diff --git a/README.md b/README.md
index d227677..be06bdd 100644
--- a/README.md
+++ b/README.md
@@ -73,6 +73,7 @@ To run the tests:
 - [expect_table_column_count_to_be_between](#expect_table_column_count_to_be_between)
 - [expect_table_column_count_to_equal_other_table](#expect_table_column_count_to_equal_other_table)
 - [expect_table_column_count_to_equal](#expect_table_column_count_to_equal)
+- [expect_table_columns_to_not_contain_set](#expect_table_columns_to_not_contain_set)
 - [expect_table_columns_to_contain_set](#expect_table_columns_to_contain_set)
 - [expect_table_columns_to_match_ordered_list](#expect_table_columns_to_match_ordered_list)
 - [expect_table_columns_to_match_set](#expect_table_columns_to_match_set)
@@ -225,6 +226,20 @@ models: # or seeds:
         compare_model: ref("other_model")
 ```
 
+### [expect_table_columns_to_not_contain_set](macros/schema_tests/table_shape/expect_table_columns_to_not_contain_set.sql)
+
+Expect the columns in a model not to contain a given list.
+
+*Applies to:* Model, Seed, Source
+
+```yaml
+models: # or seeds:
+  - name: my_model
+    tests:
+    - dbt_expectations.expect_table_columns_to_not_contain_set:
+        column_list: ["col_a", "col_b"]
+        transform: uppper # (Optional)
+```
 ### [expect_table_columns_to_contain_set](macros/schema_tests/table_shape/expect_table_columns_to_contain_set.sql)
 
 Expect the columns in a model to contain a given list.
diff --git a/integration_tests/models/schema_tests/schema.yml b/integration_tests/models/schema_tests/schema.yml
index 8a1d6bb..125302f 100644
--- a/integration_tests/models/schema_tests/schema.yml
+++ b/integration_tests/models/schema_tests/schema.yml
@@ -166,6 +166,8 @@ models:
             column_list: ["idx", "date_col", "col_numeric_a", "col_numeric_b", "col_string_a", "col_string_b", "col_null"]
         - dbt_expectations.expect_table_column_count_to_equal_other_table:
             compare_model: ref("data_test")
+        - dbt_expectations.expect_table_columns_to_not_contain_set:
+            column_list: ["col_numeric_c", "col_string_d"]
         - dbt_expectations.expression_is_true:
             expression: (col_numeric_a + col_numeric_b = 1)
         - dbt_expectations.equal_expression:
diff --git a/macros/schema_tests/table_shape/expect_table_columns_to_not_contain_set.sql b/macros/schema_tests/table_shape/expect_table_columns_to_not_contain_set.sql
new file mode 100644
index 0000000..a6f3bea
--- /dev/null
+++ b/macros/schema_tests/table_shape/expect_table_columns_to_not_contain_set.sql
@@ -0,0 +1,28 @@
+{%- test expect_table_columns_to_not_contain_set(model, column_list, transform="upper") -%}
+{%- if execute -%}
+    {%- set column_list = column_list | map(transform) | list -%}
+    {%- set relation_column_names = dbt_expectations._get_column_list(model, transform) -%}
+    {%- set matching_columns = dbt_expectations._list_intersect(column_list, relation_column_names) -%}
+    with relation_columns as (
+
+        {% for col_name in relation_column_names %}
+        select cast('{{ col_name }}' as {{ dbt_utils.type_string() }}) as relation_column
+        {% if not loop.last %}union all{% endif %}
+        {% endfor %}
+    ),
+    input_columns as (
+
+        {% for col_name in column_list %}
+        select cast('{{ col_name }}' as {{ dbt_utils.type_string() }}) as input_column
+        {% if not loop.last %}union all{% endif %}
+        {% endfor %}
+    )
+    -- catch any column in input list that is in the list of table columns
+    select *
+    from
+        input_columns i
+        inner join
+        relation_columns r on r.relation_column = i.input_column
+
+{%- endif -%}
+{%- endtest -%}