diff --git a/hsf/_cache.py b/hsf/_cache.py
new file mode 100644
index 0000000..9df77f5
--- /dev/null
+++ b/hsf/_cache.py
@@ -0,0 +1,51 @@
+"""Handling of cache files."""
+
+import logging
+import tempfile
+from shutil import rmtree
+
+from rich.logging import RichHandler
+
+FORMAT = "%(message)s"
+logging.basicConfig(level="NOTSET",
+                    format=FORMAT,
+                    datefmt="[%X]",
+                    handlers=[RichHandler()])
+
+log = logging.getLogger(__name__)
+
+
+def handle_cache(func: callable):
+    """
+    Decorator to handle cache files.
+    Fixes https://github.com/ANTsX/ANTsPy/issues/117
+
+    Args:
+        func (callable): Function to decorate.
+
+    Returns:
+        callable: Decorated function.
+    """
+
+    def cache(*args, **kwargs):
+        """
+        Wrapper for the function.
+
+        Args:
+            *args: Positional arguments.
+            **kwargs: Keyword arguments.
+
+        Returns:
+            callable: Function to decorate.
+        """
+        cache_dir = tempfile.mkdtemp()
+
+        log.debug(f"Caching in ANTs' files in {cache_dir}")
+
+        kwargs["outprefix"] = cache_dir
+        try:
+            return func(*args, **kwargs)
+        finally:
+            rmtree(cache_dir)
+
+    return cache
diff --git a/hsf/roiloc_wrapper.py b/hsf/roiloc_wrapper.py
index 816664d..9140dc0 100644
--- a/hsf/roiloc_wrapper.py
+++ b/hsf/roiloc_wrapper.py
@@ -7,6 +7,8 @@
 from rich.logging import RichHandler
 from roiloc.locator import RoiLocator
 
+from ._cache import handle_cache
+
 FORMAT = "%(message)s"
 logging.basicConfig(level="NOTSET",
                     format=FORMAT,
@@ -58,9 +60,11 @@ def get_mri(mri: PosixPath, mask_pattern: Optional[str] = None) -> tuple:
     return ants.image_read(str(mri)), mask
 
 
+@handle_cache
 def get_hippocampi(mri: ants.ANTsImage,
                    roiloc_cfg: DictConfig,
-                   mask: Optional[ants.ANTsImage] = None) -> tuple:
+                   mask: Optional[ants.ANTsImage] = None,
+                   outprefix: str = "") -> tuple:
     """
     Locate right and left hippocampi from a given mri.
 
@@ -69,6 +73,7 @@ def get_hippocampi(mri: ants.ANTsImage,
         roiloc_cfg (DictConfig): Roiloc configuration.
             See `github.com/clementpoiret/ROILoc` for more information.
         mask (ants.ANTsImage, optional): Loaded mask.
+        outprefix (str, optional): Prefix for ANTs temp files.
 
     Returns:
         RoiLocator: fitted roilocator.
@@ -76,8 +81,7 @@ def get_hippocampi(mri: ants.ANTsImage,
         left_mri (ants.ANTsImage): Left hippocampus.
     """
     locator = RoiLocator(**roiloc_cfg, mask=mask)
-
-    right_mri, left_mri = locator.fit_transform(mri)
+    right_mri, left_mri = locator.fit_transform(mri, outprefix=outprefix)
 
     return locator, right_mri, left_mri
 
diff --git a/pyproject.toml b/pyproject.toml
index 9bef26a..9763f0c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -22,7 +22,7 @@ deepsparse_support = 'hsf.engines:print_deepsparse_support'
 [tool.poetry.dependencies]
 python = "^3.7.1"
 torchio = "^0.18.56"
-roiloc = "^0.2.7"
+roiloc = "^0.2.8"
 onnxruntime = "^1.8.1"
 hydra-core = "^1.1.1"
 wget = "^3.2"