b/tests/pypi/integration/transitions.bzl
new file mode 100644
index 0000000000..b121446bb0
--- /dev/null
+++ b/tests/pypi/integration/transitions.bzl
@@ -0,0 +1,24 @@
+""" Define a custom transition that sets the pip_whl flag to no """
+
+def _flag_transition_impl(_settings, _ctx):
+    return {"//python/config_settings:pip_whl": "no"}
+
+flag_transition = transition(
+    implementation = _flag_transition_impl,
+    inputs = [],
+    outputs = ["//python/config_settings:pip_whl"],
+)
+
+# Define a rule that applies the transition to dependencies
+def _transition_rule_impl(_ctx):
+    return [DefaultInfo()]
+
+transition_rule = rule(
+    implementation = _transition_rule_impl,
+    attrs = {
+        "deps": attr.label_list(cfg = flag_transition),
+        "_allowlist_function_transition": attr.label(
+            default = "@bazel_tools//tools/allowlists/function_transition_allowlist",
+        ),
+    },
+)