diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6f1305d44..956b811a7 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## master (unreleased)
 
+### Changes
+
+- [#3521](https://github.com/clojure-emacs/cider/issues/3521): Expand `cider-clojure-compilation-regexp` to also match e.g. `Unexpected error (ExceptionInfo) macroexpanding defmulti at (src/ns.clj:1:1).`.
+
 ## 1.8.2 (2023-10-15)
 
 ### Changes
diff --git a/cider-eval.el b/cider-eval.el
index 360866a73..2f7745d6d 100644
--- a/cider-eval.el
+++ b/cider-eval.el
@@ -558,19 +558,31 @@ It delegates the actual error content to the eval or op handler."
 ;; old and the new format, by utilizing a combination of two different regular
 ;; expressions.
 
-(defconst cider-clojure-1.10-error `(sequence
-                                     "Syntax error "
-                                     (minimal-match (zero-or-more anything))
-                                     (or "compiling "
-                                         "macroexpanding "
-                                         "reading source ")
-                                     (minimal-match (zero-or-more anything))
-                                     "at ("
-                                     (group-n 2 (minimal-match (zero-or-more anything)))
-                                     ":"
-                                     (group-n 3 (one-or-more digit))
-                                     (optional ":" (group-n 4 (one-or-more digit)))
-                                     ")."))
+(defconst cider-clojure-1.10--location `("at ("
+                                         (group-n 2 (minimal-match (zero-or-more anything)))
+                                         ":"
+                                         (group-n 3 (one-or-more digit))
+                                         (optional ":" (group-n 4 (one-or-more digit)))
+                                         ")."))
+
+(defconst cider-clojure-1.10-error (append `(sequence
+                                             "Syntax error "
+                                             (minimal-match (zero-or-more anything))
+                                             (or "compiling "
+                                                 "macroexpanding "
+                                                 "reading source ")
+                                             (minimal-match (zero-or-more anything)))
+                                           cider-clojure-1.10--location))
+
+(defconst cider-clojure-unexpected-error (append `(sequence
+                                                   "Unexpected error ("
+                                                   (minimal-match (one-or-more anything))
+                                                   ") "
+                                                   (or "compiling "
+                                                       "macroexpanding "
+                                                       "reading source ")
+                                                   (minimal-match (one-or-more anything)))
+                                                 cider-clojure-1.10--location))
 
 (defconst cider-clojure-1.9-error `(sequence
                                     (zero-or-more anything)
@@ -591,23 +603,19 @@ It delegates the actual error content to the eval or op handler."
                                   (optional ":" (group-n 4 (one-or-more digit)))
                                   " - "))
 
-
 (defconst cider-clojure-compilation-regexp
   (eval
    `(rx bol (or ,cider-clojure-1.9-error
                 ,cider-clojure-warning
-                ,cider-clojure-1.10-error))
+                ,cider-clojure-1.10-error
+                ,cider-clojure-unexpected-error))
    t)
   "A few example values that will match:
 \"Reflection warning, /tmp/foo/src/foo/core.clj:14:1 - \"
 \"CompilerException java.lang.RuntimeException: Unable to resolve symbol: \\
 lol in this context, compiling:(/foo/core.clj:10:1)\"
-\"Syntax error compiling at (src/workspace_service.clj:227:3).\"")
-
-(replace-regexp-in-string cider-clojure-compilation-regexp
-                          ""
-                          "Reflection warning, /tmp/foo/src/foo/core.clj:14:1 - call to java.lang.Integer ctor can't be resolved.")
-
+\"Syntax error compiling at (src/workspace_service.clj:227:3).\"
+\"Unexpected error (ClassCastException) macroexpanding defmulti at (src/haystack/parser.cljc:21:1).\"")
 
 (defvar cider-compilation-regexp
   (list cider-clojure-compilation-regexp  2 3 4 '(1))
diff --git a/doc/modules/ROOT/pages/usage/dealing_with_errors.adoc b/doc/modules/ROOT/pages/usage/dealing_with_errors.adoc
index 000707195..82bfd72c8 100644
--- a/doc/modules/ROOT/pages/usage/dealing_with_errors.adoc
+++ b/doc/modules/ROOT/pages/usage/dealing_with_errors.adoc
@@ -23,6 +23,8 @@ temporary overlay or in the echo area:
 (setq cider-show-error-buffer nil)
 ----
 
+NOTE: you will only see the overlay if `cider-use-overlays` is non-nil.
+
 Starting from CIDER 1.8.0, only runtime exceptions (and not compilation errors)
 will cause a stacktrace buffer to be shown. This better follows Clojure 1.10's
 https://clojure.org/reference/repl_and_main#_at_repl[intended semantics].
diff --git a/test/cider-error-parsing-tests.el b/test/cider-error-parsing-tests.el
index a73e08005..d53e823d5 100644
--- a/test/cider-error-parsing-tests.el
+++ b/test/cider-error-parsing-tests.el
@@ -135,4 +135,10 @@
       (expect clojure-1.10-compiler-error :to-match cider-clojure-compilation-regexp)
       (expect (progn (string-match cider-clojure-compilation-regexp clojure-1.10-compiler-error)
                      (match-string 2 clojure-1.10-compiler-error))
-              :to-equal "src/ardoq/service/workspace_service.clj"))))
+              :to-equal "src/ardoq/service/workspace_service.clj")))
+  (it "Recognizes a clojure 'Unexpected error' message"
+    (let ((clojure-1.10-compiler-error "Unexpected error (ClassCastException) macroexpanding defmulti at (src/haystack/parser.cljc:21:1)."))
+      (expect clojure-1.10-compiler-error :to-match cider-clojure-compilation-regexp)
+      (expect (progn (string-match cider-clojure-compilation-regexp clojure-1.10-compiler-error)
+                     (match-string 2 clojure-1.10-compiler-error))
+              :to-equal "src/haystack/parser.cljc"))))