diff --git a/python/pyspark/pandas/tests/indexes/test_base.py b/python/pyspark/pandas/tests/indexes/test_base.py
index 958314c5741ff..e3e9272a33af6 100644
--- a/python/pyspark/pandas/tests/indexes/test_base.py
+++ b/python/pyspark/pandas/tests/indexes/test_base.py
@@ -25,6 +25,7 @@
 
 import pyspark.pandas as ps
 from pyspark.pandas.exceptions import PandasNotImplementedError
+from pyspark.pandas.exceptions import SparkPandasNotImplementedError
 from pyspark.pandas.missing.indexes import (
     MissingPandasLikeDatetimeIndex,
     MissingPandasLikeIndex,
@@ -65,6 +66,14 @@ def test_index_basic(self):
         with self.assertRaisesRegexp(ValueError, "The truth value of a Int64Index is ambiguous."):
             bool(ps.Index([1]))
 
+        # Negative
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.Index([1, '2'])
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.Index([[1, '2'], ['A', 'B']])
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.Index([[1, 'A'], [2, 'B']])
+
     def test_index_from_series(self):
         pser = pd.Series([1, 2, 3], name="a", index=[10, 20, 30])
         psser = ps.from_pandas(pser)
diff --git a/python/pyspark/pandas/tests/test_dataframe.py b/python/pyspark/pandas/tests/test_dataframe.py
index 1361c44404a3d..35af21fdc7d99 100644
--- a/python/pyspark/pandas/tests/test_dataframe.py
+++ b/python/pyspark/pandas/tests/test_dataframe.py
@@ -33,6 +33,7 @@
 from pyspark import pandas as ps
 from pyspark.pandas.config import option_context
 from pyspark.pandas.exceptions import PandasNotImplementedError
+from pyspark.pandas.exceptions import SparkPandasNotImplementedError
 from pyspark.pandas.frame import CachedDataFrame
 from pyspark.pandas.missing.frame import _MissingPandasLikeDataFrame
 from pyspark.pandas.typedef.typehints import (
@@ -116,6 +117,14 @@ def test_creation_index(self):
         with self.assertRaisesRegex(TypeError, err_msg):
             ps.DataFrame([1, 2], index=ps.MultiIndex.from_tuples([(1, 3), (2, 4)]))
 
+        # Negative
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.DataFrame([1, 2], index=[1, '2'])
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.DataFrame([1, 2], index=[[1, '2'], ['A', 'B']])
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.DataFrame([1, 2], index=[[1, 'A'], [2, 'B']])
+
     def _check_extension(self, psdf, pdf):
         if LooseVersion("1.1") <= LooseVersion(pd.__version__) < LooseVersion("1.2.2"):
             self.assert_eq(psdf, pdf, check_exact=False)
diff --git a/python/pyspark/pandas/tests/test_series.py b/python/pyspark/pandas/tests/test_series.py
index 144df0f986a70..229659d7ff077 100644
--- a/python/pyspark/pandas/tests/test_series.py
+++ b/python/pyspark/pandas/tests/test_series.py
@@ -36,6 +36,7 @@
 )
 from pyspark.testing.sqlutils import SQLTestUtils
 from pyspark.pandas.exceptions import PandasNotImplementedError
+from pyspark.pandas.exceptions import SparkPandasNotImplementedError
 from pyspark.pandas.missing.series import MissingPandasLikeSeries
 from pyspark.pandas.typedef.typehints import (
     extension_dtypes,
@@ -3325,6 +3326,11 @@ def test_transform(self):
         ):
             psser.transform(lambda x: x + 1, axis=1)
 
+    def test_series_creation(self):
+        # Negative
+        with self.assertRaises(SparkPandasNotImplementedError):
+            ps.Series([1, 2, '3'])
+
 
 if __name__ == "__main__":
     from pyspark.pandas.tests.test_series import *  # noqa: F401
diff --git a/python/pyspark/pandas/typedef/typehints.py b/python/pyspark/pandas/typedef/typehints.py
index 8a32a14b64e72..664fda93285f7 100644
--- a/python/pyspark/pandas/typedef/typehints.py
+++ b/python/pyspark/pandas/typedef/typehints.py
@@ -32,6 +32,8 @@
 from pandas.api.types import CategoricalDtype, pandas_dtype  # type: ignore[attr-defined]
 from pandas.api.extensions import ExtensionDtype
 
+from pyspark.pandas.exceptions import SparkPandasNotImplementedError
+
 extension_dtypes: Tuple[type, ...]
 try:
     from pandas import Int8Dtype, Int16Dtype, Int32Dtype, Int64Dtype
@@ -357,7 +359,18 @@ def infer_pd_series_spark_type(
         elif hasattr(pser.iloc[0], "__UDT__"):
             return pser.iloc[0].__UDT__
         else:
-            return from_arrow_type(pa.Array.from_pandas(pser).type, prefer_timestamp_ntz)
+            try:
+                internal_frame = pa.Array.from_pandas(pser)
+            except (pa.lib.ArrowInvalid, pa.lib.ArrowTypeError):
+                raise SparkPandasNotImplementedError(
+                    description="PySpark requires elements of homogeneous type for DataFrame, "
+                                "Series and Index, such as .Object([typeA, typeB]), which is "
+                                "supported by Pandas, but not in PySpark, you need to keep the "
+                                "values as the same dtype in PySpark. "
+                                "Got {} and dtype ({}).".format(
+                                    str(pser.values), str(pser.dtypes))
+                )
+            return from_arrow_type(internal_frame.type, prefer_timestamp_ntz)
     elif isinstance(dtype, CategoricalDtype):
         if isinstance(pser.dtype, CategoricalDtype):
             return as_spark_type(pser.cat.codes.dtype, prefer_timestamp_ntz=prefer_timestamp_ntz)