diff --git a/data/templateGroups.json b/data/templateGroups.json
index 237813ea..14ddfb62 100644
--- a/data/templateGroups.json
+++ b/data/templateGroups.json
@@ -10,6 +10,8 @@
               ],
     "templates": [
       "Chem-treats-DoP.json",
+      "Chem-applied_to_treat-DoP.json",
+      "Chem-in_clinical_trials_for-DoP.json",
       "Chem-treats-PhenoOfDisease.json",
       "Chem-regulates,affects-Gene-biomarker,associated_condition-DoP.json"
     ]
diff --git a/data/templates/Drug-treats-Disease/Chem-applied_to_treat-DoP.json b/data/templates/Drug-treats-Disease/Chem-applied_to_treat-DoP.json
new file mode 100644
index 00000000..807c0487
--- /dev/null
+++ b/data/templates/Drug-treats-Disease/Chem-applied_to_treat-DoP.json
@@ -0,0 +1,31 @@
+{
+    "message": {
+        "query_graph": {
+            "nodes": {
+                "creativeQuerySubject": {
+                    "categories":["biolink:ChemicalEntity"]
+                },
+                "creativeQueryObject": {
+                    "categories":["biolink:DiseaseOrPhenotypicFeature"]
+               }
+            },
+            "edges": {
+                "eA": {
+                    "subject": "creativeQuerySubject",
+                    "object": "creativeQueryObject",
+                    "predicates": [
+                        "biolink:applied_to_treat"
+                    ],
+                    "attribute_constraints": [
+                        {
+                          "name": "evidence_count_constraint",
+                          "id": "biolink:evidence_count",
+                          "operator": ">",
+                          "value": 20
+                        }
+                    ]
+                }
+            }
+        }
+    }
+}
\ No newline at end of file
diff --git a/data/templates/Drug-treats-Disease/Chem-in_clinical_trials_for-DoP.json b/data/templates/Drug-treats-Disease/Chem-in_clinical_trials_for-DoP.json
new file mode 100644
index 00000000..44ff997a
--- /dev/null
+++ b/data/templates/Drug-treats-Disease/Chem-in_clinical_trials_for-DoP.json
@@ -0,0 +1,31 @@
+{
+    "message": {
+        "query_graph": {
+            "nodes": {
+                "creativeQuerySubject": {
+                    "categories":["biolink:ChemicalEntity"]
+                },
+                "creativeQueryObject": {
+                    "categories":["biolink:DiseaseOrPhenotypicFeature"]
+               }
+            },
+            "edges": {
+                "eA": {
+                    "subject": "creativeQuerySubject",
+                    "object": "creativeQueryObject",
+                    "predicates": [
+                        "biolink:applied_to_treat"
+                    ],
+                    "attribute_constraints": [
+                        {
+                          "id": "elevate_to_prediction",
+                          "name": "boolean_make_prediction_constraint",
+                          "operator": "==",
+                          "value": "True"
+                        }
+                    ]
+                }
+            }
+        }
+    }
+}
\ No newline at end of file
diff --git a/data/templates/Drug-treats-Disease/Chem-treats-DoP.json b/data/templates/Drug-treats-Disease/Chem-treats-DoP.json
index 663d467b..c99917aa 100644
--- a/data/templates/Drug-treats-Disease/Chem-treats-DoP.json
+++ b/data/templates/Drug-treats-Disease/Chem-treats-DoP.json
@@ -13,7 +13,9 @@
                 "eA": {
                     "subject": "creativeQuerySubject",
                     "object": "creativeQueryObject",
-                    "predicates": ["biolink:treats_or_applied_or_studied_to_treat"]
+                    "predicates": [
+                        "biolink:treats"
+                    ]
                 }
             }
         }