diff --git a/tools/cellpose/cellpose.xml b/tools/cellpose/cellpose.xml
index 7f06f24f50..e264c55c54 100644
--- a/tools/cellpose/cellpose.xml
+++ b/tools/cellpose/cellpose.xml
@@ -1,8 +1,8 @@
-<tool id="cellpose" name="Run generalist cell and nucleus segmentation" version="@TOOL_VERSION@+galaxy@VERSION_SUFFIX@" profile="22.05">
+<tool id="cellpose" name="Run generalist cell and nucleus segmentation" version="@TOOL_VERSION@+galaxy@VERSION_SUFFIX@" profile="23.02">
     <description>with Cellpose</description>
     <macros>
         <token name="@TOOL_VERSION@">3.0.10</token>
-        <token name="@VERSION_SUFFIX@">0</token>
+        <token name="@VERSION_SUFFIX@">1</token>
         <xml name="channel">
             <option value="0" selected="true">grayscale/None</option>
             <option value="1">red</option>
@@ -76,40 +76,40 @@
             <param name="model_type" value="cyto"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
-            <output name="cp_mask" file="img02_cp_masks_cyto.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_cyto.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_cyto.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_cyto.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
             <param name="model_type" value="cyto2"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
-            <output name="cp_mask" file="img02_cp_masks_cyto2.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_cyto2.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_cyto2.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_cyto2.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
             <param name="model_type" value="cyto3"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
-            <output name="cp_mask" file="img02_cp_masks_cyto3.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_cyto3.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_cyto3.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_cyto3.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
             <param name="model_type" value="nuclei"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
-            <output name="cp_mask" file="img02_cp_masks_nuclei.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_nuclei.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_nuclei.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_nuclei.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
             <param name="model_type" value="cyto"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="1"/>
-            <output name="cp_mask" file="img02_cp_masks_chan.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_chan.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_chan.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_chan.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
@@ -117,8 +117,8 @@
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
             <param name="diameter" value="50"/>
-            <output name="cp_mask" file="img02_cp_masks_diameter.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_diameter.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_diameter.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_diameter.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="2">
             <param name="img_in" value="img02.png"/>
@@ -126,8 +126,8 @@
             <param name="model_type" value="cyto"/>
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
-            <output name="cp_mask" file="img02_cp_masks_gpu.tif" compare="sim_size" delta_frac="0.1"/>
-            <output name="cp_segm" file="img02_cp_segm_gpu.png" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_gpu.tif" compare="image_diff"/>
+            <output name="cp_segm" file="img02_cp_segm_gpu.png" compare="image_diff"/>
         </test>
         <test expect_num_outputs="1">
             <param name="img_in" value="img02.png"/>
@@ -135,7 +135,7 @@
             <param name="chan" value="2"/>
             <param name="chan2" value="3"/>
             <param name="show_segmentation" value="false"/>
-            <output name="cp_mask" file="img02_cp_masks_cyto.tif" compare="sim_size" delta_frac="0.1"/>
+            <output name="cp_mask" file="img02_cp_masks_cyto.tif" compare="image_diff"/>
         </test>
     </tests>
     <help>
diff --git a/tools/cellpose/test-data/img02_cp_masks_chan.tif b/tools/cellpose/test-data/img02_cp_masks_chan.tif
index 9f464800c8..cdd6c0d904 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_chan.tif and b/tools/cellpose/test-data/img02_cp_masks_chan.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_cyto.tif b/tools/cellpose/test-data/img02_cp_masks_cyto.tif
index cef28d1325..7766416725 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_cyto.tif and b/tools/cellpose/test-data/img02_cp_masks_cyto.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_cyto2.tif b/tools/cellpose/test-data/img02_cp_masks_cyto2.tif
index 7c6f6167b5..3e48bb42b0 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_cyto2.tif and b/tools/cellpose/test-data/img02_cp_masks_cyto2.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_cyto3.tif b/tools/cellpose/test-data/img02_cp_masks_cyto3.tif
index 904e1a98bb..7766416725 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_cyto3.tif and b/tools/cellpose/test-data/img02_cp_masks_cyto3.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_diameter.tif b/tools/cellpose/test-data/img02_cp_masks_diameter.tif
index 3bee0c4551..e1f72943e6 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_diameter.tif and b/tools/cellpose/test-data/img02_cp_masks_diameter.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_gpu.tif b/tools/cellpose/test-data/img02_cp_masks_gpu.tif
index cef28d1325..18d7510d56 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_gpu.tif and b/tools/cellpose/test-data/img02_cp_masks_gpu.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_masks_nuclei.tif b/tools/cellpose/test-data/img02_cp_masks_nuclei.tif
index 67d6d71ed2..8e07067908 100644
Binary files a/tools/cellpose/test-data/img02_cp_masks_nuclei.tif and b/tools/cellpose/test-data/img02_cp_masks_nuclei.tif differ
diff --git a/tools/cellpose/test-data/img02_cp_segm_chan.png b/tools/cellpose/test-data/img02_cp_segm_chan.png
index b72e861cd4..b4ed5e9099 100644
Binary files a/tools/cellpose/test-data/img02_cp_segm_chan.png and b/tools/cellpose/test-data/img02_cp_segm_chan.png differ
diff --git a/tools/cellpose/test-data/img02_cp_segm_cyto.png b/tools/cellpose/test-data/img02_cp_segm_cyto.png
index 9e29f6cb9f..a6809239a5 100644
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diff --git a/tools/cellpose/test-data/img02_cp_segm_cyto2.png b/tools/cellpose/test-data/img02_cp_segm_cyto2.png
index 77454dd0a9..be3df67223 100644
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diff --git a/tools/cellpose/test-data/img02_cp_segm_cyto3.png b/tools/cellpose/test-data/img02_cp_segm_cyto3.png
index 73d4ab1ba3..73ab3a7c91 100644
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diff --git a/tools/cellpose/test-data/img02_cp_segm_diameter.png b/tools/cellpose/test-data/img02_cp_segm_diameter.png
index abc6c7a483..dc99e1058c 100644
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diff --git a/tools/cellpose/test-data/img02_cp_segm_gpu.png b/tools/cellpose/test-data/img02_cp_segm_gpu.png
index 9500f2c079..2a85113729 100644
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diff --git a/tools/cellpose/test-data/img02_cp_segm_nuclei.png b/tools/cellpose/test-data/img02_cp_segm_nuclei.png
index b678ec2a44..a928b6294c 100644
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