diff --git a/app/extensions/brave/content/scripts/navigator.js b/app/extensions/brave/content/scripts/navigator.js
index 02bf81fe8af..40da1665c81 100644
--- a/app/extensions/brave/content/scripts/navigator.js
+++ b/app/extensions/brave/content/scripts/navigator.js
@@ -27,3 +27,13 @@ if (chrome.contentSettings.ads == 'block') {
 
 // Spectre hotfix (https://github.com/brave/browser-laptop/issues/12570)
 chrome.webFrame.setGlobal('window.SharedArrayBuffer', false)
+
+if (chrome.contentSettings.mediaPermission == 'block') {
+  // Needed for https://github.com/brave/browser-laptop/issues/14889
+  // Note this is not necessary in non-Electron-based codebases since Chromium
+  // automatically handles the permission for device enumeration.
+  // Also: chromium doesn't have mediaPermission in content setting. It is actually
+  // microphone && camera in chromium.
+  executeScript("window.MediaDeviceInfo.prototype.__defineGetter__('label', () => { return '' })")
+  executeScript("window.InputDeviceInfo.prototype.__defineGetter__('label', () => { return '' })")
+}
diff --git a/js/state/contentSettings.js b/js/state/contentSettings.js
index 0c9b249cede..fae51e527b0 100644
--- a/js/state/contentSettings.js
+++ b/js/state/contentSettings.js
@@ -90,6 +90,10 @@ const getDefaultUserPrefContentSettings = (braveryDefaults, appSettings, appConf
       setting: getSetting(settings.DO_NOT_TRACK, appSettings) ? 'allow' : 'block',
       primaryPattern: '*'
     }],
+    mediaPermission: [{
+      setting: 'block',
+      primaryPattern: '*'
+    }],
     passwordManager: getDefaultPasswordManagerSettings(braveryDefaults, appSettings, appConfig),
     javascript: [{
       setting: braveryDefaults.get('noScript') ? 'block' : 'allow',
@@ -280,10 +284,12 @@ const siteSettingsToContentSettings = (currentSiteSettings, defaultContentSettin
         }
       })
     }
-    if (typeof siteSetting.get('runInsecureContent') === 'boolean') {
-      contentSettings = addContentSettings(contentSettings, 'runInsecureContent', primaryPattern, '*',
-        siteSetting.get('runInsecureContent') ? 'allow' : 'block')
-    }
+    ['runInsecureContent', 'autoplay', 'mediaPermission'].forEach((permission) => {
+      if (typeof siteSetting.get(permission) === 'boolean') {
+        contentSettings = addContentSettings(contentSettings, permission, primaryPattern, '*',
+          siteSetting.get(permission) ? 'allow' : 'block')
+      }
+    })
     if (siteSetting.get('cookieControl')) {
       if (siteSetting.get('cookieControl') === 'block3rdPartyCookie') {
         contentSettings = addContentSettings(contentSettings, 'cookies', primaryPattern, '*', 'block')
@@ -323,9 +329,6 @@ const siteSettingsToContentSettings = (currentSiteSettings, defaultContentSettin
     if (typeof siteSetting.get('widevine') === 'number' && braveryDefaults.get('widevine')) {
       contentSettings = addContentSettings(contentSettings, 'plugins', primaryPattern, '*', 'allow', appConfig.widevine.resourceId)
     }
-    if (typeof siteSetting.get('autoplay') === 'boolean') {
-      contentSettings = addContentSettings(contentSettings, 'autoplay', primaryPattern, '*', siteSetting.get('autoplay') ? 'allow' : 'block')
-    }
   })
   // On the second pass we consider only shieldsUp === false settings since we want those to take precedence.
   currentSiteSettings.forEach((siteSetting, hostPattern) => {